Abstract：
BACKGROUND:Precursor colonic polyps of varied subtypes correlate with the known neoplastic pathways. When patients present with synchronous pre-malignant polyps of multiple histologies, multiple genetic mechanisms are likely to be active, potentially resulting in a more unstable, tumourigenic mucosa. METHODS:We hypothesized that patients with a combination of sessile serrated adenomas/polyps (SSA/Ps), hyperplastic (HP) polyps and adenomas would be at highest risk of developing dysplasia/cancer compared to SSA/Ps alone, due to the synergistic effect of multiple active carcinogenic pathways. A prospective colonoscopy database was examined for patients with a history of SSA/P. Patients were placed into four groups based on patterns of polyp histology as follows: (i) only SSA/Ps; (ii) SSA/P + HP; (iii) SSA/Ps + adenomas; and (iv) SSA/Ps + HP + adenomas. These groups were compared in terms of the numbers, size, location and histology of polyps and personal or family history of colorectal cancer. RESULTS:A total of 374 patients were included. The average age was 70 years (range 21-88), and 43% were male. There was a trend towards the most aggressive neoplastic pattern in group 4, associated with a tendency to larger SSA/Ps, more villous architecture in the adenomas and more high-grade dysplasia in both types of polyps. It was also associated with multiplicity of both SSA/Ps and adenomas. No SSA/Ps existing in the absence of adenomas had cytological dysplasia. CONCLUSION:The combination of SSA/Ps, HP and adenomas in the colorectal epithelium seems to be a marker for aggressive carcinogenesis and suggests that accurate and effective surveillance is important to manage this risk.
journal_name
ANZ J Surgjournal_title
ANZ journal of surgeryauthors
Dean M,Plesec T,Kalady MF,Church Jdoi
10.1111/ans.15662subject
Has Abstractpub_date
2020-05-01 00:00:00pages
807-811issue
5eissn
1445-1433issn
1445-2197journal_volume
90pub_type
杂志文章abstract：BACKGROUND:The Australian Safety and Efficacy Register for New Interventional Procedures - Surgical (ASERNIP-S) was contracted by the Commonwealth Department of Health and Aged Care to audit the procedure of endoluminal repair of abdominal aortic aneurysm. The purpose of the audit was to examine the safety and efficacy...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1046/j.1445-2197.2002.02356.x
更新日期：2002-03-01 00:00:00
abstract：:In the seventeenth century, Holland and the allied provinces of the northern Netherlands won final independence from their Spanish overlords and formed a worldwide economic empire. Dutch ships dominated the seas from the Caribbean to Japan and reconnoitred the coasts of Australia and New Zealand. Dutch society was cos...
journal_title：ANZ journal of surgery
pub_type： 传,历史文章
doi：10.1111/j.1445-2197.2007.04327.x
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND:This review examines the surgical management of acute superior mesenteric artery (SMA) occlusion and the impact of interventional radiology techniques. METHODS:Eight consecutive patients with SMA occlusion were treated at the Lismore Base Hospital, Lismore, NSW, Australia, from 1996 through to 2001 and of t...
journal_title：ANZ journal of surgery
pub_type： 杂志文章,评审
doi：10.1046/j.1445-2197.2002.02289.x
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:Worldwide, the evolution of management of liver injury has resulted in improved outcomes. The aim of this study was to examine the trend in the management and outcomes of patients with liver injury. Primary outcomes were defined as mortality and hospital length of stay. The secondary aim was to identify inde...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.13248
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:To examine any geographical variation in the management of urolithiasis amongst the Australian states and territories. METHODS:Retrospective study with data obtained from the Medicare Australia database, the Royal Australasian College of Surgeons and the Urological Society of Australia and New Zealand. RES...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.13646
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:Patients with centrally located tumours involving the nipple-areolar complex (NAC) who undergo breast-conserving treatment (BCT) are at high risk for breast deformity and asymmetry. Immediate oncoplastic breast reconstruction (OBR) can have a favourable impact on surgical outcome. METHODS:We retrospectively...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.15078
更新日期：2019-05-01 00:00:00
abstract：:Cancer of the small bowel is a rare entity but its incidence is rising. Historically, outcome is poor despite apparent curative resection. At present surgery remains the only treatment modality of proven benefit in the management of this disease. Recent data would suggest 5-year survival rates in the order of 40-50% a...
