Objective sleep measures between patients with Parkinson's disease and community-based older adults.


OBJECTIVES:Previous studies comparing objective sleep measures between patients with Parkinson's disease (PD) and control participants were limited by their small sample size. The purpose of this study was to compare objective sleep measures between large-scale cohorts of PD outpatients and community-based older adults. METHODS:In this cross-sectional study, we measured sleep parameters for 157 PD patients using an actigraph on the non-dominant wrist for six consecutive nights (95 Hoehn-Yahr stage I/II; 62 Hoehn-Yahr stage III-V). Moreover, two consecutive nights of actigraphy were performed on 1101 community-based control participants aged ≥60 years. RESULTS:In multivariable analysis, sleep efficiency (SE) was significantly lower in patients with late-stage PD by 17.5% [95% confidence interval: 15.3%-19.7%] and early-stage PD by 9.4% [7.6%-11.1%] compared to the controls (67.1% and 75.3% vs. 84.6%, respectively). Similar results were observed for wake after sleep onset (WASO) and fragmentation index (FI). Total sleep time and sleep onset latency (SOL) were significantly shorter in patients with late- and early-stage PD stage compared to the controls. Among PD patients, significant association trends between advancement of individual Hoehn-Yahr stages and worsened sleep measures of SE, WASO, and FI were observed independently of age, gender, levodopa equivalent dose, and motor function parameter. CONCLUSION:This study demonstrated significant and quantitative differences in objective sleep quality and quantity between PD patients and control participants. Furthermore, with advancement of disease stages, objectively measured sleep quality worsened in PD patients.


Sleep Med


Sleep medicine


Kataoka H,Saeki K,Kurumatani N,Sugie K,Obayashi K




Has Abstract


2020-04-01 00:00:00












  • An examination of thought control strategies employed by acute and chronic insomniacs.

    abstract:STUDY OBJECTIVES:Theoretical accounts of the progression of insomnia from acute to chronic are lacking. A framework is proposed and tested to examine differences in cognitive coping styles between acute and chronic insomniacs and the relation of cognitive processing and sleep hygiene to causal attributions of insomnia....

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Ellis J,Cropley M

    更新日期:2002-09-01 00:00:00

  • Brain iron deficiency in idiopathic restless legs syndrome measured by quantitative magnetic susceptibility at 7 tesla.

    abstract:OBJECTIVES:Altered brain iron homeostasis with regional iron deficiency has been previously reported in several studies of restless legs syndrome (RLS) patients. Inconsistencies still exist, however, in the reported iron changes in different brain regions and different RLS phenotypes. The purpose of this study was to a...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Li X,Allen RP,Earley CJ,Liu H,Cruz TE,Edden RAE,Barker PB,van Zijl PCM

    更新日期:2016-06-01 00:00:00

  • Prediction of normal values for central apnea-hypopnea index at different ages and altitudes above sea level in healthy children.

    abstract:BACKGROUND:There is a critical need for studies aimed to help clinicians to establish the normal/expected central apnea-hypopnea index (CAHI) at altitudes above sea level and ages other than those reported in the current available studies. The aim of the present study was to develop predictive models useful for determi...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Restrepo-Gualteros SM,Villamil-Osorio M,Rodriguez-Martinez CE

    更新日期:2020-12-31 00:00:00

  • The severity range of restless legs syndrome (RLS) and augmentation in a prospective patient cohort: association with ferritin levels.

    abstract:OBJECTIVES:The aim of the study was to prospectively examine all patients with a diagnosis of RLS consulting a sleep disorders clinic and to assess RLS severity and augmentation and their associations, including ferritin levels. METHODS:Patients were stratified into patients with RLS as ancillary diagnosis, RLS suffer...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Frauscher B,Gschliesser V,Brandauer E,El-Demerdash E,Kaneider M,Rücker L,Poewe W,Högl B

    更新日期:2009-06-01 00:00:00

  • Capturing PLMS and their variability in children with sickle cell disease: does ankle activity monitoring measure up to polysomnography?

    abstract:OBJECTIVES:To test agreement and define differences in periodic limb movements in sleep (PLMS) measured by polysomnography and an ankle activity monitor, and to describe PLMS variability across nights, feasibility of home monitoring, and correlates of PLMS in children with sickle cell disease (SCD). METHODS:Twenty chi...

    journal_title:Sleep medicine

    pub_type: 临床试验,杂志文章


    authors: Rogers VE,Gallagher PR,Marcus CL,Ohene-Frempong K,Traylor JT,Mason TB

    更新日期:2012-09-01 00:00:00

  • Web- vs. telehealth-based delivery of cognitive behavioral therapy for insomnia: a randomized controlled trial.

