Development of a novel murine heart failure model overexpressing human renin and angiotensinogen.

Abstract:

:Renin is the rate-limiting enzyme of the renin-angiotensin system cascade, which drives the pathophysiological progression of heart failure. Species differences in the amino acid sequence of the catalytic domain of renin limit evaluations of the potency and efficacy of human renin inhibitors in animal models, and a high dose of inhibitors is usually needed to show its organ-protective effects in rodents. In the present study, we developed a novel murine heart failure model (triple-tg) to enable us to evaluate the cardioprotective effect of renin inhibitors at more relevant doses for humans, by cross-breeding calsequestrin transgenic (CSQ-tg) mice with human renin and human angiotensinogen double-transgenic mice. The triple-tg mice exhibited increased plasma renin activity, worsened cardiac hypertrophy, and higher mortality compared to CSQ-tg mice. Triple-tg mice treated with 10 mg·kg-1 of TAK-272 (imarikiren/SCO-272), an orally active direct renin inhibitor, exhibited improvements in heart failure phenotypes, such as cardiac hypertrophy and survival rate; however, a dose of 300 mg·kg-1 was required to improve symptoms in CSQ-tg mice. Our results suggest that this newly generated triple-tg heart failure model is useful to evaluate the cardioprotective effects of human renin inhibitors at clinically relevant doses, thereby minimizing the concerns of off-target effects related to much higher drug exposure than that achieved in clinical study.

journal_name

FEBS Open Bio

journal_title

FEBS open bio

authors

Hara T,Yamamura T,Murakami-Asahina M,Matsumoto H,Takeyama M,Kanagawa R,Nishimoto T

doi

10.1002/2211-5463.12810

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

718-725

issue

5

issn

2211-5463

journal_volume

10

pub_type

杂志文章
  • Dysregulation of the Sirt5/IDH2 axis contributes to sunitinib resistance in human renal cancer cells.

    abstract::Sunitinib (Sun), a tyrosine kinase inhibitor of vascular endothelial growth factor receptor, is the standard first-line treatment against advanced clear cell renal cell carcinoma (RCC), but resistance to therapy is inevitable. Reactive oxygen species production is associated with sensitivity to chemotherapy, but the u...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1002/2211-5463.13090

    authors: Meng L,Chen D,Meng G,Lu L,Han C

    更新日期:2021-01-16 00:00:00

  • A novel cell-penetrating peptide derived from WT1 enhances p53 activity, induces cell senescence and displays antimelanoma activity in xeno- and syngeneic systems.

    abstract::The Wilms tumor protein 1 (WT1) transcription factor has been associated in malignant melanoma with cell survival and metastasis, thus emerging as a candidate for targeted therapy. A lysine-arginine rich peptide, WT1-pTj, derived from the ZF domain of WT1 was evaluated as an antitumor agent against A2058 human melanom...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1016/j.fob.2014.01.007

    authors: Massaoka MH,Matsuo AL,Figueiredo CR,Girola N,Faria CF,Azevedo RA,Travassos LR

    更新日期:2014-01-21 00:00:00

  • Serum long non-coding RNA LINC00887 as a potential biomarker for diagnosis of renal cell carcinoma.

    abstract::The identification of non-invasive biomarkers for the detection of renal cell carcinoma (RCC) in early-stage patients may help improve disease outcome. Certain long non-coding RNAs (lncRNAs) have been reported to be possible biomarkers for the diagnosis and prognosis of cancer. Here, we examined the suitability of the...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1002/2211-5463.12930

    authors: Xie J,Zhong Y,Chen R,Li G,Luo Y,Yang J,Sun Z,Liu Y,Liu P,Wang N,An J,Li C,Song Y

    更新日期:2020-09-01 00:00:00

  • Spatiotemporal immunolocalisation of REST in the brain of healthy ageing and Alzheimer's disease rats.

