Impact of mental disorders and chronic physical conditions on quality-adjusted life years in Singapore.

abstract：:Histone acetylation has been linked to cardiac hypertrophy and heart failure. However, the pathological implications of changes in histone methylation and the effects of interventions with histone methyltransferase inhibitors for heart failure have not been fully clarified. Here, we focused on H3K9me3 status in the he...

journal_title：Scientific reports

authors： Ono T,Kamimura N,Matsuhashi T,Nagai T,Nishiyama T,Endo J,Hishiki T,Nakanishi T,Shimizu N,Tanaka H,Ohta S,Suematsu M,Ieda M,Sano M,Fukuda K,Kaneda R

更新日期：2017-01-04 00:00:00

abstract：:The estrogen receptor (ER) regulates the survival and growth of breast cancer cells, but it is less clear how components of the tissue microenvironment affect ER-mediated responses. We set out to test how human mammary fibroblasts (HMFs) modulate ER signaling and downstream cellular responses. We exposed an organotypi...

journal_title：Scientific reports

authors： Morgan MM,Livingston MK,Warrick JW,Stanek EM,Alarid ET,Beebe DJ,Johnson BP

更新日期：2018-05-08 00:00:00

abstract：:In a 250-kyr transient simulation of the Community Earth System Model (CESM), we identified a precessional forced seesaw of the summer middle-upper tropospheric eddy temperature between Asia and the North Pacific as the paleo-APO (Asian-Pacific oscillation). The paleo-APO variability is out of phase with the precessio...

journal_title：Scientific reports

authors： Wang Y,Jian Z,Zhao P,Xiao D,Chen J

更新日期：2016-07-06 00:00:00

abstract：:A large number of drugs are administered on different mucosal surfaces. However, due to the poor mucoadhesion of the current formulations, their bioavailability is often very low. The development of efficient mucoadhesive drug delivery systems is thus crucial for improving the performance of these drugs. The mucoadhes...

journal_title：Scientific reports

authors： Ouellette M,Masse F,Lefebvre-Demers M,Maestracci Q,Grenier P,Millar R,Bertrand N,Prieto M,Boisselier É

更新日期：2018-09-25 00:00:00

abstract：:Theory predicts that social interactions can induce an alignment of behavioral asymmetries between individuals (i.e., population-level lateralization), but evidence for this effect is mixed. To understand how interaction with other individuals affects behavioral asymmetries, we systematically manipulated the social en...

journal_title：Scientific reports

authors： Versace E,Caffini M,Werkhoven Z,de Bivort BL

更新日期：2020-03-11 00:00:00

abstract：:Calcium (Ca) deficiency in cabbage plants induces oxidative damage, hampering growth and decreasing quality, however, it is hypothesized that silicon (Si) added to the nutrient solution may alleviate crop losses. Therefore, this study aims at evaluating whether silicon supplied in the nutrient solution reduces, in fac...

journal_title：Scientific reports

authors： da Silva DL,de Mello Prado R,Tenesaca LFL,da Silva JLF,Mattiuz BH

更新日期：2021-01-19 00:00:00

abstract：:Calcium plays a role of universal cellular regulator in the living cell and one of the crucial regulators of proper fetal development during gestation. Mitochondria are important for intracellular calcium handling and signaling. Mitochondrial calcium uniporter (mtCU) is a multiprotein complex of the mitochondrial inne...

journal_title：Scientific reports

authors： Vishnyakova PA,Tarasova NV,Volodina MA,Tsvirkun DV,Sukhanova IA,Kurchakova TA,Kan NE,Medzidova MK,Sukhikh GT,Vysokikh MY

更新日期：2019-04-02 00:00:00

abstract：:On the basis of diet induced obesity and KO mice models, nitric oxide is implied to play an important role in the initiation of dyslipidemia induced insulin resistance. However, outcomes using iNOS KO mice have so far remained inconclusive. The present study aimed to assess IR in iNOS KO mice after 5 weeks of LFD feed...

journal_title：Scientific reports

authors： Kanuri BN,Kanshana JS,Rebello SC,Pathak P,Gupta AP,Gayen JR,Jagavelu K,Dikshit M

更新日期：2017-01-20 00:00:00

abstract：:Metasurfaces, owing to their attractive features, provide a wide range of potential applications. Electromagnetic absorbers based on metasurfaces have significantly improved responses compared to the earlier absorbers made from composite materials. Active metasurfaces, in contrast to the passive designs, can exhibit m...

journal_title：Scientific reports

authors： Ghosh S,Lim S

更新日期：2018-07-05 00:00:00

abstract：:We propose a novel scheme to realize an optical waveguide induced by an active Raman gain (ARG) process in a four-level N-type atomic system. Because of the nature of the ARG, there are two distinct features related to the waveguide: i) It is not absorptive, on the contrary, weak gain is presented; ii) It can be impro...

journal_title：Scientific reports

authors： Cui N,Gan Z,Zhang L

更新日期：2017-10-27 00:00:00

abstract：:Obstructive heart defects (OHDs) are a major health concern worldwide. The platelet-derived growth factor (PDGF) genes are known to have regulatory functions that are essential for proper heart development. In a zebrafish model, Pdgfra was further demonstrated to interact with ethanol during craniofacial development. ...

