The global spread of 2019-nCoV: a molecular evolutionary analysis.


:The global spread of the 2019-nCoV is continuing and is fast moving, as indicated by the WHO raising the risk assessment to high. In this article, we provide a preliminary phylodynamic and phylogeographic analysis of this new virus. A Maximum Clade Credibility tree has been built using the 29 available whole genome sequences of 2019-nCoV and two whole genome sequences that are highly similar sequences from Bat SARS-like Coronavirus available in GeneBank. We are able to clarify the mechanism of transmission among the countries which have provided the 2019-nCoV sequence isolates from their patients. The Bayesian phylogeographic reconstruction shows that the 2019-2020 nCoV most probably originated from the Bat SARS-like Coronavirus circulating in the Rhinolophus bat family. In agreement with epidemiological observations, the most likely geographic origin of the new outbreak was the city of Wuhan, China, where 2019-nCoV time of the most recent common ancestor emerged, according to molecular clock analysis, around November 25th, 2019. These results, together with previously recorded epidemics, suggest a recurring pattern of periodical epizootic outbreaks due to Betacoronavirus. Moreover, our study describes the same population genetic dynamic underlying the SARS 2003 epidemic, and suggests the urgent need for the development of effective molecular surveillance strategies of Betacoronavirus among animals and Rhinolophus of the bat family.


Pathog Glob Health


Benvenuto D,Giovanetti M,Salemi M,Prosperi M,De Flora C,Junior Alcantara LC,Angeletti S,Ciccozzi M




Has Abstract


2020-03-01 00:00:00












  • Body iron delocalization: the serious drawback in iron disorders in both developing and developed countries.

    abstract::Over 2 billion people in both developing as well as developed countries - over 30% of the world's population - are anaemic. With the classical preconception that oral iron administration or the intake of foods rich in iron increase haemoglobin concentration and reduce the prevalence of anaemia, specific programs have...

    journal_title:Pathogens and global health

    pub_type: 杂志文章,评审


    authors: Paesano R,Natalizi T,Berlutti F,Valenti P

    更新日期:2012-08-01 00:00:00

  • Malaria, clinical features and acute crisis in children suffering from sickle cell disease in resource-limited settings: a retrospective description of 90 cases.

    abstract:BACKGROUND:The prevalence of sickle cell disease (SCD) is extremely high in the Democratic Republic of Congo (DRC). Despite the high prevalence of this disease in our midst, there has been no report on the clinical features in the sickle cell pediatric population suffering from malaria in our midst. METHODS:A retrospe...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Aloni MN,Tshimanga BK,Ekulu PM,Ehungu JL,Ngiyulu RM

    更新日期:2013-06-01 00:00:00

  • A study investigating the knowledge and responses of Italian medical students to the COVID-19 pandemic.

    abstract::Italy was initially one of the worse affected countries by the novel coronavirus (COVID-19). Medical students frequenting hospitals are more susceptible to be infected by the virus but also able to see the effects of the pandemic from the frontline. The aim of this study was to assess the COVID-19 related knowledge, b...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Wheeler DR,Chibbaro S,Karoutis I,Safa A,Tinterri B,Calgaro G,Chung Yin W,Zaed I

    更新日期:2021-01-31 00:00:00

  • Prevalence of Toxoplasma gondii infection among individuals with severe mental illness in Nigeria: a case control study.

    abstract:BACKGROUND:While the aetiology for most psychotic disorders is unknown, a strong association has been observed between Toxoplasma gondii infection and psychosis. The proportion of individuals with psychotic disorders who have current or past infection with toxoplasma has been varied. Reports from the African continent ...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: James BO,Agbonile IO,Okolo M,Lawani AO,Omoaregba JO

    更新日期:2013-06-01 00:00:00

  • Active detection of tuberculosis and paragonimiasis in the remote areas in North-Eastern India using cough as a simple indicator.

    abstract::One of the essential steps in targeting tuberculosis (TB) intervention is early diagnosis and treatment of patients by reducing the reservoir of infection in the community. In the North-Eastern (NE) region of India pulmonary TB and paragonimiasis are overlapping public health issues. We performed a cross-sectional stu...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Rekha Devi K,Narain K,Mahanta J,Deori R,Lego K,Goswami D,Kumar Rajguru S,Agatsuma T

    更新日期:2013-04-01 00:00:00

  • Neurocysticercosis in sub-Saharan Africa: a review of prevalence, clinical characteristics, diagnosis, and management.

    abstract::Neurocysticercosis has been recognized as a major cause of secondary epilepsy worldwide. So far, most of the knowledge about the disease comes from Latin America and the Indian subcontinent. Unfortunately, in sub-Saharan Africa the condition was neglected for a long time, mainly owing to the lack of appropriate diagn...

