Objective sleep measures between patients with Parkinson's disease and community-based older adults.


OBJECTIVES:Previous studies comparing objective sleep measures between patients with Parkinson's disease (PD) and control participants were limited by their small sample size. The purpose of this study was to compare objective sleep measures between large-scale cohorts of PD outpatients and community-based older adults. METHODS:In this cross-sectional study, we measured sleep parameters for 157 PD patients using an actigraph on the non-dominant wrist for six consecutive nights (95 Hoehn-Yahr stage I/II; 62 Hoehn-Yahr stage III-V). Moreover, two consecutive nights of actigraphy were performed on 1101 community-based control participants aged ≥60 years. RESULTS:In multivariable analysis, sleep efficiency (SE) was significantly lower in patients with late-stage PD by 17.5% [95% confidence interval: 15.3%-19.7%] and early-stage PD by 9.4% [7.6%-11.1%] compared to the controls (67.1% and 75.3% vs. 84.6%, respectively). Similar results were observed for wake after sleep onset (WASO) and fragmentation index (FI). Total sleep time and sleep onset latency (SOL) were significantly shorter in patients with late- and early-stage PD stage compared to the controls. Among PD patients, significant association trends between advancement of individual Hoehn-Yahr stages and worsened sleep measures of SE, WASO, and FI were observed independently of age, gender, levodopa equivalent dose, and motor function parameter. CONCLUSION:This study demonstrated significant and quantitative differences in objective sleep quality and quantity between PD patients and control participants. Furthermore, with advancement of disease stages, objectively measured sleep quality worsened in PD patients.


Sleep Med


Sleep medicine


Kataoka H,Saeki K,Kurumatani N,Sugie K,Obayashi K




Has Abstract


2020-04-01 00:00:00












  • "My child has a sleep problem": a cross-cultural comparison of parental definitions.

    abstract:BACKGROUND:Sleep problems are highly prevalent in early childhood. In many cases, parents seek professional help when they suspect their child suffers from a sleep problem. The aim of this study was to explore sleep, demographic and cultural factors associated with parental definition of child sleep problem in a large-...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Sadeh A,Mindell J,Rivera L

    更新日期:2011-05-01 00:00:00

  • Sleep in children with autistic spectrum disorder.

    abstract::Children and adolescents with autistic spectrum disorders (ASD) suffer from sleep problems, particularly insomnia, at a higher rate than typically developing children, ranging from 40% to 80%. Sleep problems in ASD might occur as a result of complex interactions between biological, psychological, social/environmental,...

    journal_title:Sleep medicine

    pub_type: 杂志文章,评审


    authors: Cortesi F,Giannotti F,Ivanenko A,Johnson K

    更新日期:2010-08-01 00:00:00

  • Clinical characteristics of Korean pediatric patients with restless legs syndrome.

    abstract:OBJECTIVES:Restless legs syndrome (RLS) is a common neurological disorder but it is not sufficiently recognized in children and adolescents. It often overlaps with growing pains in children, and as a result the clinical characteristics of pediatric RLS are not well studied, especially in Asia. The purpose of this study...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Kim S,Kim KT,Motamedi GK,Cho YW

    更新日期:2020-05-01 00:00:00

  • A 2-week efficacy and safety study of gaboxadol and zolpidem using electronic diaries in primary insomnia outpatients.

    abstract:OBJECTIVES:To evaluate the efficacy and safety profile of gaboxadol, a selective extrasynaptic GABA(A) agonist (SEGA) previously in development for the treatment of insomnia. METHODS:This was a randomised, double-blind, placebo-controlled, parallel-group, 2-week, Phase III study of gaboxadol 5, 10 and 15mg in outpatie...

    journal_title:Sleep medicine

    pub_type: 杂志文章,随机对照试验


    authors: Hajak G,Hedner J,Eglin M,Loft H,Stórustovu SI,Lütolf S,Lundahl J,Gaboxadol Study 99775 Group.