journal_title：Scientific reports

authors： Tang X,Eberhart JK,Cleves MA,Li J,Li M,MacLeod S,Nembhard WN,Hobbs CA

更新日期：2018-07-23 00:00:00

abstract：:Carbapenem resistant Enterobacteriaceae (CRE) pose an urgent risk to global human health. CRE that are non-susceptible to all commercially available antibiotics threaten to return us to the pre-antibiotic era. Using Single Molecule Real Time (SMRT) sequencing we determined the complete genome of a pandrug-resistant Kl...

journal_title：Scientific reports

authors： Zowawi HM,Forde BM,Alfaresi M,Alzarouni A,Farahat Y,Chong TM,Yin WF,Chan KG,Li J,Schembri MA,Beatson SA,Paterson DL

更新日期：2015-10-19 00:00:00

abstract：:Nitrogen (N) deposition is a key factor that affects terrestrial biogeochemical cycles with a growing trend, especially in the southeast region of China, where shortage of available phosphorus (P) is particularly acute and P has become a major factor limiting plant growth and productivity. Arbuscular mycorrhizal fungi...

journal_title：Scientific reports

authors： Lin C,Wang Y,Liu M,Li Q,Xiao W,Song X

更新日期：2020-07-23 00:00:00

abstract：:The opening of connexin (Cx) hemichannels in the membrane is tightly regulated by calcium (Ca2+) and membrane voltage. Electrophysiological and atomic force microscopy experiments indicate that Ca2+ stabilizes the hemichannel closed state. However, structural data show that Ca2+ binding induces an electrostatic seal p...

journal_title：Scientific reports

authors： Pinto BI,Pupo A,García IE,Mena-Ulecia K,Martínez AD,Latorre R,Gonzalez C

更新日期：2017-11-20 00:00:00

abstract：:Prenatal skeletal muscle development genetically determines postnatal muscle characteristics such as growth and meat quality in pigs. However, the molecular mechanisms underlying prenatal skeletal muscle development remain unclear. Here, we performed the first genome-wide analysis of chimeric RNAs, single nuclear poly...

journal_title：Scientific reports

authors： Yang Y,Tang Z,Fan X,Xu K,Mu Y,Zhou R,Li K

更新日期：2016-06-29 00:00:00

abstract：:Ruthenium(II) complexes with 6-methyl-2-thiouracil cis-[Ru(6m2tu)2(PPh3)2] (1) and [Ru(6m2tu)2(dppb)] (2) (where PPh3 = triphenylphosphine; dppb = 1,4-bis(diphenylphosphino)butane; and 6m2tu = 6-methyl-2-thiouracil) are potent cytotoxic agents and able to bind DNA. The aim of this study was to evaluate in vitro cellul...

journal_title：Scientific reports

authors： Bomfim LM,de Araujo FA,Dias RB,Sales CBS,Rocha CAG,Correa RS,Soares MBP,Batista AA,Bezerra DP

更新日期：2019-08-07 00:00:00

abstract：:The biggest challenge in colorectal cancer therapy is to avoid intestinal drug absorption before reaching the colon, while focusing on tumor specific delivery with high local concentration and minimal toxicity. In our work, thymoquinone (TQ)-loaded polymeric nanocapsules were prepared using the nanoprecipitation techn...

journal_title：Scientific reports

authors： Ramzy L,Metwally AA,Nasr M,Awad GAS

更新日期：2020-07-03 00:00:00

abstract：:Legionella pneumophila is a ubiquitous, pathogenic, Gram-negative bacterium responsible for legionellosis. Like many other amoeba-resistant microorganisms, L. pneumophila resists host clearance and multiplies inside the cell. Through its Dot/Icm type IV secretion system, the bacterium injects more than three hundred e...

journal_title：Scientific reports

authors： Mengue L,Régnacq M,Aucher W,Portier E,Héchard Y,Samba-Louaka A

更新日期：2016-11-02 00:00:00

abstract：:Nowadays, one of the main challenges is moving towards an eco-sustainable agriculture, able to preserve the food production through a reduced use of pesticides. Current global food sustenance by intensive agriculture is mainly based on economic crop monocultures and drastically reduces the biodiversity, increasing the...

journal_title：Scientific reports

authors： Zambon Y,Contaldo N,Laurita R,Várallyay E,Canel A,Gherardi M,Colombo V,Bertaccini A

更新日期：2020-11-05 00:00:00

abstract：:The 37 currently recognized Bemisia tabaci cryptic species are economically important species and contain both primary and secondary endosymbionts, but their diversity has never been mapped systematically across the group. To achieve this, PacBio sequencing of full-length bacterial 16S rRNA gene amplicons was carried ...

journal_title：Scientific reports

authors： Wang HL,Lei T,Xia WQ,Cameron SL,Liu YQ,Zhang Z,Gowda MMN,De Barro P,Navas-Castillo J,Omongo CA,Delatte H,Lee KY,Patel MV,Krause-Sakate R,Ng J,Wu SL,Fiallo-Olivé E,Liu SS,Colvin J,Wang XW

