当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Impact of mental disorders and chronic physical conditions on quality-adjusted life years in Singapore.

Impact of mental disorders and chronic physical conditions on quality-adjusted life years in Singapore.

Abstract：

:The current study aims to evaluate the burden of disease in Singapore by estimating the quality-adjusted life years (QALYs) lost due to mental disorders and chronic physical conditions. The second Singapore Mental Health Study (SMHS-2016) was conducted in 2016 among 6126 respondents aged 18 years and above. The World Health Organization Composite International Diagnostic Interview version 3.0 (WHO-CIDI 3.0) and a modified version of the CIDI chronic medical disorders checklist were used to assess the 12-month diagnoses of mental and chronic physical disorders while the SF-6D scores derived from the 12-item Short Form Health Survey instrument was used to estimate the QALYs lost. The mean SF-6D score in this population was 0.87. The largest reduction in SF-6D scores among people with mental disorders was observed in Generalized Anxiety Disorder (GAD), followed by Major Depressive Disorder (MDD), alcohol abuse, bipolar disorder and Obsessive Compulsive Disorder (OCD) while the largest reduction in SF-6D score among people with chronic physical conditions was observed in ulcer, followed by lung disease, chronic pain and cardiovascular disease. At the population level, chronic pain was associated with the greatest QALY loss followed by MDD (14,204 and 6,889 respectively). Lung disease was associated with the smallest QALY loss (376). These findings highlight chronic pain, MDD, OCD, cardiovascular disease and GAD as the five leading contributors of QALYs lost in the general population which deserve prioritisation in public health prevention programmes.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Abdin E,Chong SA,Vaingankar JA,Shafie S,Verma S,Luo N,Tan KB,James L,Heng D,Subramaniam M

doi

10.1038/s41598-020-59604-0

subject

Has Abstract

pub_date

2020-02-14 00:00:00

pages

2695

issue

1

issn

2045-2322

pii

10.1038/s41598-020-59604-0

journal_volume

10

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Engraftment of human induced pluripotent stem cell-derived hepatocytes in immunocompetent mice via 3D co-aggregation and encapsulation.

    abstract：:Cellular therapies for liver diseases and in vitro models for drug testing both require functional human hepatocytes (Hum-H), which have unfortunately been limited due to the paucity of donor liver tissues. Human pluripotent stem cells (hPSCs) represent a promising and potentially unlimited cell source to derive Hum-H...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16884

    authors： Song W,Lu YC,Frankel AS,An D,Schwartz RE,Ma M

    更新日期：2015-11-23 00:00:00

  • Study of the Binding Energies between Unnatural Amino Acids and Engineered Orthogonal Tyrosyl-tRNA Synthetases.

    abstract：:We utilized several computational approaches to evaluate the binding energies of tyrosine (Tyr) and several unnatural Tyr analogs, to several orthogonal aaRSes derived from Methanocaldococcus jannaschii and Escherichia coli tyrosyl-tRNA synthetases. The present study reveals the following: (1) AutoDock Vina and ROSETT...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12632

    authors： Ren W,Truong TM,Ai HW

    更新日期：2015-07-29 00:00:00

  • Enhanced segregation of concurrent sounds with similar spectral uncertainties in individuals with autism spectrum disorder.

    abstract：:When acoustic signals from different sound sources are mixed upon arrival at the ears, the auditory system organizes these acoustic elements by their features. This study shows that individuals with autism spectrum disorder (ASD) performed better in terms of hearing a target sequence among distractors that had similar...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep10524

    authors： Lin IF,Yamada T,Komine Y,Kato N,Kashino M

    更新日期：2015-05-22 00:00:00

  • Nucleotide lipid-based hydrogel as a new biomaterial ink for biofabrication.

    abstract：:One of the greatest challenges in the field of biofabrication remains the discovery of suitable bioinks that satisfy physicochemical and biological requirements. Despite recent advances in tissue engineering and biofabrication, progress has been limited to the development of technologies using polymer-based materials....

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-59632-w

    authors： Dessane B,Smirani R,Bouguéon G,Kauss T,Ribot E,Devillard R,Barthélémy P,Naveau A,Crauste-Manciet S

    更新日期：2020-02-18 00:00:00

  • Enhancement of Perivascular Spaces in 7 T MR Image using Haar Transform of Non-local Cubes and Block-matching Filtering.

    abstract：:Perivascular spaces (PVSs) in brain have a close relationship with typical neurological diseases. The quantitative studies of PVSs are meaningful but usually difficult, due to their thin and weak signals and also background noise in the 7 T brain magnetic resonance images (MRI). To clearly distinguish the PVSs in the ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09336-5

    authors： Hou Y,Park SH,Wang Q,Zhang J,Zong X,Lin W,Shen D

    更新日期：2017-08-17 00:00:00

  • Comparison of Computed Tomography derived Fractional Flow Reserve to invasive Fractional Flow Reserve in Diagnosis of Functional Coronary Stenosis: A Meta-Analysis.

