Telomere length in leukocytes and cervical smears of women with high-risk human papillomavirus (HR HPV) infection.


OBJECTIVE:Persistent high-risk HPV (HR HPV) infection leads to the development of squamous intraepithelial lesions, which in turn may progress to cervical cancer. Telomere elongation or shortening may indicate a carcinogenesis process. In the present study, we analyzed telomere length from blood and cervical smears of women without and with high-risk HPV infection. MATERIALS AND METHODS:Telomere length was quantified by real-time PCR in blood and cervical smears from 48 women with high-risk HPV infection and HGSIL or LGSIL, 29 women HR-HPV positive without SIL, and 11 HPV-negative women. RESULTS:No correlation was found between age and telomere length in blood and cervical smears. Women with high-risk HPV infection had shorter telomeres in cervical smears, but not in blood compared to the control group. CONCLUSION:These findings suggest that telomere shortening occurs in cervical cells of women with HR HPV infection both with LGSIL and HGSIL and may indicate the onset of carcinogenesis. In turn, there is no correlation between leukocyte telomere length and cervical cancer risk in women with HR HPV infection.


Pańczyszyn A,Boniewska-Bernacka E,Głąb G




Has Abstract


2020-01-01 00:00:00














  • Human papillomavirus and vaccination in cervical cancer.

    abstract::Cervical cancer is not only the most frequently reported cancer among women, but also the most common female genital tract neoplasm in Taiwan. Early detection is effective, because the development, maintenance and progression of precursor lesions (cervical intraepithelial neoplasia [CIN]) evolve slowly into invasive c...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章,评审


    authors: Wang KL

    更新日期:2007-12-01 00:00:00

  • Non-classical estrogen receptors action on human dermal fibroblasts.

    abstract:OBJECTIVE:To study the possible non-genomic effect of selective estrogen receptor modulators on human dermal fibroblasts (HDF). MATERIALS AND METHODS:WS1 cells were used to test the effect of raloxifene. The mRNA expressions of estrogen receptor (ER) α and β and G protein-coupled ER 1(GRP30) were examined by reverse t...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Tsui KH,Wang PH,Chen CK,Chen YJ,Chiou SH,Sung YJ,Li HY

    更新日期:2011-12-01 00:00:00

  • Gene set-based analysis of mucinous ovarian carcinoma.

    abstract:OBJECTIVE:Mucinous ovarian carcinoma (MOC) is an uncommon subtype of epithelial ovarian cancers, and the pathogenesis is still poorly understood because of its rarity. We conducted a gene set-based analysis to investigate the pathogenesis of MOC by integrating microarray gene expression datasets based on the regularity...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Chang CM,Wang PH,Horng HC

    更新日期:2017-04-01 00:00:00

  • Prenatal diagnosis of a case with SEA-HPFH deletion thalassemia with whole HBB gene deletion.

    abstract:OBJECTIVE:The thalassemias is a group of hereditary disorders with impaired production of functional hemoglobin. In this report we described a rare case of compound heterozygous mutation of South-East Asia type hereditary persistence of fetal hemoglobin (SEA-HPFH) and β -thalassemia that allowed prenatal diagnosis to b...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Ly Thi Thanh H,Le Thi Thanh H,Hoang Luong L,Huy Tran T,Liu SC,Truong HN,Ta TV,Bui TH,Tran VK

    更新日期:2018-06-01 00:00:00

  • Prevalence of nocturia in Taiwanese women aged 20-59 years.

    abstract:OBJECTIVE:To estimate the prevalence of nocturia in Taiwanese women aged 20-59 years. MATERIALS AND METHODS:A random sample of 4,549 women within the age range was selected by a multistage sampling design. Face-to-face visits with 3,537 women were completed by well-trained professional interviewers. Nocturia, accordin...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Hsieh CH,Chen HY,Hsu CS,Chang ST,Chiang CD

    更新日期:2007-03-01 00:00:00

  • Comparison of the offspring sex ratio between cleavage stage embryo transfer and blastocyst transfer.

    abstract:OBJECTIVE:To compare the sex ratio of offspring born after cleavage stage embryo transfer and blastocyst transfer. MATERIALS AND METHODS:In this retrospective study of embryo transfer (ET), we included 473 offspring from 446 deliveries during the period January 2002 to December 2007. Statistical analysis was performed...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Lin PY,Huang FJ,Kung FT,Wang LJ,Chang SY,Lan KC

    更新日期:2010-03-01 00:00:00

  • The effects of resveratrol on ovarian hyperstimulation syndrome in a rat model.

