Patterns of polyp histology: predictors of peril in the mucosa.


BACKGROUND:Precursor colonic polyps of varied subtypes correlate with the known neoplastic pathways. When patients present with synchronous pre-malignant polyps of multiple histologies, multiple genetic mechanisms are likely to be active, potentially resulting in a more unstable, tumourigenic mucosa. METHODS:We hypothesized that patients with a combination of sessile serrated adenomas/polyps (SSA/Ps), hyperplastic (HP) polyps and adenomas would be at highest risk of developing dysplasia/cancer compared to SSA/Ps alone, due to the synergistic effect of multiple active carcinogenic pathways. A prospective colonoscopy database was examined for patients with a history of SSA/P. Patients were placed into four groups based on patterns of polyp histology as follows: (i) only SSA/Ps; (ii) SSA/P + HP; (iii) SSA/Ps + adenomas; and (iv) SSA/Ps + HP + adenomas. These groups were compared in terms of the numbers, size, location and histology of polyps and personal or family history of colorectal cancer. RESULTS:A total of 374 patients were included. The average age was 70 years (range 21-88), and 43% were male. There was a trend towards the most aggressive neoplastic pattern in group 4, associated with a tendency to larger SSA/Ps, more villous architecture in the adenomas and more high-grade dysplasia in both types of polyps. It was also associated with multiplicity of both SSA/Ps and adenomas. No SSA/Ps existing in the absence of adenomas had cytological dysplasia. CONCLUSION:The combination of SSA/Ps, HP and adenomas in the colorectal epithelium seems to be a marker for aggressive carcinogenesis and suggests that accurate and effective surveillance is important to manage this risk.


ANZ J Surg


ANZ journal of surgery


Dean M,Plesec T,Kalady MF,Church J




Has Abstract


2020-05-01 00:00:00












  • Delayed/non-union of upper limb fractures with bisphosphonates: systematic review and recommendations.

    abstract:BACKGROUND:Bisphosphonates (BPs) are widely used for the treatment of osteoporosis. Oversuppression of bone turnover with BPs may paradoxically limit the reserve capacity of bone to heal. The aim of this review was to study the predisposition of some patients to delayed/non-union of upper limb fractures associated with...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,评审


    authors: Ng AJ,Yue B,Joseph S,Richardson M

    更新日期:2014-04-01 00:00:00

  • Prioritizing patients for prostatectomy: balancing clinical and psychosocial factors.

    abstract:BACKGROUND:The aim of this study was to develop a points-based approach to prioritize patients for elective transurethral resection of the prostate and to determine the relative contributions that clinical and psychosocial characteristics should make to a measurement of urgency for surgery. Another objective was to mea...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Curtis AJ,Wolfe R,Russell CO,Costello AJ,Travis DG,Snow R,McNeil JJ

    更新日期:2007-03-01 00:00:00

  • Towards painless colonoscopy: a randomized controlled trial on carbon dioxide-insufflating colonoscopy.

    abstract:BACKGROUND:Carbon dioxide (CO2) insufflation during colonoscopy was reported to reduce pain, but data are limited. The objective of this randomized controlled trial was to assess the effect of CO2 insufflation on pain during and after colonoscopy. METHODS:Patients were randomized into CO2 insufflation (CO2i) or air in...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,随机对照试验


    authors: Wong JC,Yau KK,Cheung HY,Wong DC,Chung CC,Li MK

    更新日期:2008-10-01 00:00:00

  • Gastrointestinal complications after cardiac surgery: 10-year experience of a single Australian centre.

    abstract:BACKGROUND:Gastrointestinal (GI) complications after cardiac surgery are uncommon, but are associated with high morbidity and mortality as well as significant hospital resource utilization. METHODS:We analysed a prospectively collected database containing all adult cardiac surgery procedures performed from July 2001 t...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Viana FF,Chen Y,Almeida AA,Baxter HD,Cochrane AD,Smith JA

    更新日期:2013-09-01 00:00:00

  • Parathyroid hormone venous sampling prior to reoperation for primary hyperparathyroidism.

    abstract:BACKGROUND:The surgical cure rate for primary hyperparathyroidismis greater than 95%. For those who have recurrent or persistent disease, preoperative localization improves reoperation success rates. Selective parathyroid venous sampling (SPVS) for intact parathyroid hormone is particularly useful when non-invasive loc...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Estella E,Leong MS,Bennett I,Hartley L,Wetzig N,Archibald CA,Harper JS,Cuneo RC

