Imiquimod-related dermatitis is mainly mediated by mast cell degranulation via Mas-related G-protein coupled receptor B2.

Abstract:

:While imiquimod (IMQ) has been widely used in dermatology, its side effect manifested as dermatitis couldn't be ignored. However, the underlying mechanism has not been fully understood. Considering the clinical features of IMQ-related dermatitis similar to pseudo-allergic reaction and the presence of large numbers of mast cell in tissues treated with IMQ, the possibility that IMQ-related dermatitis mediated by mast cell-specific Mas-related G protein-coupled receptor X2 (MRGPRX2) should be addressed. To investigate the role of MRGPRX2 in vivo, MrgprB2, the mice homology of human MRGPRX2, was detected in IMQ-induced dermatitis mouse model. Histopathological changes including mast cell degranulation and footpad swelling were assayed in wild-type and MrgprB2-/- mice. The results showed that IMQ application induced dermatitis and footpad swelling with inflammatory cells infiltration plus mast cell activation in the skin of wild-type mice but reduced significantly in MrgprB2-/- mice. Further, compared to wild-type mice, serum histamine and inflammatory cytokine levels were compromised in MrgprB2-/- mice treated with IMQ, while the serum IgE level didn't change significantly. In vitro studies, levels of mediators released from murine peritoneal mast cells (MPMCs) after IMQ treatment were increased in a dose-dependent manner, which were much mild in MPMCs from MrgprB2-/- mice. Intracellular Ca2+ concentration was increased in a dose dependent manner after IMQ treatment both in MrgprB2-HEK293 and MRGPRX2-HEK293 cells. Moreover, β-hexosaminidase released after IMQ treatment was blocked by siRNA directed at the MRGPRX2 receptor in LAD2 cells. In summary, MrgprB2 /MRGPRX2 mediate mast cell activation and participate in IMQ-related dermatitis.

journal_name

Int Immunopharmacol

authors

Hao Y,Peng B,Che D,Zheng Y,Kong S,Liu R,Shi J,Han H,Wang J,Cao J,Zhang Y,Gao J,He L,Geng S

doi

10.1016/j.intimp.2020.106258

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

106258

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(19)32219-2

journal_volume

81

pub_type

杂志文章
  • Synthesized peptides 705-734 from hepatitis C virus E2 glycoprotein induce dendritic cell maturation by activating p38 MAPK signaling.

    abstract::Hepatitis C virus (HCV) envelope E2 is a glycoprotein that are implicated in HCV infection by facilitating its entry and immune evasion, which in turn leads to hepatitis, hepatocellular carcinoma and other chronic liver diseases. It is reported that the HCV E2 stem region comprise a functional region for HCV entry; ho...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2015.11.009

    authors: Liu X,Chen N,Lin S,Liu M

    更新日期:2016-01-01 00:00:00

  • Anemoside B4 prevents acute ulcerative colitis through inhibiting of TLR4/NF-κB/MAPK signaling pathway.

    abstract::Anemoside B4 (B4) is a compound extracted from Pulsatilla chinensis(P. chinensis). Pharmacological studies have proved that it has certain anti-inflammatory activity. Acute ulcerative colitis (ulcerative colitis) is a non-specific inflammatory disease whose pathogenesis is not completely known, and there is no effecti...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106794

    authors: Ma H,Zhou M,Duan W,Chen L,Wang L,Liu P

    更新日期:2020-10-01 00:00:00

  • Evaluation of stem cell administration in a model of kidney ischemia-reperfusion injury.

    abstract::Ischemia-reperfusion injury is a common early event in kidney transplantation and contributes to a delay in organ function. Acute tubular necrosis, impaired kidney function and organ leukocyte infiltration are the major findings. The therapeutic potential of stem cells has been the focus of recent research as these ce...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2007.08.014

    authors: da Silva LB,Palma PV,Cury PM,Bueno V

    更新日期:2007-12-15 00:00:00

  • Efficacy of steroid and immunosuppressant combined therapy in Chinese patients with Henoch-Schönlein purpura nephritis: A retrospective study.

