Abstract:
BACKGROUND:Immunoglobulin (Ig)G4-related disease is classified as an immune-mediated disease. The etiology of this condition has not been explained to date. Manifestations of the disease are diverse, and simultaneous involvement of multiple organs is not unusual. CASE REPORT:We report the case of a patient referred to us after multiple unsuccessful paranasal sinus operations who presented with enophthalmos and a resultant migratory keratitis with a suspected diagnosis of silent sinus syndrome. Preservation of the orbit was no longer feasible. After five years without a definitive diagnosis, we ascertained that this was a case of IgG4-related disease. DISCUSSION:IgG4-related disease represents an important element in the differential diagnosis of chronic advanced diseases of the orbit and paranasal sinuses. The diagnosis should be considered in the case of unclear disease presentations. Typical histological findings include a storiform pattern of fibrosis, vasculopathy, and tissue infiltration by IgG4 plasma cells. ZUSAMMENFASSUNG:HINTERGRUND: Mit Immunglobulin (Ig)G4 assoziierte Erkrankungen werden als immunvermittelte Erkrankungen klassifiziert. Die Ätiologie dieser Krankheiten ist bisher noch nicht geklärt. Sie manifestieren sich auf verschiedene Weise, und die gleichzeitige Beteiligung mehrerer Organe ist nicht ungewöhnlich. KASUISTIK:Es wird der Fall eines Patienten vorgestellt, der in die Klinik der Autoren überwiesen wurde, nachdem mehrere erfolglose Nasennebenhöhlenoperationen bei ihm durchgeführt worden waren; bei Vorliegen eines Enophthalmus und einer resultierenden Durchwanderungskeratitis bestand die Verdachtsdiagnose eines Silent-Sinus-Syndroms. Der Erhalt der Orbita war nicht mehr möglich. Nach 5 Jahren ohne definitive Diagnose wurde nun die Diagnose einer IgG4-assoziierten Erkrankung gesichert. DISKUSSION:IgG4-assoziierte Erkrankungen stellen einen wichtigen Baustein bei der Differenzialdiagnose chronischer fortgeschrittener Erkrankungen der Orbita und der Nasennebenhöhlen dar. Bei unklaren Krankheitszeichen sollte diese Diagnose in Erwägung gezogen werden. Zu den typischen histologischen Befunden gehören ein storiformes Muster der Fibrose, Vaskulopathie und Gewebeinfiltration durch IgG4-Plasmazellen.
journal_name
HNOjournal_title
HNOauthors
Jurkov M,Olze H,Klauschen F,Bertelmann E,Schneider U,Arens Pdoi
10.1007/s00106-019-00798-9subject
Has Abstractpub_date
2020-11-01 00:00:00pages
864-868issue
11eissn
0017-6192issn
1433-0458pii
10.1007/s00106-019-00798-9journal_volume
68pub_type
杂志文章,评审相关文献
HNO文献大全abstract::Pretherapeutic staging is essential for the management of head and neck cancer. The diagnostic value of liver, brain and bone scanning was estimated by a retrospective study of 281 patients. Bone and liver scans are useful for detecting distant metastases from head and neck cancer. Brain scanning should be replaced by...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1988-11-01 00:00:00
abstract::For the medicolegal assessment of vestibular disorders, vestibulospinal tests are necessary. A minimum program includes the Romberg test, the Unterberger stepping test, and walking with eyes closed. When positive results are found, semi-quantitative evaluation is possible. However, this value is less important than is...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1981-05-01 00:00:00
abstract::Four low-vacuum systems and 6 high-vacuum systems were examined concerning their pressure-volume relationships. For each type the maximum filling volume for sufficient drainage of wound secretions was determined. The use of a wound fluid substitute instead of water resulted in a lower aspiration volume. Enlargement of...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
abstract::Using the European-American classification criteria the diagnosis of autoimmune sialadenitis in Sjögren's syndrome can generally be easily established or excluded. In addition, sonography performed by the ENT physician is helpful in diagnosing and especially in follow-up screening for MALT lymphomas, which 5%-10% of p...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-009-2074-1
