Abstract:
AIM:Alzheimer's disease (AD) is the most common neurodegenerative disease. In 2000, Mendiondo et al. reported on a model predicting that AD progresses at an accelerating rate and cognitive function worsens rapidly. Recently, anti-AD drugs and non-pharmacological intervention have been established, but the effect of intervention is unclear and might depend on the stage of AD progression. Here, we examined the prediction of Mendiondo's model in patients with different severities of AD. METHODS:A total of 163 new outpatients with AD at four memory clinics were retrospectively analyzed. The Revised Hasegawa Dementia Scale (HDS-R) and Mini-Mental State Examination (MMSE) were administered to all AD patients at the first visit and after approximately 12 months. We divided the patients into three groups according to scores at the first visit: mild, moderate and moderate-to-severe. We compared the scores at the first visit with those obtained after 12 months of anti-AD drug and non-pharmacological interventions. RESULTS:The HDS-R score improved from 14.5 to 15.0, and the MMSE score improved from 18.8 to 19.1 after 12 months of intervention. Also, the HDS-R and MMSE scores at the first visit were significantly associated with the annual change in the scores. Among the three groups, lower HDS-R and MMSE scores at the first visit were associated with significantly greater annual improvement in the scores after 12 months of intervention. CONCLUSIONS:Contrary to the prediction of Mendiondo's model, mild or moderate AD progressed more rapidly than moderate-to-severe AD under pharmacological and non-pharmacological interventions. Geriatr Gerontol Int 2020; 20: 324-328.
journal_name
Geriatr Gerontol Intjournal_title
Geriatrics & gerontology internationalauthors
Honjo Y,Ide K,Takechi Hdoi
10.1111/ggi.13883subject
Has Abstractpub_date
2020-04-01 00:00:00pages
324-328issue
4eissn
1444-1586issn
1447-0594journal_volume
20pub_type
杂志文章abstract:AIM:Falls are a prevalent issue for the older population, and for the healthcare system in terms of emergency department (ED) access and hospitalizations. There is still a lack of knowledge and guidelines, however, regarding the need to hospitalize older patients accessing the ED after a fall. In the present study, we ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13497
更新日期:2018-09-01 00:00:00
abstract:AIM:Low alanine aminotransferase (ALT) level is associated with frailty in the older adult population. We investigated the usefulness of ALT in predicting low muscle strength among older patients with diabetes. METHODS:We included 550 men aged ≥50 years and 525 postmenopausal women. All participants had diabetes, and ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13868
更新日期:2020-04-01 00:00:00
abstract:AIM:The National Health and Nutrition Survey, Japan, has annually monitored two indicators of physical activity in adults. They are contrasting in the association with age; the prevalence of exercise habit is lower and step counts are higher among younger participants. The present study aimed to examine the effects of ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12956
更新日期:2017-10-01 00:00:00
abstract:AIM:Sarcopenia causes a decline in physical performance and decreased quality of life. However, there is little evidence for effective treatments. Because of the similarities between osteoporosis and sarcopenia, alfacalcidol used for osteoporosis might be beneficial for low muscle mass. Therefore, we investigated the e...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12222
更新日期:2014-02-01 00:00:00
abstract:AIM:The aim of this study was to examine how geriatricians decide the indication of tube feeding in the elderly with eating difficulty as a result of several disorders, and to determine the factors associated with their decision making and interventions for dysphagia. METHODS:The design was a cross-sectional study. Al...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2011.00831.x
更新日期:2012-10-01 00:00:00
abstract:AIM:Functional status at one moment in time is a determinant of future functional status and survival. Physical deterioration tends to occur early in the disabling process; however, etiological questions remain. This study investigated the association between physical performance characteristics and functioning indepen...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2012.00890.x
更新日期:2013-04-01 00:00:00
abstract:AIM:Skeletal muscle loss is a common feature of aging, and is associated with unfavorable outcomes. Although several indexes of skeletal muscle mass measurement have been developed, the most optimal index for sarcopenia diagnosis among Asian populations has remained unclear. The present study aimed to evaluate the rela...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12040