    abstract::In the brain, REST (Repressor Element-1 Silencing Transcription factor) is a key regulator of neuron cell-specific gene expression. Nuclear translocation of neuronal REST has been shown to be neuroprotective in a healthy ageing context. In contrast, inability to upregulate nuclear REST is thought to leave ageing neuro...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1002/2211-5463.13036

    authors: Mampay M,Velasco-Estevez M,Rolle SO,Chaney AM,Boutin H,Dev KK,Moeendarbary E,Sheridan GK

    更新日期:2020-11-13 00:00:00

  • Characterization of an intertidal zone metagenome oligoribonuclease and the role of the intermolecular disulfide bond for homodimer formation and nuclease activity.

    abstract::The gene encoding MG Orn has been identified from a metagenomic library created from the intertidal zone in Svalbard and encodes a protein of 184 amino acid residues. The mg orn gene has been cloned, recombinantly expressed in Escherichia coli, and purified to homogeneity. Biochemical characterization of the enzyme sh...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1002/2211-5463.12720

    authors: Piotrowski Y,Berg K,Klebl DP,Leiros I,Larsen AN

    更新日期:2019-10-01 00:00:00

  • Identification of small-molecule elastase inhibitors as antagonists of IL-36 cytokine activation.

    abstract::IL-1 family cytokines act as apical initiators of inflammation in many settings and can promote the production of a battery of inflammatory cytokines, chemokines and other inflammatory mediators in diverse cell types. IL-36α, IL-36β and IL-36γ, which belong to the extended IL-1 family, have been implicated as key init...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1002/2211-5463.12406

    authors: Sullivan GP,Davidovich PB,Sura-Trueba S,Belotcerkovskaya E,Henry CM,Clancy DM,Zinoveva A,Mametnabiev T,Garabadzhiu AV,Martin SJ

    更新日期:2018-03-25 00:00:00

  • Survey and analysis of simple sequence repeats (SSRs) present in the genomes of plant viroids.

    abstract::Extensive simple sequence repeat (SSR) surveys have been performed for eukaryotic prokaryotic and viral genomes, but information regarding SSRs in viroids is limited. We undertook a survey to examine the presence of SSRs in viroid genomes. Our results show that the distribution of SSRs in viroids may influence seconda...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1016/j.fob.2014.02.001

    authors: Qin L,Zhang Z,Zhao X,Wu X,Chen Y,Tan Z,Li S

    更新日期:2014-02-07 00:00:00

  • Regulation of Neisseria meningitidis cytochrome bc1 components by NrrF, a Fur-controlled small noncoding RNA.

    abstract::NrrF is a small regulatory RNA of the human pathogen Neisseria meningitidis. NrrF was previously shown to repress succinate dehydrogenase (sdhCDAB) under control of the ferric uptake regulator (Fur). Here, we provide evidence that cytochrome bc 1 , encoded by the polycistro...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1002/2211-5463.12266

    authors: Pannekoek Y,Huis In 't Veld R,Schipper K,Bovenkerk S,Kramer G,Speijer D,van der Ende A

    更新日期:2017-08-05 00:00:00

  • Masc-induced dosage compensation in silkworm cultured cells.

    abstract::The Masculinizer (Masc) gene encodes a CCCH-tandem zinc finger protein that controls both masculinization and dosage compensation in the silkworm Bombyx mori. We previously measured the masculinizing activity of the lepidopteran Masc proteins using B. mori ovary-derived cell line BmN-4. Here, we established an RNA-seq...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1002/2211-5463.12698

    authors: Katsuma S,Shoji K,Sugano Y,Suzuki Y,Kiuchi T

    更新日期:2019-09-01 00:00:00

  • Proteasome inhibitors prevent cell death and prolong survival of mice challenged by Shiga toxin.

    abstract::Shiga toxin (Stx) causes fatal systemic complications. Stx induces apoptosis, but the mechanism of which is unclear. We report that Stx induced rapid reduction of short-lived anti-apoptotic proteins followed by activation of caspase 9 and the progression of apoptosis. Proteasome inhibitors prevented the reduction of a...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1016/j.fob.2015.06.005

    authors: Hattori T,Watanabe-Takahashi M,Ohoka N,Hamabata T,Furukawa K,Nishikawa K,Naito M

