Patterns of polyp histology: predictors of peril in the mucosa.


BACKGROUND:Precursor colonic polyps of varied subtypes correlate with the known neoplastic pathways. When patients present with synchronous pre-malignant polyps of multiple histologies, multiple genetic mechanisms are likely to be active, potentially resulting in a more unstable, tumourigenic mucosa. METHODS:We hypothesized that patients with a combination of sessile serrated adenomas/polyps (SSA/Ps), hyperplastic (HP) polyps and adenomas would be at highest risk of developing dysplasia/cancer compared to SSA/Ps alone, due to the synergistic effect of multiple active carcinogenic pathways. A prospective colonoscopy database was examined for patients with a history of SSA/P. Patients were placed into four groups based on patterns of polyp histology as follows: (i) only SSA/Ps; (ii) SSA/P + HP; (iii) SSA/Ps + adenomas; and (iv) SSA/Ps + HP + adenomas. These groups were compared in terms of the numbers, size, location and histology of polyps and personal or family history of colorectal cancer. RESULTS:A total of 374 patients were included. The average age was 70 years (range 21-88), and 43% were male. There was a trend towards the most aggressive neoplastic pattern in group 4, associated with a tendency to larger SSA/Ps, more villous architecture in the adenomas and more high-grade dysplasia in both types of polyps. It was also associated with multiplicity of both SSA/Ps and adenomas. No SSA/Ps existing in the absence of adenomas had cytological dysplasia. CONCLUSION:The combination of SSA/Ps, HP and adenomas in the colorectal epithelium seems to be a marker for aggressive carcinogenesis and suggests that accurate and effective surveillance is important to manage this risk.


ANZ J Surg


ANZ journal of surgery


Dean M,Plesec T,Kalady MF,Church J




Has Abstract


2020-05-01 00:00:00












  • Laparoscopic liver resection in cirrhotics: feasibility and short-term outcomes compared to non-cirrhotics.

    abstract:BACKGROUND:Laparoscopic liver resection (LLR) is increasingly common worldwide but its suitability in patients with cirrhosis is not clearly defined. There are minimal data in the western literature on this topic and previous work has compared LLR to open hepatectomy rather than to LLR in non-cirrhotic patients. This s...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Srinivasa S,Hughes M,Azodo IA,Adair A,Ravindran R,Harrison E,Wigmore SJ

    更新日期:2020-06-01 00:00:00

  • The effect of indole-3-carbinol and sulforaphane on a prostate cancer cell line.

    abstract:BACKGROUND:Cruciferous vegetable consumption is inversely related to the incidence of prostate cancer. We examined the effect of indole-3-carbinol (I3C) and of sulforaphane (constituents of cruciferous vegetables) on cell proliferation of a PC-3 prostate cancer cell line, in order to observe if an inhibitory effect mig...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Frydoonfar HR,McGrath DR,Spigelman AD

    更新日期:2003-03-01 00:00:00

  • Repair of mandible defect with tissue engineering bone in rabbits.

    abstract:BACKGROUND:The aim of the present study was to investigate the effect of tissue engineering bone composed of bone marrow-derived osteoblasts and demineralized bone in repairing mandible defect. METHODS:Bone marrow-derived osteoblasts of 20 rabbits were cultured and seeded into scaffold of allogeneic demineralized bone...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Li Z,Li ZB

    更新日期:2005-11-01 00:00:00

  • Geographical variation in the management of urolithiasis in Australia.

    abstract:BACKGROUND:To examine any geographical variation in the management of urolithiasis amongst the Australian states and territories. METHODS:Retrospective study with data obtained from the Medicare Australia database, the Royal Australasian College of Surgeons and the Urological Society of Australia and New Zealand. RES...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Tran MA,Chak-Lee M,Bariol SV

    更新日期:2017-06-01 00:00:00

  • U-shaped prostatobulbar anastomosis for urethral injury after pelvic trauma.

    abstract:BACKGROUND:We describe a technique of U-shaped bulboprostatic anastomosis for urethral injury after pelvic trauma. METHODS:Sixty-eight male patients were included in our study. Suprapubic cystostomy was carried out initially, followed by U-shaped prostatobulbar anastomosis after 6-12 weeks. Follow ups were carried out...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Mathur RK,Aggarwal H,Odiya S,Lubana PS

