Abstract:
:Nervous systems have the ability to select appropriate actions and action sequences in response to sensory cues. The circuit mechanisms by which nervous systems achieve choice, stability and transitions between behaviors are still incompletely understood. To identify neurons and brain areas involved in controlling these processes, we combined a large-scale neuronal inactivation screen with automated action detection in response to a mechanosensory cue in Drosophila larva. We analyzed behaviors from 2.9x105 larvae and identified 66 candidate lines for mechanosensory responses out of which 25 for competitive interactions between actions. We further characterize in detail the neurons in these lines and analyzed their connectivity using electron microscopy. We found the neurons in the mechanosensory network are located in different regions of the nervous system consistent with a distributed model of sensorimotor decision-making. These findings provide the basis for understanding how selection and transition between behaviors are controlled by the nervous system.
journal_name
PLoS Genetjournal_title
PLoS geneticsauthors
Masson JB,Laurent F,Cardona A,Barré C,Skatchkovsky N,Zlatic M,Jovanic Tdoi
10.1371/journal.pgen.1008589subject
Has Abstractpub_date
2020-02-14 00:00:00pages
e1008589issue
2eissn
1553-7390issn
1553-7404pii
PGENETICS-D-19-01524journal_volume
16pub_type
杂志文章相关文献
PLoS Genetics文献大全abstract::Polygenic scores are increasingly powerful predictors of educational achievement. It is unclear, however, how sets of polygenic scores, which partly capture environmental effects, perform jointly with sets of environmental measures, which are themselves heritable, in prediction models of educational achievement. Here,...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1009153
更新日期:2020-11-17 00:00:00
abstract::A growing literature in human social genomics has begun to analyze how everyday life circumstances influence human gene expression. Social-environmental conditions such as urbanity, low socioeconomic status, social isolation, social threat, and low or unstable social status have been found to associate with differenti...
journal_title:PLoS genetics
pub_type: 杂志文章,评审
doi:10.1371/journal.pgen.1004601
更新日期:2014-08-28 00:00:00
abstract::Microbial populations founded by a single clone and propagated under resource limitation can become polymorphic. We sought to elucidate genetic mechanisms whereby a polymorphism evolved in Escherichia coli under glucose limitation and persisted because of cross-feeding among multiple adaptive clones. Apart from a 29 k...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1000713
更新日期:2009-11-01 00:00:00
abstract::Gene conversion, the non-reciprocal exchange of genetic information, is one of the potential products of meiotic recombination. It can shape genome structure by acting on repetitive DNA elements, influence allele frequencies at the population level, and is known to be implicated in human disease. But gene conversion i...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1002968
更新日期:2012-01-01 00:00:00
abstract::Significant interest has emerged in mapping genetic susceptibility for complex traits through whole-genome association studies. These studies rely on the extent of association, i.e., linkage disequilibrium (LD), between single nucleotide polymorphisms (SNPs) across the human genome. LD describes the nonrandom associat...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.0020142
更新日期:2006-09-08 00:00:00
abstract::A cascade of alternative sigma factors directs developmental gene expression during spore formation by the bacterium Bacillus subtilis. As the spore develops, a tightly regulated switch occurs in which the early-acting sigma factor σF is replaced by the late-acting sigma factor σG. The gene encoding σG (sigG) is trans...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1007350
更新日期:2018-04-27 00:00:00
abstract::Most of the somatic cells of adult metazoans, including mammals, do not undergo continuous cycles of replication. Instead, they are quiescent and devote most of their metabolic activity to gene expression. The mutagenic consequences of exposure to DNA-damaging agents are well documented, but less is known about the im...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1000577
更新日期:2009-07-01 00:00:00
abstract::In understanding the etiology of breast cancer, the contributions of both genetic and environmental risk factors are further complicated by the impact of breast developmental stage. Specifically, the time period ranging from childhood to young adulthood represents a critical developmental window in a woman's life when...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1006261
更新日期:2016-08-18 00:00:00
abstract::There is increasing evidence that non-coding macroRNAs are major elements for silencing imprinted genes, but their mechanism of action is poorly understood. Within the imprinted Gnas cluster on mouse chromosome 2, Nespas is a paternally expressed macroRNA that arises from an imprinting control region and runs antisens...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1001347
更新日期:2011-03-01 00:00:00
abstract::Candida albicans is a normal resident of the gastrointestinal tract and also the most prevalent fungal pathogen of humans. It last shared a common ancestor with the model yeast Saccharomyces cerevisiae over 300 million years ago. We describe a collection of 143 genetically matched strains of C. albicans, each of which...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1000783
更新日期:2009-12-01 00:00:00
abstract::Understanding cell proliferation mechanisms has been a long-lasting goal of the scientific community and specifically of cancer researchers. Previous genome-scale studies of cancer proliferation determinants have mainly relied on knockdown screens aimed to gauge their effects on cancer growth. This powerful approach h...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1003806
更新日期:2013-01-01 00:00:00
abstract::Vertical growth of plants is a dynamic process that is influenced by genetic and environmental factors and has a pronounced effect on overall plant architecture and biomass composition. We have performed six controlled growth trials of an interspecific Setaria italica x Setaria viridis recombinant inbred line populati...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1006841
更新日期:2017-06-23 00:00:00
abstract::Mimulus guttatus and M. nasutus are an evolutionary and ecological model sister species pair differentiated by ecology, mating system, and partial reproductive isolation. Despite extensive research on this system, the history of divergence and differentiation in this sister pair is unclear. We present and analyze a po...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1004410
更新日期:2014-06-26 00:00:00
