[IgG4-Related Orbitopathy as an Important Differential Diagnosis of Advanced Silent Sinus Syndrome. German version].


BACKGROUND:Immunoglobulin (Ig)G4-related disease is classified as an immune-mediated disease. The etiology of this condition has not been explained to date. Manifestations of the disease are diverse, and simultaneous involvement of multiple organs is not unusual. CASE REPORT:We report the case of a patient referred to us after multiple unsuccessful paranasal sinus operations who presented with enophthalmos and a resultant migratory keratitis with a suspected diagnosis of silent sinus syndrome. Preservation of the orbit was no longer feasible. After five years without a definitive diagnosis, we ascertained that this was a case of IgG4-related disease. DISCUSSION:IgG4-related disease represents an important element in the differential diagnosis of chronic advanced diseases of the orbit and paranasal sinuses. The diagnosis should be considered in the case of unclear disease presentations. Typical histological findings include a storiform pattern of fibrosis, vasculopathy, and tissue infiltration by IgG4 plasma cells. ZUSAMMENFASSUNG:HINTERGRUND: Mit Immunglobulin (Ig)G4 assoziierte Erkrankungen werden als immunvermittelte Erkrankungen klassifiziert. Die Ätiologie dieser Krankheiten ist bisher noch nicht geklärt. Sie manifestieren sich auf verschiedene Weise, und die gleichzeitige Beteiligung mehrerer Organe ist nicht ungewöhnlich. KASUISTIK:Es wird der Fall eines Patienten vorgestellt, der in die Klinik der Autoren überwiesen wurde, nachdem mehrere erfolglose Nasennebenhöhlenoperationen bei ihm durchgeführt worden waren; bei Vorliegen eines Enophthalmus und einer resultierenden Durchwanderungskeratitis bestand die Verdachtsdiagnose eines Silent-Sinus-Syndroms. Der Erhalt der Orbita war nicht mehr möglich. Nach 5 Jahren ohne definitive Diagnose wurde nun die Diagnose einer IgG4-assoziierten Erkrankung gesichert. DISKUSSION:IgG4-assoziierte Erkrankungen stellen einen wichtigen Baustein bei der Differenzialdiagnose chronischer fortgeschrittener Erkrankungen der Orbita und der Nasennebenhöhlen dar. Bei unklaren Krankheitszeichen sollte diese Diagnose in Erwägung gezogen werden. Zu den typischen histologischen Befunden gehören ein storiformes Muster der Fibrose, Vaskulopathie und Gewebeinfiltration durch IgG4-Plasmazellen.






Jurkov M,Olze H,Klauschen F,Bertelmann E,Schneider U,Arens P




Has Abstract


2020-11-01 00:00:00
















  • [Perforation of the skull base during nasogastric intubation].

    abstract::The skull base was perforated and extensive wounds occurred in the brain during the passage of a nasogastric tube on a 48 year old woman, under general anaesthetic. The patient was treated by artificial respiration but died on the 14th day. The site of entry was the sphenoid sinus. False passage of the tube was favour...


    pub_type: 杂志文章


    authors: Krauland W,Schneider S

    更新日期:1983-07-01 00:00:00

  • [An unusual case of carotid arrosion bleeding].

    abstract::Carotid bleeding is one of the most severe complications in ear, nose and throat (ENT) surgery. It is a rare complication in patients with cancer of the head and neck after radiochemotherapy. We report the case of a 65-year-old man who suffered from cancer of the tonsils (pT2pN1M0) and was treated in 1987 with surgery...


    pub_type: 杂志文章


    authors: Zengel P,Mees K,Müller-Schunk S,Suckfüll M

    更新日期:2009-11-01 00:00:00

  • [Rare malignant tumor of the parotid gland. Myoepithelial carcinoma].

    abstract::A parotid mass in a 62-year-old woman presented intraoperatively as a highly malignant tumor with facial nerve infiltration. Classification by means of rapid section histology was not possible. Immunohistochemical studies were necessary to diagnose this rare case of myoepithelial carcinoma of the parotid gland. We per...


    pub_type: 杂志文章


    authors: Haubner F,Gassner HG,Eder F,Müller-Vogt U

    更新日期:2010-11-01 00:00:00

  • [Function and physiology of the maxillary sinus].

    abstract:BACKGROUND:The question of the "true" function of the maxillary sinus and the paranasal sinuses (PS) has been a controversial issue in the literature for decades, leading to many discussions and speculations. OBJECTIVE:This review briefly summarizes various theories on the possible physiology and functions of the maxi...


    pub_type: 杂志文章,评审


    authors: Sieron HL,Sommer F,Hoffmann TK,Grossi AS,Scheithauer MO,Stupp F,Lindemann J

