Abstract:
:Introduction. Retinoblastoma is the most common primary intraocular neoplasm in children. With the advances in medicine, the armamentarium of available treatment modalities has grown. Intraarterial chemotherapy is a relatively new treatment method with promising outcomes. The purpose of this literature review is to evaluate its role in the management of retinoblastoma. Methods:A systematic online search was conducted using Ovid Embase and Ovid Medline. The final results included 23 studies. The studies were published between 2011 and 2019. The studies evaluated the technical success rate of IAC, globe salvage rate, and ocular and systemic complications, as well as the occurrence of deaths, metastasis, and secondary neoplasms. In total, 1827 eyes with retinoblastoma were analysed. The follow-up was between 0 and 252 months. Results:Overall globe retention rate ranged from 30% to 100%. Sixteen out of 23 studies reported ocular salvage between 60 and 80%. Eyelid oedema and erythema were the most commonly reported ocular complications following IAC. The most common systemic complications included nausea, vomiting, and neutropenia. Metastases and deaths were reported in 6 out of 23 studies. Three studies reported the development of secondary neoplasms. The technical success rate of IAC procedure ranged from 91% to 100%. Discussion. The studies have shown that IAC is a safe and effective treatment for advanced retinoblastoma, especially group D. It allows to save the globe without compromising patients' survival. Local and systemic complications are acceptable. The role of IAC in less advanced tumours is yet to be established. Future work should focus on conducting larger prospective studies with longer follow-up. Multiple novel therapies for the management of retinoblastoma are currently being tested, including angiogenic inhibitors and targeted agents. The results seem to be promising. Future advances require a further in-depth understanding of unique genetics of retinoblastoma and complex interactions between tumour cells and their microenvironment.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
Pekacka Adoi
10.1155/2020/3638410subject
Has Abstractpub_date
2020-01-24 00:00:00pages
3638410eissn
2090-004Xissn
2090-0058journal_volume
2020pub_type
杂志文章,评审abstract:Background:To evaluate the outcome and complications of transscleral suture-fixated posterior chamber intraocular lens (PCIOL) implantation combined with Ahmed glaucoma valve (AGV) surgery in Asian eyes. Design:This was a retrospective study that included 22 eyes from 22 participants. The surgeries were performed at S...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/9824035
更新日期:2018-03-25 00:00:00
abstract::Central retinal vein occlusion (CRVO) is a common retinal disease. Recent works mentioned spontaneous retinal arterial pulsations (SRAPs) as a feature of some CRVOs. This is a retrospective study on patients presenting with CRVO who were followed up for at least 6 months. The objective was to identify SRAP in the acut...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/3107472
更新日期:2020-06-09 00:00:00
abstract::Purpose. Ischemic central retinal vein occlusion (CRVO) eyes are at high risk of developing neovascular glaucoma (NVG). Our purpose is to investigate the effect of anti-VEGF therapy for macular edema after CRVO on the development of neovascular glaucoma (NVG) in ischemic CRVO eyes. Methods. This is a retrospective cas...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2014/317694
更新日期:2014-01-01 00:00:00
abstract::Fifty-two eyes of 52 patients with treatment-naïve macular edema associated with perfused branch retinal vein occlusion were retrospectively reviewed. Twenty-seven cases received PRN intravitreal bevacizumab, and 25 cases were treated by PRN intravitreal aflibercept with monthly follow-ups for 12 months. Both afliberc...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/8421940
更新日期:2016-01-01 00:00:00
abstract::Traumatic macular hole (TMH) is not a rare clinical condition, especially in young population. Its prognosis is of complexity and uncertainty, with a relatively high rate of spontaneous closure in some cases. Modern vitrectomy surgery plays an important role in the treatment of TMH, although the functional outcomes ma...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2017/1748135
更新日期:2017-01-01 00:00:00
abstract::Current data permit only speculations regarding sex differences in the prevalence of infectious uveitis between women and men because uveitis case surveys do not uniformly report gender data. Differences in prevalence that are reported in the literature could relate to simple differences in the number of women and men...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2014/683246
更新日期:2014-01-01 00:00:00
abstract:Purpose:To investigate the association between regional solar radiation and myopia occurrence in South Korean children. Materials and Methods:A population-based cross-sectional study using data of 1218 children aged 7-9 years from the Korea National Health and Nutritional Examination Survey was conducted from January ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/7643850