    journal_title:Pathogens and global health

    pub_type: 杂志文章,评审


    authors: Winkler AS

    更新日期:2012-09-01 00:00:00

  • Evaluation of Syrian refugees' emergency service admissions in the western region of Turkey.

    abstract::Immigration increases physical, mental, and social health problems. Emergency departments constitute resources that refugees can easily access and where they frequently present. Physicians from every specialty (chest diseases, thoracic surgery, internal diseases, etc.) may be consulted if needed. We aimed to compare d...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Kaya H,Sengoren Dikis O,Sezgin B,Demirci H,Haberal MA,Akar E,Yüksel M

    更新日期:2021-01-24 00:00:00

  • Factors associated with parasitic infection amongst street children in orphanages across Lima, Peru.

    abstract::Infection caused by intestinal parasites has significant public health consequences amongst children in the developing world. Street children are an under-studied group of society subjected to increased health risks when compared to their peers. To estimate the prevalence of intestinal parasitic infection and ascertai...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Bailey C,Lopez S,Camero A,Taiquiri C,Arhuay Y,Moore DA

    更新日期:2013-03-01 00:00:00

  • Association of high plasma TNF-alpha levels and TNF-alpha/IL-10 ratios with TNF2 allele in severe P. falciparum malaria patients in Sri Lanka.

    abstract::Plasma levels of pro- and anti-inflammatory cytokines of Plasmodium falciparum-infected patients with severe malaria (SM; n = 62) and uncomplicated malaria (UM; n = 69) from Sri Lanka were assessed. SM patients had significantly higher levels of TNF-alpha (P < 0·01), IL-6 (P < 0·01), and IL-10 (P < 0·05) compared to t...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Perera MK,Herath NP,Pathirana SL,Phone-Kyaw M,Alles HK,Mendis KN,Premawansa S,Handunnetti SM

    更新日期:2013-01-01 00:00:00

  • Effect of halofantrine on QT interval in children.

    abstract::In order to assess cardiac tolerance of halofantrine in children, we studied, retrospectively, 15 non complicated falciparum malaria cases treated with halofantrine, and focused on the effect on ventricular repolarisation. Our data showed that halofantrine can produce a moderate QTc prolongation without any life-thre...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Siriez JY,Lupoglazoff JM,Bouchy-Bagros ML,Pull L,Denjoy I

    更新日期:2012-05-01 00:00:00

  • Cystic echinococcosis in Mundari tribe-members of South Sudan.

    abstract::Many neglected tropical diseases, including the zoonotic disease cystic echinococcosis (hydatidosis), are endemic to East Africa. However, their geographical distribution is heterogenous and incompletely characterized. The aim of this study was to determine if Mundari pastoralists harbor endemic human hydatidosis. The...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Stewart BT,Jacob J,Finn T,Lado M,Napoleon R,Brooker S,Sidhu PS,Kolaczinski J

    更新日期:2013-09-01 00:00:00

  • HIV P24 antigen among HIV antibody seronegative blood donors in Osogbo Osun State, South Western Nigeria.

    abstract:BACKGROUND:Efforts to curb the spread of HIV transmission through transfusion of blood and its products is still a problem because of challenge in countries using antibody-based rapid methods to detect infection during window period. Transmission of HIV through infected blood and its products accounts for approximately...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Olowe OA,Mabayoje VO,Akanbi O,Adefioye OJ,Olowe RA,Fadeni EK,Oluremi AS,Opaleye OO

    更新日期:2016-06-01 00:00:00

  • Community mobilization and household level waste management for dengue vector control in Gampaha district of Sri Lanka; an intervention study.

    abstract:INTRODUCTION:Waste management through community mobilization to reduce breeding places at household level could be an effective and sustainable dengue vector control strategy in areas where vector breeding takes place in small discarded water containers. The objective of this study was to assess the validity of this a...

    journal_title:Pathogens and global health

    pub_type: 杂志文章,随机对照试验


    authors: Abeyewickreme W,Wickremasinghe AR,Karunatilake K,Sommerfeld J,Axel K

    更新日期:2012-12-01 00:00:00

  • Humans parasitized by the hard tick Ixodes ricinus are seropositive to Midichloria mitochondrii: is Midichloria a novel pathogen, or just a marker of tick bite?

    abstract::Midichloria mitochondrii is an intracellular bacterium found in the hard tick Ixodes ricinus. In this arthropod, M. mitochondrii is observed in the oocytes and in other cells of the ovary, where the symbiont is present in the cell cytoplasm and inside the mitochondria. No studies have so far investigated whether M. m...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Mariconti M,Epis S,Gaibani P,Dalla Valle C,Sassera D,Tomao P,Fabbi M,Castelli F,Marone P,Sambri V,Bazzocchi C,Bandi C

