Abstract：
Purpose:To evaluate the long-term safety and efficacy of the intravitreal dexamethasone implant in the treatment of diabetic macular edema (DME) as initial therapy. Methods:A hospital-based prospective, non-comparative case study of recently detected DME patients was conducted between July 2016 and December 2017, in which30 eyes of 30 patients were studied. Presenting vision, age, gender, duration of diabetes, general and ocular examination, intraocular pressure, indirect ophthalmoscopy, fundus fluorescein angiography, optical coherence tomography (OCT), and blood sugar levels were noted. Patients with increased central macular thickness (CMT) received an intravitreal dexamethasone implant as initial therapy. All were followed up at 1 week, 1 month, 3 months, 6 months, and 1 year, and the findings were recorded and analyzed using SPSS software. Results:30 eyes of 30 patients were studied which included 22 males and 8 females. The mean age of presentation was 58.7 ± 4.45 years. The mean decrease in CMT following intravitreal dexamethasone was 269.27 ± 112.002, 253.5 ± 108.294, and 286.73 ± 143.395 μm at the end of 3, 6, and 12 months, respectively, and the mean improvement in visual acuity (VA) was 2.27 ± 1.70 lines at 3 months, 2.27 ± 1.83 lines at 6 months, and 1.17 ± 2.00 lines at 12 months. Out of 30 cases, 4 had persistent DME and 6 had recurrence of DME at completion of 1 year of follow-up. Conclusion:Intravitreal dexamethasone as initial therapy in the treatment of DME is both safe and efficacious in the reduction of CMT and improvement of vision and can be considered as primary therapy for DME.
journal_name
Indian J Ophthalmoljournal_title
Indian journal of ophthalmologyauthors
Mahapatra SK,Kumari Sdoi
10.4103/ijo.IJO_620_19subject
Has Abstractpub_date
2020-03-01 00:00:00pages
490-493issue
3eissn
0301-4738issn
1998-3689pii
IndianJOphthalmol_2020_68_3_490_278368journal_volume
68pub_type
杂志文章abstract：:A retrospective review of 154 trabeculectomies with releasable sutures was performed to assess the effect of suture release on intraocular pressure (IOP) at various postoperative periods. Release of the suture was necessary in 38% of cases. The immediate reduction in IOP was significant (p < 0.01) when the suture was ...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1997-03-01 00:00:00
abstract：:A 10-year-old girl presented to us with inferonasally displaced, non-axial proptosis of oculus dexter (OD), with ipsilateral, painless massive cervical lymphadenopathy of ten weeks duration. After a detailed hematological work-up and imaging, the histological evidence obtained on cervical lymph node biopsy established...
journal_title：Indian journal of ophthalmology
pub_type：
doi：10.4103/ijo.IJO_1596_18
更新日期：2019-07-01 00:00:00
abstract：:110 cases of keratomycosis were treated with itraconazole administered either orally or topically or by both routes. Excellent or moderate response was obtained in 69 percent of the patients. Ulcers due to Aspergillus and dematiaceous fungi and non-sevee ulcers responded better than did severe ulcers and ulcers due to...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:A 65-year-old known diabetic, hypertensive, and asthmatic patient was admitted for suspected coronavirus disease 19 (COVID-19) infection following complaints of breathlessness. He tested positive for COVID-19 and was put on ventilation. He developed severe follicular conjunctivitis of the right eye while on a ventilat...
journal_title：Indian journal of ophthalmology
pub_type：
doi：10.4103/ijo.IJO_1682_20
更新日期：2020-08-01 00:00:00
abstract：:The early detection of malignancy, particularly uveal melanoma, is crucial in protecting visual acuity, salvaging the eye, and preventing metastasis. Risk factors for early detection of uveal melanoma have been clearly delineated in the literature and allow identification of melanoma when it is tiny and simulates a ne...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.4103/0301-4738.154373
更新日期：2015-02-01 00:00:00
abstract：:We report a case of intraconal grease gun injury along with traumatic optic neuropathy in a 20-year-old male. He presented with dimness of vision and proptosis of the left eye (LE) following an accidental injury at work place. The computer tomography of orbit revealed hypodense grease orbit. Cream colored grease was c...
