Abstract:
:The global spread of the 2019-nCoV is continuing and is fast moving, as indicated by the WHO raising the risk assessment to high. In this article, we provide a preliminary phylodynamic and phylogeographic analysis of this new virus. A Maximum Clade Credibility tree has been built using the 29 available whole genome sequences of 2019-nCoV and two whole genome sequences that are highly similar sequences from Bat SARS-like Coronavirus available in GeneBank. We are able to clarify the mechanism of transmission among the countries which have provided the 2019-nCoV sequence isolates from their patients. The Bayesian phylogeographic reconstruction shows that the 2019-2020 nCoV most probably originated from the Bat SARS-like Coronavirus circulating in the Rhinolophus bat family. In agreement with epidemiological observations, the most likely geographic origin of the new outbreak was the city of Wuhan, China, where 2019-nCoV time of the most recent common ancestor emerged, according to molecular clock analysis, around November 25th, 2019. These results, together with previously recorded epidemics, suggest a recurring pattern of periodical epizootic outbreaks due to Betacoronavirus. Moreover, our study describes the same population genetic dynamic underlying the SARS 2003 epidemic, and suggests the urgent need for the development of effective molecular surveillance strategies of Betacoronavirus among animals and Rhinolophus of the bat family.
journal_name
Pathog Glob Healthjournal_title
Pathogens and global healthauthors
Benvenuto D,Giovanetti M,Salemi M,Prosperi M,De Flora C,Junior Alcantara LC,Angeletti S,Ciccozzi Mdoi
10.1080/20477724.2020.1725339subject
Has Abstractpub_date
2020-03-01 00:00:00pages
64-67issue
2eissn
2047-7724issn
2047-7732journal_volume
114pub_type
杂志文章abstract::Bovine lactoferrin (bLf) is a multifunctional glycoprotein that plays an important role in innate immunity against infections, including influenza. Here we have dissected bLf into its C- and N-lobes and show that inhibition of influenza virus hemagglutination and cell infection is entirely attributable to the C-lobe ...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773212Y.0000000004
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:While the aetiology for most psychotic disorders is unknown, a strong association has been observed between Toxoplasma gondii infection and psychosis. The proportion of individuals with psychotic disorders who have current or past infection with toxoplasma has been varied. Reports from the African continent ...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773213Y.0000000093
更新日期:2013-06-01 00:00:00
abstract::Italy was initially one of the worse affected countries by the novel coronavirus (COVID-19). Medical students frequenting hospitals are more susceptible to be infected by the virus but also able to see the effects of the pandemic from the frontline. The aim of this study was to assess the COVID-19 related knowledge, b...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1080/20477724.2021.1878447
更新日期:2021-01-31 00:00:00
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journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1080/20477724.2015.1136130
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Acute hepatitis A is a worldwide public health problem especially in developing countries. Recently, a large, community-wide outbreak of hepatitis A occurred in the northeast part of Thailand. METHODS:Demographic and clinical data as well as blood samples were collected and analyzed from patients with acu...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773213Y.0000000116
更新日期:2013-10-01 00:00:00
abstract::Trichomonas vaginalis is a flagellated protozoan parasite that infects the human urogenital tract, causing the most common non-viral, sexually transmitted disease worldwide. In this study, genetic variants of T. vaginalis were identified in Henan Province, China. Fragments of the small subunit of nuclear ribosomal RNA...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773215Y.0000000020
更新日期:2015-07-01 00:00:00
abstract::Plasmodium vivax is now recognized as a cause of severe and fatal infection in many parts of the world. This prospective observational study was undertaken in a tertiary health setting to understand the spectrum of the disease burden and associated complications due to P. vivax malaria in central India. A malaria clin...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/204777213X13777615588180
更新日期:2013-09-01 00:00:00
abstract::Genetic control strategies aimed to bias the sex of progenies towards males present a promising new paradigm to eliminate malaria-transmitting mosquitoes. A synthetic sex-ratio distortion (SD) system was successfully engineered in Anopheles gambiae by exploiting the meiotic activity of the I-PpoI endonuclease targetin...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1080/20477724.2020.1803628
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Visceral leishmaniasis (VL), also known as kala-azar in the Indian sub-continent (ISC), is a major public health concern in Bangladesh, India, and Nepal, where it is caused by Leishmania donovani transmitted by the sand fly Phlebotomus argentipes. Various ecological parameters including air temperature, rain...