    更新日期:2008-07-01 00:00:00

  • Single-stage laparoscopic cholecystectomy and intraoperative endoscopic retrograde cholangiopancreatography: is this strategy feasible in Australia?

    abstract::Currently in Australasia, concomitant cholecystolithiasis and choledocholithiasis are usually managed with two procedures: laparoscopic cholecystectomy (LC) and pre or postoperative endoscopic retrograde cholangiopancreatography (ERCP). This approach exposes the patient to the risk of complications from the common bil...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,评审


    authors: March B,Burnett D,Gani J

    更新日期:2016-11-01 00:00:00

  • Validation of data submitted by the treating surgeon in the Victorian Audit of Surgical Mortality.

    abstract:BACKGROUND:The Victorian Audit of Surgical Mortality (VASM) seeks to peer review all deaths associated with surgical care in Victoria, Australia. The effectiveness of the VASM as an educational and quality improvement tool is dependent on the accuracy of source data it receives. We aimed to examine the accuracy and qua...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Hansen D,Hansen E,Retegan C,Morphet J,Beiles CB

    更新日期:2019-01-01 00:00:00

  • Mastectomy flap design: the 'waisted teardrop' and a method to reduce the lateral fold.

    abstract:BACKGROUND:There are various methods to design mastectomy flaps but few are standardized. Lateral skin folds or 'dog ears' are a common, unsightly and uncomfortable consequence following a surgery in overweight patients. METHODS:We describe a simple technique for designing mastectomy flaps and a method to eliminate th...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Thomas R,Mouat C,King B

    更新日期:2012-05-01 00:00:00

  • Tracheal repair in children: reduction of mortality with advent of slide tracheoplasty.

    abstract:BACKGROUND:Severe tracheal stenosis is a rare life-threatening condition that often requires early surgical intervention. The management of this anomaly has been associated with significant mortality and morbidity. We describe our experience with repair of this condition. METHODS:From 1986 to 2011, 20 patients underwe...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Yong MS,d'Udekem Y,Robertson CF,Butt W,Brizard CP,Konstantinov IE

    更新日期:2014-10-01 00:00:00

  • Sustaining the surgical educator workforce in Australia and New Zealand.

    abstract:BACKGROUND:The education and training of tomorrow’s surgeons are predicated upon the involvement of a broad spectrum of surgical educators. Identification of the factors that influence their ongoing participation is crucial for its continuity. METHODS:A study was performed on 695 surgeons identified as having major in...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Collins JP,Smith MJ,Lambert T,Hillis DJ

    更新日期:2011-06-01 00:00:00

  • Neoadjuvant chemoradiotherapy for rectal cancer: how important is tumour regression?

    abstract:BACKGROUND:Pathological complete response following neoadjuvant chemoradiotherapy (CRT) for locally advanced rectal cancer is associated with reduced local recurrence and improved long-term outcome. However, the prognostic value of a partial response, or of tumour regression in patients with metastatic disease, is less...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: McCoy MJ,Hemmings C,Hillery S,Penter C,Bulsara MK,Zeps N,Platell CF

    更新日期:2017-12-01 00:00:00

  • Laparoscopic EndoClose fixation of a peritoneal catheter reduces migration.

    abstract:BACKGROUND:With the introduction of laparoscopic Tenckhoff catheter insertion in the early 1990s, catheter malposition resulting in malfunction remains a frequent complication, often requiring surgical or radiological intervention. In this pioneer study, we describe the technique of suturing the Tenckhoff catheter usin...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Rouse M,Choi J,Bakhit J,Soh B,Chan S

    更新日期:2020-01-01 00:00:00

  • Surgical treatment of hepatic haemangiomas: a 15-year experience.

    abstract:BACKGROUND:Hepatic haemangiomas are congenital vascular malformations. They are the most common benign tumours of the liver and are often asymptomatic. Spontaneous or traumatic rupture, intratumoral bleeding, consumption coagulopathy and rapid growth are the mandatory surgical indications. We present our experience ove...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Gourgiotis S,Moustafellos P,Zavos A,Dimopoulos N,Vericouki C,Hadjiyannakis EI

