Molecular underpinnings of cytoskeletal cross-talk.

abstract：:Canonical Wnt signaling plays an important role in development and disease, regulating transcription of target genes and stabilizing many proteins phosphorylated by glycogen synthase kinase 3 (GSK3). We observed that the MiT family of transcription factors, which includes the melanoma oncogene MITF (micropthalmia-asso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ploper D,Taelman VF,Robert L,Perez BS,Titz B,Chen HW,Graeber TG,von Euw E,Ribas A,De Robertis EM

更新日期：2015-02-03 00:00:00

abstract：:Helicobacter pylori VacA, a pore-forming toxin secreted by an autotransporter pathway, causes multiple alterations in human cells, contributes to the pathogenesis of peptic ulcer disease and gastric cancer, and is a candidate antigen for inclusion in an H. pylori vaccine. Here, we present a 2.4-A crystal structure of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gangwer KA,Mushrush DJ,Stauff DL,Spiller B,McClain MS,Cover TL,Lacy DB

更新日期：2007-10-09 00:00:00

abstract：:In mammalian brains, multielectrode recordings during sensory stimulation have revealed oscillations in different cortical areas that are transiently synchronous. These synchronizations have been hypothesized to support integration of sensory information or represent the operation of attentional mechanisms, but their ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prechtl JC

更新日期：1994-12-20 00:00:00

abstract：:Some tumor cell lines secrete high concentrations of TGFbeta or IL-1. Similarly high concentrations of each of these cytokines cross-activate the other pathway: TGFbeta activates NFkappaB, and IL-1beta activates Smads. The IL-1 signaling components IRAK, MyD88, TRAF6, and TAK1 are all required for cross-activation of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu T,Tian L,Han Y,Vogelbaum M,Stark GR

更新日期：2007-03-13 00:00:00

abstract：:Integral feedback control is a basic engineering strategy for ensuring that the output of a system robustly tracks its desired value independent of noise or variations in system parameters. In biological systems, it is common for the response to an extracellular stimulus to return to its prestimulus value even in the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yi TM,Huang Y,Simon MI,Doyle J

更新日期：2000-04-25 00:00:00

abstract：:Activator protein-1 (AP-1) is a crucial transcription factor implicated in numerous cancers. For this reason, nine homologues of the AP-1 leucine zipper region have been characterized: Fos (c-Fos, FosB, Fra1, and Fra2), Jun (c-Jun, JunB, and JunD), and semirational library-designed winning peptides FosW and JunW. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mason JM,Schmitz MA,Müller KM,Arndt KM

更新日期：2006-06-13 00:00:00

abstract：:It has recently been recognized that human serum contains a protein that specifically binds human growth hormone (hGH). This protein has the same restricted specificity for hGH as the membrane-bound GH receptor. To determine whether the GH-binding protein is a derivative of, or otherwise related to, the GH receptor, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daughaday WH,Trivedi B

更新日期：1987-07-01 00:00:00

abstract：:Cardiomyopathy (CM) is a primary degenerative disease of myocardium and is traditionally categorized into hypertrophic and dilated CMs (HCM and DCM) according to its gross appearance. Cardiomyopathic hamster (CM hamster), a representative model of human hereditary CM, has HCM and DCM inbred sublines, both of which des...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sakamoto A,Ono K,Abe M,Jasmin G,Eki T,Murakami Y,Masaki T,Toyo-oka T,Hanaoka F

更新日期：1997-12-09 00:00:00

abstract：:The hypothetical scanning (HS) method is a general approach for calculating the absolute entropy and free energy by analyzing Boltzmann samples obtained by Monte Carlo (MC) or molecular dynamics techniques. With HS applied to a fluid, each configuration i of the sample is reconstructed by adding its atoms gradually to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： White RP,Meirovitch H

更新日期：2004-06-22 00:00:00

abstract：:Droplet manipulation is playing an important role in various fields, including scientific research, industrial production, and daily life. Here, inspired by the microstructures and functions of Namib desert beetles, Nepenthes pitcher plants, and emergent aquatic plants, we present a multibioinspired slippery surface f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang X,Sun L,Wang Y,Bian F,Wang Y,Zhao Y

更新日期：2019-10-15 00:00:00

abstract：:In early brain development, ascending thalamocortical axons (TCAs) navigate through the ventral telencephalon (VTel) to reach their target regions in the young cerebral cortex. Descending, deep-layer cortical axons subsequently target appropriate thalamic and subcortical target regions. However, precisely how and when...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robichaux MA,Chenaux G,Ho HY,Soskis MJ,Dravis C,Kwan KY,Šestan N,Greenberg ME,Henkemeyer M,Cowan CW