    abstract:OBJECTIVE:The aim of the present study was to investigate effects of resveratrol (RSV) over ovarian hyperstimulation syndrome (OHSS) in rat model. MATERIALS AND METHODS:24 female Wistar rats (22 days old) were divided into four groups. Group 1 (control group; n = 6) received 0.1 ml intraperitoneal (IP) saline from day...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Ozgur S,Oktem M,Altinkaya SO,Oktem EO,Cenksoy C,Erdem O,Elbeg S,Helvaci A,Erdem A,Erdem M

    更新日期:2018-06-01 00:00:00

  • Small cell neuroendocrine carcinoma of the endometrium: a clinicopathologic study of six cases.

    abstract:OBJECTIVES:Primary small cell carcinoma of the endometrium is a rare disease that can only be diagnosed at an advanced stage, and thus has a poor prognosis. In this study, the clinicopathologic characteristics of endometrial small cell carcinoma are described and the survival outcomes are discussed. MATERIALS AND METH...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Koo YJ,Kim DY,Kim KR,Kim JH,Kim YM,Kim YT,Nam JH

    更新日期:2014-09-01 00:00:00

  • Frequency of postnatal hydronephrosis in infants with a renal anterior-posterior pelvic diameter > 4 mm on midtrimester ultrasound.

    abstract:OBJECTIVE:To examine the association of antenatal renal pelvic dilatation observed on midtrimester ultrasound screening with the presence of hydronephrosis in newborn infants. MATERIALS AND METHODS:The records of patients who received fetal ultrasound examination at 18-28 weeks' gestation from May 2008 to March 2012 w...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Chou CY,Chen LC,Cheong ML,Tsai MS

    更新日期:2015-10-01 00:00:00

  • Microarray analysis of gene expression of cancer to guide the use of chemotherapeutics.

    abstract::The beauty of microarray analysis of gene expression (MAGE) is that it can be used to discover some genes that were previously thought to be unrelated to a physiologic or pathologic event. During the period from 1999 to 2007, applications of MAGE in cancer investigation have shifted from molecular profiling, identifyi...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章,评审


    authors: Wang TH,Chao A

    更新日期:2007-09-01 00:00:00

  • Pathogens in maternal blood and fetal cord blood using Q-PCR assay.

    abstract:OBJECTIVE:To evaluate the rates of infection of asymptomatic fetuses and mothers through fetal cord blood and maternal blood examination results. MATERIALS AND METHODS:Quantitative PCR (Q-PCR) was used to detect pathogens in maternal peripheral blood and fetal cord blood after delivery of term pregnancy at Buddhist Tz...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Hou GQ,Chen SS,Lee CP

    更新日期:2006-06-01 00:00:00

  • Meta-analysis on the use of hyaluronic acid gel to prevent recurrence of intrauterine adhesion after hysteroscopic adhesiolysis.

    abstract::Intrauterine adhesion is a severe complication after intrauterine operation, Various adjuvant therapies failed to improve clinical symptoms and pregnancy rates among patients with moderate-to-severe intrauterine adhesion. At present, hyaluronic acid gel is widely used in the primary prevention of adhesion after hyster...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章,meta分析,评审


    authors: Fei Z,Bin Z,Xin X,Fei H,Yuechong C

    更新日期:2019-11-01 00:00:00

  • A comparative study of laparoscopic sacrocolpopexy and total vaginal mesh procedure using lightweight polypropylene meshes for prolapse repair.

    abstract:OBJECTIVE:Use of vaginal meshes for treatment of pelvic organ prolapse (POP) remains controversial. A trend toward abdominal approaches and the development of new meshes has been noted. We compared the 1-year results of two different approaches using new lightweight meshes. MATERIALS AND METHODS:Sixty-nine (95.8%) of ...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 临床试验,杂志文章


    authors: Liu CK,Tsai CP,Chou MM,Shen PS,Chen GD,Hung YC,Hung MJ

    更新日期:2014-12-01 00:00:00

  • Preliminary preventive protocol from first trimester of pregnancy to reduce preterm birth rate for dichorionic-diamniotic twins.

    abstract:OBJECTIVE:The preterm birth rate of twins is reportedly higher than that of single pregnancies. We performed preliminary preventive interventions at our center focused on evaluating the risk of each case before 14 weeks of gestation to reduce the spontaneous preterm birth rate. MATERIALS AND METHODS:The participants i...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Matsui M,Takahashi Y,Iwagaki S,Chiaki R,Asai K,Kawabata I

    更新日期:2017-02-01 00:00:00

  • Prenatal diagnosis and perinatal management of maternal-fetal congenital parvovirus B19 infection.