    abstract::Suitable and efficient treatments for Henoch-Schönlein purpura nephritis (HSPN) with proteinuria remains unclear. Whether steroids combined with immunosuppressive agents improves prognosis compared to steroid therapy alone also remains controversial. This study explored whether combined therapy reduces proteinuria in ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106229

    authors: Yu Y,Chen J,Yin H,Deng Z,Xie Y,Yuan Q,Xu H,Liu S,Tao L,Peng Z

    更新日期:2020-04-01 00:00:00

  • Identification of integrative molecular and clinical profiles of Fibrinogen-like protein 2 in gliomas using 1323 samples.

    abstract:BACKGROUND:Fibrinogen-like protein 2 (FGL2), a member of the fibrinogen superfamily, has been described to augment immunosuppression in gliomas. However, the precise clinical molecular features and the prognostic relevance of FGL2 in gliomas remain unclear. Therefore, a comprehensive analysis of the role of FGL2 in gli...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106894

    authors: Song Z,Wang Y,Du Y,Zhang Z,Yuan Y

    更新日期:2020-11-01 00:00:00

  • Isoliquiritigenin ameliorates dextran sulfate sodium-induced colitis through the inhibition of MAPK pathway.

    abstract::Isoliquiritigenin (isoLQ), a chalcone found in licorice, has shown a variety of biological activity including anti-inflammatory and antioxidative effects, and the distribution of isoLQ in gastrointestinal tract was higher than any other tissues. Thus, we evaluated whether or not isoLQ attenuated the dextran sulfate so...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2015.12.024

    authors: Choi YH,Bae JK,Chae HS,Choi YO,Nhoek P,Choi JS,Chin YW

    更新日期:2016-02-01 00:00:00

  • Neuroprotective effects of Astilbin on MPTP-induced Parkinson's disease mice: Glial reaction, α-synuclein expression and oxidative stress.

    abstract::Astilbin (AST), a dihydro-flavonol glycoside, is a major bioactive ingredient in Astilbe thunbergii, Engelhardia roxburghiana, Smilax corbularia and Erythroxylum gonocladum, and has been shown to have anti-inflammatory, antioxidative and neuroprotective effects, suggesting potential therapeutic value in the treatment ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2018.11.004

    authors: Zhu YL,Sun MF,Jia XB,Cheng K,Xu YD,Zhou ZL,Zhang PH,Qiao CM,Cui C,Chen X,Yang XS,Shen YQ

    更新日期:2019-01-01 00:00:00

  • Effects of propolis from different areas on mast cell degranulation and identification of the effective components in propolis.

    abstract::Propolis is considered to down-regulate type I allergy, but the effective components of propolis remain unknown. In addition, propolis components vary depending on the area from which they are collected due to variations among wild plants in an area. Therefore, we compared the effects of water and ethanol extracts of ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2010.06.013

    authors: Nakamura R,Nakamura R,Watanabe K,Oka K,Ohta S,Mishima S,Teshima R

    更新日期:2010-09-01 00:00:00

  • Protective effect of SKLB010 against D-galactosamine/lipopolysaccharide-induced acute liver failure via nuclear factor-κB signaling pathway in macrophages.

    abstract::Acute liver failure is characterized by the sudden loss of hepatic function and a high mortality. SKLB010, a derivative of thiazolidinediones, has been proved to be effective in protecting mice from acute liver failure caused by concanavalin A and carbon tetrachloride in our previous work. The purpose of the current s...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2014.05.012

    authors: Xie C,Jingjing W,Li X,Zeng F,Ma L,Li C,Wei Z,Peng A,Chen L

    更新日期:2014-08-01 00:00:00

  • Butyrate alleviates inflammatory response and NF-κB activation in human degenerated intervertebral disc tissues.

    abstract::Butyrate has multiple protective effects in inflammation-related intestinal diseases. Previous studies have found that butyrate could inhibit inflammation in rheumatoid arthritis. Inflammation is a pivotal inducement in the degeneration progress of the intervertebral disc. The anti-inflammatory treatment has an appare...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2019.106004

    authors: Jia J,Nie L,Liu Y

    更新日期:2020-01-01 00:00:00

  • Long non-coding RNA PVT1 promote LPS-induced septic acute kidney injury by regulating TNFα and JNK/NF-κB pathways in HK-2 cells.

