Imiquimod-related dermatitis is mainly mediated by mast cell degranulation via Mas-related G-protein coupled receptor B2.

abstract：:The hepatoprotective effect of Gypsophila elegans isoorientin (GEI) was evaluated using a hepatic fibrosis model induced by CCl4 in rats. The results revealed that GEI significantly prevented CCl4-induced liver injury and fibrosis, as evidenced by the attenuation of histopathological changes, the decrease in serum ami...

journal_title：International immunopharmacology

authors： Lin X,Chen Y,Lv S,Tan S,Zhang S,Huang R,Zhuo L,Liang S,Lu Z,Huang Q

更新日期：2015-09-01 00:00:00

abstract：:Acute liver failure is characterized by the sudden loss of hepatic function and a high mortality. SKLB010, a derivative of thiazolidinediones, has been proved to be effective in protecting mice from acute liver failure caused by concanavalin A and carbon tetrachloride in our previous work. The purpose of the current s...

journal_title：International immunopharmacology

authors： Xie C,Jingjing W,Li X,Zeng F,Ma L,Li C,Wei Z,Peng A,Chen L

更新日期：2014-08-01 00:00:00

abstract：:Baicalein (5,6,7-trihydroxyflavone), isolated from the root of traditional Chinese herb Scutellaria baicalensis Georgi, has anti-inflammatory and anti-oxidative activities. This study explored the protective and modulatory mechanisms of baicalein on neuroinflammation, oxidative stress and metabolic abnormality in lipo...

journal_title：International immunopharmacology

authors： Yan JJ,Du GH,Qin XM,Gao L

更新日期：2020-02-01 00:00:00

abstract：:The anti-inflammatory effects of glycyrol, a benzofuran coumarin isolated from Glycyrrhizae Radix, were studied. Glycyrol of 5, 25 and 50 microM dose-dependently inhibited nitric oxide (NO) production by down-regulating inducible nitric oxide synthase (iNOS), and alleviated cyclooxygenase-2 (COX-2) expression in LPS-s...

journal_title：International immunopharmacology

authors： Shin EM,Zhou HY,Guo LY,Kim JA,Lee SH,Merfort I,Kang SS,Kim HS,Kim S,Kim YS

更新日期：2008-11-01 00:00:00

abstract：:The quaternary ammonium salt, sanguinarine (SG) was reported to possess widespread anti-microbial and anti-inflammatory effects in experimental animals and it has been used to treat many inflammatory diseases. The aim of this study was to evaluate the anti-inflammatory effect and the possible mechanisms underlying the...

journal_title：International immunopharmacology

authors： Li W,Li H,Mu Q,Zhang H,Yao H,Li J,Niu X

更新日期：2014-10-01 00:00:00

abstract：:Recombinant immunotoxins are chimeric proteins composed of a targeting peptide that binds to a specific tumor antigen and a toxin protein killing target cells. Recombinant immunotoxin exhibits potent cancer inhibiting effects both in vivo and in vitro. However, the non-specific toxicity causes severe syndromes limitin...

journal_title：International immunopharmacology

authors： Wang J,Han L,Chen J,Xie Y,Jiang H,Zhu J

更新日期：2019-01-01 00:00:00

abstract：:An expansion of regulatory T cells (Tregs) in ankylosing spondylitis (AS) was observed. However, AS patients continue to exhibit aberrant inflammation. In this study, we collected PBMCs from 26 AS patients and 26 healthy controls, and investigated the functional capacity of Treg cells from these subjects. In AS patien...

journal_title：International immunopharmacology

authors： Wang M,Liu C,Bond A,Yang J,Zhou X,Wang J,Ji B

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:There is no vaccine or specific antiviral treatment for HCoVs infection. The use of type I interferons for coronavirus is still under great debate in clinical practice. MATERIALS AND METHODS:A literature search of all relevant studies published on PubMed, Cochrane library, Web of Science database, Science D...

journal_title：International immunopharmacology

authors： Yu C,Kang L,Chen J,Zang N

更新日期：2020-09-01 00:00:00

abstract：UNLABELLED:Dendritic cells (DC) were implicated as the mediators of primary stimulation of the immune response against donor antigen. Anti-lymphocytes globulin (ALG) and anti-thymocytes globulin (ATG) antibodies have been widely used as an immunosuppressive agent in the treatment and prevention of rejection after organ...

journal_title：International immunopharmacology

authors： Monti P,Allavena P,Di Carlo V,Piemonti L

更新日期：2003-02-01 00:00:00

abstract：:High-mobility group protein 1 (HMGB1) has been identified as a late-acting mediator of inflammation. The receptor for advanced glycation end products (RAGE) is the main receptor and mediates the cytokine activity of HMGB1. Since HMGB1 also exhibits heparin-binding activity, we investigated whether heparin interferes w...