更新日期：2014-02-11 00:00:00

abstract：:A revelation of the genomic age has been the contributions of the mobile DNA segments called transposable elements to chromosome structure, function, and evolution in virtually all organisms. Substantial fractions of vertebrate genomes derive from transposable elements, being dominated by retroelements that move via R...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitra R,Li X,Kapusta A,Mayhew D,Mitra RD,Feschotte C,Craig NL

更新日期：2013-01-02 00:00:00

abstract：:Renal excretion of water and major electrolytes exhibits a significant circadian rhythm. This functional periodicity is believed to result, at least in part, from circadian changes in secretion/reabsorption capacities of the distal nephron and collecting ducts. Here, we studied the molecular mechanisms underlying circ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zuber AM,Centeno G,Pradervand S,Nikolaeva S,Maquelin L,Cardinaux L,Bonny O,Firsov D

更新日期：2009-09-22 00:00:00

abstract：:The class II transactivator (CIITA) is the master integrator of expression of MHC class II genes. It interacts with variety of basal transcription factors to initiate and elongate transcription of these genes. Among others, it recruits positive transcription elongation factor b (P-TEFb) to MHC class II promoters. In c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kohoutek J,Blazek D,Peterlin BM

更新日期：2006-11-14 00:00:00

abstract：:To identify the binding domain for dihydropyridine Ca2+ antagonists, skeletal muscle Ca2+ channels were photolabeled with [3H](+)-PN200-110 and [3H]azidopine. Regions of alpha 1 photolabeled by these ligands were then identified by antibody mapping of proteolytic fragments. Approximately 50% of the specific labeling b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Striessnig J,Murphy BJ,Catterall WA

更新日期：1991-12-01 00:00:00

abstract：:The three lipin phosphatidate phosphatase (PAP) enzymes catalyze a step in glycerolipid biosynthesis, the conversion of phosphatidate to diacylglycerol. Lipin-1 is critical for lipid synthesis and homeostasis in adipose tissue, liver, muscle, and peripheral nerves. Little is known about the physiological role of lipin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dwyer JR,Donkor J,Zhang P,Csaki LS,Vergnes L,Lee JM,Dewald J,Brindley DN,Atti E,Tetradis S,Yoshinaga Y,De Jong PJ,Fong LG,Young SG,Reue K

更新日期：2012-09-11 00:00:00

abstract：:This is a multinanosecond molecular dynamics study of a bio-nano complex formed by a carbon nanoparticle, a buckyball C(60), and a biological molecule, an antibody, with high binding affinity and specificity. In the simulation, the ball is completely desolvated by the binding site of the antibody by means of a nearly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Noon WH,Kong Y,Ma J

更新日期：2002-04-30 00:00:00

abstract：:Pseudoxanthoma elasticum (PXE) is an autosomal recessive disease characterized by progressive ectopic mineralization of the skin, eyes, and arteries, for which no effective treatment exists. PXE is caused by inactivating mutations in the gene encoding ATP-binding cassette sub-family C member 6 (ABCC6), an ATP-dependen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jansen RS,Küçükosmanoglu A,de Haas M,Sapthu S,Otero JA,Hegman IE,Bergen AA,Gorgels TG,Borst P,van de Wetering K

更新日期：2013-12-10 00:00:00

abstract：:T cell activation and tolerance are regulated by costimulatory molecules. Although PD-1 serves as a crucial negative regulator of T cells, the function of its ligands, PDL1 and PDL2, is still controversial. In this study, we created a PDL2-deficient mouse to characterize its function in T cell activation and tolerance...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Chung Y,Bishop C,Daugherty B,Chute H,Holst P,Kurahara C,Lott F,Sun N,Welcher AA,Dong C

更新日期：2006-08-01 00:00:00

abstract：:Ca(2+)-sensitive kinases are thought to play a role in long-term potentiation (LTP). To test the involvement of Ca2+/calmodulin-dependent kinase II (CaM-K II), truncated, constitutively active form of this kinase was directly injected into CA1 hippocampal pyramidal cells. Inclusion of CaM-K II in the recording pipette...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lledo PM,Hjelmstad GO,Mukherji S,Soderling TR,Malenka RC,Nicoll RA