    更新日期:2015-06-12 00:00:00

  • A new split-luciferase complementation assay identifies pentachlorophenol as an inhibitor of apoptosome formation.

    abstract::The expense and time required for in vivo reproductive and developmental toxicity studies have driven the development of in vitro alternatives. Here, we used a new in vitro split luciferase-based assay to screen a library of 177 toxicants for inhibitors of apoptosome formation. The apoptosome contains seven Apoptotic ...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1002/2211-5463.12646

    authors: Tashakor A,H-Dehkordi M,O'Connell E,Gomez Ganau S,Gozalbes R,Eriksson LA,Hosseinkhani S,Fearnhead HO

    更新日期:2019-07-01 00:00:00

  • Presence of O-glycosidically linked oligosaccharides in the cell wall mannan of Candida krusei purified with Benanomicin A.

    abstract::Cell wall mannan of the pathogenic yeast Candida krusei was prepared using the antibiotic Benanomicin A, which has a lectin-like function. The chemical structure of this molecule was found to be similar to that of mannan prepared from the same yeast by the conventional method using Fehling reagent. Only a few degradat...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1002/2211-5463.12558

    authors: Kuraoka T,Ishiyama A,Oyamada H,Ogawa Y,Kobayashi H

    更新日期:2018-12-10 00:00:00

  • Dynamics of protein secretion during adipocyte differentiation.

    abstract::The major functions of adipocytes include both lipid storage and the production of secretory factors. However, the type of proteins released from mouse 3T3-L1 cells during adipocyte differentiation remains poorly understood. We examined the dynamics of secreted proteins during adipocyte differentiation using mass spec...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1002/2211-5463.12091

    authors: Ojima K,Oe M,Nakajima I,Muroya S,Nishimura T

    更新日期:2016-06-15 00:00:00

  • Fluoride resistance capacity in mammalian cells involves complex global gene expression changes.

    abstract::Fluorine is a bone-seeking element ubiquitously present in the environment and widely used in many oral hygiene products. In humans, excessive intake of fluoride may cause dental and skeletal fluorosis. However, endemic fluorosis does not appear to develop in a proportion of individuals exposed to the same levels of f...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1002/2211-5463.12236

    authors: Ran S,Sun N,Liu Y,Zhang W,Li Y,Wei L,Wang J,Liu B

    更新日期:2017-06-05 00:00:00

  • Characterization of the cHS4 insulator in mouse embryonic stem cells.

    abstract::Synthetic biology circuits are often constructed with multiple gene expression units assembled in close proximity, and they can be used to perform complex functions in embryonic stem cells (ESCs). However, mutual interference between transcriptional units has not been well studied in mouse ESCs. To assess the efficien...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1002/2211-5463.12818

    authors: Lu XB,Guo YH,Huang W

    更新日期:2020-04-01 00:00:00

  • Reconstruction and applications of consensus yeast metabolic network based on RNA sequencing.

    abstract::One practical application of genome-scale metabolic reconstructions is to interrogate multispecies relationships. Here, we report a consensus metabolic model in four yeast species (Saccharomyces cerevisiae, S. paradoxus, S. mikatae, and S. bayanus) by integrating metabolic network simulations with RNA sequencing (RNA-...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1002/2211-5463.12033

    authors: Zhao Y,Wang Y,Zou L,Huang J

    更新日期:2016-02-27 00:00:00

  • Expression patterns of kiss2 and gpr54-2 in Monopterus albus suggest these genes may play a role in sex reversal in fish.

    abstract::Due to its exceptionally small genome size and protogynous hermaphroditism, Monopterus albus has been proposed as a model for vertebrate sexual development. The Kiss/GPR54 system is a central regulator of sexual development in most vertebrates, but its role in sex reversal remains hypothetical. In contrast to mammals,...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1002/2211-5463.12727

    authors: Yi TL,Pei MT,Yang DQ

    更新日期:2019-10-01 00:00:00

  • The levels of RAC3 expression are up regulated by TNF in the inflammatory response.