更新日期:2019-06-10 00:00:00
abstract::Purpose. To evaluate the corneal higher-order aberrations (HOA), contrast sensitivity function (CSF), and light distortion (LD) in patients undergoing orthokeratology (OK). Methods. Twenty healthy subjects (mean age: 21.40 ± 8 years) with mean spherical equivalent refractive error M = -2.19 ± 0.97 D were evaluated at ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/8453462
更新日期:2016-01-01 00:00:00
abstract::Age-related macular degeneration (AMD) is one of the main socioeconomical health issues worldwide. AMD has a multifactorial etiology with a variety of risk factors. Smoking is the most important modifiable risk factor for AMD development and progression. The present review summarizes the epidemiological studies evalua...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2013/895147
更新日期:2013-01-01 00:00:00
abstract:Purpose:To investigate the correlation between decentration index (index of height decentration, IHD) automatically calculated by the Pentacam HR software and the manually calculated inferior minus superior (I-S) value. Setting:Al Watany Eye Hospital, Cairo, Egypt. Methods:In a retrospective study, history taking, cl...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/7875148
更新日期:2018-10-02 00:00:00
abstract::Purpose. To compare the surgically induced astigmatism from clear corneal and square posterior limbal incisions at the time of cataract surgery. Methods. Surgically induced astigmatism was calculated for a set of eyes after cataract surgery using a temporal 2.2 mm square posterior limbal incision. Results were compare...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2011/243170
更新日期:2011-01-01 00:00:00
abstract::Purpose. To investigate the local relationship between quantified global-flash multifocal electroretinogram (mfERG) optic nerve head component (ONHC) and visual field defects in patients with glaucoma. Methods. Thirty-nine patients with glaucoma and 30 normal controls were enrolled. The ONHC amplitude was measured fro...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/397495
更新日期:2015-01-01 00:00:00
abstract:Purpose:To evaluate the response of intravitreal aflibercept injection (IAI) in eyes with detachment of retinal pigment epithelium (DEP) secondary to nAMD refractory to monthly ranibizumab. Patients and Methods:This is a retrospective, multicenter study. All patients received 3 IAI then treated as needed every 4 weeks...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/8984313
更新日期:2017-01-01 00:00:00
abstract:Purpose:The purpose of this meta-analysis was to assess the percent reduction in the intraocular pressure (IOP) after argon laser peripheral iridoplasty (ALPI) and systemic medical therapy in patients with acute primary angle closure (APAC). Methods:We searched a number of electronic databases, including MEDLINE, EMBA...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2019/7697416
更新日期:2019-05-02 00:00:00
abstract:Purpose:To evaluate early macular circulation in open-angle glaucoma (OAG), normal-tension glaucoma (NTG), ocular hypertension (OHT), and healthy subjects via optical coherence tomography angiography (OCTA). Methods:A retrospective cross-sectional study was conducted. Medical records were reviewed, and the patients wh...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/7419470
更新日期:2019-01-15 00:00:00
abstract::Zeaxanthin is a nutritional carotenoid with a considerable amount of safety data based on regulatory studies, which form the basis of its safety evaluation. Subchronic OECD guideline studies with mice and rats receiving beadlet formulations of high purity synthetic zeaxanthin in the diet at dosages up to 1000 mg/kg bo...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2016/3690140
更新日期:2016-01-01 00:00:00
abstract:Purpose:To assess anterior corneal surface stability 12 months following hyperopic LASIK correction with a light propagation algorithm. Setting:Vissum Instituto Oftalmológico de Alicante, Universidad Miguel Hernández, Alicante, Spain. Methods:This retrospective consecutive observational study includes 37 eyes of 37 p...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/3060939
更新日期:2018-03-28 00:00:00
abstract::Purpose. To evaluate interobserver, intervisit, and interinstrument agreements for gonioscopy and Fourier domain anterior segment optical coherence tomography (FD ASOCT) for classifying open and narrow angle eyes. Methods. Eighty-six eyes with open or narrow anterior chamber angles were included. The superior angle wa...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/1727039
更新日期:2016-01-01 00:00:00
abstract:Purpose:To examine and spot systemic findings commonly associated with a serious form of ocular Behcet's disease. This could potentially help ophthalmologists categorize their patients based on future risk and plan treatment accordingly. Subjects and Methods:The data of 249 patients with Behcet's disease were examined...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/9518065
更新日期:2018-04-26 00:00:00
abstract::[This corrects the article DOI: 10.1155/2016/3690140.]. ...