更新日期：1995-11-21 00:00:00

abstract：:Monoamines, including dopamine (DA), have been linked to aggression in various species. However, the precise role or roles served by the amine in aggression have been difficult to define because dopaminergic systems influence many behaviors, and all can be altered by changing the function of dopaminergic neurons. In t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alekseyenko OV,Chan YB,Li R,Kravitz EA

更新日期：2013-04-09 00:00:00

abstract：:The role played by postsynaptic alpha-adrenergic receptors in the stimulation of pineal N-acetyltransferase (EC 2.3.1.5) and [3H]melatonin production was investigated in the rat. In vivo studies indicated that phenylephrine, an alpha-adrenergic agonist, potentiated and prolonged the effects of isoproterenol, a beta-ad...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klein DC,Sugden D,Weller JL

更新日期：1983-01-01 00:00:00

abstract：:Regulated exocytosis requires tight coupling of the membrane fusion machinery to a triggering signal and a fast response time. Complexins are part of this regulation and, together with synaptotagmins, control calcium-dependent exocytosis. Stimulatory and inhibitory functions have been reported for complexins. To test ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malsam J,Seiler F,Schollmeier Y,Rusu P,Krause JM,Söllner TH

更新日期：2009-02-10 00:00:00

abstract：:Insulin provides a classical model of a globular protein, yet how the hormone changes conformation to engage its receptor has long been enigmatic. Interest has focused on the C-terminal B-chain segment, critical for protective self-assembly in β cells and receptor binding at target tissues. Insight may be obtained fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Menting JG,Yang Y,Chan SJ,Phillips NB,Smith BJ,Whittaker J,Wickramasinghe NP,Whittaker LJ,Pandyarajan V,Wan ZL,Yadav SP,Carroll JM,Strokes N,Roberts CT Jr,Ismail-Beigi F,Milewski W,Steiner DF,Chauhan VS,Ward CW,Weis

更新日期：2014-08-19 00:00:00

abstract：:We compared private and social decision making to investigate the neural underpinnings of the effect of social comparison on risky choices. We measured brain activity using functional MRI while participants chose between two lotteries: in the private condition, they observed the outcome of the unchosen lottery, and in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bault N,Joffily M,Rustichini A,Coricelli G

更新日期：2011-09-20 00:00:00

abstract：:Recent observations suggest that p53 mutations are responsible not only for growth of primary tumors but also for their dissemination. However, mechanisms involved in p53-mediated control of cell motility and invasion remain poorly understood. By using the primary ovarian surface epithelium cell culture, we show that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang CI,Matoso A,Corney DC,Flesken-Nikitin A,Körner S,Wang W,Boccaccio C,Thorgeirsson SS,Comoglio PM,Hermeking H,Nikitin AY

更新日期：2011-08-23 00:00:00

abstract：:Human capabilities in manipulating many different tools with dexterity suggest modular neural organization at functional levels, but anatomical modularity underlying the capabilities has yet to be demonstrated. Although modularity in phylogenetically older parts of the cerebellum is well known, comparable modularity i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Imamizu H,Kuroda T,Miyauchi S,Yoshioka T,Kawato M

更新日期：2003-04-29 00:00:00

abstract：:The human papillomavirus E7 protein is phosphorylated at the two serines in positions 31/32, which are part of a consensus sequence for casein kinase II (CKII). In this study, we have investigated the effect of CKII phosphorylation site mutations, all of which lead to unphosphorylated E7 proteins. The replacement of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Firzlaff JM,Lüscher B,Eisenman RN

更新日期：1991-06-15 00:00:00

abstract：:We studied regional cerebral blood flow using the H2(15)O method while normal subjects performed four similar tasks involving three-letter word beginnings (stems). Prior to each task, subjects studied a list of words. Local blood flow was then monitored during a 40-sec period while subjects (i) silently viewed word st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Squire LR,Ojemann JG,Miezin FM,Petersen SE,Videen TO,Raichle ME

更新日期：1992-03-01 00:00:00

abstract：:Polyaromatic hydrocarbons are ubiquitous environmental chemicals that are important mutagens and carcinogens. The purpose of this study was to determine whether genes within the major histocompatibility complex (MHC) influence their biological activities. Cell-mediated immunity to dimethylbenz(a)anthracene (DMBA) was ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elmets CA,Athar M,Tubesing KA,Rothaupt D,Xu H,Mukhtar H

更新日期：1998-12-08 00:00:00