journal_title:Pathogens and global health
pub_type: 杂志文章,评审
doi:10.1080/20477724.2016.1180775
更新日期:2016-05-01 00:00:00
abstract::Carbapenem-resistant Klebsiella pneumoniae (CRKP) has been known as a nosocomial pathogen, both for the last 10 years in Turkey and for 20 years worldwide. Due to limited treatment options and high mortality rates, despite improvements in the field of medicine at the present time, CRKP is still a big threat for public...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1080/20477724.2016.1254976
更新日期:2016-01-01 00:00:00
abstract::Anti-bacterial proteins in mosquitoes are known to play an important modulatory role on immune responses to infections with human pathogens including malaria parasites. In this study we characterized two members of the Anopheles gambiae Nimrod superfamily, namely AgNimB2 and AgEater. We confirm that current annotation...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/204777213X13867543472674
更新日期:2013-12-01 00:00:00
abstract::Many neglected tropical diseases, including the zoonotic disease cystic echinococcosis (hydatidosis), are endemic to East Africa. However, their geographical distribution is heterogenous and incompletely characterized. The aim of this study was to determine if Mundari pastoralists harbor endemic human hydatidosis. The...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773213Y.0000000111
更新日期:2013-09-01 00:00:00
abstract::We previously attempted to identify 96 nonpolio enteroviruses (EVs) recovered in RD cell culture from children <15 years with acute flaccid paralysis in Nigeria. We succeeded in identifying 69 of the isolates. Here, we describe an attempt to identify the remaining 27 isolates. Twenty-six (the 27th isolate was exhauste...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1080/20477724.2018.1548117
更新日期:2018-12-01 00:00:00
abstract::The objective of this work is to compare the phenotypic and virulence genes characteristics in human and chicken isolates of Proteus mirabilis. The bacterial examination of 50 livers of individual broilers, marketed by four major outlets, revealed a high recovery of P. mirabilis (66%), and a low recovery frequency of ...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773212Y.0000000042
更新日期:2012-10-01 00:00:00
abstract::Eastern Europe (EE) has been severely affected by mosquito-borne viruses (moboviruses). In this review, we summarize the epidemiology of moboviruses, with particular attention to West Nile virus (WNV). The study of WNV human cases in EE between 2010 and 2016, revealed that the epidemiology of WNV in EE is complex with...
journal_title:Pathogens and global health
pub_type: 杂志文章,评审
doi:10.1080/20477724.2018.1483567
更新日期:2018-07-01 00:00:00
abstract::During the last decade, the chikungunya (CHIKV) virus has expanded its range of activity, conquering new territories and becoming an important global health threat. In particular, the challenge represented by the recent emergence of CHIKV in the Americas has strengthened the need of a safe and effective vaccine. Altho...
journal_title:Pathogens and global health
pub_type: 杂志文章,评审
doi:10.1179/2047773215Y.0000000017
更新日期:2015-06-01 00:00:00
abstract::The second largest outbreak of Ebolavirus is currently ongoing in Eastern Democratic Republic of the Congo (DRC) and is characterized by lack of compliance with recommended control measures. Trusted local health agents, including medical students, may be valuable social mobilizers in this challenging context. We repor...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1080/20477724.2020.1754654
更新日期:2020-05-18 00:00:00
abstract::Approximately 120 years ago the link between mosquito and the malaria transmission was discovered. However, even today it remains an open question whether the parasite is able to direct the blood-seeking and feeding behavior of its mosquito vector to maximize the probability of transmission. If the parasite has this a...
journal_title:Pathogens and global health
pub_type: 杂志文章,评审
doi:10.1080/20477724.2019.1703398
更新日期:2019-12-01 00:00:00
abstract::The spread of P. falciparum resistant strain has led to a significant resurgence of malaria morbidity and mortality. The current cornerstone in malaria treatment in India is Artemisinin based Combination (Artesunate + Sulphadoxine-Pyrimethamine) Therapy (ACT) for treatment of uncomplicated P. falciparum malaria since ...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1080/20477724.2017.1331875
更新日期:2017-06-01 00:00:00
abstract::Over 2 billion people in both developing as well as developed countries - over 30% of the world's population - are anaemic. With the classical preconception that oral iron administration or the intake of foods rich in iron increase haemoglobin concentration and reduce the prevalence of anaemia, specific programs have...