    abstract:OBJECTIVES:The purpose of our study was to evaluate and compare two methods of service delivery (web-based and telehealth-based) for chronic insomnia with regard to patient preference, clinical effectiveness, and patient satisfaction. METHODS:Our study was a randomized controlled trial with manualized telehealth- and ...

    journal_title:Sleep medicine

    pub_type: 杂志文章,随机对照试验


    authors: Holmqvist M,Vincent N,Walsh K

    更新日期:2014-02-01 00:00:00

  • Management of augmentation of restless legs syndrome with rotigotine: a 1-year observational study.

    abstract:AIM:The aim of this study is to assess the effect of switching to rotigotine transdermal patch on severity of restless legs syndrome (RLS) in patients who experienced acute augmentation with previous oral dopaminergics. METHODS:In this 13-month observational study, adults with moderate-to-severe RLS and augmentation w...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Trenkwalder C,Canelo M,Lang M,Schroeder H,Kelling D,Berkels R,Schollmayer E,Heidbrede T,Benes H

    更新日期:2017-02-01 00:00:00

  • Association between subjective well-being and sleep among the elderly in Japan.

    abstract:OBJECTIVE:The purpose of this study was to examine the association between sleep and subjective quality of life in an elderly Japanese population. METHODS:Elderly people aged 70 years or more (n=1,769) were selected randomly from all areas of Japan. They were visited and interviewed in November 2003. Subjective well-b...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Yokoyama E,Saito Y,Kaneita Y,Ohida T,Harano S,Tamaki T,Ibuka E,Kaneko A,Nakajima H,Takeda F

    更新日期:2008-01-01 00:00:00

  • Hearing loss mediates executive function impairment in sleep-disordered breathing.

    abstract:BACKGROUND:Sleep-disordered breathing (SDB) is often co-morbid with conductive hearing loss in early childhood due to a shared aetiology of adenotonsillar hypertrophy. Hearing loss is independently associated with impairment of executive function and behavioural difficulties. We hypothesised that these impairments in c...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Hill CM,Bucks RS,Kennedy CR,Harrison D,Carroll A,Upton N,Hogan AM

    更新日期:2017-06-01 00:00:00

  • Relationships between REM and NREM in the NREM-REM sleep cycle: a review on competing concepts.

    abstract::Sixty-five years after the discovery of rapid eye movement (REM) sleep, the reasons why we sleep and why we need two states of sleep are still largely unclear. Moreover, the functional relationship between the two types of sleep remains the matter of much conjecture. Several questions come to mind. How does sleep regu...

    journal_title:Sleep medicine

    pub_type: 杂志文章,评审


    authors: Le Bon O

    更新日期:2020-06-01 00:00:00

  • An assessment of the efficacy and safety of eszopiclone in the treatment of transient insomnia in healthy adults.

    abstract:BACKGROUND AND PURPOSE:This randomized, double-blind, placebo-controlled study assessed the efficacy and safety of eszopiclone, a non-benzodiazepine hypnotic agent, in healthy adults using the first-night effect model of transient insomnia. PATIENTS AND METHODS:A total of 436 healthy, normal sleeping participants were...

    journal_title:Sleep medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rosenberg R,Caron J,Roth T,Amato D

    更新日期:2005-01-01 00:00:00

  • Mothers' postpartum sleep disturbance is associated with the ability to sustain sensitivity toward infants.

    abstract:BACKGROUND/OBJECTIVE:Infancy is a period of rapid development when the quality of caregiving behavior may be particularly consequential for children's long-term functioning. During this critical period for caregiving behavior, parents experience changes in their sleep that may affect their ability to provide sensitive ...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: King LS,Rangel E,Simpson N,Tikotzky L,Manber R

    更新日期:2020-01-01 00:00:00

  • Moderate-to-severe obstructive sleep apnea is associated with cerebral small vessel disease.

    abstract:BACKGROUND:Cerebral small vessel disease (SVD) is associated with increased risk of cerebral infarction and hemorrhage. Obstructive sleep apnea (OSA) is known to increase the risk of cerebrovascular disease. This study aimed to investigate the association between cerebral SVD and severity of OSA. METHODS:A total of 17...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Song TJ,Park JH,Choi KH,Chang Y,Moon J,Kim JH,Choi Y,Kim YJ,Lee HW

    更新日期:2017-02-01 00:00:00

  • Childhood sleep problems, early onset of substance use and behavioral problems in adolescence.