    abstract::RAC3 is a coactivator of glucocorticoid receptor and nuclear factor-κB (NF-κB) that is usually over-expressed in tumors and which also has important functions in the immune system. We investigated the role of the inflammatory response in the control of RAC3 expression levels in vivo and in vitro. We found that inflamm...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1016/j.fob.2014.04.009

    authors: Alvarado CV,Rubio MF,Fernández Larrosa PN,Panelo LC,Azurmendi PJ,Ruiz Grecco M,Martínez-Nöel GA,Costas MA

    更新日期:2014-05-02 00:00:00

  • Decorin-mediated inhibition of the migration of U87MG glioma cells involves activation of autophagy and suppression of TGF-β signaling.

    abstract::Decorin (DCN) is a major member of the small leucine-rich proteoglycan (SLRP) family that is critically involved in tumorigenesis and the development of metastasis of cancers, including glioma. Overexpression of DCN was indicated to suppress glioma cell growth. However, the role of DCN in the migration of glioma cells...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1002/2211-5463.12076

    authors: Yao T,Zhang CG,Gong MT,Zhang M,Wang L,Ding W

    更新日期:2016-05-31 00:00:00

  • A comparative study of the degradation of yeast cyclins Cln1 and Cln2.

    abstract::The yeast cyclins Cln1 and Cln2 are very similar in both sequence and function, but some differences in their functionality and localization have been recently described. The control of Cln1 and Cln2 cellular levels is crucial for proper cell cycle initiation. In this work, we analyzed the degradation patterns of Cln1...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1002/2211-5463.12157

    authors: Quilis I,Igual JC

    更新日期:2016-12-14 00:00:00

  • High-intensity focused ultrasound inhibits invasion and metastasis of colon cancer cells by enhancing microRNA-124-mediated suppression of STAT3.

    abstract::Metastasis is the primary contributor to colorectal cancer mortality. High-intensity focused ultrasound (HIFU) is an emerging technology for tumor therapy that exerts its effects through tumor ablation, mechanical disruption, and enhancement of immune responses. However, it remains unclear whether HIFU can influence t...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1002/2211-5463.12642

    authors: Li M,Wan G,Yu H,Xiong W

    更新日期:2019-06-01 00:00:00

  • Inhibition of cyclophilin A suppresses H2O2-enhanced replication of HCMV through the p38 MAPK signaling pathway.

    abstract::Human cytomegalovirus (HCMV) infection can be accelerated by intracellular and extracellular hydrogen peroxide (H2O2) stimulation, mediated by the activation of the p38 mitogen-activated protein kinase (MAPK) pathway. However, it remains unknown whether host gene expression is involved in H2O2-upregulated HCMV replica...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1002/2211-5463.12105

    authors: Xiao J,Song X,Deng J,Lv L,Ma P,Gao B,Zhou X,Zhang Y,Xu J

    更新日期:2016-08-15 00:00:00

  • Alterations in DNA methylation profiles in cancellous bone of postmenopausal women with osteoporosis.

    abstract::Osteoporosis is characterized by systemic microarchitecture impairment and bone loss, which ultimately lead to fragility fractures. This disease is most common in older people, especially in postmenopausal women. Cancellous bone is affected by osteoporosis earlier than cortical bone, and DNA methylation microarray ana...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1002/2211-5463.12907

    authors: Zhou Y,Yang L,Wang H,Chen X,Jiang W,Wang Z,Liu S,Liu Y

    更新日期:2020-08-01 00:00:00

  • The gene expression of numerous SLC transporters is altered in the immortalized hypothalamic cell line N25/2 following amino acid starvation.

    abstract::Amino acids are known to play a key role in gene expression regulation, and in mammalian cells, amino acid signaling is mainly mediated via two pathways, the mammalian target of rapamycin complex 1 (mTORC1) pathway and the amino acid responsive (AAR) pathway. It is vital for cells to have a system to sense amino acid ...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1002/2211-5463.12181

    authors: Hellsten SV,Lekholm E,Ahmad T,Fredriksson R

    更新日期:2017-01-11 00:00:00

  • p38α controls self-renewal and fate decision of neurosphere-forming cells in adult hippocampus.