journal_title：Indian journal of ophthalmology
pub_type：
doi：10.4103/ijo.IJO_2281_19
更新日期：2020-08-01 00:00:00
abstract：:We describe a surgical technique for the correction of isolated congenital lenticular coloboma associated with high corneal astigmatism. Transscleral fixation of the capsular bag with a single eyelet Cionni capsular tension ring was followed by in-the-bag implantation of a toric intraocular lens (IOL). This lead to co...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/ijo.IJO_1026_17
更新日期：2018-04-01 00:00:00
abstract：:Cataractous-opacification of the lens is one of the leading causes of blindness in India. The situation can be managed by surgical removal of the cataractous lens. Various pharmacological strategies have been proposed for the prevention and treatment of cataract. Information on possible benefits of putative anticatara...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.4103/0301-4738.49390
更新日期：2009-05-01 00:00:00
abstract：:Ocular bee stings are known to cause corneal melts, corneal infiltrates, cataracts, and secondary glaucoma. Our patient presented with scleritis, corneal infiltrates, and endophthalmitis after a ocular bee sting. Topical treatment led to resolution of anterior segment inflammation, but the scleritis and vitreous infla...
journal_title：Indian journal of ophthalmology
pub_type：
doi：10.4103/ijo.IJO_889_17
更新日期：2018-03-01 00:00:00
abstract：:Advancements in physics, computers, and imaging science in the last century have seen neuro-imaging evolving from a plain X-ray to computed tomography, magnetic resonance imaging scans, noninvasive angiography, and special sequences such as fat suppression, fluid attenuation recovery and diffusion-weighted imaging. A ...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.77015
更新日期：2011-03-01 00:00:00
abstract：AIM:To study the relative effects of high and low fluidic parameters on endothelial cell density (ECD), central corneal thickness (CCT), and central macular thickness (CMT) after phacoemulsification with torsional ultrasound. SETTINGS AND DESIGN:Prospective, randomized clinical trial based on a tertiary eye hospital. ...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.4103/0301-4738.169786
更新日期：2015-08-01 00:00:00
abstract：:Objective: The objective was to provide evidence-based care for patients with traumatic cataracts, we assessed whether a posterior capsulotomy and anterior vitrectomy, as part of the primary surgical procedure, could be a positive predictor of final visual outcome. Materials and Methods: This is a prospective randomiz...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.146757
更新日期：2014-11-01 00:00:00
abstract：:Femtosecond laser-assisted cataract surgery was performed in a patient with high myopia, who had undergone posterior chamber phakic intraocular lens surgery (Implantable Collamer Lens, ICL). During docking the machine erroneously focused the laser on the anterior surface of ICL and laser for lens fragmentation was als...
journal_title：Indian journal of ophthalmology
pub_type：
doi：10.4103/ijo.IJO_1852_18
更新日期：2019-10-01 00:00:00
abstract：Purpose:To objectively evaluate surgically induced astigmatism (SIA) after phacotrabeculectomy using keratometry and topography and to compare the magnitude of SIA and the refractive outcomes of single-site and twin-site phacotrabeculectomies. Methods:Forty prospective subjects were enrolled in the study and were rand...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/ijo.IJO_588_19
更新日期：2020-04-01 00:00:00
abstract：: ...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/ijo.IJO_1483_18
更新日期：2019-03-01 00:00:00
abstract：:An intraocular biopsy is performed for diagnostic, prognostic and investigational purposes. Biopsies help to confirm or exclude malignancies and differentiate inflammatory from infectious processes. Histopathological analysis is the final verdict in unresponsive uveitis, atypical inflammation, metastases and masquerad...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.4103/ijo.IJO_1325_20
更新日期：2020-09-01 00:00:00
abstract：Purpose:To evaluate the effect of cyanidin-3-glucoside (C3G) in oxygen-induced retinopathy (OIR) mouse model. Methods:In this experimental study, 10 C57BL / 6J type mice exposed to room air comprised two control groups (n = 5 each; a negative control and a group receiving intravitreal sterile dimethyl sulfoxide [IVS D...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/ijo.IJO_166_18
更新日期：2019-06-01 00:00:00
abstract：Purpose:To evaluate the effect of acute submaximal exercise on intraocular pressure (IOP) fluctuations in open-angle glaucoma (OAG) subjects using an ocular telemetry sensor (OTS, Sensimed TriggerFish®). Methods:Twelve OAG subjects aged 45-65 years with no medical limitation for exercise were included in this prospect...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/ijo.IJO_585_18