journal_title：International immunopharmacology

authors： Ling Y,Yang ZY,Yin T,Li L,Yuan WW,Wu HS,Wang CY

更新日期：2011-02-01 00:00:00

abstract：:B1 kinin receptor (B1R) is up-regulated by endotoxins and thus may represent a therapeutic target in sepsis. We investigated the expression and role of B1R and B2R in the acute phase of lipopolysaccharide (LPS)-induced endotoxin shock in C57BL/6 mice (WT) and B1R and B2R knock out mice (B1KO, B2KO). B1R mRNA was enhan...

journal_title：International immunopharmacology

authors： Seguin T,Buleon M,Destrube M,Ranera MT,Couture R,Girolami JP,Tack I

更新日期：2008-02-01 00:00:00

abstract：:In this study, we investigated the preventive effects of curcumin using dextran sulfate sodium (DSS)-induced colitis and the potential role of curcumin in regulation of anti-inflammation through S-nitrosylation. After curcumin treatment for 6days, the body weight and disease activity index of DSS-induced mice was alle...

journal_title：International immunopharmacology

authors： Kao NJ,Hu JY,Wu CS,Kong ZL

更新日期：2016-09-01 00:00:00

abstract：:Inflammation plays an important role in the process of atherosclerosis (AS). Inhibition of inflammation is an effective way to prevent AS. Imperatorin (IMP) is a kind of furan coumarin with various activities. In this study, the anti-inflammatory effect of IMP was explored in oxidized low-density lipoprotein (ox-LDL)-...

journal_title：International immunopharmacology

authors： Li W,Yu J,Xiao X,Zang L,Yang Y,Yu J,Huang Q,Niu X,Li W

更新日期：2021-01-01 00:00:00

abstract：:This study was aimed to introduce a novel algorithm for determining linear B- and T-cell epitopes from Crimean-Congo haemorrhagic fever virus (CCHFV) antigens. To this end, 387 approved B- and T-cell epitopes, as well as 331 non-epitope peptides from different serotypes of the virus were collected from IEDB database f...

journal_title：International immunopharmacology

authors： Nosrati M,Mohabatkar H,Behbahani M

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Inhaled corticosteroids (ICS) are generally used to treat patients with chronic obstructive pulmonary disease (COPD) who suffer from repeated exacerbations. Recently, it was reported that ICS treatment increased the risk of pneumonia in COPD patients. But it is controversial.The objective of this paper is to ...

journal_title：International immunopharmacology

authors： Yang M,Du Y,Chen H,Jiang D,Xu Z

更新日期：2019-12-01 00:00:00

abstract：:Dopamine (DA), an important neurotransmitter, has been reported to play a negative role in tumor progression. DA acts its role via dopamine receptors (DRs), which can be divided into five receptor subtypes (D1R-D5R). Among these receptor subtypes, D2R has been found to inhibit IGF-I-induced gastric cancer cell growth....

journal_title：International immunopharmacology

authors： Huang H,Wu K,Ma J,Du Y,Cao C,Nie Y

更新日期：2016-10-01 00:00:00

abstract：:In the present study, the anomalin was investigated to determine the protective effects and underlying mechanism against LPS-induced acute lung injury in mice. Anomalin administration 30 min after the LPS injection, significantly attenuated the mechanical allodynia, decrease body temperature, and improved the histolog...

journal_title：International immunopharmacology

authors： Khan A,Khan S,Ali H,Shah KU,Ali H,Shehzad O,Onder A,Kim YS

更新日期：2019-08-01 00:00:00

abstract：:The effects of TGF-β on dendritic cells (DCs) in the tumor microenvironment are not well-understood. In this study, we investigated the effect of TGF-β on the induction of programmed death ligand-1 (PD-L1) expression in DCs and the underlying mechanism, and we further investigated the influence of the DCs with PD-L1 e...

journal_title：International immunopharmacology

authors： Song S,Yuan P,Wu H,Chen J,Fu J,Li P,Lu J,Wei W

更新日期：2014-05-01 00:00:00

abstract：:Accumulating evidence indicates that microRNA-146a (miR-146a), a well-known anti-inflammatory miRNA, acts as a negative feedback regulator of the innate immune response, but its role in modulation of inflammatory bowel disease (IBD) remains unclear and the issue related to the stability of exogenous miR-146a in blood ...

journal_title：International immunopharmacology

authors： Wu H,Fan H,Shou Z,Xu M,Chen Q,Ai C,Dong Y,Liu Y,Nan Z,Wang Y,Yu T,Liu X

更新日期：2019-03-01 00:00:00

abstract：:Dihydrofisetin is a flavanonol derived from some edible wild herbs and traditional Chinese medicines. It has been found to possess many biological activities. However, the anti-inflammatory potential of Dihydrofisetin remains uncharacterized. The aim of the present study was to investigate the anti-inflammatory activi...