    更新日期:2006-09-01 00:00:00

  • Achieving quality in colonoscopy: bowel preparation timing and colon cleanliness.

    abstract:BACKGROUND:Colonoscopy is considered the gold standard for investigation of large bowel pathology. Numerous factors influence the efficacy of bowel preparation for colonoscopy. Inadequate bowel preparation can lead to missed pathology. Timing of fasting and bowel preparation, timing of procedure and possibly patient bo...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,随机对照试验


    authors: Athreya PJ,Owen GN,Wong SW,Douglas PR,Newstead GL

    更新日期:2011-04-01 00:00:00

  • Blood loss and transfusion in elective abdominal aortic aneurysm surgery.

    abstract:BACKGROUND:Intraoperative blood loss and transfusion are known determinants of mortality and morbidity of elective abdominal aortic aneurysm (AAA) repair. The present study analysed the pattern of blood loss and transfusion and evaluated the risk factors of blood loss during open repair of infrarenal AAA. METHODS:Bloo...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Ho P,Ting AC,Cheng SW

    更新日期:2004-08-01 00:00:00

  • Carotid redo surgery: both safe and durable.

    abstract:AIM:To examine the outcomes and complications of surgery for recurrent carotid stenosis. METHODS:From 1974 to 2000, 1922 carotid endarterectomies were performed in our unit. A retrospective cohort analysis of these records identified 24 patients (1.2%) who underwent surgery for recurrent stenosis. RESULTS:There were ...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Harris RA,Stow N,Fisher CM,Neale ML,Appleberg M

    更新日期:2003-12-01 00:00:00

  • Does composite repair of giant paraoesophageal hernia improve patient outcomes?

    abstract:BACKGROUND:Paraoesophageal hernia (PEH) is often symptomatic and reduces patients' quality of life (QoL). There is ongoing debate regarding the most effective surgical technique to repair giant PEH. This study aimed to see if an elective laparoscopic non-mesh composite technique of giant PEH repair offered an advantage...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Lee F,Khoma O,Mendu M,Falk G

    更新日期:2020-11-08 00:00:00

  • Surgical procedures for melanoma in public and private New South Wales hospitals, 2001-2002.

    abstract:BACKGROUND:Evidence suggests that there is considerable variation in the types of procedures used to treat cancer. This variation may result in suboptimal or cost-ineffective care. The present study examined the variation in surgical treatment of melanoma before the establishment of a Melanoma Network that could promot...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Barton MB,Gabriel GS,Frommer MS,Holt PE,Thompson JF

    更新日期:2006-05-01 00:00:00

  • Fatal flaws in clinical decision making.

    abstract:BACKGROUND:Clinical decision making is a core competency of surgical practice, involving a continuous and evolving process of data interpretation and evaluation. The aim of this article is twofold. First, to recognize patient deaths where a clinical incident arose following unsatisfactory clinical decision making, dete...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Davis SS,Babidge WJ,McCulloch GAJ,Maddern GJ

    更新日期:2019-06-01 00:00:00

  • Kasai hepatoportoenterostomy in South Australia: a case for 'centralized decentralization'.

    abstract:BACKGROUND:Recent follow-up studies have demonstrated significant improvement in overall survival as well as survival with native liver following geographic centralization of services to three centres in the UK. However, this model has not been replicated in countries with relatively low population density such as Aust...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Tu CG,Khurana S,Couper R,Ford AW

    更新日期:2015-11-01 00:00:00

  • Nicolaes Tulp and the golden age of the Dutch Republic.

    abstract::In the seventeenth century, Holland and the allied provinces of the northern Netherlands won final independence from their Spanish overlords and formed a worldwide economic empire. Dutch ships dominated the seas from the Caribbean to Japan and reconnoitred the coasts of Australia and New Zealand. Dutch society was cos...

    journal_title:ANZ journal of surgery

    pub_type: 传,历史文章


    authors: Simpson D

    更新日期:2007-12-01 00:00:00

  • Extended medial gastrocnemius myocutaneous flap in repair of the quadriceps extension mechanism.