更新日期：2019-01-01 00:00:00
abstract：:A case of orbitofrontal fibrous dysplasia with optic canal involvement is reported. Surgical excision of the mass with unroofing of the optic canal followed by orbito-cranian reconstruction by methyl methacrylate gave excellent results. ...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Posterior polar annual choroidal dystrophy is a rare disease which affects the retina and choroid in an annular pattern. Our patient was referred to us a case of atypical retinitis pigmentosa. Fundus examination showed a normal optic disc, normal arterioles, and no bone spicules. The right eye showed a hemispheric pat...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/ijo.IJO_367_18
更新日期：2018-12-01 00:00:00
abstract：:Ocular dirofilariasis mostly presents as a subconjunctival or eyelid lesion. Intraocular dirofilarial infestation is rare. We report a case of a young woman who was accidentally detected to have a live motile worm in the anterior segment in one eye and a cystic lesion on the optic disc in the other eye. To our knowled...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.116252
更新日期：2014-03-01 00:00:00
abstract：:An eight-year-old male child presented with drooping of the left eyelid with a history of penetrating injury of hard palate by an iron spoon seven days ago, which had already been removed by the neurosurgeon as the computed tomography scan revealed a spoon in the left posterior ethmoid and sphenoid bone penetrating in...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.55072
更新日期：2009-09-01 00:00:00
abstract：:A 75-year-old man presented to us with sudden onset of profound vision loss in his right eye and was identified as suffering from an ophthalmic artery occlusion. Apart from the retinal whitening and box-carring of the retinal arteries, there were characteristic triangular patches of retinal whitening in the midperiphe...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/ijo.IJO_42_17
更新日期：2017-10-01 00:00:00
abstract：:The purpose of the study is to describe epidemiology, clinical features, diagnosis, and treatment of Acanthamoeba keratitis (AK) with special focus on the disease in nonusers of contact lenses (CLs). This study was a perspective based on authors' experience and review of published literature. AK accounts for 2% of mic...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.4103/ijo.IJO_826_17
更新日期：2017-11-01 00:00:00
abstract：:Optical coherence tomography (OCT) has revolutionized imaging of ocular structures and various disease conditions. Though it has been used in the clinic for some decades, the OCT has only recently found its way into the operating theater. Early attempts at intraoperative OCT, hand-held and microscope mounted, have alr...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.4103/0301-4738.159865
更新日期：2015-05-01 00:00:00
abstract：: ...
journal_title：Indian journal of ophthalmology
pub_type： 评论,信件
doi：10.4103/ijo.IJO_1124_18
更新日期：2019-01-01 00:00:00
abstract：PURPOSE:The purpose was to measure the concentrations of various cytokines and growth factors (including vascular endothelial growth factor [VEGF] and pigment epithelium-derived factor [PEDF]) in the vitreous of patients with proliferative diabetic retinopathy (PDR) and to investigate interaction between inflammatory a...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.151464
更新日期：2015-01-01 00:00:00
abstract：Purpose:In 1-12 years old children, we assessed correlation, regression, and agreement between spherical equivalents (SE) obtained on Mohindra's near retinoscopy (MNR) and the post cycloplegic refraction (PCRef), performed 72 h after a cycloplegic refraction (CRef) using cyclopentolate 1% drops. Methods:In this prospe...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/ijo.IJO_229_20
更新日期：2020-11-01 00:00:00
abstract：:The incidence of the craniofacial cleft is rare ranging between 1.43 and 4.85/100,000 births. Tessier number nine cleft being the rarest, there are a few reports of detailed ophthalmologic examinations performed in them. In this study, 1-day-old female neonate delivered by normal vaginal delivery at term, weighing 148...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/ijo.IJO_914_16
更新日期：2017-07-01 00:00:00
abstract：:A, 46-year-old Indian male, known hypertensive presented with left esotropia of 25 prism diopters (PD) after head injury in a roadside accident 9 months back. The deviation was constant in nature and was associated with complaints of diplopia in left lateral gaze. Traumatic sixth nerve palsy was diagnosed. The patien...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.162619
更新日期：2015-06-01 00:00:00