    abstract::This study aimed to investigate the effect and underlying mechanism of long non-coding RNA plasmacytoma variant translocation 1 (PVT1) in lipopolysaccharide (LPS)-induced inflammation injury in HK-2 cells. We established LPS-induced septic acute kidney injury (AKI) model in HK-2 cells. LPS-induced HK-2 cells were tran...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2017.03.030

    authors: Huang W,Lan X,Li X,Wang D,Sun Y,Wang Q,Gao H,Yu K

    更新日期:2017-06-01 00:00:00

  • Oleanolic acid ameliorates dextran sodium sulfate-induced colitis in mice by restoring the balance of Th17/Treg cells and inhibiting NF-κB signaling pathway.

    abstract::In a preliminary experiment, it was found that oleanolic acid (OA), which is widely distributed in food and medicinal plants, inhibited interleukin (IL)-6/tumor growth factor beta-induced differentiation of splenic T cells into Th17 cells. Moreover, OA induced the differentiation of splenic T cells into Treg cells. Th...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2015.10.024

    authors: Kang GD,Lim S,Kim DH

    更新日期:2015-12-01 00:00:00

  • New thiazolidinedione LPSF/GQ-2 inhibits NFκB and MAPK activation in LPS-induced acute lung inflammation.

    abstract::Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are responsible for high mortality rates in critical patients. Despite >50 years of intensive research, there is no pharmacologically effective treatment to treat ALI. PPARs agonists, chemically named thiazolidinediones (TZDs) have emerged as poten...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2018.02.011

    authors: Santos LAMD,Rodrigues GB,Mota FVB,França MER,de Souza Barbosa KP,Oliveira WH,Rocha SWS,Lós DB,Silva AKS,Silva TGD,Peixoto CA

    更新日期:2018-04-01 00:00:00

  • Anandamide prior to sensitization increases cell-mediated immunity in mice.

    abstract::The endocannabinoid system has become a topic of great interest in pharmacology due to its remarkable distribution in mammal organisms and capacity to play a modulatory role on several physiological systems, including modulation of immunity. Many studies have shown that administration of cannabinoids causes inhibitory...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2009.12.017

    authors: Ribeiro A,Ferraz-de-Paula V,Pinheiro ML,Sakai M,Costa-Pinto FA,Palermo-Neto J

    更新日期:2010-04-01 00:00:00

  • Inhaled corticosteroids and risk of pneumonia in patients with chronic obstructive pulmonary disease: A meta-analysis of randomized controlled trials.

    abstract:OBJECTIVE:Inhaled corticosteroids (ICS) are generally used to treat patients with chronic obstructive pulmonary disease (COPD) who suffer from repeated exacerbations. Recently, it was reported that ICS treatment increased the risk of pneumonia in COPD patients. But it is controversial.The objective of this paper is to ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.intimp.2019.105950

    authors: Yang M,Du Y,Chen H,Jiang D,Xu Z

    更新日期:2019-12-01 00:00:00

  • Immunotherapeutic modulation of the suppressive liver and tumor microenvironments.

    abstract::The liver is an immunologically unique organ, consisting of resident hematopoietic and parenchymal cells which often contribute to a relatively tolerant microenvironment. It is also becoming increasingly clear that tumor-induced immunosuppression occurs via many of the same cellular mechanisms which contribute to the ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.intimp.2010.12.024

    authors: Chan T,Wiltrout RH,Weiss JM

    更新日期:2011-07-01 00:00:00

  • (E)-1-(4-ethoxyphenyl)-3-(4-nitrophenyl)-prop-2-en-1-one suppresses LPS-induced inflammatory response through inhibition of NF-κB signaling pathway.