更新日期:2010-03-01 00:00:00
abstract::In a series of 390 cases with suspicion of acoustic neurinomas 78 such tumors could be diagnosed, including 12 early stage neurinomas. This relatively high detection quote of small neurinomas is due to a special diagnostical programme: Every patient with unilateral and sensorineural hearing loss, independent of vertig...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1981-11-01 00:00:00
abstract::Color-coded duplex sonography is being increasingly used in the head and neck as another method for diagnosis of such disorders as stenosis of arteries or veins or hemangiomas. A possible additional advantage of testing is the ability to differentiate benign from malignant tumors. Since the underlying cause of a suspi...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s001060050073
更新日期:1996-12-01 00:00:00
abstract::Two cases of Sipple's syndrome with the typical signs of medullary carcinoma of the thyroid, pheochromecytoma and parathyroid adenoma are presented. Cushing's disease and marfanoid habitus were demonstrated. They are classified as multiple endocrine adenopathy type 2A and 2B according to the modern nomenclature. ...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract::Up to 80 % of children can develop otitis media with effusion (OME) between birth and school age. Responsible are longstanding impairments of tubal ventilation which are based primarily on mechanical or functional obstructions. A quarter of the subjects affected by OME show either recurrent episodes over 3 months or p...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-013-2700-9
更新日期:2013-10-01 00:00:00
abstract::The diagnosis of foreign bodies in the gastrointestinal (G-I) tract can sometimes be difficult. Esophageal foreign bodies are dangerous and should be extracted as soon as possible whereas foreign bodies in the stomach usually pass through the GI-tract without complications. Exceptions are large, sharp or potentially t...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-012-2488-z
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Comorbid physical and psychological complaints are more common in patients with dysphonia than in the general population. In a prospective randomized study the effects of structured psychosomatic diagnostics and verbal intervention on the satisfaction of patients with dysphonia were investigated. MATERIALS ...
journal_title:HNO
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00106-009-1949-5
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Counselling is a basic psychological intervention for chronic tinnitus the effectiveness of which has not yet been evaluated. SCIENTIFIC QUESTION:The therapeutic effect of counselling was compared to that of a self-help manual. Outcome was analysed for tinnitus disability, tendency to become chronic, and ac...
journal_title:HNO
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00106-005-1350-y
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:In contrast to alcohol- and nicotine-induced head and neck tumors, human papillomavirus (HPV)-positive oropharyngeal carcinoma rather affects younger patients, and the incidence of this entity is continuously increasing. Due to the significantly better prognosis of HPV-positive oropharyngeal carcinoma, vario...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-020-00955-5
更新日期:2020-10-13 00:00:00
abstract::Although fibrin glues have been successful in many areas of surgery, they have not become fully established in nerve anastomosis, even in ENT surgery, an area where significant advantages were expected. As the fibrin clot dissolves prematurely, and dehiscences follow, antifibrinolytic substances must be added to the a...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1989-06-01 00:00:00
abstract::The detailed evaluation of anatomy and pathology of the temporal bone requires imaging modalities that are superior to plain x-ray films. Conventional polytomography has today largely been replaced by high-resolution CT. High-resolution CT provides excellent demonstration of the delicate bony structures and provides s...