    更新日期:2020-08-01 00:00:00

  • [Cerebellopontine angle surgery. Part 1: General remarks].

    abstract:OBJECTIVES:Cerebellopontine angle tumors, although uniform in location, are diverse with regard to the site of tumor origin and displacement of the neurovascular structures. With the increasing use of magnetic resonance imaging in the diagnosis of brain lesions, the treatment of tumors of the cerebellopontine angle has...


    pub_type: 杂志文章,评审


    authors: Schaller B

    更新日期:2003-04-01 00:00:00

  • [Voice rehabilitation after total laryngectomy in West Germany. Current state of the art].

    abstract::In 1987 Lopez published the results of a survey of voice rehabilitation after total laryngectomy as carried out by 400 North American ENT surgeons. In order to obtain the same information on the current state of voice rehabilitation in the German Federal Republic we did a similar survey of 103 ENT clinics. Ninety-five...


    pub_type: 杂志文章


    authors: Hagen R

    更新日期:1990-11-01 00:00:00

  • [Local use of tranexamic acid in ENT surgery].

    abstract::Bleeding is a main complication in ENT surgery especially in oral and nasal interventions. Based on good results in local application of tranexamic acid after dental extraction, the different possibilities of local application of tranexamic acid in ENT surgery are discussed and the current literature is presented. In ...


    pub_type: 杂志文章


    authors: Abrams J

    更新日期:2012-11-01 00:00:00

  • [Branchio-oto-renal syndrome (BOR syndrome). A dysplasia syndrome with branchial abnormalities, deafness and kidney disease].

    abstract::The branchio-oto-renal syndrome (BOR syndrome) is characterized by auricular abnormalities, lateral cervical fistulas and preauricular tags. The hearing impairment may be a conductive, a sensorineural or a mixed hearing loss. The renal disease is oligomeganephronia, a bilateral, congenital renal abnormality with reduc...


    pub_type: 杂志文章


    authors: Holzmüller M

    更新日期:2000-11-01 00:00:00

  • [Evaluation of standardized questionnaires for diagnosis and differentiation of obstructive and patulous Eustachian tube dysfunction].

    abstract:BACKGROUND:Patulous Eustachian tube (ET) dysfunction can impair quality of life (QOL) due to autophony, pressure sensation, and an altered impression of sound. In cases of nonspecific complaints the diagnosis of patulous ET can be difficult, and its distinction from chronic obstructive ET dysfunction is particularly ch...


    pub_type: 杂志文章


    authors: Lönnecker J,Weiss NM,Heinrichs A,Mlynski R,Rettschlag S

    更新日期:2020-09-03 00:00:00

  • [Validation of an automatic speech analysis in children with isolated cleft palate].

    abstract:BACKGROUND:Following surgical repair of cleft lip and palate, hearing and speech and language development are important issues for the continued care of affected childhood and adolescent patients. Therefore, PEAKS (Program for Evaluation and Analysis of all Kinds of Speech Disorders) was developed in order to rate spee...


    pub_type: 临床试验,杂志文章


    authors: Schulz A,Bocklet T,Eysholdt U,Bohr C,Döllinger M,Ziethe A

    更新日期:2014-07-01 00:00:00

  • [Anteromedial maxillectomy for improvement of nasal breathing : Advanced procedure in surgery of the lateral nasal wall].

    abstract::The aim of classical surgical correction for nasal breathing impairment is to harmonically extend the physiological space in the nose by an operation of the nasal septum and inferior nasal turbinate. In this way the airflow character should be maintained and the mucosa protected in order not to endanger the respirator...


    pub_type: 杂志文章,评审


    authors: Weber RK,Giotakis EI,Kühnel T,Hosemann WG

    更新日期:2019-02-01 00:00:00

  • [Malignant hemangiopericytomas in the head and neck area].

    abstract::Since 1975 we have treated nine patients with a malignant haemangiopericytoma. Three patients died 5, 9 and 14 years later of metastasis in the lung, liver, skeletal system and mastoid. However, five of the patients are still alive. Regular clinical and radiological follow-up is performed, the average period of follow...


    pub_type: 杂志文章


    authors: Weber BP,Schrader M,Inniger R

    更新日期:1990-09-01 00:00:00

  • [Hearing impairment in children and adolescents with Down's syndrome].

    abstract:BACKGROUND:There are controversial opinions about the incidence of hearing impairment of children and adolescents with Down's syndrome as an additional cause for obstruction in social and communicative live. Next to congenital diseases of the inner ear, functional limitations can often lead to conductive hearing disord...