journal_title：ANZ journal of surgery
pub_type： 杂志文章,评审
doi：10.1046/j.1440-1622.2001.02149.x
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:The objective of the research was to validate our results on sentinel lymph node biopsy (SLNB) and to determine factors affecting false-negative (FN) rates of SLNB in Chinese patients with invasive breast cancers. METHODS:A retrospective study of patients with clinically node-negative invasive breast cancer...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/j.1445-2197.2007.04260.x
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND:Abdominal actinomycosis (AA) is a rare infection. The aim of this study was to summarize the evidence available on AA. METHODS:A systematic review was conducted. Data sources included Trip Database, BIREME, SciELO, Cochrane Library, WoS, MEDLINE, EMBASE, SCOPUS, IBECS and LILACS. Eligibility criteria includ...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.16141
更新日期：2020-07-01 00:00:00
abstract：:About 50% of the trauma victims die at the scene mostly because of exsanguinating haemorrhage. Most trials of resuscitation fail in face of the ongoing bleeding. Ongoing research/studies to save these victims by inducing rapid hypothermia using cardiopulmonary bypass as an emergency initial measure along with delayed ...
journal_title：ANZ journal of surgery
pub_type： 杂志文章,评审
doi：10.1111/ans.14313
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Human facial allotransplantation (FA) is a testament to the impressive progress, which was and is still happening in the field of transplantation medicine and reconstructive surgery. Like every pioneering treatment option, FA faces both the clinicians' and public opinion with a huge amount of medical and psy...
journal_title：ANZ journal of surgery
pub_type： 杂志文章,评审
doi：10.1111/j.1445-2197.2009.05140.x
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:This study investigates case cancellations on the intended day of surgery (DOS) at a paediatric hospital in Melbourne, Australia. The hospital in Melbourne treats over 32 000 inpatients annually and handles both elective and emergency cases. METHODS:The data for this paper were collected over a period of 12...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/j.1445-2197.2009.05019.x
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:Treatment decisions for metastatic spine disease are complex and depend on prognosis. Four prognostic systems in use are the Oswestry Risk Index, modified Bauer score (MBS), van der Linden score and New England Spinal Metastasis Score (NESMS). We aimed to determine the performance of these scoring systems in...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.15821
更新日期：2020-06-01 00:00:00
abstract：:To the ancient Greeks, physical exercise was an essential part of life, especially during adolescence and young adulthood. Long after the end of the Classical Greek era, Roman conquest brought a shift towards martial training, increased professionalism in athletic competition and a weak strand of restorative gymnastic...
journal_title：ANZ journal of surgery
pub_type： 历史文章,杂志文章
doi：10.1111/j.1445-2197.2009.05149.x
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:Although various methods for quantifying outcomes following total knee replacement (TKR) are used, there are few studies of the relationships between patient reported scores and functional tests. This paper aims to assess the relationships between commonly used outcome scores after TKR through a prospective ...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.13708
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Although several growth factors are known to be essential for liver regeneration, the role of gastrin remains controversial. METHODS:Liver regeneration was examined in wild-type (WT) and gastrin-deficient (gastrin KO) mice at days 2 and 10 after partial (40%) hepatectomy by measurement of liver weight. Hepa...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/j.1445-2197.2007.04360.x
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Few studies have investigated the risk factors associated with developing intestinal stoma complications using appropriate multivariable methods. We aimed to determine the prevalence of, and risk factors for, stomal complications. METHODS:A retrospective, case-control methodology was used to investigate 12 ...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.13397
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Surgical approach into the fissural parenchyma may be an important and modifiable factor for the prevention of air leak after anatomical lung resections. Fissureless fissure-last technique has been described as useful technique to reduce air leak, yet in video-assisted thoracoscopic surgery (VATS) data are l...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.13884
更新日期：2017-12-01 00:00:00
abstract：INTRODUCTION:Sigmoid volvulus typically occurs in older patients who have multiple co-morbidities. Therefore, often, a conservative approach to management is chosen. However, there is little data on long-term outcomes of this approach in Australasia. The aim of this study was to review the recurrence and mortality outc...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/j.1445-2197.2012.06182.x
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Parkland formula (PF) is the most often used schema for calculating intravenous resuscitation fluid requirement in burn patients. Some studies have reported that PF underestimates the fluid requirement in 45-63% of patients. The aim of this retrospective study was to analyse factors influencing first-day int...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/j.1445-2197.2007.04221.x
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:Acute appendicitis is the most common non-obstetric surgical presentation during pregnancy. There were concerns that laparoscopic appendicectomy increases the risk of foetal loss compared to an open approach. Therefore, with recent advances in perioperative care, it is likely the risk has changed. Here, we p...