    更新日期:2003-10-01 00:00:00

  • Surgical volume influences survival in patients undergoing resections for stage II colon cancers.

    abstract:BACKGROUND:There is current interest in the correlation between surgical volume and outcomes. Survival in patients with rectal cancer appears to improve when carried out by surgeons who do high volumes of procedures. A similar correlation for patients with colon cancer has never been clearly established. The aim of thi...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,多中心研究


    authors: Morris M,Platell CF

    更新日期:2007-10-01 00:00:00

  • Blood management in total hip replacement: an analysis of factors associated with allogenic blood transfusion.

    abstract:BACKGROUND:The aim of this study was to audit the blood transfusion practice throughout the Epworth Healthcare Hospitals for patients undergoing primary total hip replacement (THR). We determined if blood-saving techniques were having an impact on the risk of allogenic blood transfusion and which patients were at risk ...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Wong S,Tang H,de Steiger R

    更新日期:2015-06-01 00:00:00

  • Severe trauma caused by stabbing and firearms in metropolitan Sydney, New South Wales, Australia.

    abstract:BACKGROUND:Stabbing and firearm trauma causing severe injuries (injury severity score (ISS) >15) and death is uncommon in Australia. The present study describes the experience with stabbings and firearm trauma causing severe injuries at a major Australian urban trauma centre. METHODS:Data from a prospectively generate...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Wong K,Petchell J

    更新日期:2005-04-01 00:00:00

  • Comparison of outcomes between minimally invasive oesophagectomy and open oesophagectomy for oesophageal cancer.

    abstract:BACKGROUND:A systematic review with meta-analysis was performed to compare perioperative outcomes between minimally invasive oesophagectomy (MIE) and open oesophagectomy (OE). METHODS:PubMed and Cochrane databases were searched up to January 2015 using keywords: esophageal cancer, MIE, OE, hybrid MIE. Randomized contr...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,meta分析,评审


    authors: Xiong WL,Li R,Lei HK,Jiang ZY

    更新日期:2017-03-01 00:00:00

  • Sentinel node biopsy and large (≥3 cm) breast cancer.

    abstract:BACKGROUND:Sentinel node biopsy is an accurate method for staging the axilla in early (small) breast cancers. However, data for the role of this technique for large breast cancers remain limited. METHOD:From the Royal Adelaide Hospital Sentinel Node database and the SNAC trial database, 100 subjects were identified wi...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Beumer JD,Gill G,Campbell I,Wetzig N,Ung O,Farshid G,Uren R,Stockler M,Gebski V

    更新日期:2014-03-01 00:00:00

  • Laparoscopic common bile duct exploration for patients with a history of prior biliary surgery: a comparative study with an open approach.

    abstract:BACKGROUND:Laparoscopic common bile duct exploration (LCBDE) is increasingly being used to treat choledocholithiasis. However, few studies have examined the treatment of recurrent common bile duct stones (CBDS) in patients with a history of prior biliary surgery. The current research aimed to compare the outcomes of la...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Zhu J,Du P,He J,Tong F,Xiao W,Li Y

    更新日期:2020-12-28 00:00:00

  • Review of epiglottitis in the post Haemophilus influenzae type-b vaccine era.

    abstract:BACKGROUND:This study reviewed the demographics, presentation, management, complications and outcomes of acute epiglottitis post Haemophilus influenzae type-b vaccine introduction in Australia. METHODS:Retrospective review of acute epiglottitis at four Victorian tertiary centres from 2011 to 2016 was conducted. Patien...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Baird SM,Marsh PA,Padiglione A,Trubiano J,Lyons B,Hays A,Campbell MC,Phillips D

    更新日期:2018-11-01 00:00:00

  • Predicting complications in hepatic resection for colorectal liver metastasis: the lymphocyte-to-monocyte ratio.

    abstract:BACKGROUND:Colorectal cancer is one of the most common malignancies worldwide; whilst approximately 20% of patients have hepatic disease at presentation. Hepatic resection remains the gold standard of care; however, it is associated with significant morbidity. We sought to establish whether the lymphocyte-to-monocyte r...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: McCluney SJ,Giakoustidis AA,Segler A,Bissel J,Miller RL,Valente R,Hutchins RR,Abraham A,Bhattacharya S,Kocher HM