journal_title:Journal of ophthalmology
pub_type: 已发布勘误
doi:10.1155/2019/6212745
更新日期:2019-06-11 00:00:00
abstract:Purpose:To present a new method of measuring ocular axial dimensions, termed OCT biometry (B-OCT). Design:Observational cross-sectional study and evaluation of new diagnostic technology. Methods:B-OCT was implemented in the spectral domain OCT device for posterior and anterior segment imaging (REVO NX, Optopol Techno...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/9192456
更新日期:2019-08-14 00:00:00
abstract:Purpose:To evaluate the effect of corneal cap thickness on visual acuity and corneal biomechanics in small incision lenticule extraction (SMILE) for the treatment of myopia. Methods:Forty eyes of 20 patients undergoing SMILE for the treatment of myopia were enrolled in this prospective controlled study. The patients w...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/6040873
更新日期:2018-06-28 00:00:00
abstract::Purpose. To evaluate the outcome of combined vitrectomy with phacoemulsification without postoperative face-down positioning for idiopathic macular holes (MHs). Design. Retrospective, observational case series. Participants. Forty-two eyes of 42 patients with MH. Methods. We studied 42 eyes of 42 cases followed up for...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2012/571748
更新日期:2012-01-01 00:00:00
abstract:Purpose:Healthcare access is one of the determinants of visual impairment (VI), as a public health problem. The objective of this study was to estimate VI prevalence, related causes, and its correlation with access to physicians in Iran. Methods:: This systematic review and meta-analysis include observational studies ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2020/4710328
更新日期:2020-11-23 00:00:00
abstract::Purpose. To compare the clinical features of community-associated (CA) and healthcare-associated (HA) methicillin-resistant Staphylococcus aureus (MRSA) keratitis. Methods. Patients presenting with culture-proven MRSA keratitis between January 1, 2006, and December 31, 2010, at Chang Gung Memorial Hospital, Taiwan, we...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/923941
更新日期:2015-01-01 00:00:00
abstract::Purpose. To compare near, intermediate, and distance vision and quality of vision, when refractive rotational multifocal intraocular lenses with 3.0 diopters or diffractive multifocal intraocular lenses with 2.5 diopters near addition are implanted. Methods. 41 eyes of 41 patients in whom rotational +3.0 diopters near...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/1395302
更新日期:2016-01-01 00:00:00
abstract::Aim. To evaluate the possible structural and functional changes in the retinal nerve fibre layer (RNFL) and the ganglion cell complex (GCC) of chronic smokers and compare them with those of passive healthy smokers using spectral domain optical coherence tomography (SD-OCT) and pattern electroretinogram (PERG). Materia...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/6354025
更新日期:2017-01-01 00:00:00
abstract:Objective:In a group case series, the clinical characteristics of congenital membranous cataract in children were studied to establish a system of classification and determine the surgical method suited for each type. Methods:Children (18 eyes) with congenital membranous cataract were examined by slit lamp, ultrasound...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/2370969
更新日期:2017-01-01 00:00:00
abstract:Objective:To calculate the Q values from the human anterior corneal surface with the tangential radius of curvature and analyze its distribution characteristics in different age and refractive status groups. Methods:Tangential power maps of the anterior cornea from Orbscan II were acquired for 201 subjects' right eyes...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/7263564
更新日期:2018-04-17 00:00:00
abstract::Aim. To examine subscale and total scores of NEI-VFQ questionnaire of type 2 diabetes patients at different diabetic retinopathy (DRP) stages. Methods. A total number of 201 patients have been included. Prior to ophthalmological examination all patients participated in the NEI-VFQ questionnaire. The patients were divi...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/1549318
更新日期:2016-01-01 00:00:00