    abstract：:Computed Tomography derived Fractional Flow Reserve (CTFFR) is an emerging non-invasive imaging modality to assess functional significance of coronary stenosis. We performed a meta-analysis to compare the diagnostic performance of CTFFR to invasive Fractional Flow reserve (FFR). Electronic search was performed to iden...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41598-018-29910-9

    authors： Agasthi P,Kanmanthareddy A,Khalil C,Egbuche O,Yarlagadda V,Sachdeva R,Arsanjani R

    更新日期：2018-08-01 00:00:00

  • Oral administration of N-acetyl cysteine prevents osteoarthritis development and progression in a rat model.

    abstract：:The number of osteoarthritis patients is increasing with the rise in the number of elderly people in developed countries. Osteoarthritis, which causes joint pain and deformity leading to loss of activities of daily living, is often treated surgically. Here we show that mechanical stress promotes accumulation of reacti...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-55297-2

    authors： Kaneko Y,Tanigawa N,Sato Y,Kobayashi T,Nakamura S,Ito E,Soma T,Miyamoto K,Kobayashi S,Harato K,Matsumoto M,Nakamura M,Niki Y,Miyamoto T

    更新日期：2019-12-10 00:00:00

  • Speeding up GW Calculations to Meet the Challenge of Large Scale Quasiparticle Predictions.

    abstract：:Although the GW approximation is recognized as one of the most accurate theories for predicting materials excited states properties, scaling up conventional GW calculations for large systems remains a major challenge. We present a powerful and simple-to-implement method that can drastically accelerate fully converged ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep36849

    authors： Gao W,Xia W,Gao X,Zhang P

    更新日期：2016-11-11 00:00:00

  • Loss of miR-144 signaling interrupts extracellular matrix remodeling after myocardial infarction leading to worsened cardiac function.

    abstract：:We have previously shown that MicroRNA (miR) -144 is a key modulator of the acute cardioprotection associated with remote ischemic preconditioning and post myocardial infarction (MI) remodeling. In this study we examine the biology of the remodeling response after permanent ligation of the left anterior descending cor...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35314-6

    authors： He Q,Wang F,Honda T,James J,Li J,Redington A

    更新日期：2018-11-15 00:00:00

  • Nano-structured glaucoma drainage implant safely and significantly reduces intraocular pressure in rabbits via post-operative outflow modulation.

    abstract：:Glaucoma is a leading cause of irreversible vision loss predicted to affect more than 100 million people by 2040. Intraocular pressure (IOP) reduction prevents development of glaucoma and vision loss from glaucoma. Glaucoma surgeries reduce IOP by facilitating aqueous humor outflow through a vent fashioned from the wa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69687-4

    authors： Parikh KS,Josyula A,Omiadze R,Ahn JY,Ha Y,Ensign LM,Hanes J,Pitha I

    更新日期：2020-07-31 00:00:00

  • Association between plasma levels of homocysteine, folate, and vitamin B12, and dietary folate intake and hypertension in a cross-sectional study.

    abstract：:There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B12 as related to Hcy level. We simultaneously examined the associations of plasma levels of Hcy, folate, and vitamin B12, and dietary folate intake with the prevalenc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-75267-3

    authors： Tamura T,Kuriyama N,Koyama T,Ozaki E,Matsui D,Kadomatsu Y,Tsukamoto M,Kubo Y,Okada R,Hishida A,Sasakabe T,Kawai S,Naito M,Takashima N,Kadota A,Tanaka K,Hara M,Suzuki S,Nakagawa-Senda H,Takezaki T,Shimoshikiryo I,

    更新日期：2020-10-28 00:00:00

  • Group task-related component analysis (gTRCA): a multivariate method for inter-trial reproducibility and inter-subject similarity maximization for EEG data analysis.

    abstract：:EEG is known to contain considerable inter-trial and inter-subject variability, which poses a challenge in any group-level EEG analyses. A true experimental effect must be reproducible even with variabilities in trials, sessions, and subjects. Extracting components that are reproducible across trials and subjects bene...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56962-2

    authors： Tanaka H

    更新日期：2020-01-09 00:00:00

  • C70 Fullerene Cage as a Novel Catalyst for Efficient Proton Transfer Reactions between Small Molecules: A Theoretical study.