    abstract:BACKGROUND:Very few prospective studies examine the relationship between childhood sleep problems and subsequent substance use. In this study, we examined how sleep problems at ages 3-8 predicted onset of alcohol, cigarette, and marijuana use in adolescence. We also investigated the relationships between childhood slee...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Wong MM,Brower KJ,Zucker RA

    更新日期:2009-08-01 00:00:00

  • Iron deficiency with normal ferritin levels in restless legs syndrome.

    abstract::This report describes a patient with iron deficiency in bone marrow examination and iron-responsive restless legs syndrome (RLS), in whom serum ferritin levels were well above the conventional cutoff for considering iron deficiency. The predictive value of serum ferritin for iron deficiency in RLS depends on the cutof...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: O'Keeffe ST

    更新日期:2005-05-01 00:00:00

  • Light exposure in the natural environment: relevance to mood and sleep disorders.

    abstract::In addition to being necessary for vision, light also plays a primary role in circadian physiology. Humans are diurnal animals and their biological clock synchronizes their physiological functions in such a way that functions associated with activity happen in the daytime while functions associated with rest occur at ...

    journal_title:Sleep medicine

    pub_type: 杂志文章,评审


    authors: Dumont M,Beaulieu C

    更新日期:2007-09-01 00:00:00

  • Cytokine polymorphisms are associated with daytime napping in adults living with HIV.

    abstract:OBJECTIVE/BACKGROUND:Daytime napping longer than one hour has been associated with an increased risk for all-cause mortality. Associations between cytokine polymorphisms and daytime napping in chronic illnesses such as HIV, however, have not been well described. The purpose of this study was to examine cytokine polymor...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Byun E,Gay CL,Portillo CJ,Pullinger CR,Aouizerat BE,Lee KA

    更新日期:2017-04-01 00:00:00

  • Cholinergic neurotransmission and olfactory function in obstructive sleep apnea syndrome: a TMS study.

    abstract:BACKGROUND/OBJECTIVE:Odor identification and discrimination are reduced in subjects with obstructive sleep apnea syndrome (OSAS), but the pathophysiology of the olfactory dysfunction in OSAS is still poorly understood. Experimental evidence suggests that olfactory impairment could be related to central cholinergic dysf...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Versace V,Langthaler PB,Sebastianelli L,Golaszewski S,Kunz AB,Brigo F,Saltuari L,Nardone R

    更新日期:2017-09-01 00:00:00

  • Multiple sleep latency test and polysomnography in patients with central disorders of hypersomnolence.

    abstract::A multiple sleep latency test (MSLT) with occurrence of sleep onset REM periods (SOREMP) is considered one of the central diagnostic criteria for narcolepsy according to the International Classification of Sleep Disorders, but its sensitivity and specificity have been questioned. This study aims to describe MSLT and p...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Dietmann A,Gallino C,Wenz E,Mathis J,Bassetti CLA

    更新日期:2021-01-02 00:00:00

  • Restless Legs Syndrome and the five-factor model of personality: results from a community sample.

    abstract:OBJECTIVE:To examine personality characteristics as potential mediators of the association between Restless Legs Syndrome (RLS) and psychiatric disorders. METHOD:Revised NEO Personality Inventory traits are compared in respondents with (n=42) versus without (n=982) a diagnosis of RLS in a general population sample. R...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Kalaydjian A,Bienvenu OJ,Hening WA,Allen RP,Eaton WW,Lee HB

    更新日期:2009-06-01 00:00:00

  • Can a school-based sleep education programme improve sleep knowledge, hygiene and behaviours using a randomised controlled trial.

    abstract:OBJECTIVES:The present study investigated the effectiveness of a school-based sleep education programme in improving key sleep behaviours, sleep knowledge, and sleep hygiene. DESIGN AND METHODS:A cross-sectional cluster-randomised controlled trial with two groups (Intervention and Control) and three assessment time po...

    journal_title:Sleep medicine

    pub_type: 杂志文章,随机对照试验


    authors: Rigney G,Blunden S,Maher C,Dollman J,Parvazian S,Matricciani L,Olds T

    更新日期:2015-06-01 00:00:00

  • Sleep perception in insomniacs, sleep-disordered breathing patients, and healthy volunteers--an important biologic parameter of sleep.

    abstract:BACKGROUND:The mechanisms involved in sleep perception are not widely known. Therefore, we believe that investigating this phenomenon is the best way to understand some of the mechanisms involved in several sleep disturbances, particularly insomnias. OBJECTIVE:The objective of our study was to evaluate sleep perceptio...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Pinto LR Jr,Pinto MC,Goulart LI,Truksinas E,Rossi MV,Morin CM,Tufik S