journal_title：ANZ journal of surgery
pub_type： 杂志文章,meta分析
doi：10.1111/ans.14963
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:Solid pseudopapillary tumour of the pancreas is a rare pancreatic tumour that occurs predominantly in women, with very few cases reported in men. This is a tumour with low malignancy potential and surgical resection usually results in cure. METHODS:A retrospective review of our experience with solid pseudop...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1046/j.1445-2197.2003.t01-1-02634.x
更新日期：2003-06-01 00:00:00
abstract：BACKGROUND:Emergency laparotomies (ELs) are associated with high mortality and substantial outcome variation. There is no prospective Australian data on ELs. The aim of this study was to audit outcome after ELs in Western Australia. METHODS:A 12-week prospective audit was completed in 10 hospitals. Data collected incl...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.14208
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:Haemorrhoidectomy is associated with significant post-operative pain which is primarily managed pharmacologically. Whether a non-pharmacological adjunct such as a checklist can improve pain outcomes after an open haemorrhoidectomy has yet to be studied. The purpose of this study was to determine if a patient...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.15732
更新日期：2020-04-01 00:00:00
abstract：INTRODUCTION:There are very little clinical and pathological data on colorectal cancer among Indigenous people in Australia. METHODS:A retrospective study on Indigenous patients treated for colorectal cancer at the Townsville and Cairns Base Hospitals from 1999 to 2004 was carried out in order to better characterise t...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/j.1445-2197.2005.03592.x
更新日期：2005-11-01 00:00:00
abstract：BACKGROUND:Urgent assessment of haematuria is critical to exclude malignancy. The objective of this study is to report the outcomes of the first 3 years of a dedicated haematuria clinic at the Royal Melbourne Hospital, a Victorian tertiary hospital. METHODS:All patients assessed in the haematuria clinic from April 201...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.12742
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Tumour regression grade is gaining interest as a prognostic factor of patients undergoing neoadjuvant chemoradiotherapy and surgery for locally advanced rectal cancer. METHODS:A series of 68 consecutive patients with locally advanced rectal cancer treated by neoadjuvant chemoradiotherapy and surgery between...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.16476
更新日期：2020-12-14 00:00:00
abstract：BACKGROUND:The role of minimally invasive major hepatectomy (MIMH) remains controversial and questions remain about its safety and reproducibility outside expert centres. This study examines the changing trends, safety and outcomes associated with the adoption of MIMH based on a contemporary single institution experien...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.15563
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:We aim to analyse the difference of clinical efficacy between middle pancreatectomy (MP) and distal pancreatectomy (DP). METHODS:A retrospective study was used to analyse 39 cases of MP and 52 cases of DP from the Department of Hepatopancreatobiliary Surgery of the Affiliated Hospital of Qingdao University ...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.15095
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:The Pacific Island nation of Samoa faces a number of challenges in delivering surgical care. Our group aimed to identify the barriers and opportunities to improving the delivery of safe, affordable, timely surgical care in Samoa. METHODS:A mixed-methods approach was undertaken. The quantitative analysis use...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.15295
更新日期：2019-06-18 00:00:00