更新日期：2019-04-25 00:00:00

abstract：:To evaluate the corneal spherical aberrations in cataract patients with and without high myopia, we conducted a retrospective case series of 502 cataract eyes with high myopia and 1500 age-related cataract eyes and measure their corneal biometric data and axial length using Pentacam and IOLMaster. Both the anterior an...

journal_title：Scientific reports

authors： Zhang M,Qian D,Jing Q,Chen J,Jiang Y

更新日期：2019-02-05 00:00:00

abstract：:This study was intended to determine the efficacy of nivolumab, we evaluated treatment response with respect to PD-1/PD-L1 SNPs among patients with NSCLC. A total of 50 patients with NSCLC were treated with nivolumab and were also evaluated for PD-1/PD-L1 single nucleotide polymorphisms (SNPs) from plasma DNA. We inve...

journal_title：Scientific reports

authors： Nomizo T,Ozasa H,Tsuji T,Funazo T,Yasuda Y,Yoshida H,Yagi Y,Sakamori Y,Nagai H,Hirai T,Kim YH

更新日期：2017-03-23 00:00:00

abstract：:Spontaneous activity found in neural networks usually results in a reduction of computational performance. As a consequence, artificial neural networks are often operated at the edge of chaos, where the network is stable yet highly susceptible to input information. Surprisingly, regular spontaneous dynamics in Neural ...

journal_title：Scientific reports

authors： Marquez BA,Larger L,Jacquot M,Chembo YK,Brunner D

更新日期：2018-02-20 00:00:00

abstract：:Influenza virus remains an emerging virus and causes pandemics with high levels of fatality. After screening different plant extracts with potential anti-influenza activity, a water extract of Taxodium distichum stems (TDSWex) showed excellent activity against influenza viruses. The EC50 of TDSWex was 0.051 ± 0.024 mg...

journal_title：Scientific reports

authors： Hsieh CF,Chen YL,Lin CF,Ho JY,Huang CH,Chiu CH,Hsieh PW,Horng JT

更新日期：2016-10-31 00:00:00

abstract：:Mechanical forces are critical to modulate cell spreading, contractility, gene expression, and even stem cell differentiation. Yet, existing tools that can apply controllable subcellular forces to a large number of single cells simultaneously are still limited. Here we report a novel ultrasound tweezing cytometry util...

journal_title：Scientific reports

authors： Fan Z,Sun Y,Di Chen,Tay D,Chen W,Deng CX,Fu J

更新日期：2013-01-01 00:00:00

abstract：:While previous studies separately demonstrate EEG spectral modulations during speech preparation and ERP responses to the listened speech, it is unclear whether these responses are related on a trial-by-trial basis between a speaker and listener. In order to determine whether these responses are related in real-time, ...

journal_title：Scientific reports

authors： Bridwell DA,Henderson S,Sorge M,Plis S,Calhoun VD

更新日期：2018-08-27 00:00:00

abstract：:The flagellum is a rotary motor that enables bacteria to swim in liquids and swarm over surfaces. Numerous global regulators control flagellar assembly in response to cellular and environmental factors. Previous studies have also shown that flagellar assembly is affected by the growth-rate of the cell. However, a syst...

journal_title：Scientific reports

authors： Sim M,Koirala S,Picton D,Strahl H,Hoskisson PA,Rao CV,Gillespie CS,Aldridge PD

更新日期：2017-01-24 00:00:00

abstract：:To better understand the brain function based on neural activity, a minimally invasive analysis technology in a freely moving animal is necessary. Such technology would provide new knowledge in neuroscience and contribute to regenerative medical techniques and prosthetics care. An application that combines optogenetic...

journal_title：Scientific reports

authors： Kobayashi T,Haruta M,Sasagawa K,Matsumata M,Eizumi K,Kitsumoto C,Motoyama M,Maezawa Y,Ohta Y,Noda T,Tokuda T,Ishikawa Y,Ohta J

更新日期：2016-02-16 00:00:00

abstract：:Numerous studies have reported cold atmospheric plasma cytotoxic activities in various cancer cell lines, either by direct exposure to non-thermal plasma or indirectly by activating a medium (plasma-activated medium, PAM) prior to cell treatment. We suggested the use of in vitro 3D tumor model spheroids to determine t...

journal_title：Scientific reports

authors： Chauvin J,Gibot L,Griseti E,Golzio M,Rols MP,Merbahi N,Vicendo P

更新日期：2019-03-19 00:00:00

abstract：:Human African trypanosomiasis (sleeping sickness) is a neglected tropical disease caused by Trypanosoma brucei spp. The parasites are transmitted by tsetse flies and adapt to their different hosts and environments by undergoing a series of developmental changes. During differentiation, the trypanosome alters its prote...

journal_title：Scientific reports

authors： Wenzler T,Schumann Burkard G,Schmidt RS,Mäser P,Bergner A,Roditi I,Brun R

更新日期：2016-03-02 00:00:00