    abstract：:When acids are supplied with an excess electron (or placed in an Ar or the more polarizable N2 matrix) in the presence of species such as NH3, the formation of ion-pairs is a likely outcome. Using density functional theory and first-principles calculations, however, we show that, without supplying an external electron...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46725-4

    authors： Varadwaj PR,Varadwaj A,Marques HM

    更新日期：2019-07-23 00:00:00

  • Dispersal-competition tradeoff in microbiomes in the quest for land colonization.

    abstract：:Ancestor microbes started colonizing inland habitats approximately 2.7 to 3.5 billion years ago. With some exceptions, the key physiological adaptations of microbiomes associated with marine-to-land transitions have remained elusive. This is essentially caused by the lack of suitable systems that depict changes in mic...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-27783-6

    authors： Dini-Andreote F,van Elsas JD,Olff H,Salles JF

    更新日期：2018-06-21 00:00:00

  • Pitch sensation involves stochastic resonance.

    abstract：:Pitch is a complex hearing phenomenon that results from elicited and self-generated cochlear vibrations. Read-off vibrational information is relayed higher up the auditory pathway, where it is then condensed into pitch sensation. How this can adequately be described in terms of physics has largely remained an open que...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep02676

    authors： Martignoli S,Gomez F,Stoop R

    更新日期：2013-01-01 00:00:00

  • Positive and negative cooperativity of TNF and Interferon-γ in regulating synovial fibroblast function and B cell survival in fibroblast/B cell co-cultures.

    abstract：:Synovial fibroblasts (SF) were reported to produce B cell activating factor (BAFF) in response to stimulation with interferon-γ (IFN-γ) or tumor necrosis factor (TNF). However, the influence of these pro-inflammatory cytokines on other receptors/ligands of the TNF superfamily or associated cytokine receptors in SF has...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-57772-7

    authors： Lowin T,Anssar TM,Bäuml M,Classen T,Schneider M,Pongratz G

    更新日期：2020-01-21 00:00:00

  • A crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two β-GlcNAcase homologs.

    abstract：:Selective inhibition of function-specific β-GlcNAcase has great potential in terms of drug design and biological research. The symmetrical bis-naphthalimide M-31850 was previously obtained by screening for specificity against human glycoconjugate-lytic β-GlcNAcase. Using protein-ligand co-crystallization and molecular...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep06188

    authors： Liu T,Guo P,Zhou Y,Wang J,Chen L,Yang H,Qian X,Yang Q

    更新日期：2014-08-26 00:00:00

  • Concurrent guiding of light and heat by transformation optics and transformation thermodynamics via soft matter.

    abstract：:Controlling light and heat via metamaterials has presented interesting technological applications using transformation optics (TO) and transformation thermodynamics (TT). However, such devices are commonly mono-physics and mono-purpose, because the used metamaterial is designed to deal with one type of physical mechan...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29866-w

    authors： Barros WKP,Pereira E

    更新日期：2018-07-30 00:00:00

  • MicroRNAs Associated with Caste Determination and Differentiation in a Primitively Eusocial Insect.

    abstract：:In eusocial Hymenoptera (ants, bees and wasps), queen and worker adult castes typically arise via environmental influences. A fundamental challenge is to understand how a single genome can thereby produce alternative phenotypes. A powerful approach is to compare the molecular basis of caste determination and different...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45674

    authors： Collins DH,Mohorianu I,Beckers M,Moulton V,Dalmay T,Bourke AF

    更新日期：2017-03-31 00:00:00

  • Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases.

    abstract：:Transcriptome analysis by RNA-seq technology allows novel insights into gene expression and regulatory networks in health and disease. To better understand the molecular basis of renal fibrosis, we performed RNA-seq analysis in the Unilateral Ureteric Obstruction (UUO) mouse model. We analysed sham operated, 2- and 8-...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep26235

    authors： Arvaniti E,Moulos P,Vakrakou A,Chatziantoniou C,Chadjichristos C,Kavvadas P,Charonis A,Politis PK

    更新日期：2016-05-18 00:00:00

  • A missing color area extraction approach from high-resolution statue images for cultural heritage documentation.

    abstract：:Ancient statues are usually fragile and have a tendency to deteriorate over time, developing cracks, corrosion, and losing color. Before any intervention on the object of art, a conservator must map degradation and take measurements. Deterioration mapping is an extremely long process, as the conservator or restorer mu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-78254-w

    authors： Nasri A,Huang X

    更新日期：2020-12-14 00:00:00

  • From the Age of 5 Humans Decide Economically, Whereas Crows Exhibit Individual Preferences.

    abstract：:Human societies greatly depend on tools, which spare us considerable time and effort. Humans might have evolved a bias to employ tools, using them even when they are unnecessary. This study aimed to investigate whether adult humans and a distantly related habitually tool-using vertebrate species, the New Caledonian cr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-16984-0

    authors： Danel S,Osiurak F,von Bayern AMP

    更新日期：2017-12-06 00:00:00

  • Seed yield can be explained by altered yield components in field-grown western wheatgrass (Pascopyrum smithii Rydb.).