    abstract::Flavonoids are a class of compounds that exist in nature with the structure of 2-phenyl-chromone. In Chinese traditional medicine, herbal drugs containing flavonoids are widely used for the treatment of inflammation, cardiovascular disease, tumor and so on. In this study, we investigated the anti-inflammatory effect a...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2013.02.024

    authors: Xu J,Jia YY,Chen SR,Ye JT,Bu XZ,Hu Y,Ma YZ,Guo JL,Liu PQ

    更新日期:2013-04-01 00:00:00

  • γδ T cells in infection and autoimmunity.

    abstract::Standing at the interface of innate and adaptive immune, γδ T cells play important pathophysiologic roles in infection, autoimmunity, and tumorigenesis. Recent studies indicate that γδ T cells could be categorized into IFN-γ(+) and IL-17(+) subsets, both of which possess select TCR usages, bear unique surface markers ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.intimp.2015.03.038

    authors: Hou L,Wang T,Sun J

    更新日期:2015-10-01 00:00:00

  • The fungal metabolite, citrinin, inhibits lipopolysaccharide/interferon-γ-induced nitric oxide production in glomerular mesangial cells.

    abstract::The mycotoxin, citrinin (CTN), is a secondary metabolite of the fermented products of Monascus. The mycotoxin can either suppress or stimulate immune responses. In the present study, the immunomodulatory role of CTN in nitric oxide (NO) production, a proinflammatory mediator in the process of inflammation, was investi...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2010.09.017

    authors: Liu BH,Chi JY,Hsiao YW,Tsai KD,Lee YJ,Lin CC,Hsu SC,Yang SM,Lin TH

    更新日期:2010-12-01 00:00:00

  • Icariin attenuates glucocorticoid insensitivity mediated by repeated psychosocial stress on an ovalbumin-induced murine model of asthma.

    abstract::Evidence shows that psychosocial stress exacerbates asthma, but there is little intervention to alleviate negative effects of psychosocial stress on asthma. We investigated the role of icariin in anti-inflammation and anti-anxiety potential in a murine model combined psychosocial stress with allergic exposure. The res...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2014.01.009

    authors: Li B,Duan X,Xu C,Wu J,Liu B,Du Y,Luo Q,Jin H,Gong W,Dong J

    更新日期:2014-04-01 00:00:00

  • Effect of elevated carbon dioxide on bronchial epithelial innate immune receptor response to organic dust from swine confinement barns.

    abstract::Hypercapnia is known to have immunoregulatory effects within the lung. Cell culture systems demonstrate this in both macrophages and alveolar cell lines, suggesting that the alveoli are affected by changes in CO2 levels. We hypothesized that hypercapnia would also modulate human bronchial epithelial cell immune respon...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2015.04.031

    authors: Schneberger D,Cloonan D,DeVasure JM,Bailey KL,Romberger DJ,Wyatt TA

    更新日期:2015-07-01 00:00:00

  • The therapeutic potential of resveratrol in a mouse model of melanoma lung metastasis.

    abstract::Resveratrol is an anticancer phytochemical polyphenol isolated from a natural origin, without any significant side effects. Resveratrol was investigated in immunocompetent mice with regards to its possible effect on lung cancer metastasis. Cytotoxicity was assessed in three melanoma cell lines (B16F10, B6, and A375) b...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106905

    authors: Davoodvandi A,Darvish M,Borran S,Nejati M,Mazaheri S,Reza Tamtaji O,Hamblin MR,Masoudian N,Mirzaei H

    更新日期:2020-11-01 00:00:00

  • The role of prostaglandin E2 receptor signaling of dendritic cells in rheumatoid arthritis.

    abstract::Prostaglandin E2 (PGE2), a very potent lipid mediator produced from arachidonic acid (AA) through the action of cyclooxygenase (COX) enzymes, is implicated in the regulation of dendritic cell (DC) functions such as differentiation ability, cytokine-producing capacity, Th-cell polarizing ability, migration and maturati...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.intimp.2014.08.024

    authors: Jia XY,Chang Y,Sun XJ,Dai X,Wei W

    更新日期:2014-11-01 00:00:00

  • Comprehensive analysis of elastase-induced pulmonary emphysema in mice: effects of ambient existing particulate matters.