    abstract::Neural stem cells (NSC) from the adult hippocampus easily lose their activity in vitro. Efficient in vitro expansion of adult hippocampus-derived NSC is important for generation of tools for research and cell therapy. Here, we show that a single copy disruption or pharmacological inhibition of p38α enables successful ...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1016/j.fob.2015.05.001

    authors: Yoshioka K,Namiki K,Sudo T,Kasuya Y

    更新日期:2015-05-08 00:00:00

  • Identification of distinctive interdomain interactions among ZP-N, ZP-C and other domains of zona pellucida glycoproteins underlying association of chicken egg-coat matrix.

    abstract::The vertebrate egg coat, including mammalian zona pellucida, is an oocyte-specific extracellular matrix comprising two to six zona pellucida (ZP) glycoproteins. The egg coat plays important roles in fertilization, especially in species-specific interactions with sperm to induce the sperm acrosome reaction and to form ...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1016/j.fob.2015.05.005

    authors: Okumura H,Sato T,Sakuma R,Fukushima H,Matsuda T,Ujita M

    更新日期:2015-05-27 00:00:00

  • Transformation of the fungus Absidia glauca by complementation of a methionine-auxotrophic strain affected in the homoserine-acetyltransferase gene.

    abstract::Transformation of fungi by complementation of auxotrophs is generally much more reliable than usage of antibiotic resistance markers. In order to establish such a system for the model zygomycete Absidia glauca, a stable methionine auxotrophic mutant was isolated after X-ray mutagenesis of the minus mating type and cha...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1016/j.fob.2012.07.002

    authors: Karimi S,Wetzel J,Wöstemeyer J,Burmester A

    更新日期:2012-07-20 00:00:00

  • Knockout of cytochrome P450 1A1 enhances lipopolysaccharide-induced acute lung injury in mice by targeting NF-κB activation.

    abstract::Acute lung injury (ALI) is accompanied by overactivation of multiple pro-inflammatory factors. Cytochrome P450 1A1 (CYP1A1) has been shown to aggravate lung injury in response to hyperoxia. However, the relationship between CYP1A1 and lipopolysaccharide (LPS)-induced ALI is unknown. In this study, CYP1A1 was shown to ...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1002/2211-5463.12977

    authors: Tian LX,Tang X,Ma W,Wang J,Zhang W,Liu K,Chen T,Zhu JY,Liang HP

    更新日期:2020-09-15 00:00:00

  • Mutational and crystallographic analysis of l-amino acid oxidase/monooxygenase from Pseudomonas sp. AIU 813: Interconversion between oxidase and monooxygenase activities.

    abstract::In this study, it was shown for the first time that l-amino acid oxidase of Pseudomonas sp. AIU813, renamed as l-amino acid oxidase/monooxygenase (l-AAO/MOG), exhibits l-lysine 2-monooxygenase as well as oxidase activity. l-Lysine oxidase activity of l-AAO/MOG was increased in a p-chloromercuribenzoate (p-CMB) concent...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1016/j.fob.2014.02.002

    authors: Matsui D,Im DH,Sugawara A,Fukuta Y,Fushinobu S,Isobe K,Asano Y

    更新日期:2014-02-07 00:00:00

  • Antipsychotics inhibit glucose transport: Determination of olanzapine binding site in Staphylococcus epidermidis glucose/H(+) symporter.

    abstract::The antipsychotic drug olanzapine is widely prescribed to treat schizophrenia and other psychotic disorders. However, it often causes unwanted side effects, including diabetes, due to disruption of insulin-dependant glucose metabolism through a mechanism yet to be elucidated. To determine if olanzapine can affect the ...

    journal_title:FEBS open bio

    pub_type: 杂志文章

    doi:10.1016/j.fob.2015.04.006

    authors: Babkin P,George Thompson AM,Iancu CV,Walters DE,Choe JY

    更新日期:2015-04-15 00:00:00