更新日期:2013-10-01 00:00:00
abstract:AIM:To assess the nutritional status, and its association with sociodemographic factors, health and functional status of community-dwelling older adults living in the Greater Beirut area. METHODS:This was a cross-sectional study involving 905 randomly selected community dwelling older adults aged ≥65 years living in G...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12732
更新日期:2017-03-01 00:00:00
abstract:AIM:The study aimed to study the prevalence, etiologies, clinical profile and outcome of delirium in hospitalized elderly in medicine wards. METHODS: Four hundred elderly patients of more than 60years of age admitted with delirium in the emergency and medicine wards of Sir Sunderlal Hospital Varanasi, India, were eva...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2011.00710.x
更新日期:2011-10-01 00:00:00
abstract:AIM:In the present study, we aimed to update the data of frailty status in the European community-dwelling population of older adults, based on the latest data released (wave 6) of the Survey of Health, Aging and Retirement in Europe database, and to study the impact of each criterion on frailty assessment. METHODS:Fr...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13689
更新日期:2019-08-01 00:00:00
abstract:AIM:There is little data regarding the prevalence and associated comorbidities of anemia in Chinese nursing home older adults. The objective of this study was to investigate the prevalence and associated comorbidities of anemia in Chinese nursing home older adults. METHODS:We carried out a retrospective cross-sectiona...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1447-0594.2012.00942.x
更新日期:2013-07-01 00:00:00
abstract:AIM:The behavioral and psychological symptoms of dementia place a heavy burden on caregivers. Antipsychotic drugs, though used to reduce the symptoms, frequently decrease patients' activities of daily living and reduce their quality of life. Recently, it was suggested that ferulic acid is an effective treatment for beh...
journal_title:Geriatrics & gerontology international
pub_type: 临床试验,杂志文章
doi:10.1111/j.1447-0594.2010.00687.x
更新日期:2011-07-01 00:00:00
abstract:AIM:The aim of the present study was to find out physicians' perceptions about the transfer of dying nursing home residents to emergency departments. METHOD:This qualitative study used semi-structured interviews, and data were analyzed using qualitative methods. Participants were medical directors of nursing homes who...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13600
更新日期:2019-03-01 00:00:00
abstract:AIM:The present study examined the association between vision, fear of falling and fear-related activity restriction, and assessed the effect of vision on the relationship between fear of falling and mobility, using data from a nationally representative sample of community-dwelling adults aged ≥ 50 years. METHODS:Part...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12174
更新日期:2014-10-01 00:00:00
abstract:AIM:Primitive reflexes can reappear with diseases of the brain, particularly those affecting the frontal lobes. Most studies on primitive reflexes have reported an association between such reflexes and brain damage, and the clinical symptoms of dementia. These reflexes can also be present during eating; however, their ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12078
更新日期:2014-01-01 00:00:00
abstract:AIM:Chronic diseases are frequent in older adults, particularly hypertension and diabetes. The relationship between frailty and these two conditions is still unclear. The aim of the present analyses was to explore the association between frailty with diabetes and hypertension in Mexican older adults. METHODS:Analyses ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12805
更新日期:2017-06-01 00:00:00
abstract:AIM:To establish the validity of the Norwegian General Motor Function (NGMF) assessment scale. METHOD:To establish construct and criteria validity, Spearman's rank correlation coefficients were calculated for the NGMF, and age, sex, medical conditions, history of falls and to four functional tests. Content validity wa...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12491
更新日期:2016-04-01 00:00:00
abstract:AIM:The health and well-being of older adults are closely related to their economic and living statuses. Socioeconomic inequality has a substantial impact on the healthcare received by these older adults. The present study aimed to understand the current economic and living statuses of community older adults, and exami...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12875
更新日期:2017-10-01 00:00:00
abstract:AIM:To examine the prevalence of potentially reversible conditions in dementia and mild cognitive impairment (MCI) patients in a geriatric clinic. METHODS:We retrospectively reviewed the medical records of patients who attended the outpatient geriatric clinic at Siriraj Hospital, Bangkok between January 2005 and Decem...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2011.00728.x
