Lysosome biology in autophagy.


:Autophagy is a major intracellular degradation system that derives its degradative abilities from the lysosome. The most well-studied form of autophagy is macroautophagy, which delivers cytoplasmic material to lysosomes via the double-membraned autophagosome. Other forms of autophagy, namely chaperone-mediated autophagy and microautophagy, occur directly on the lysosome. Besides providing the means for degradation, lysosomes are also involved in autophagy regulation and can become substrates of autophagy when damaged. During autophagy, they exhibit notable changes, including increased acidification, enhanced enzymatic activity, and perinuclear localization. Despite their importance to autophagy, details on autophagy-specific regulation of lysosomes remain relatively scarce. This review aims to provide a summary of current understanding on the behaviour of lysosomes during autophagy and outline unexplored areas of autophagy-specific lysosome research.


Cell Discov


Cell discovery


Yim WW,Mizushima N




Has Abstract


2020-02-11 00:00:00










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    journal_title:Cell discovery

    pub_type: 杂志文章


    authors: Yang Y,Hao H,Wu X,Guo S,Liu Y,Ran J,Li T,Li D,Liu M,Zhou J

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    journal_title:Cell discovery

    pub_type: 杂志文章


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  • Intronic cleavage and polyadenylation regulates gene expression during DNA damage response through U1 snRNA.

    abstract::The DNA damage response involves coordinated control of gene expression and DNA repair. Using deep sequencing, we found widespread changes of alternative cleavage and polyadenylation site usage on ultraviolet-treatment in mammalian cells. Alternative cleavage and polyadenylation regulation in the 3' untranslated regio...

    journal_title:Cell discovery

    pub_type: 杂志文章


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  • Increased dysbindin-1B isoform expression in schizophrenia and its propensity in aggresome formation.

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    pub_type: 杂志文章


    authors: Xu Y,Sun Y,Ye H,Zhu L,Liu J,Wu X,Wang L,He T,Shen Y,Wu JY,Xu Q

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  • TRPA1 channel mediates organophosphate-induced delayed neuropathy.

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  • Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro.

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  • Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling.

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    journal_title:Cell discovery

    pub_type: 杂志文章


    authors: Xia J,Wang R,Zhang T,Ding J

    更新日期:2016-09-13 00:00:00

  • Two approaches reveal a new paradigm of 'switchable or genetics-influenced allele-specific DNA methylation' with potential in human disease.

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    authors: Martos SN,Li T,Ramos RB,Lou D,Dai H,Xu JC,Gao G,Gao Y,Wang Q,An C,Zhang X,Jia Y,Dawson VL,Dawson TM,Ji H,Wang Z

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  • Light chain modulates heavy chain conformation to change protection profile of monoclonal antibodies against influenza A viruses.

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    authors: Pulito C,Mori F,Sacconi A,Goeman F,Ferraiuolo M,Pasanisi P,Campagnoli C,Berrino F,Fanciulli M,Ford RJ,Levrero M,Pediconi N,Ciuffreda L,Milella M,Steinberg GR,Cioce M,Muti P,Strano S,Blandino G

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    journal_title:Cell discovery

    pub_type: 杂志文章


    authors: Briens A,Bardou I,Lebas H,Miles LA,Parmer RJ,Vivien D,Docagne F

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Zhou Y,Hou Y,Shen J,Huang Y,Martin W,Cheng F

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    pub_type: 杂志文章


    authors: Yu X,Wang QL,Li YF,Wang XD,Xu A,Li Y

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    abstract::The prokaryotic CRISPR-Cas adaptive immune systems provide valuable resources to develop genome editing tools, such as CRISPR-Cas9 and CRISPR-Cas12a/Cpf1. Recently, CRISPR-Cas12b/C2c1, a distinct type V-B system, has been characterized as a dual-RNA-guided DNA endonuclease system. Though being active in vitro, its cle...

    journal_title:Cell discovery

    pub_type: 杂志文章


    authors: Teng F,Cui T,Feng G,Guo L,Xu K,Gao Q,Li T,Li J,Zhou Q,Li W

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    journal_title:Cell discovery

    pub_type: 杂志文章


    authors: Chu Q,Yao C,Qi X,Stripp BR,Tang N

    更新日期:2019-07-16 00:00:00

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    journal_title:Cell discovery

    pub_type: 杂志文章


    authors: Ahmed KA,Xiang J

    更新日期:2017-04-25 00:00:00

  • Malat1 regulates myogenic differentiation and muscle regeneration through modulating MyoD transcriptional activity.

    abstract::Malat1 is one of the most abundant long non-coding RNAs in various cell types; its exact cellular function is still a matter of intense investigation. In this study we characterized the function of Malat1 in skeletal muscle cells and muscle regeneration. Utilizing both in vitro and in vivo assays, we demonstrate that ...

    journal_title:Cell discovery

    pub_type: 杂志文章


    authors: Chen X,He L,Zhao Y,Li Y,Zhang S,Sun K,So K,Chen F,Zhou L,Lu L,Wang L,Zhu X,Bao X,Esteban MA,Nakagawa S,Prasanth KV,Wu Z,Sun H,Wang H