    abstract：:Western wheatgrass (Pascopyrum smithii Rydb.) is an important cool-season forage and turfgrass. However, due to seed dormancy and poor seedling vigor, it is difficult to develop high seed yield production systems, and assessing these components in response to seed yield. Based on multifactor orthogonally designed fiel...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54586-0

    authors： Chen Z,Niu J,Cao X,Jiang W,Cui J,Wang Q,Zhang Q

    更新日期：2019-11-29 00:00:00

  • Preclinical dosimetry models and the prediction of clinical doses of novel positron emission tomography radiotracers.

    abstract：:Dosimetry models using preclinical positron emission tomography (PET) data are commonly employed to predict the clinical radiological safety of novel radiotracers. However, unbiased clinical safety profiling remains difficult during the translational exercise from preclinical research to first-in-human studies for nov...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-72830-w

    authors： Garrow AA,Andrews JPM,Gonzalez ZN,Corral CA,Portal C,Morgan TEF,Walton T,Wilson I,Newby DE,Lucatelli C,Tavares AAS

    更新日期：2020-09-29 00:00:00

  • Differential brain mechanisms during reading human vs. machine translated fiction and news texts.

    abstract：:Few neuroimaigng studies on reading comprehension have been conducted under natural reading settings. In this study, we showed texts presented in a natural way during functional MRI (fMRI) measurements to reveal brain areas sensitive to reading comprehension. Specifically, this paradigm independently manipulated two h...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49632-w

    authors： Lin FH,Liu YF,Lee HJ,Chang CHC,Jaaskelainen IP,Yeh JN,Kuo WJ

    更新日期：2019-09-13 00:00:00

  • Electron beam irradiated silver nanowires for a highly transparent heater.

    abstract：:Transparent heaters have attracted increasing attention for their usefulness in vehicle windows, outdoor displays, and periscopes. We present high performance transparent heaters based on Ag nanowires with electron beam irradiation. We obtained an Ag-nanowire thin film with 48 ohm/sq of sheet resistance and 88.8% (sub...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep17716

    authors： Hong CH,Oh SK,Kim TK,Cha YJ,Kwak JS,Shin JH,Ju BK,Cheong WS

    更新日期：2015-12-07 00:00:00

  • Tudor Domain Containing Protein 3 Promotes Tumorigenesis and Invasive Capacity of Breast Cancer Cells.

    abstract：:Tudor domain containing protein 3 (TDRD3) is a modular protein identified based on its ability to recognize methylated arginine motifs through its Tudor domain. We have previously shown that TDRD3 localizes to cytoplasmic stress granules, a structure shown to promote survival upon treatment with chemotherapeutic drugs...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04955-4

    authors： Morettin A,Paris G,Bouzid Y,Baldwin RM,Falls TJ,Bell JC,Côté J

    更新日期：2017-07-11 00:00:00

  • Closing the Loop of Satellite Soil Moisture Estimation via Scale Invariance of Hydrologic Simulations.

    abstract：:Surface soil moisture plays a crucial role on the terrestrial water, energy, and carbon cycles. Characterizing its variability in space and time is critical to increase our capability to forecast extreme weather events, manage water resources, and optimize agricultural practices. Global estimates of surface soil moist...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-52650-3

    authors： Mascaro G,Ko A,Vivoni ER

    更新日期：2019-11-06 00:00:00

  • Non-targeted urine metabolomics and associations with prevalent and incident type 2 diabetes.

    abstract：:Better risk prediction and new molecular targets are key priorities in type 2 diabetes (T2D) research. Little is known about the role of the urine metabolome in predicting the risk of T2D. We aimed to use non-targeted urine metabolomics to discover biomarkers and improve risk prediction for T2D. Urine samples from two...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-72456-y

    authors： Salihovic S,Broeckling CD,Ganna A,Prenni JE,Sundström J,Berne C,Lind L,Ingelsson E,Fall T,Ärnlöv J,Nowak C

    更新日期：2020-10-05 00:00:00

  • Fragment-based screening identifies inhibitors of ATPase activity and of hexamer formation of Cagα from the Helicobacter pylori type IV secretion system.

    abstract：:Type IV secretion systems are multiprotein complexes that mediate the translocation of macromolecules across the bacterial cell envelope. In Helicobacter pylori a type IV secretion system encoded by the cag pathogenicity island encodes 27 proteins and most are essential for virulence. We here present the identificatio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42876-6

    authors： Arya T,Oudouhou F,Casu B,Bessette B,Sygusch J,Baron C

    更新日期：2019-04-24 00:00:00