journal_title:HNO
pub_type: 杂志文章,评审
doi:
更新日期:1988-03-01 00:00:00
abstract::The various stages of tumor growth are characterized by typical epithelial, vascular, and secondary connective tissue changes. Narrow Band Imaging (NBI) endoscopy is a minimally invasive imaging technique that presents vascular structures in particular at a higher contrast than white light endoscopy alone. In combinat...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-016-0284-x
更新日期:2017-01-01 00:00:00
abstract::We carried out a transnasal insufflation test according to Blom and Singer on 27 laryngectomy patients as well as a speech communications test with the help of reverse speech audiometry, i.e. the post laryngectomy telephone test according to Zenner and Pfrang. The combined evaluation of both tests provided basic infor...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00
abstract::The current adjustment of cochlear implant (CI) speech processors is based on a knowledge of the lower and upper limits (T- and C-levels) for electrical stimulus currents. These data are usually acquired from subjective classifications of individual patients. In cases with non-reliable patient responses, objective met...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s001060050304
更新日期:1998-08-01 00:00:00
abstract::The large number of craniocerebral injuries with fractured bones entails an essential field of diagnostic and therapeutic activities for the hospital-based otorhinolaryngologist. It is only with the active involvement of experienced clinicians that paranasal sinuses can be inspected, lesions of the dura mater closed a...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:High doses of acetylsalicylic acid (ASS) induce tinnitus and hearing loss. This ototoxic side effect of ASS is characterized by a decrease in spontaneous and evoked otoacoustic emissions. A decrease in otoacoustic emissions is found not only in mammals, but also in non-mammalian ears without electromotile ou...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-005-1358-3
更新日期:2006-09-01 00:00:00
abstract::From 1988 to 1994, 75 patients with congenital aural atresias were operated on at the University ENT Department, Würzburg. Sixty-two patients (70 ears) could be followed up in their postoperative outcomes. The surgical approach used in all patients was a direct one through the atresia plate. To avoid infection and ste...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
abstract::The current paper reports on a patient with recurrent rotational vertigo and persistent dizziness and imbalance lasting weeks, who underwent extensive neurootological and radiological examination. Pathological findings initially included right-sided benign paroxysmal positional vertigo (BPPV), persistent horizontal sp...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-016-0316-6
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:In pre-school children suffering from pure non-inflammatory hyperplasia of the tonsils, tonsillotomy has recently been recommended in preference to tonsillectomy. Absence of inflammatory tonsillitis in the previous medical history is accepted as evidence that tonsillotomy is indicated. In this study, we ther...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-007-1544-6
更新日期:2007-12-01 00:00:00
abstract::Serum vitamin A levels of 104 patients with head and neck cancer were analysed and compared with those of 74 normal subjects (standard values 1.1-3.7 micromol/l). Lower values of vitamin A (0.91 +/- 0.33-1.37 +/- 0.99) were found 2.4 times oftener in patients with stage III and IV disease. We were unable to determine ...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1988-09-01 00:00:00
abstract::The Groningen voice prosthesis is a self-retaining silicone device, placed in the tracheooesophageal wall as a primary procedure during laryngectomy or some time after surgery. Prosthetic vocal rehabilitation was successful in 80% of the patients. Indications, contra-indications, advantages, disadvantages and complica...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND:Patients with single-sided deafness (SSD) are limited by their asymmetric hearing in various areas of everyday life. OBJECTIVE:The aim of this investigation was to perform an age-correlated comparison of the hearing threshold of the better ear of SSD patients with a normal-hearing (NH) reference cohort. In ...
journal_title:HNO
pub_type: 杂志文章,多中心研究
doi:10.1007/s00106-019-00739-6
更新日期:2020-01-01 00:00:00
abstract::Compared to other countries, the prevalence of speech-language disorders among children and also the intervention frequency appear to be much higher in Germany. Since otorhinolaryngologists often initiate speech-language interventions, the first part of this review systematically outlines the guideline-conform diagnos...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-018-0509-2
更新日期:2018-06-01 00:00:00
abstract::The production of sweat in the temporal skin region may be a serious problem for patients with hearing aids, active middle ear implants or cochlear implants. We report on two patients suffering from a loss of function of their hearing aid and a reduction of the "wear comfort" of an active middle ear implant. The patie...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-012-2530-1
更新日期:2012-11-01 00:00:00
abstract::The risk for a smoker of developing cancer of the larynx depends on the activity of the enzyme arylhydroxcarbonhydroxylase in his cells. The higher the genetically determined arylhydroxcarbonhydroxylase activity, the higher is the probability of developing the disease. ...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1985-03-01 00:00:00
abstract::Although many studies are available concerning the treatment of sudden deafness using hyperbaric oxygenation, only a few of these deal with tinnitus. The aim of the present study was to evaluate the therapeutic use of hyperbaric oxygenation in cases of tinnitus. A total of 193 patients, having undergone primary intrav...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s001060050488
更新日期:1999-12-01 00:00:00
abstract::The incidence of intraosseous hemangiomas is very low. Most of them occur in adult females. The mandible,the zygoma,the maxilla, and the frontal and nasal bones are the areas of most frequent localization in the facial region. The intraosseous hemangioma is a benign, slowly growing,bony hard tumor causing facial defor...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-002-0678-9
更新日期:2003-02-01 00:00:00