Abstract:
:Introduction. Retinoblastoma is the most common primary intraocular neoplasm in children. With the advances in medicine, the armamentarium of available treatment modalities has grown. Intraarterial chemotherapy is a relatively new treatment method with promising outcomes. The purpose of this literature review is to evaluate its role in the management of retinoblastoma. Methods:A systematic online search was conducted using Ovid Embase and Ovid Medline. The final results included 23 studies. The studies were published between 2011 and 2019. The studies evaluated the technical success rate of IAC, globe salvage rate, and ocular and systemic complications, as well as the occurrence of deaths, metastasis, and secondary neoplasms. In total, 1827 eyes with retinoblastoma were analysed. The follow-up was between 0 and 252 months. Results:Overall globe retention rate ranged from 30% to 100%. Sixteen out of 23 studies reported ocular salvage between 60 and 80%. Eyelid oedema and erythema were the most commonly reported ocular complications following IAC. The most common systemic complications included nausea, vomiting, and neutropenia. Metastases and deaths were reported in 6 out of 23 studies. Three studies reported the development of secondary neoplasms. The technical success rate of IAC procedure ranged from 91% to 100%. Discussion. The studies have shown that IAC is a safe and effective treatment for advanced retinoblastoma, especially group D. It allows to save the globe without compromising patients' survival. Local and systemic complications are acceptable. The role of IAC in less advanced tumours is yet to be established. Future work should focus on conducting larger prospective studies with longer follow-up. Multiple novel therapies for the management of retinoblastoma are currently being tested, including angiogenic inhibitors and targeted agents. The results seem to be promising. Future advances require a further in-depth understanding of unique genetics of retinoblastoma and complex interactions between tumour cells and their microenvironment.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
Pekacka Adoi
10.1155/2020/3638410subject
Has Abstractpub_date
2020-01-24 00:00:00pages
3638410eissn
2090-004Xissn
2090-0058journal_volume
2020pub_type
杂志文章,评审abstract::Purpose. This study investigated the effects of oral propolis on the progression of galactose-induced sugar cataracts in rats and the in vitro effects of propolis on high-glucose-induced reactive oxygen species (ROS) and cell death in cultured rat lens cells (RLECs). Methods. Galactose-fed rats and RLECs cultured in h...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/1917093
更新日期:2016-01-01 00:00:00
abstract:Purpose:To present a new method of measuring ocular axial dimensions, termed OCT biometry (B-OCT). Design:Observational cross-sectional study and evaluation of new diagnostic technology. Methods:B-OCT was implemented in the spectral domain OCT device for posterior and anterior segment imaging (REVO NX, Optopol Techno...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/9192456
更新日期:2019-08-14 00:00:00
abstract::Aim. The aim of this study was to determine the intra- and interobserver variability of two Scheimpflug based camera systems, Pentacam and Sirius. In addition, the comparability of the measurements was tested in healthy subjects, subjects with regular astigmatism, and keratoconus patients. Methods. Intra- and interobs...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/315281
更新日期:2015-01-01 00:00:00
abstract:Purpose:To compare the qualitative and quantitative choroidal neovascularization (CNV) changes after antivascular endothelial growth factor (anti-VEGF) therapy in treatment-naïve and treated eyes with age-related macular degeneration (AMD) using optical coherence tomography angiography (OCTA). Methods:Consecutive pati...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/3751702
更新日期:2018-02-04 00:00:00
abstract:Purpose:Although optical coherence tomography (OCT) is essential for ophthalmologists, reading of findings requires expertise. The purpose of this study is to test deep learning with image augmentation for automated detection of chorioretinal diseases. Methods:A retina specialist diagnosed 1,200 OCT images. The diagno...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/6319581
更新日期:2019-04-09 00:00:00
abstract::Purpose. To investigate the agreement between morphometric optic nerve head parameters assessed with the confocal laser ophthalmoscope HRT III and the stereoscopic fundus camera Kowa nonmyd WX3D retrospectively. Methods. Morphometric optic nerve head parameters of 40 eyes of 40 patients with primary open angle glaucom...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/4764857
更新日期:2016-01-01 00:00:00