    abstract:OBJECTIVE:In nonimmune pregnant woman, the primary infection with parvovirus B19 may lead to transplacental transmission to the fetus with variable outcomes, including congenital anemia, hydrops fetalis, fetal death or spontaneous resolution. CASE REPORT:The first case was of a 28-year-old woman, gravida 2, para 1, wh...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Hsu ST,Chen YT,Huang YF,Yeh TT,Chen WC,Ho ES,Chou MM

    更新日期:2007-12-01 00:00:00

  • Alobar holoprosencephaly, cebocephaly, and micropenis in a Klinefelter fetus of a diabetic mother.

    abstract:OBJECTIVE:Coexistence of Klinefelter syndrome and holoprosencephaly (HPE) is rare. We report alobar HPE, cebocephaly, and micropenis in a Klinefelter fetus of a mother with type 2 diabetes mellitus with obesity and poor metabolic control. CASE REPORT:A 38-year-old woman was referred for therapy of type 2 diabetes mell...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Chen CP,Su TH,Chern SR,Su JW,Lee CC,Wang W

    更新日期:2012-12-01 00:00:00

  • Establishment of human-embryonic-stem-cell line from mosaic trisomy 9 embryo.

    abstract:OBJECTIVE:Human-embryonic-stem-cell (hESC) lines derived from chromosomally or genetically abnormal embryos obtained following preimplantation genetic diagnosis are valuable in investigating genetic disorders. MATERIALS AND METHODS:In this study, a new hESC line, Center of Clinical Reproductive Medicine 8 (CCRM8) was ...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Huang B,Jiang C,Chen A,Cui Y,Xie J,Shen J,Chen J,Cai L,Liao T,Ning S,Jiang SW,Fan G,Qin L,Liu J

    更新日期:2015-10-01 00:00:00

  • Operative hysteroscopy intravascular absorption syndrome is more than just the gynecological transurethral resection of the prostate syndrome: A case series and literature review.

    abstract:OBJECTIVE:Operative hysteroscopy intravascular absorption (OHIA) syndrome refers to fluid overload complications from operative hysteroscopies. Despite guidelines for safe operative hysteroscopies, instances of OHIA syndrome have been reported. CASE REPORT:We reported three cases of OHIA syndrome. A 48-year-old female...

    journal_title:Taiwanese journal of obstetrics & gynecology



    authors: Wang MT,Chang CC,Hsieh MH,Chang CW,Fan Chiang YH,Tsai HC

    更新日期:2020-09-01 00:00:00

  • Metalloestrogen cadmium stimulates proliferation of stromal cells derived from the eutopic endometrium of women with endometriosis.

    abstract:OBJECTIVE:To assess the effect of metalloestrogen cadmium (Cd) on the proliferation of endometrial stromal cells (ESC) isolated from the eutopic endometrium of women with endometriosis MATERIALS AND METHODS:ESC were isolated from eutopic endometrial samples from 10 women with endometriosis and 10 women without endomet...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Silva N,Tennekoon K,Senanayake H,Samarakoon S

    更新日期:2013-12-01 00:00:00

  • Molecular cytogenetic characterization of Xp22.32→pter deletion and Xq26.3→qter duplication in a male fetus associated with 46,Y,rec(X)dup(Xq) inv(X)(p22.3q26.3), a hypoplastic left heart, short stature, and maternal X chromosome pericentric inversion.

    abstract:OBJECTIVE:We present molecular cytogenetic characterization of an Xp22.32→pter deletion and an Xq26.3→qter duplication in a male fetus with congenital malformations and maternal X chromosome pericentric inversion. MATERIALS AND METHODS:A 22-year-old woman underwent amniocentesis at 17 weeks of gestation because of an ...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Chen CP,Chen CY,Chern SR,Wu PS,Chen YN,Chen SW,Lee CC,Town DD,Lee MS,Yang CW,Wang W

    更新日期:2016-10-01 00:00:00

  • Three-cycle fentanyl patch system contributes to stable control of plasma fentanyl concentration in gynecologic cancer pain patients.

    abstract:OBJECTIVE:Pain affects many cancer patients in advancing stages, lowering the level of their quality of life. Morphine has long been the "gold standard" for the treatment of cancer pain; however, its side effects, particularly sedation and cognitive impairment at high doses, have encouraged the use of "opioid rotation"...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Kanamori C,Kanamori T,Tanaka Y,Kanzaki H

    更新日期:2011-03-01 00:00:00

  • Work hours of employed obstetricians in Taiwan.

    abstract:OBJECTIVE:Obstetricians have longer work hours and work hour restriction of employed physicians will be implemented thereafter. This study was to survey the impact of work hour restriction and determine the weekly work hours of obstetricians. MATERIALS AND METHODS:Since December 1, 2017, to January 31, 2018, a questio...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Huang MC,Huang WC,Hsieh CH,Kuo TC,Lee MS