    更新日期:2009-09-01 00:00:00

  • The longitudinal course and impact of non-restorative sleep: a five-year community-based follow-up study.

    abstract:BACKGROUND:There is a dearth of data on the longitudinal course and outcome of non-restorative sleep (NRS). METHODS:A total of 2291 middle-aged adults (mean [SD]=46.3 [5.1] years old, 50.0% males at follow-up) were recruited into a 5-year follow-up study. NRS was defined as morning unfreshness after getting up ≥ 3 tim...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Zhang J,Lam SP,Li SX,Li AM,Wing YK

    更新日期:2012-06-01 00:00:00

  • The effects of dexamethasone on sleep in young children with acute lymphoblastic leukemia.

    abstract:PURPOSE:Corticosteroids, which are a mainstay in the treatment of acute lymphoblastic leukemia (ALL), have a well-documented adverse effect on sleep. We sought to characterize the effects of dexamethasone on sleep over an entire 28-day treatment cycle using actigraphy, an objective measure of sleep. METHODS:The sleep ...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Rosen G,Harris AK,Liu M,Dreyfus J,Krueger J,Messinger YH

    更新日期:2015-04-01 00:00:00

  • Associations between pain, objective sleep efficiency and cognition in patients with implantable cardioverter defibrillators.

    abstract:INTRODUCTION:Patients with implantable cardioverter defibrillators (ICDs) frequently experience sleep disruption. Prior work shows associations between objective (actigraphic) sleep and cognition in these patients, but whether pain affects associations between measures of sleep fragmentation (eg, sleep efficiency, SE) ...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Curtis AF,Roth AJ,Sears SF,Conti JB,Berry RB,Dzierzewski JM,McCrae CS

    更新日期:2020-08-01 00:00:00

  • Association of sleep habits with behavior problems and resilience of 6- to 7-year-old children: results from the A-CHILD study.

    abstract:BACKGROUND:Childhood sleep habits are associated with mental health development; however, little is known about the impact of irregular bedtimes on the mental health of early school-aged children. The aims of this study were to examine the effect of weekday sleep habits (varying bedtimes depending on the night of the w...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Doi S,Fujiwara T,Ochi M,Isumi A,Kato T

    更新日期:2018-05-01 00:00:00

  • Prevalence and quality of life and sleep in children and adolescents with restless legs syndrome/Willis-Ekbom disease.

    abstract:OBJECTIVE:To estimate the prevalence of restless legs syndrome/Willis-Ekbom disease (RLS/WED) and its impact on sleep and quality of life in children and adolescents. METHODS:This was a cross-sectional study conducted in the Municipality of Cássia dos Coqueiros, Brazil. Participants included 383 children and adolescen...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Sander HH,Eckeli AL,Costa Passos AD,Azevedo L,Fernandes do Prado LB,França Fernandes RM

    更新日期:2017-02-01 00:00:00

  • Wrist actigraphy in estimation of sleep and wake in intellectually disabled subjects with motor handicaps.

    abstract:BACKGROUND AND PURPOSE:We studied the applicability of wrist actigraphy to sleep-wake estimation in patients with motor handicaps. PATIENTS AND METHODS:Concomitant polysomnographic and actigraphic recordings (16-24 h) were compared in three groups: normally moving subjects with normal sleep (n=10), sleep-disordered su...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Laakso ML,Leinonen L,Lindblom N,Joutsiniemi SL,Kaski M

    更新日期:2004-11-01 00:00:00

  • A double-blind, crossover study of Doxazosin and Enalapril on peripheral vascular tone and nocturnal blood pressure in sleep apnea patients.

    abstract:OBJECTIVE:Pulse wave attenuation, which occurs in association with obstructive sleep apnea (OSA), is sympathetically mediated. We compared the effect of Doxazosin (DO, a peripheral alpha-receptor inhibitor) and Enalapril (EN, an ACE inhibitor) on digital vasoconstriction and nocturnal blood pressure (BP) in hypertensiv...

    journal_title:Sleep medicine

    pub_type: 杂志文章,随机对照试验


    authors: Zou D,Grote L,Eder DN,Radlinski J,Hedner J

    更新日期:2010-03-01 00:00:00

  • A preliminary study of sleep-disordered breathing in major depressive disorder.

    abstract:BACKGROUND AND PURPOSE:Individuals with obstructive sleep-disordered breathing (OSDB) commonly report symptoms of depression; however, the percentage of individuals with major depressive disorder (MDD) who experience OSDB is less clear. This study aimed to examine OSDB in a sample of individuals with MDD, unselected fo...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Deldin PJ,Phillips LK,Thomas RJ

    更新日期:2006-03-01 00:00:00