    更新日期:2018-11-01 00:00:00

  • Modified saphenous-peritoneal shunt in refractory ascites: new technique.

    abstract:BACKGROUND:Refractory ascites is a serious complication for patients with decompensated liver cirrhosis. Saphenous-peritoneal shunting is a possible surgical treatment for its relief, but tends to lead to higher groin infections. The purpose of the present paper was to determine whether a modified procedure could resol...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Chen JH,Liu HD,Yu JC,Chen CJ,Shih ML,Liu YC,Hsieh CB

    更新日期:2005-03-01 00:00:00

  • Comparison between video-assisted retroperitoneal debridement and small incision pancreatic necrosectomy in infected pancreatic necrosis.

    abstract:BACKGROUND:Debridement and drainage have always been mainstream treatment for infected pancreatic necrosis (IPN), and the application of minimally invasive necrosectomy is becoming increasingly widespread. However, few studies have compared video-assisted retroperitoneal debridement (VARD) and small incision pancreatic...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Zhang JB,Sun B

    更新日期:2020-08-11 00:00:00

  • Laparoscopic gastric resection for benign and malignant conditions: lessons learned from 35 consecutive cases.

    abstract:INTRODUCTION:Despite significant advances in laparoscopy, gastric surgery is still generally carried out by conventional open techniques. The aim of the study was to report the short- and medium-term outcomes of gastric surgery when carried out laparoscopically for a variety of benign and malignant conditions. METHODS...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Liew V,Taylor C,Ghusn M,Jamnagerwalla M,Layani L

    更新日期:2007-09-01 00:00:00

  • Complete natal cleft removal with kite incision in the treatment of extensive sacrococcygeal pilonidal sinus.

    abstract:BACKGROUND:Pilonidal sinus (PS) is a benign disease for which different treatment modalities are used, varying from non-surgical treatments to surgical treatments with flap use for big defects. High recurrence is the main problem in complicated cases. We presented complete natal cleft excision with kite incision and fa...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Ozdemir H,Unal Ozdemir Z,Sunamak O

    更新日期:2020-04-01 00:00:00

  • Anal abscesses and fistulas.

    abstract::Anal abscesses and fistulas are a common part of surgical practice. Most abscesses simply need to be drained and most fistulas can be safely laid open. Excessive probing should not be attempted when draining abscesses as this may lead to iatrogenic fistulas. A small percentage of fistulas are complex and very challeng...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,评审


    authors: Rickard MJ

    更新日期:2005-01-01 00:00:00

  • Operative experience in the Victorian general surgical training programme.

    abstract:BACKGROUND:The Royal Australasian College of Surgeons recommends minimum operative and endoscopy training requirements for advanced trainees in general surgery. This study examines the influences of trainee seniority, geographical location of surgical rotation, and surgeons' remuneration arrangements on the operative a...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Wong K,Birks D

    更新日期:2003-12-01 00:00:00

  • Acute cholecystitis or simple biliary colic after an emergency presentation: why it matters.

    abstract:BACKGROUND:Laparoscopic cholecystectomy (LC) is often performed during the index admission after emergency presentation for acute biliary pain. Many patients have acute cholecystitis (AC) that may increase operative difficulty and complications. Our primary aim was to assess the validity of Tokyo Guidelines (TG18) for ...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Nguyen CL,van Dijk A,Smith G,Leibman S,Mittal A,Albania M,de Reuver P,Hugh TJ

    更新日期:2020-03-01 00:00:00

  • Necrotizing myositis: highlighting the hidden depths - case series and review of the literature.

    abstract:BACKGROUND:Necrotizing myositis (NM) is a life-threatening emergency. It causes focal muscle necrosis without abscess formation or extensive involvement of the overlying fascia and soft tissue. It is a clinical diagnosis requiring a high index of clinical suspicion. Usual presentation can readily be mistaken to represe...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,评审


    authors: Khanna A,Gurusinghe D,Taylor D

    更新日期:2020-01-01 00:00:00

  • Clinical and molecular aspects of adrenocortical tumourigenesis.

    abstract::Adrenal masses are a common problem affecting 3-7% of the population. The majority turn out to be benign adrenocortical adenomas, which may be functional or non-functional. Much more rarely, these masses represent a primary adrenal carcinoma. It is becoming increasingly recognized that of the benign functioning adenom...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,评审


    authors: Sidhu S,Gicquel C,Bambach CP,Campbell P,Magarey C,Robinson BG,Delbridge LW