    abstract::The gastrocnemius muscle is versatile in flap repair of defects from anterior knee to lower leg. We describe a case of extensor reconstruction using an extended medial gastrocnemius myocutaneous flap. A medial gastrocnemius flap was raised distal to its musculotendinous insertion. At its point of rotation, it was anch...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Warrier SK,Mah E,Morrison WA

    更新日期:2006-12-01 00:00:00

  • Modified elliptical rotation flap for sacrococcygeal pilonidal sinus disease.

    abstract:BACKGROUND:Although various surgical procedures have been described for pilonidal sinus disease, the best surgical technique is still controversial. The aim of this study was to evaluate the short-term results of modified elliptical rotation flap (MERF) for pilonidal sinus disease in terms of post-operative complicatio...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Dizen H,Yoldas Ö,Yıldız M,Cilekar M,Dilektaşlı E

    更新日期:2014-10-01 00:00:00

  • Workplace-based assessment: assessing technical skill throughout the continuum of surgical training.

    abstract::The Royal Colleges of Surgeons and Surgical Specialty Associations in the UK have introduced competence-based syllabi and curricula for surgical training. The syllabi of the Intercollegiate Surgical Curriculum Programme (ISCP) and Orthopaedic Curriculum and Assessment Programme (OCAP) define the core competencies, tha...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Beard J,Rowley D,Bussey M,Pitts D

    更新日期:2009-03-01 00:00:00

  • Do we need to scan the whole neuraxis for coexistent abnormalities in children with surgically treated occult spinal dysraphism?

    abstract:BACKGROUND:Spina bifida occulta (SBO) is generally known as a benign isolated entity; however, there are ambiguous approaches for neuroaxial screening in cases of symptomatic SBO among institutions. This study aims to demonstrate the infrequency of cranial anomalies associated with symptomatic SBO and inquire the neces...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Börcek AÖ,Aslan A,Uçar M

    更新日期:2019-07-01 00:00:00

  • Macrophages, more than just scavengers: their role in breast development and cancer.

    abstract::Macrophages, derived from circulating monocytes, are located within virtually all adult tissues. There, these specialized cells adopt tissue-specific functions that are important for normal tissue homeostasis and response to physiological challenges. Increasing evidence suggests that macrophages play a role in the nor...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Gyorki DE,Lindeman GJ

    更新日期:2008-06-01 00:00:00

  • Mortality data 2004-2019: an audit of the Royal Adelaide Hospital Adult Burn Service.

    abstract:BACKGROUND:Burns are complex, multifaceted injuries that can pose significant challenges to the treating team. The Royal Adelaide Hospital (RAH) Burns Service has undergone a major evolution over the past two decades, with perceived improvement in outcomes. We present here a longitudinal audit of the RAH Burns Service ...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Stefani K,Wagstaff MJD,Damkat I,Greenwood JE

    更新日期:2020-11-02 00:00:00

  • Parotidectomy: preoperative investigations and outcomes in a single surgeon practice.

    abstract:BACKGROUND:The aim of this study was to assess the value of fine-needle aspiration cytology (FNAC) as a preoperative evaluation for parotid tumours. METHODS:Prospectively collected data on 77 patients, collected on a parotid database, were retrospectively analysed. Preoperative investigations were carried out and cyto...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Burgess AN,Serpell JW

    更新日期:2008-09-01 00:00:00

  • Art of preserving health: studies on the medical supervision of physical exercise.

    abstract::To the ancient Greeks, physical exercise was an essential part of life, especially during adolescence and young adulthood. Long after the end of the Classical Greek era, Roman conquest brought a shift towards martial training, increased professionalism in athletic competition and a weak strand of restorative gymnastic...

    journal_title:ANZ journal of surgery

    pub_type: 历史文章,杂志文章


    authors: Thurston AJ

    更新日期:2009-12-01 00:00:00

  • Total knee replacement in the morbidly obese: a literature review.

    abstract:BACKGROUND:The 'obesity epidemic' is expected to result in an increased incidence of knee osteoarthritis and hence total knee replacements (TKRs). Reviews have demonstrated the conflicting results of TKR for all obese (body mass index (BMI) >30). The aim of this literature review was to specifically evaluate outcomes o...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,评审


    authors: Samson AJ,Mercer GE,Campbell DG

    更新日期:2010-09-01 00:00:00