abstract::We aimed to investigate the efficacy of frequency doubling technology (FDT) perimetry for glaucoma detection in comprehensive screening examinations. We performed a retrospective analysis of prospectively collected data of participants who underwent a comprehensive health checkup service. Participants with glaucoma we...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/4687398
更新日期:2020-03-29 00:00:00
abstract:Purpose:To compare two calculators for toric intraocular lens (IOL) calculation and to evaluate the prediction of refractive outcome. Methods:Sixty-four eyes of forty-five patients underwent cataract surgery followed by implantation of a toric intraocular lens (Zeiss Torbi 709 M) calculated by a standard industry calc...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/2840246
更新日期:2018-01-10 00:00:00
abstract:Background:The advantage of using an autostereoscopic smartphone is that it can achieve 3D effects without the need for glasses. The purpose of this study was to evaluate whether this technology could be utilized to detect stereoacuity. Methods:An autostereoscopic smartphone was used to imitate Lang stereotest I & II,...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/1570309
更新日期:2019-10-31 00:00:00
abstract::Cross-linking of corneal collagen (CXL) is a promising approach for the treatment of keratoconus and secondary ectasia. Several long-term and short-term complications of CXL have been studied and documented. The possibility of a secondary infection after the procedure exists because the patient is subjected to epithel...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2011/869015
更新日期:2011-01-01 00:00:00
abstract:Purpose:The iStent provides a direct pathway for aqueous outflow from the anterior chamber to Schlemm's canal in patients with open-angle glaucoma (OAG). We performed a meta-analysis to evaluate the effectiveness of iStent as a standalone operation in patients with OAG in reducing the intraocular pressure (IOP) and the...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2020/8754730
更新日期:2020-05-24 00:00:00
abstract:Purpose:To evaluate a new technique of posterior capsulorhexis using air support to treat primary posterior capsular opacification (PCO) during cataract extraction surgery or to prevent postoperative PCO. Setting:(1) Ophthalmology department, Faculty of Medicine, Minia University, 61519, El-Minia, Egypt. (2) Security ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/3174709
更新日期:2019-12-21 00:00:00
abstract::Purpose. To evaluate intraobserver and interobserver agreement in locating the scleral spur landmark (SSL) and anterior chamber angle measurements obtained using Fourier Domain Anterior Segment Optical Coherence Tomography (ASOCT) images. Methods. Two independent, masked observers (SR and AZC) identified SSLs on ASOCT...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2012/487309
更新日期:2012-01-01 00:00:00
abstract:Objective:To determine whether accommodation induced by reading alters intraocular pressure (IOP) in healthy, young, emmetropic adults and to document the duration and magnitude of this effect. Design:Cross-sectional study. Participants. Fifteen healthy, emmetropic young adults. Methods:Subjects performed 20 minutes ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/1352434
更新日期:2020-01-28 00:00:00
abstract::Purpose. To investigate the thickness of the retinal nerve fiber layer (RNFL) and choroid in patients who have migraines in comparison to healthy controls. Methods. This study included 76 eyes and patients in the migraine group, 36 with aura (MWA group) and 40 without (MWoA group), and 38 eyes as control subjects. The...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/868967
更新日期:2015-01-01 00:00:00
abstract:Purpose:The purpose of this study was to evaluate 2-year visual outcomes in patients with diabetic macular edema (DME) treated with anti-VEGF agents in a routine clinical setting. Methods:The medical records of patients treated with ranibizumab or aflibercept due to DME at the Eye Hospital, University Medical Centre L...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/6979758
更新日期:2020-03-16 00:00:00
abstract:Introduction:To assess long-term efficacy of bimedial rectus tendon elongation with Tutopatch in thyroid-associated orbitopathy (TAO). Materials and Methods:Retrospective chart review of 5 patients with TAO undergoing bimedial rectus recession with Tutopatch tendon elongation between 2009 and 2015. We analyzed horizon...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/1294761
更新日期:2018-07-24 00:00:00
abstract:Background:For so long, corneal diseases have been known as one of the leading causes to blindness in the global. This blindness might be due to failure to accept the corneal transplantation. Therefore, this study aimed to determine the prevalence and the root challenges for corneal transplantation acceptance at the Un...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/4560649
更新日期:2019-12-13 00:00:00