    更新日期:2003-09-01 00:00:00

  • Perioperative complications in patients on low-molecular-weight heparin bridging therapy.

    abstract:BACKGROUND:Patients taking warfarin are often given interim anticoagulation in the perioperative period. Institutional guidelines that use low-molecular-weight heparin (LMWH) 'bridging' while the international normalized ratio (INR) is sub-therapeutic are often based on the American College of Chest Physicians Anticoag...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Breen DT,Chavalertsakul N,Paul E,Gruen RL,Serpell J

    更新日期:2016-03-01 00:00:00

  • Subjective and objective outcome measures after total knee replacement: is there a correlation?

    abstract:BACKGROUND:Although various methods for quantifying outcomes following total knee replacement (TKR) are used, there are few studies of the relationships between patient reported scores and functional tests. This paper aims to assess the relationships between commonly used outcome scores after TKR through a prospective ...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Graff C,Hohmann E,Bryant AL,Tetsworth K

    更新日期:2016-11-01 00:00:00

  • Quantifying the lumbar spine movements of surgeons during surgical lists in a teaching hospital.

    abstract:BACKGROUND:Low back pain (LBP) is a common occupational musculoskeletal complaint among health professionals. No research has quantified lumbar movement patterns in the surgical workplace, identifying 'at risk' behaviours with objective measures. This project aimed to identify lumbar movement patterns and change in LBP...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,评审


    authors: Wartski M,Williams CM,Broughton NS,Bowles KA

    更新日期:2019-03-01 00:00:00

  • Dupuytren's disease or Cooper's contracture?: Kenneth Fitzpatrick Russell Memorial Lecture.

    abstract::In his position as curator of the Cowlishaw collection of historical medical books in the Library of the College, Kenneth Russell prepared the definitive catalogue of the collection. This catalogue is comprehensive and for almost all entries there is an annotation that demonstrates his meticulous attention to detail a...

    journal_title:ANZ journal of surgery

    pub_type: 传,历史文章


    authors: Thurston A

    更新日期:2003-07-01 00:00:00

  • Impact of COVID-19-related social restrictions on orthopaedic trauma in a level 1 trauma centre in Sydney: the first wave.

    abstract:BACKGROUND:The coronavirus disease 2019 (COVID-19) pandemic has affected communities worldwide. This study examines the impact that public health measures to control viral spread have had on orthopaedic trauma presenting to an Australian level 1 trauma centre. We hypothesized that the volume of orthopaedic trauma in th...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Probert AC,Sivakumar BS,An V,Nicholls SL,Shatrov JG,Symes MJ,Ellis AM

    更新日期:2020-10-13 00:00:00

  • Laparoscopic-assisted colectomy with Duhamel procedure for idiopathic megacolon in adults: a retrospective study.

    abstract:BACKGROUND:Idiopathic megacolon (IMC) is an uncommon disease in adults. To date, only a few laparoscopic experiences and functional outcomes of IMC have been reported. This study was to retrospectively analyse our 12 year surgical experience and functional outcomes in adult patients with IMC. METHODS:A 12-year retrosp...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Wang L,Zheng H,Tian Y,Mou J,Zhang L,Liu B,Tong W

    更新日期:2020-11-01 00:00:00

  • Severe acute respiratory syndrome in surgical patients: a diagnostic dilemma.

    abstract:BACKGROUND:The diagnosis of severe acute respiratory syndrome (SARS) in surgical patients can potentially be missed based on current World Health Organization (WHO) case definitions. METHOD:We report a retrospective case series of 10 surgical inpatients diagnosed with SARS following an outbreak in the surgical wards. ...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Tan FL,Loo WL,Tan SG,Wong CY,Tan YM

    更新日期:2005-01-01 00:00:00

  • Ten-year review of gastrointestinal stromal tumours at a tertiary referral hospital in New Zealand.

    abstract:BACKGROUND:Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours of the gastrointestinal tract and make up 1-2% of all gastrointestinal malignancies. Traditionally, the treatment of choice for primary disease is surgical resection; however, no single surgeon or institution gets extensive expo...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Siu J,Lim M,Fischer J,Dobbs B,Wakeman C,Ing A,Frizelle F

    更新日期:2016-03-01 00:00:00