    pub_type: 杂志文章


    authors: Hess C,Rosanowski F,Eysholdt U,Schuster M

    更新日期:2006-03-01 00:00:00

  • [Expression and localization profile of tenascin in squamous cell carcinomas of the head and neck].

    abstract::Tenascin is a glycoprotein of the extracellular matrix and is mainly expressed in association with a high proliferative and migratory activity. This characteristic has made it a successfully used target molecule in the treatment of glioblastoma. An application of anti-tenascin therapy concept in squamous cell carcinom...


    pub_type: 杂志文章


    authors: Herold-Mende C,Andl T,Laemmler F,Reisser C,Eichhorn S

    更新日期:1999-08-01 00:00:00

  • [Significance of emissary veins in surgical treatment of temporal paragangliomas].

    abstract::With the surgical removal of temporal paraganglioma, possible changes of the cerebral blood pathways of the Circle of Willis should be considered. If the cerebral blood drains dominates unilaterally and the pathway of drainage over the Bulbus venae jugularis is inadequate due to vessel malformation or variations or by...


    pub_type: 杂志文章,评审


    authors: Schipper J,Hoffmann T,Wagenmann M,Stummer W,Knapp F,Klenzner T,Turowski B

    更新日期:2009-02-01 00:00:00

  • [Frequency-dependent cochlear microphonics in inner ear hearing loss with various pitch thresholds].

    abstract::Promontory recordings of the cochlear microphonics (CM) after stimulation with 0.5, 1 and 2 kHz tone bursts at 120 dB SPL were performed on normal subjects and patients with various, levels of sensory hearing loss. A significant correlation was found between frequency-related CM amplitudes and the configuration of the...


    pub_type: 杂志文章


    authors: Marangos N,Hesse G,Mausolf A

    更新日期:1989-01-01 00:00:00

  • [Vertigo and vertebral artery stenosis (author's transl)].

    abstract::Forty nine elderly patients with osteochondrosis of the cervical spine and on whom carotid angiography had been performed were divided into two groups. In one 36 patients had vestibular symptoms whereas the other group of remaining patients was free of such symptoms. Comparison of both groups showed that vertigo (20 p...


    pub_type: 杂志文章


    authors: Rieger P,Lischewski R,Sindermann F,Schurig E

    更新日期:1979-03-01 00:00:00

  • [Prolactinoma of the sphenoid sinus. Case report and literature review].

    abstract::In this case study, we report on a patient complaining of headache who, after CT and MRI, was found to have a neoplasia of the left sphenoid sinus. After a transnasal biopsy and histological examination, a prolactinoma was diagnosed. Based on this case, we discuss important aspects of tumor biology, diagnostic procedu...


    pub_type: 杂志文章,评审


    authors: Burkert S,Bilkenroth U,Agha-Mir-Salim P,Kunze C,Holzhausen HJ,Fröhlich J,Berghaus A

    更新日期:2004-06-01 00:00:00

  • [Autologous composite grafts from the cavum conchae for reconstruction of multilayer nasal defects].

    abstract:BACKGROUND:Autologous transplants comprising skin and cartilage, so-called composite grafts (cgs), are an important reconstructive tool for multilayered defects of the nose. A cg from the auricular cavum conchae needs to fulfill both functional and esthetic demands. OBJECTIVE:This article illustrates the indications f...


    pub_type: 杂志文章,评审


    authors: Nordmann M,Veit J,Rotter N,Hoffmann TK,Scheithauer MO

    更新日期:2016-05-01 00:00:00

  • [Laryngopharyngeal reflux and larynx-related symptoms].

    abstract:BACKGROUND:Chronic hoarseness, globus sensation or mucous obstruction are among a wide range of symptoms possibly related to laryngopharyngeal reflux (LPR). METHOD AND RESULTS:A selective literature research was carried out using PubMed, in which original articles and reviews in German and English were included. Altog...


    pub_type: 杂志文章,评审


    authors: Ptok M,Ptok A

    更新日期:2012-03-01 00:00:00

  • [G-DRG System 2005. Analysis and evaluation of significant changes from the viewpoint of HNO medical science].

    abstract::With the release of the new Global Case Agreement by Self Administration in Public Health on the 16 September 2004, the adjustment of the G-DRG System for the year 2005 was completed. Otorhinolaryngology, and head and neck surgery face several changes in the fields of diagnosis and procedural coding (ICD-10-GM 2005, O...


    pub_type: 杂志文章


    authors: Franz D,Roeder N,Leuwer R,Büter J,Hörmann K,Alberty J

    更新日期:2005-03-01 00:00:00

  • [Bite injuries in the head and neck area].