    更新日期:2018-12-01 00:00:00

  • Phenotype to genotype characterization by array-comparative genomic hydridization (a-CGH) in case of fetal malformations: A systematic review.

    abstract::The aim of the current review is to report a-CGH abnormalities identified in fetuses with prenatally diagnosed fetal malformations in whom a normal karyotype was diagnosed with conventional cytogenetic analysis. A systematic electronic search of databases (PubMed/Medline, EMBASE/SCOPUS) has been conducted from incepti...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Tonni G,Palmisano M,Perez Zamarian AC,Rabachini Caetano AC,Santana EFM,Peixoto AB,Armbruster-Moraes E,Ruano R,Araujo Júnior E

    更新日期:2019-01-01 00:00:00

  • Human sex ratio at amniocentesis and at birth in Taiwan.

    abstract:OBJECTIVES:An increase in the proportion of male-to-female live births has raised concerns in Taiwan. Disclosure of fetal sex during prenatal screening is not allowed by the Taiwan government. Fetal sex annotation in clinical genetic reports is also prohibited. This study tested the hypothesis that the male-to-female s...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Lee IW,Lai YC,Kuo PL,Chang CM

    更新日期:2012-12-01 00:00:00

  • Single-port laparoscopic hysterectomy for uteri greater than 500 grams.

    abstract:OBJECTIVES:To study the operative outcomes of single-port laparoscopic hysterectomy in uteri greater than 500 g, using either laparoscopic assisted vaginal hysterectomy (LAVH) or laparoscopic supracervical hysterectomy (LSH). MATERIALS AND METHODS:78 patients were included in a single institute by a single surgeon fro...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Shen H,Torng PL,Chen IH,Hsu HC

    更新日期:2020-07-01 00:00:00

  • Risk of malignancy index validity assessment in premenopausal and postmenopausal women with adnexal tumors.

    abstract:OBJECTIVE:The aim of this study was to investigate the validity of the risk of malignancy index (RMI) in premenopausal and postmenopausal patients with adnexal masses. MATERIALS AND METHODS:The study involved all women treated for adnexal tumors throughout an 18-month period in the Clinic for Gynecology and Obstetrics...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Terzic M,Dotlic J,Likic I,Brndusic N,Pilic I,Ladjevic N,Maricic S,Arsenovic N,Maricic Z

    更新日期:2013-06-01 00:00:00

  • Unexpected uterine smooth muscle tumor of uncertain malignant potential and sarcoma: A single center cohort study in South Korea.

    abstract:OBJECTIVE:To evaluate the risk of encountering unexpected uterine smooth muscle tumors of uncertain malignant potential (STUMPs) or sarcomas during surgical treatment of mesenchymal tumors of the uterus using morcellation. MATERIAL AND METHODS:Data were collected retrospectively from subjects who were pathologically d...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Han AKW,Hong K,Kim M,Kim MK,Kim ML,Jung YW,Yun BS,Seong SJ

    更新日期:2020-03-01 00:00:00

  • Embryo splitting can increase the quantity but not the quality of blastocysts.

    abstract:OBJECTIVE:In this study, we investigated the developmental potential of single blastomeres that were obtained from 4-cell mice embryos that were split during the blastocyst stage. MATERIALS AND METHODS:Imprinting Control Region (ICR) mice (age: 6-8 weeks), were superovulated and mated with a single fertile male of the...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Tang HH,Tsai YC,Kuo CT

    更新日期:2012-06-01 00:00:00

  • Combined treatment for big submucosal myoma with High Intensity Focused Ultrasound and hysteroscopic resection.

    abstract:OBJECTIVE:Big submucosal myoma often causes heavy menstrual bleeding and are complicated in hysterscopic surgery. High Intensity Focused Ultrasound (HIFU), is a method for myoma ablation therapy, which may benefit on size reduction, and assist following hysterscopic myomectomy. CASE REPORT:Two cases, case one,. 44-yea...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Liao WL,Ying TH,Shen HP,Wu PJ

    更新日期:2019-11-01 00:00:00

  • Toxicity of intraperitoneal chemotherapy and risk factors for severe toxicity in optimally debulked ovarian cancer patients.

    abstract:OBJECTIVE:To assess the effect and toxicity of intraperitoneal (IP) chemotherapy for epithelial ovarian cancer and to determine the risk factors for severe toxicity. MATERIALS AND METHODS:Patients who received IP chemotherapy after optimal debulking surgery for ovarian cancer between 2006 and 2012 were retrospectively...

    journal_title:Taiwanese journal of obstetrics & gynecology

    pub_type: 杂志文章


    authors: Koo YJ,Lim KT

    更新日期:2015-06-01 00:00:00