    更新日期:2012-11-01 00:00:00

  • Cellular mechanisms regulating synthetic sex ratio distortion in the Anopheles gambiae germline.

    abstract::Genetic control strategies aimed to bias the sex of progenies towards males present a promising new paradigm to eliminate malaria-transmitting mosquitoes. A synthetic sex-ratio distortion (SD) system was successfully engineered in Anopheles gambiae by exploiting the meiotic activity of the I-PpoI endonuclease targetin...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Haghighat-Khah RE,Sharma A,Wunderlich MR,Morselli G,Marston LA,Bamikole C,Hall A,Kranjc N,Taxiarchi C,Sharakhov I,Galizi R

    更新日期:2020-10-01 00:00:00

  • Care-seeking behaviour and diagnostic processes for symptomatic giardiasis in children attending an academic paediatric hospital.

    abstract::Giardiasis is one of the commonest intestinal parasitic infections in Cuba. In order to determine care-seeking behaviour and diagnostic processes in paediatric in-patients with giardiasis, structured questionnaires were administered by interview mothers of children with giardiasis during January to December 2010. Duri...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Escobedo AA,Almirall P,Ávila I,Salazar Y,Alfonso M

    更新日期:2014-09-01 00:00:00

  • Bovine lactoferrin-derived peptides as novel broad-spectrum inhibitors of influenza virus.

    abstract::Bovine lactoferrin (bLf) is a multifunctional glycoprotein that plays an important role in innate immunity against infections, including influenza. Here we have dissected bLf into its C- and N-lobes and show that inhibition of influenza virus hemagglutination and cell infection is entirely attributable to the C-lobe ...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Ammendolia MG,Agamennone M,Pietrantoni A,Lannutti F,Siciliano RA,De Giulio B,Amici C,Superti F

    更新日期:2012-03-01 00:00:00

  • Genetic diversity of Trichomonas vaginalis clinical isolates from Henan province in central China.

    abstract::Trichomonas vaginalis is a flagellated protozoan parasite that infects the human urogenital tract, causing the most common non-viral, sexually transmitted disease worldwide. In this study, genetic variants of T. vaginalis were identified in Henan Province, China. Fragments of the small subunit of nuclear ribosomal RNA...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Mao M,Liu HL

    更新日期:2015-07-01 00:00:00

  • Implication of vector characteristics of Phlebotomus argentipes in the kala-azar elimination programme in the Indian sub-continent.

    abstract:BACKGROUND:Visceral leishmaniasis (VL), also known as kala-azar in the Indian sub-continent (ISC), is a major public health concern in Bangladesh, India, and Nepal, where it is caused by Leishmania donovani transmitted by the sand fly Phlebotomus argentipes. Various ecological parameters including air temperature, rain...

    journal_title:Pathogens and global health

    pub_type: 杂志文章,评审


    authors: Chowdhury R,Kumar V,Mondal D,Das ML,Das P,Dash AP,Kroeger A

    更新日期:2016-05-01 00:00:00

  • The important role of early diagnosis and preventive management during a large-scale outbreak of hepatitis A in Thailand.

    abstract:INTRODUCTION:Acute hepatitis A is a worldwide public health problem especially in developing countries. Recently, a large, community-wide outbreak of hepatitis A occurred in the northeast part of Thailand. METHODS:Demographic and clinical data as well as blood samples were collected and analyzed from patients with acu...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Poovorawan K,Chattakul P,Chattakul S,Thongmee T,Theamboonlers A,Komolmit P,Poovorawan Y

    更新日期:2013-10-01 00:00:00

  • Ebola crisis in Eastern Democratic Republic of Congo: student-led community engagement.

    abstract::The second largest outbreak of Ebolavirus is currently ongoing in Eastern Democratic Republic of the Congo (DRC) and is characterized by lack of compliance with recommended control measures. Trusted local health agents, including medical students, may be valuable social mobilizers in this challenging context. We repor...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Masumbuko Claude K,Hawkes MT

    更新日期:2020-05-18 00:00:00

  • Neonatal liver abscesses due to Candida infection in a preterm infant, secondary to malpositioned umbilical lines--a rare entity.

    abstract::Neonatal liver abscess is an uncommon seen condition in neonatology and it holds a very high neonatal mortality because of difficulty in diagnosis and treatment. Till today, only few instances are reported that too are mainly in preterm. Its diagnosis requires a high index of suspicion. Fungal hepatic abscess is very ...

    journal_title:Pathogens and global health

    pub_type: 杂志文章,评审


    authors: Sharma D,Choudhary M,Shastri S,Sharma PK

    更新日期:2015-03-01 00:00:00

  • Risk factors and mortality in the Carbapenem-resistant Klebsiella pneumoniae infection: case control study.