    abstract::In Germany about 8500 dog-bite injuries in the face occur every year; more than 50% of the victims are infants and schoolchildren. Besides dogs, other animals such as cats or horses may be responsible for these accidents. Even human bites are reported. The predominant areas are the nose and the auricles. The tissue de...


    pub_type: 杂志文章,评审


    authors: Scheithauer MO,Rettinger G

    更新日期:1997-11-01 00:00:00

  • [Manifestations of inactivity in unilateral hearing aid management of patients with a high degree of hearing loss].

    abstract::Concluding from audiometrical practice using hearing aids unilaterally we could find an inactivity of the unused contralateral ear. We have investigated if it is possible to measure this inactivity by common psychoacoustic methods. We tested 92 persons with advanced combined hearing loss. We had to state that the inac...


    pub_type: 杂志文章


    authors: Dieroff HG,Meissner W

    更新日期:1989-11-01 00:00:00

  • [Electrophysiologic evaluation of the facial nerve in patients with acoustic neuromas. Preliminary results of a comparative study between conventional electroneurography and transcranial magnetic pulse stimulation].

    abstract::Subclinical invasion of the facial nerve by acoustic neuromas may be identified preoperatively using conventional electroneurography (ENOG). The clinical application of extratemporal stimulation distal to the stylomastoid foramen is limited in these cases because of the more proximal site of the lesion. Transcranial m...


    pub_type: 杂志文章


    authors: Höhmann D,DeMeester C,Duckert LG

    更新日期:1991-11-01 00:00:00

  • [Lightning strike to a vehicle causing acute acoustic trauma].

    abstract::The cochlea and vestibular organ is often affected in lightning strikes. A lightning strike to a motor vehicle with cochlear injury has not been described hitherto in the literature. We report the case of a 44-year-old male patient with sensorineural hearing loss and tinnitus after his car was struck by lightning. Whi...


    pub_type: 杂志文章


    authors: Angerer F,Hoppe U,Schick B

    更新日期:2009-10-01 00:00:00

  • Pyoderma gangraenosum und Pseudotumor orbitae.

    abstract::Pyoderma gangrenosum belongs to the chronic, neutrophilic and necrotic dermatoses. These very painful, inflammable and purulent skin-ulcers often arise after injury or surgical intervention. About half of the patients suffer from systemic disease, for example hematological, gastrointestinal or rheumatic diseases.Our r...


    pub_type: 杂志文章


    authors: Welzel C,Bloching M,Born S,Berghaus A

    更新日期:2003-06-01 00:00:00

  • [Ultrasound-guided minimally invasive diagnostics and treatment in the head and neck area].

    abstract::Tumoral lesions in the head and neck region represent a diagnostic and therapeutic challenge in otorhinolaryngologic routine. High-resolution ultrasound is usually able to guide diagnosis. Nevertheless, a definite differentiation between benign and malignant lesions can only be achieved by tissue biopsy. The various o...


    pub_type: 杂志文章


    authors: Bozzato A,Neubert C,Yeter Y

    更新日期:2021-01-08 00:00:00

  • Management of transmodiolar and transmacular cochleovestibular schwannomas with and without cochlear implantation.

    abstract:INTRODUCTION:Hearing rehabilitation with cochlear implants has attracted increasing interest also for patients with cochleovestibular schwannoma. The authors report their experience with the surgical management of tumors with rare transmodiolar or transmacular extension and outcomes after cochlear implantation (CI). M...


    pub_type: 杂志文章


    authors: Plontke SK,Caye-Thomasen P,Strauss C,Kösling S,Götze G,Siebolts U,Vordermark D,Wagner L,Fröhlich L,Rahne T

    更新日期:2020-10-12 00:00:00

  • [Transseptal surgery of the sellar region from the neurosurgical viewpoint].

    abstract::The indication for the transsphenoidal procedure in tumors of the sellar region is being presented. The authors prefer the transseptal - transsphenoidal approach after cut in the orifice of the nasal cavity. ENT-surgeon and neurosurgeon perform the operation together. Advantages and disadvantages as well as the necess...


    pub_type: 杂志文章


    authors: Ischebeck W,Lange G

    更新日期:1984-03-01 00:00:00

  • [Cochlear implantation with deep brain or occipital nerve stimulation : Case studies for parallel application].

    abstract::We were able to demonstrate that simultaneous treatment of a patient with a neuromodulation device for deep brain stimulation (DBS) or occipital nerve stimulation (ONS) plus a cochlear implant is a possible treatment option, and that both systems are able to work within their specifications without interference from e...


    pub_type: 杂志文章


    authors: Jansen N,Glaas M,Volpert S,Slotty P,Vesper J,Klenzner T

    更新日期:2019-10-01 00:00:00