abstract:Purpose:To compare the efficacy of passive drainage (PD) and repeated fluid-air (FA) exchange for removing emulsified silicone oil (SO) droplets. Methods:Twenty rhegmatogenous retinal detachment (RRD) patients who underwent primary pars plana vitrectomy (PPV) with SO tamponade were randomly and evenly divided into two...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/8184607
更新日期:2020-07-04 00:00:00
abstract:Purpose:To analyze the results of three-year outcomes of combined epithelium-on cross-linking with femtosecond laser ICRS (cross-linking PLUS) for keratoconus management. Design:A retrospective multicenter clinical study. Methods:43 eyes of 38 patients were subjected to preoperative and postoperative UCVA, BCVA, refr...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/6907573
更新日期:2018-01-17 00:00:00
abstract::Traumatic macular hole (TMH) is not a rare clinical condition, especially in young population. Its prognosis is of complexity and uncertainty, with a relatively high rate of spontaneous closure in some cases. Modern vitrectomy surgery plays an important role in the treatment of TMH, although the functional outcomes ma...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2017/1748135
更新日期:2017-01-01 00:00:00
abstract::SD-OCT has become an essential tool for evaluating macular pathology; however several aspects of data collection and analysis affect the accuracy of retinal thickness measurements. Here we evaluated sampling density, scan centering, and axial length compensation as factors affecting the accuracy of macular thickness m...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2011/692574
更新日期:2011-01-01 00:00:00
abstract::We established a chronic dacryocystitis model by injecting of 0.05, 0.1, and 0.15 ml self-curing resin via the lacrimal punctum in rabbits. Animals were randomized into four groups (n = 11 animals/group). The control group received 0.15 ml normal saline. Within three months postinjection, epiphora and eye discharge we...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/3438041
更新日期:2017-01-01 00:00:00
abstract::Purpose. To examine the clinical implications of change in choroidal neovascularization (CNV) size on indocyanine green (ICG) angiography in subjects with idiopathic CNV undergoing bevacizumab therapy. Methods. The charts of subjects with an idiopathic CNV treated by a modified PRN regimen with intravitreal bevacizuma...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/642624
更新日期:2015-01-01 00:00:00
abstract:AIM:To discuss the clinical characteristics of immune-related dry eye. METHODS:Simple dry eye (SDE) group: we selected 224 patients of simple dry eye with no systemic lesions. Immune-related dry eye (IRDE) group: we selected 207 patients of dry eye complicated with immune system diseases, including 70 cases of Sjögren...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/8532397
更新日期:2017-01-01 00:00:00
abstract:Purpose:To identify the clinical characteristics and risk factors for secondary choroidal neovascularization (CNV) in central serous chorioretinopathy (CSC). Methods:In this retrospective study, we included a total of 108 eyes in 106 CSC patients. Group A was defined as patients initially diagnosed with CSC who develo...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/7217906
更新日期:2020-02-07 00:00:00
abstract::Purpose. To determine the efficacy of povidone-iodine (P-I) prophylaxis for ophthalmia neonatorum (ON) in Angola and to document maternal prevalence and mother-to-child transmission rates. Methods. Endocervical samples from mothers (n = 317) and newborn conjunctival smears (n = 245) were analysed by multiplex polymera...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/326526
更新日期:2015-01-01 00:00:00
abstract::Primary congenital glaucoma is a worldwide diagnostic and therapeutic challenge. Although medical management is often a temporizing measure, early surgical intervention is the definitive treatment. As the abundance of surgical treatment options continues to expand, the authors will compare and contrast the available o...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2013/612708
更新日期:2013-01-01 00:00:00
abstract:Purpose:To evaluate the efficacy and safety of MyoRing implantation in eyes with keratoconus managed at a tertiary eye hospital in the Eastern Province of Saudi Arabia. Methods:This one-armed historical cohort study included keratoconus patients operated for MyoRing implant. The cases were assessed before and 6 months...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/2630704
更新日期:2019-08-29 00:00:00
abstract::Aim. To assess the effects of mydriatics commonly used in clinical practice on choroidal thickness and anterior chamber change. Methods. This was a prospective, randomized, controlled, double-blinded study including a single eye of the participants. The subjects were assigned into 4 groups to receive tropicamide 1%, p...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/981274
更新日期:2015-01-01 00:00:00