journal_title：International immunopharmacology

authors： Li KK,Shen SS,Deng X,Shiu HT,Siu WS,Leung PC,Ko CH,Cheng BH

更新日期：2018-01-01 00:00:00

abstract：:Acute lung injury (ALI) is one of the most serious complications in critically ill patients which often leads to morbidity and mortality. ALI characterized by severe inflammation of lungs occurs due to uncontrolled inflammatory immune response. However, the immunological mechanism(s) are far from being understood. The...

journal_title：International immunopharmacology

authors： Nadeem A,Ahmad SF,Al-Harbi NO,Al-Harbi MM,Ibrahim KE,Kundu S,Attia SM,Alanazi WA,AlSharari SD

更新日期：2019-03-01 00:00:00

abstract：:Senescence is an irreversible growth arrest which can be triggered by stresses such as oxidative reaction, telomere shortening, DNA damage, or oncogene signaling. Oxidative stress accelerates vascular endothelial cell senescence, and may promote atherosclerosis in humans. Interleukin-8 (IL-8) has been shown to play an...

journal_title：International immunopharmacology

authors： Shen XH,Xu SJ,Jin CY,Ding F,Zhou YC,Fu GS

更新日期：2013-06-01 00:00:00

abstract：:Endomorphin-1 is a recently isolated endogenous opioid peptide, and potent and selective high affinity mu-opioid receptor agonist. We evaluate the role of endomorphin-1 on macrophage functions. Endomorphin-1 potentiated macrophage adhesion and the expression of adhesion molecule Mac-1 on macrophages. However, endomorp...

journal_title：International immunopharmacology

authors： Inui Y,Azuma Y,Ohura K

更新日期：2002-07-01 00:00:00

abstract：:This work evaluated the in vitro influence of digitalis and furosemide on the phagocytic function of neutrophils of healthy individuals. Phagocytosis of Saccharomyces cerevisiae by peripheral blood neutrophils of 20 healthy individuals was assessed in the absence or presence of deslanoside or furosemide. The Wilcoxon ...

journal_title：International immunopharmacology

authors： Muniz-Junqueira MI,Mota LM,Aires RB,Junqueira LF Jr

更新日期：2003-10-01 00:00:00

abstract：:Myocardial fibrosis plays a central role in the development of heart failure. It has been shown that recurrent exposure to subclinical lipopolysaccharide (LPS) increases mortality and induces cardiac fibrosis in mice, which is not mediated by the common renin-angiotensin system. LPS increased NADPH oxidase2 (NOX2) in ...

journal_title：International immunopharmacology

authors： Huang L,Zhu J,Zheng M,Zou R,Zhou Y,Zhu M

更新日期：2018-07-01 00:00:00

abstract：:Visfatin plays an important role in inflammatory and metabolic conditions. In this study, the effects of septic stress on the serum, white-adipose-tissue (WAT), and liver visfatin levels of male and female rats were examined. Both gonadally intact (sham) and ovariectomized (OVX) female rats were used in order to evalu...

journal_title：International immunopharmacology

authors： Iwasa T,Matsuzaki T,Matsui S,Tungalagsuvd A,Munkhzaya M,Takiguchi E,Kawakita T,Kuwahara A,Yasui T,Irahara M

更新日期：2016-06-01 00:00:00

abstract：:Cyclosporine A (CsA) is the first immunosuppressant universally used in allotransplantation. However, it has been demonstrated that this drug produces side effects in several organs, particularly in the kidney and in the heart. Since the immunosuppressive therapy induces myocardial toxicity, the aim of this study was ...

journal_title：International immunopharmacology

authors： Bianchi R,Rodella L,Rezzani R

更新日期：2003-03-01 00:00:00

abstract：:Excessive activation of microglial cells has been implicated in various neurodegenerative diseases. Resveratrol, a polyphenolic compound found in grapes and wine, has been reported to reduce the activation of microglia. In the present study, 5-[2-(4-bromothiophen-2-yl)vinyl]benzene-1,3-diol (RV09), a novel resveratrol...

journal_title：International immunopharmacology

authors： Meng XL,Yang JY,Chen GL,Zhang LJ,Wang LH,Li J,Wang JM,Wu CF

更新日期：2008-08-01 00:00:00

abstract：:Deciphering the molecular mechanisms of amyloid pathology and glial cell-mediated neuroinflammation, offers a novel avenue for therapeutic intervention against neurodegeneration. Recent findings demonstrate a crucial link between activation of glycogen synthase kinase-3β (GSK-3β), amyloid deposition and a neuroinflamm...

journal_title：International immunopharmacology

authors： Sathiya Priya C,Vidhya R,Kalpana K,Anuradha CV

更新日期：2019-05-01 00:00:00

abstract：:Previous work has shown that morphine suppresses the pulmonary immune response to infection and reduces pulmonary inflammation. No published studies have addressed the impact of morphine on lymphocyte function in the lungs without infection. This study addressed this question by assessing the impact of acute morphine ...

journal_title：International immunopharmacology

authors： Coussons-Read ME,Giese S

更新日期：2001-08-01 00:00:00