更新日期:2012-01-01 00:00:00
abstract:AIM:To test the hypothesis that static balance is associated with site-specific loss of muscle mass in older adults. METHODS:A total of 57 active women aged 52-83 years had their muscle thickness (MTH) measured by ultrasound at four sites on the anterior and posterior aspects of their upper- and lower-leg. MTH ratios ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12112
更新日期:2014-04-01 00:00:00
abstract:AIM:Previous studies on the association between intraoral conditions and mortality in community-dwelling older individuals reported that fewer present teeth (PT) are significant risk factors for mortality. However, how the number of PT relative to the number of functional teeth (FT), including both present and rehabili...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13911
更新日期:2020-06-01 00:00:00
abstract:AIM:We investigated whether mental stress-induced blood pressure elevation was related to cognitive function in the elderly, and further examined the effects of the dual-type calcium channel blocker, cilnidipine, on stress induced hypertension in subjects with mild cognitive impairment. METHODS:In study I, 39 consecut...
journal_title:Geriatrics & gerontology international
pub_type: 临床试验,杂志文章
doi:10.1111/j.1447-0594.2008.00482.x
更新日期:2008-12-01 00:00:00
abstract:AIM:The purpose of the present study was to investigate the injury types and medical utilization profiles of veterans in emergency department visits by using big data from the National Health Insurance program in Taiwan. METHOD:We used the outpatient prescriptions and treatment records between 1997 and 2010 of veteran...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12620
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Health-related quality of life (HRQOL) in older adults is determined by personal conditions, as well as by the social and physical environment. The purpose of the present study was to describe the factors related to health conditions and residential environment that influence HRQOL of older adults. METHODS:...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12325
更新日期:2015-05-01 00:00:00
abstract:AIM:To validate and standardize the Brazilian version of the Medication Regimen Complexity Index (MRCI) for older adults in primary healthcare. METHODS:A cross-sectional methodological study was carried out with elderly patients attending primary healthcare centers in southeastern Brazil. Convergent validity was teste...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13261
更新日期:2018-06-01 00:00:00
abstract:AIM:Nutrition is the focus of a new treatment target in older hospitalized cardiac patients. However, little is known about the differences in nutritional status in relation to physical performance in these inpatients. We determined the differences in physical performance based on the Geriatric Nutritional Risk Index (...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12257
更新日期:2015-02-01 00:00:00
abstract:AIMS:We aimed to investigate whether older age leads to limitations in the starting dose of imatinib in daily treatment of chronic myeloid leukemia, and to determine the compliance of elderly patients with tyrosine kinase inhibitors (TKI) therapy. METHODS:Data including the clinical characteristics, therapeutic outcom...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,多中心研究
doi:10.1111/ggi.12341
更新日期:2015-06-01 00:00:00
abstract:AIM:Heart diseases and social factors are associated with physical frailty, but there are few studies of older people living in the community. Consequently, the aim of this study was to examine the association between heart diseases, social factors and physical frailty in community-dwelling older populations including ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.14002
更新日期:2020-10-01 00:00:00
abstract:AIM:Frailty and sarcopenia affect the prognosis and quality of life of patients with chronic obstructive pulmonary disease (COPD). However, it remains uncertain which model is the most suitable for evaluating vulnerability in patients with COPD. We evaluated the validity of three frailty models - the Kihon Checklist (K...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13740
更新日期:2019-09-01 00:00:00
abstract:AIM:To investigate whether positive affect independently predicts a lower risk of functional decline among community-dwelling older Japanese. METHODS:A 2-year prospective study was carried out among 505 residents of Tosa Town aged 65 years and older without disability in carrying out basic activities of daily living (...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12008
更新日期:2013-10-01 00:00:00