journal_title:Pathogens and global health
pub_type: 杂志文章,评审
doi:10.1179/2047773212Y.0000000043
更新日期:2012-08-01 00:00:00
abstract::We report a case of facultative intestinal myiasis due to larvae of the drone fly Eristalis tenax, also named the rat-tailed maggots. The development of larvae in the lower bowel was responsible for non-specific gastrointestinal symptoms that resembled ulcerative proctitis. The diagnosis was established upon the obser...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773214Y.0000000135
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:The prevalence of sickle cell disease (SCD) is extremely high in the Democratic Republic of Congo (DRC). Despite the high prevalence of this disease in our midst, there has been no report on the clinical features in the sickle cell pediatric population suffering from malaria in our midst. METHODS:A retrospe...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773213Y.0000000089
更新日期:2013-06-01 00:00:00
abstract::Acanthamoeba keratitis is a painful and progressive infection of the cornea that can result in loss of vision. Here, for the first time in Pakistan, we report two cases of Acanthamoeba keratitis. The first patient was a 37-year-old female who presented with severe itching, redness, pain, along with loss of vision. The...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773213Y.0000000124
更新日期:2014-01-01 00:00:00
abstract::Plasma levels of pro- and anti-inflammatory cytokines of Plasmodium falciparum-infected patients with severe malaria (SM; n = 62) and uncomplicated malaria (UM; n = 69) from Sri Lanka were assessed. SM patients had significantly higher levels of TNF-alpha (P < 0·01), IL-6 (P < 0·01), and IL-10 (P < 0·05) compared to t...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773212Y.0000000069
更新日期:2013-01-01 00:00:00
abstract::Neurocysticercosis has been recognized as a major cause of secondary epilepsy worldwide. So far, most of the knowledge about the disease comes from Latin America and the Indian subcontinent. Unfortunately, in sub-Saharan Africa the condition was neglected for a long time, mainly owing to the lack of appropriate diagn...
journal_title:Pathogens and global health
pub_type: 杂志文章,评审
doi:10.1179/2047773212Y.0000000047
更新日期:2012-09-01 00:00:00
abstract::In order to assess cardiac tolerance of halofantrine in children, we studied, retrospectively, 15 non complicated falciparum malaria cases treated with halofantrine, and focused on the effect on ventricular repolarisation. Our data showed that halofantrine can produce a moderate QTc prolongation without any life-thre...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773212Y.0000000007
更新日期:2012-05-01 00:00:00
abstract::One of the essential steps in targeting tuberculosis (TB) intervention is early diagnosis and treatment of patients by reducing the reservoir of infection in the community. In the North-Eastern (NE) region of India pulmonary TB and paragonimiasis are overlapping public health issues. We performed a cross-sectional stu...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773213Y.0000000086
更新日期:2013-04-01 00:00:00
abstract::Methicillin-resistant Staphylococcus aureus (MRSA) is one of the important pathogens worldwide showing resistance to several widely used antibiotics. This has made the treatment of MRSA infections harder, especially due to their prevalence in the hospital setting. We evaluated the antibiotic susceptibility patterns of...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1080/20477724.2020.1827197
更新日期:2020-12-01 00:00:00
abstract::Giardiasis is one of the commonest intestinal parasitic infections in Cuba. In order to determine care-seeking behaviour and diagnostic processes in paediatric in-patients with giardiasis, structured questionnaires were administered by interview mothers of children with giardiasis during January to December 2010. Duri...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773214Y.0000000152
更新日期:2014-09-01 00:00:00
abstract::Recent data strongly suggest an association between the current outbreak of ZIKA virus (ZIKV) in many countries of Central and South America and a sharp increase in the detection of microcephaly and fetal malformations. The link with brain defect, which has been detected mainly in some areas of Brazil, is supported by...
journal_title:Pathogens and global health
pub_type: 杂志文章,评审
doi:10.1080/20477724.2016.1234804
更新日期:2016-01-01 00:00:00