    abstract::Pulmonary exposure of rodents to porcine pancreatic elastase (PPE) induces lesions that morphologically resemble human panacinar emphysema. However, there has been little work on the comprehensive analysis of this model. The present study was designed to extensively examine the biological effects of PPE on inflammatio...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2010.07.016

    authors: Inoue K,Koike E,Takano H

    更新日期:2010-11-01 00:00:00

  • Attenuation of pristimerin on TNF-α-induced endothelial inflammation.

    abstract:OBJECTIVE:Pristimerin is known to have anti-cancer and anti-inflammatory activities; however, its therapeutic mechanism has not been described. In this study, to investigate the therapeutic mechanism of pristimerin, we examined the effect of pristimerin on TNF-α-induced endothelial inflammatory response both in vitro a...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106326

    authors: Liang J,Yuan S,Wang X,Lei Y,Zhang X,Huang M,Ouyang H

    更新日期:2020-03-02 00:00:00

  • Human bone mesenchymal stem cells-derived exosomes overexpressing microRNA-26a-5p alleviate osteoarthritis via down-regulation of PTGS2.

    abstract::Osteoarthritis (OA) is a degenerative disease characterized by synovium inflammation and articular cartilage damage. The aberrant expression profile of microRNAs (miRNAs) has been implicated in the cartilage of patients with OA. However, how microRNAs carried by exosomes derived from mesenchymal stem cells (MSCs) asso...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2019.105946

    authors: Jin Z,Ren J,Qi S

    更新日期:2020-01-01 00:00:00

  • A specific prebiotic oligosaccharide mixture stimulates delayed-type hypersensitivity in a murine influenza vaccination model.

    abstract::Analogous to reported immunomodulatory effects of probiotics, this study was performed to analyse the immunomodulatory properties of prebiotic oligosaccharides that share chemical characteristics with human milk oligosaccharides. A mixture containing galacto- and fructo-oligosaccharides (GOS/FOS; ratio 9:1) was tested...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2006.03.010

    authors: Vos AP,Haarman M,Buco A,Govers M,Knol J,Garssen J,Stahl B,Boehm G,M'Rabet L

    更新日期:2006-08-01 00:00:00

  • Swertiamarin, a natural steroid, prevent bone erosion by modulating RANKL/RANK/OPG signaling.

    abstract::Bone erosion is a central feature of rheumatoid arthritis (RA) that is characterized by the infiltration of the synovial lining by osteoclasts and lymphocytes. In the present study, swertiamarin a major secoiridoid glycoside was evaluated for anti-osteoclastogenic property to prevent bone erosion in Freund's complete ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2017.10.022

    authors: Hairul-Islam MI,Saravanan S,Thirugnanasambantham K,Chellappandian M,Simon Durai Raj C,Karikalan K,Gabriel Paulraj M,Ignacimuthu S

    更新日期:2017-12-01 00:00:00

  • Impaired function of hepatic natural killer cells from murine chronic HBsAg carriers.

    abstract::In the present study, we demonstrated hepatic NK cells in murine chronic HBsAg carriers for the first time. It was found that the number of hepatic NK cells was decreased; natural activation of hepatic NK cells was declined; and cytotoxicity of hepatic NK cells was attenuated, which might relate to the down-regulated ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2005.06.004

    authors: Chen Y,Wei H,Sun R,Tian Z

    更新日期:2005-12-01 00:00:00

  • Adoptive immunotherapy for non-small cell lung cancer by NK and cytotoxic T lymphocytes mixed effector cells: retrospective clinical observation.

    abstract::The objective of the current study was to retrospectively investigate the efficacy of adaptive transfer of natural killer (NK) and cytotoxic T lymphocytes mixed effector (NKTm) cells in non-small cell lung cancer (NSCLC) patients in comparison to a control group of NSCLC patients. NKTm cells were obtained by ex vivo e...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2014.04.026

    authors: Zhang G,Zhao H,Wu J,Li J,Xiang Y,Wang G,Wu L,Jiao S

    更新日期:2014-08-01 00:00:00