abstract::It is now widely recognized that robustness is an inherent property of biological systems [1],[2],[3]. The contribution of close sequence homologs to genetic robustness against null mutations has been previously demonstrated in simple organisms [4],[5]. In this paper we investigate in detail the contribution of gene d...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1000014
更新日期:2008-03-14 00:00:00
abstract::The origin and evolution of new microRNAs (miRNAs) is important because they can impact the transcriptome broadly. As miRNAs can potentially emerge constantly and rapidly, their rates of birth and evolution have been extensively debated. However, most new miRNAs identified appear not to be biologically significant. Af...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1004096
更新日期:2014-01-01 00:00:00
abstract::The heart has emerged as an important organ in the regulation of systemic lipid homeostasis; however, the underlying mechanism remains poorly understood. Here, we show that Drosophila cardiomyocytes regulate systemic lipid metabolism by producing apolipoprotein B-containing lipoproteins (apoB-lipoproteins), essential ...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1006555
更新日期:2017-01-17 00:00:00
abstract::Dietary restriction (DR) is the most consistent means of extending longevity in a wide range of organisms. A growing body of literature indicates that mitochondria play an important role in longevity extension by DR, but the impact of mitochondrial genotypes on the DR process have received little attention. Mitochondr...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1004354
更新日期:2014-05-15 00:00:00
abstract::Entry into mitosis is triggered by activation of Cdk1 and inactivation of its counteracting phosphatase PP2A/B55. Greatwall kinase inactivates PP2A/B55 via its substrates Ensa and ARPP19. Both Greatwall and Ensa/ARPP19 are regulated by phosphorylation, but the dynamic regulation of Greatwall activity and the phosphata...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1004004
更新日期:2014-01-01 00:00:00
abstract::Dimethylation of histone H3 lysine 9 (H3K9m2) and trimethylation of histone H3 lysine 27 (H3K27m3) are two hallmarks of transcriptional repression in many organisms. In Arabidopsis thaliana, H3K27m3 is targeted by Polycomb Group (PcG) proteins and is associated with silent protein-coding genes, while H3K9m2 is correla...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1003062
更新日期:2012-01-01 00:00:00
abstract::Genotoxic agents that cause double-strand breaks (DSBs) often generate damage at the break termini. Processing enzymes, including nucleases and polymerases, must remove damaged bases and/or add new bases before completion of repair. Artemis is a nuclease involved in mammalian nonhomologous end joining (NHEJ), but in S...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1000060
更新日期:2008-04-25 00:00:00
abstract::Intragenomic conflicts arise when a genetic element favours its own transmission to the detriment of others. Conflicts over sex chromosome transmission are expected to have influenced genome structure, gene regulation, and speciation. In the mouse, the existence of an intragenomic conflict between X- and Y-linked mult...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1002900
更新日期:2012-09-01 00:00:00
abstract::In flat-faced dog breeds, air resistance caused by skull conformation is believed to be a major determinant of Brachycephalic Obstructive Airway Syndrome (BOAS). The clinical presentation of BOAS is heterogeneous, suggesting determinants independent of skull conformation contribute to airway disease. Norwich Terriers,...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008102
更新日期:2019-05-16 00:00:00
abstract::Chromosome breakage is a major threat to genome integrity. The most accurate way to repair DNA double strand breaks (DSB) is homologous recombination (HR) with an intact copy of the broken locus. Mobility of the broken DNA has been seen to increase during the search for a donor copy. Observing chromosome dynamics duri...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1004187
更新日期:2014-03-13 00:00:00
abstract::Fanconi Anemia (FA) is a rare autosomal recessive disorder characterized by hypersensitivity to inter-strand crosslinks (ICLs). FANCD2, a central factor of the FA pathway, is essential for the repair of double strand breaks (DSBs) generated during fork collapse at ICLs. While lesions different from ICLs can also trigg...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1005792
更新日期:2016-01-14 00:00:00
abstract::Comparison of whole genomes has revealed large and frequent changes in the size of gene families. These changes occur because of high rates of both gene gain (via duplication) and loss (via deletion or pseudogenization), as well as the evolution of entirely new genes. Here we use the genomes of 12 fully sequenced Dros...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.0030197
更新日期:2007-11-01 00:00:00
abstract::Zn²(+)-finger proteins comprise one of the largest protein superfamilies with diverse biological functions. The ATM substrate Chk2-interacting Zn²(+)-finger protein (ASCIZ; also known as ATMIN and ZNF822) was originally linked to functions in the DNA base damage response and has also been proposed to be an essential c...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1001170
更新日期:2010-10-21 00:00:00
abstract::Although DNA methylation is the best characterized epigenetic mark, the mechanism by which it is targeted to specific regions in the genome remains unclear. Recent studies have revealed that local DNA methylation profiles might be dictated by cis-regulatory DNA sequences that mainly operate via DNA-binding factors. Co...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1009189
更新日期:2020-11-20 00:00:00
abstract::Massively parallel pyrosequencing of hypervariable regions from small subunit ribosomal RNA (SSU rRNA) genes can sample a microbial community two or three orders of magnitude more deeply per dollar and per hour than capillary sequencing of full-length SSU rRNA. As with full-length rRNA surveys, each sequence read is a...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1000255
更新日期:2008-11-01 00:00:00
abstract::In haploid cells of Ogataea (Hansenula) polymorpha an environmental signal, nitrogen starvation, induces a reversible change in the structure of a chromosome. This process, mating-type switching, inverts a 19-kb DNA region to place either MATa or MATα genes under centromeric repression of transcription, depending on t...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1007092
更新日期:2017-11-27 00:00:00
abstract::Although multiple environmental cues regulate the transition to flowering in Arabidopsis thaliana, previous studies have suggested that wild A. thaliana accessions fall primarily into two classes, distinguished by their requirement for vernalization (extended winter-like temperatures), which enables rapid flowering un...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.0010006
更新日期:2005-07-01 00:00:00