    更新日期:2017-03-14 00:00:00

  • Erratum: Author Correction: Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing.

    abstract::[This corrects the article DOI: 10.1038/s41421-020-0168-9.]. ...

    journal_title:Cell discovery

    pub_type: 杂志文章,已发布勘误


    authors: Wen W,Su W,Tang H,Le W,Zhang X,Zheng Y,Liu X,Xie L,Li J,Ye J,Dong L,Cui X,Miao Y,Wang D,Dong J,Xiao C,Chen W,Wang H

    更新日期:2020-06-20 00:00:00

  • ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells.

    abstract::Loss of organelle homeostasis is a hallmark of aging. However, it remains elusive how this occurs at gene expression level. Here, we report that human mesenchymal stem cell (hMSC) aging is associated with dysfunction of double-membrane organelles and downregulation of transcription factor ATF6. CRISPR/Cas9-mediated in...

    journal_title:Cell discovery

    pub_type: 杂志文章


    authors: Wang S,Hu B,Ding Z,Dang Y,Wu J,Li D,Liu X,Xiao B,Zhang W,Ren R,Lei J,Hu H,Chen C,Chan P,Li D,Qu J,Tang F,Liu GH

    更新日期:2018-01-05 00:00:00

  • A growth factor-free culture system underscores the coordination between Wnt and BMP signaling in Lgr5+ intestinal stem cell maintenance.

    abstract::Lgr5+ intestinal stem cells (ISCs) drive the fast renewal of intestinal epithelium. Several signaling pathways have been shown to regulate ISC fates. However, it is unclear what are the essential signals to sustain the ISC self-renewal. Here we show that coordination between Wnt and BMP signaling activity is necessary...

    journal_title:Cell discovery

    pub_type: 杂志文章


    authors: Li Y,Liu Y,Liu B,Wang J,Wei S,Qi Z,Wang S,Fu W,Chen YG

    更新日期:2018-09-04 00:00:00

  • DNA methylation reprogramming of functional elements during mammalian embryonic development.

    abstract::DNA methylation plays important roles during development. However, the DNA methylation reprogramming of functional elements has not been fully investigated during mammalian embryonic development. Herein, using our modified MethylC-Seq library generation method and published post-bisulphite adapter-tagging (PBAT) metho...

    journal_title:Cell discovery

    pub_type: 杂志文章


    authors: Li C,Fan Y,Li G,Xu X,Duan J,Li R,Kang X,Ma X,Chen X,Ke Y,Yan J,Lian Y,Liu P,Zhao Y,Zhao H,Chen Y,Yu Y,Liu J

    更新日期:2018-08-07 00:00:00

  • Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer's disease-related pathogenesis.

    abstract::Despite decades of intense global effort, no disease-modifying drugs for Alzheimer's disease have emerged. Molecules targeting catalytic activities of γ-secretase or β-site APP-cleaving enzyme 1 (BACE1) have been beset by undesired side effects. We hypothesized that blocking the interaction between BACE1 and γ-secreta...

    journal_title:Cell discovery

    pub_type: 杂志文章


    authors: Cui J,Wang X,Li X,Wang X,Zhang C,Li W,Zhang Y,Gu H,Xie X,Nan F,Zhao J,Pei G

    更新日期:2015-08-18 00:00:00

  • Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade.

    abstract::The use of antibodies to target immune checkpoints, particularly PD-1/PD-L1, has made a profound impact in the field of cancer immunotherapy. Here, we identified KN035, an anti-PD-L1 nanobody that can strongly induce T-cell responses and inhibit tumor growth. The crystal structures of KN035 complexed with PD-L1 and fr...

    journal_title:Cell discovery

    pub_type: 杂志文章


    authors: Zhang F,Wei H,Wang X,Bai Y,Wang P,Wu J,Jiang X,Wang Y,Cai H,Xu T,Zhou A

    更新日期:2017-03-07 00:00:00

  • Bloom syndrome complex promotes FANCM recruitment to stalled replication forks and facilitates both repair and traverse of DNA interstrand crosslinks.

    abstract::The recruitment of FANCM, a conserved DNA translocase and key component of several DNA repair protein complexes, to replication forks stalled by DNA interstrand crosslinks (ICLs) is a step upstream of the Fanconi anemia (FA) repair and replication traverse pathways of ICLs. However, detection of the FANCM recruitment ...

    journal_title:Cell discovery

    pub_type: 杂志文章


    authors: Ling C,Huang J,Yan Z,Li Y,Ohzeki M,Ishiai M,Xu D,Takata M,Seidman M,Wang W

    更新日期:2016-12-20 00:00:00

  • The metacaspase Yca1 maintains proteostasis through multiple interactions with the ubiquitin system.

    abstract::Metacaspase enzymes are critical regulatory factors that paradoxically engage apoptosis and also maintain cell viability. For example, the Saccharomyces cerevisiae metacaspase Yca1 has been shown to be important for maintaining cellular proteostasis during stress, and the loss of this enzyme results in increased reten...

    journal_title:Cell discovery

    pub_type: 杂志文章


    authors: Shrestha A,Brunette S,Stanford WL,Megeney LA

    更新日期:2019-01-22 00:00:00