    abstract::Carbapenem-resistant Klebsiella pneumoniae (CRKP) has been known as a nosocomial pathogen, both for the last 10 years in Turkey and for 20 years worldwide. Due to limited treatment options and high mortality rates, despite improvements in the field of medicine at the present time, CRKP is still a big threat for public...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Akgul F,Bozkurt I,Sunbul M,Esen S,Leblebicioglu H

    更新日期:2016-01-01 00:00:00

  • Failure of chemotherapy in the first reported cases of Acanthamoeba keratitis in Pakistan.

    abstract::Acanthamoeba keratitis is a painful and progressive infection of the cornea that can result in loss of vision. Here, for the first time in Pakistan, we report two cases of Acanthamoeba keratitis. The first patient was a 37-year-old female who presented with severe itching, redness, pain, along with loss of vision. The...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Siddiqui R,Chaudhry T,Lakhundi S,Ahmad K,Khan NA

    更新日期:2014-01-01 00:00:00

  • Implementation challenges of a TB programme in rural northern mozambique: evaluation of 2012-2013 outcomes.

    abstract:BACKGROUND:We aimed to identify challenges and to propose solutions for the implementation of tuberculosis (TB) programmes in rural Sub-Saharan Africa (SSA) by evaluating the outcomes of the TB programme in the Ancuabe district in rural Northern Mozambique. METHODS:Retrospective descriptive study of the patients inclu...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Wikman-Jorgensen PE,Morales-Cartagena A,Llenas-García J,Pérez-Porcuna TM,Hobbins M,Ehmer J,Mussa MA,Abellana R,Ascaso C

    更新日期:2015-07-01 00:00:00

  • Methicillin-resistant Staphylococcus aureus: epidemiology and antimicrobial susceptibility experiences from the University Hospital 'Luigi Vanvitelli' of Naples.

    abstract::Methicillin-resistant Staphylococcus aureus (MRSA) is one of the important pathogens worldwide showing resistance to several widely used antibiotics. This has made the treatment of MRSA infections harder, especially due to their prevalence in the hospital setting. We evaluated the antibiotic susceptibility patterns of...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Pignataro D,Foglia F,Della Rocca MT,Melardo C,Santella B,Folliero V,Shinde S,Pafundi PC,Sasso FC,Iovene MR,Galdiero M,Boccia G,Franci G,Finamore E,Galdiero M

    更新日期:2020-12-01 00:00:00

  • wsp-based analysis of Wolbachia strains associated with Phlebotomus papatasi and P. sergenti (Diptera: Psychodidae) main cutaneous leishmaniasis vectors, introduction of a new subgroup wSerg.

    abstract::Sand flies of Phlebotomus papatasi and P. sergenti are the main vectors of cutaneous leishmanisis (CL) in the old world. We aimed to screen Iranian P. papatasi and P. sergenti for their natural infections with Wolbachia and to determine their phylogenetic association with other species. Wolbachia surface protein (wsp)...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Karimian F,Vatandoost H,Rassi Y,Maleki-Ravasan N,Choubdar N,Koosha M,Arzamani K,Moradi-Asl E,Veysi A,Alipour H,Shirani M,Oshaghi MA

    更新日期:2018-05-01 00:00:00

  • Malaria in a tertiary health care facility of Central India with special reference to severe vivax: implications for malaria control.

    abstract::Plasmodium vivax is now recognized as a cause of severe and fatal infection in many parts of the world. This prospective observational study was undertaken in a tertiary health setting to understand the spectrum of the disease burden and associated complications due to P. vivax malaria in central India. A malaria clin...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Jain V,Agrawal A,Singh N

    更新日期:2013-09-01 00:00:00

  • Discovery and characterization of two Nimrod superfamily members in Anopheles gambiae.

    abstract::Anti-bacterial proteins in mosquitoes are known to play an important modulatory role on immune responses to infections with human pathogens including malaria parasites. In this study we characterized two members of the Anopheles gambiae Nimrod superfamily, namely AgNimB2 and AgEater. We confirm that current annotation...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Midega J,Blight J,Lombardo F,Povelones M,Kafatos F,Christophides GK

    更新日期:2013-12-01 00:00:00

  • Direct healthcare costs for patients hospitalized with Crimean-Congo haemorrhagic fever can be predicted by a clinical illness severity scoring system.

    abstract::Crimean-Congo hemorrhagic fever (CCHF) is endemic in Turkey, with peak incidence of hospital admissions in the summer months. The aim of this pilot study was to evaluate the role of the severity grading score (SGS) in predicting length of hospital stay, laboratory usage, need for blood products, and hence total costs ...

    journal_title:Pathogens and global health

    pub_type: 杂志文章


    authors: Bozkurt I,Sunbul M,Yilmaz H,Esen S,Leblebicioglu H,Beeching NJ

    更新日期:2016-01-01 00:00:00