    更新日期:2009-08-01 00:00:00

  • Increased plasma level of tumor necrosis factor α in patients with narcolepsy in Taiwan.

    abstract:BACKGROUND:Narcolepsy is a neuropsychiatric disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, and abnormal rapid eye movement (REM) sleep. Tumor necrosis factor α (TNF α) and its cognate receptors have been reported to be involved in the pathophysiology of narcolepsy in addit...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Chen YH,Huang YS,Chen CH

    更新日期:2013-12-01 00:00:00

  • Sleep perception in insomniacs, sleep-disordered breathing patients, and healthy volunteers--an important biologic parameter of sleep.

    abstract:BACKGROUND:The mechanisms involved in sleep perception are not widely known. Therefore, we believe that investigating this phenomenon is the best way to understand some of the mechanisms involved in several sleep disturbances, particularly insomnias. OBJECTIVE:The objective of our study was to evaluate sleep perceptio...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Pinto LR Jr,Pinto MC,Goulart LI,Truksinas E,Rossi MV,Morin CM,Tufik S

    更新日期:2009-09-01 00:00:00

  • Cognitive and behavioral effects of obstructive sleep apnea syndrome in children: a systematic literature review.

    abstract::Obstructive sleep apnea syndrome (OSA) is a common respiratory sleep disorder in children that is believed to adversely affect both quality of life and cognition. The purpose of the present systematic review was to obtain evidence of the impact of OSA on children's cognitive/behavioral abilities from primary studies p...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: da Silva Gusmão Cardoso T,Pompéia S,Miranda MC

    更新日期:2018-06-01 00:00:00

  • Telemetric CPAP titration at home in patients with sleep apnea-hypopnea syndrome.

    abstract:BACKGROUND:Home continuous positive airway pressure (CPAP) titration with automatic devices is not possible in a non-negligible percentage of patients with sleep apnea-hypopnea syndrome (SAHS). OBJECTIVES:To test the feasibility of a novel telemetric system for home CPAP titration. METHODS:One-night home CPAP titrati...

    journal_title:Sleep medicine

    pub_type: 临床试验,杂志文章


    authors: Dellacà R,Montserrat JM,Govoni L,Pedotti A,Navajas D,Farré R

    更新日期:2011-02-01 00:00:00

  • Insufficient sleep rather than the apnea-hypopnea index can be associated with sleepiness-related driving problems of Japanese obstructive sleep apnea syndrome patients residing in metropolitan areas.

    abstract:OBJECTIVE:Obstructive sleep apnea syndrome (OSAS) and insufficient sleep might increase the risk of drowsy driving and sleepiness-related vehicular accidents. This study retrospectively investigated the factors associated with these driving problems, particularly addressing OSAS severity and sleep amounts of affected d...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Matsui K,Sasai-Sakuma T,Ishigooka J,Inoue Y

    更新日期:2017-05-01 00:00:00

  • Nasal bilevel positive airway pressure therapy in children with a sleep-related breathing disorder and attention-deficit hyperactivity disorder: effects on electrophysiological measures of brain function.

    abstract:OBJECTIVE:To examine the effect of nasal bilevel positive airway pressure (BiPAP) treatment for concurrent sleep-related breathing disorders (SRBDs) and attention-deficit hyperactivity disorder (ADHD) on electrophysiological measures of spontaneous brain activity and auditory stimulus processing. METHODS:Nineteen chil...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Johnstone SJ,Tardif HP,Barry RJ,Sands T

    更新日期:2001-09-01 00:00:00

  • Treatment of insomnia with tricyclic antidepressants: a meta-analysis of polysomnographic randomized controlled trials.

    abstract:BACKGROUND:Insomnia represents a significant public health burden worldwide. Antidepressants have often been the insomnia treatment of choice in recent decades. Some tricyclic antidepressants (TCAs) have been shown to improve sleep efficiency. OBJECTIVE:Assess the efficacy and safety of TCAs for the treatment of insom...

    journal_title:Sleep medicine

    pub_type: 杂志文章,meta分析,评审


    authors: Liu Y,Xu X,Dong M,Jia S,Wei Y

    更新日期:2017-06-01 00:00:00

  • Polysomnographic study of sleeplessness and oneiricisms in the alcohol withdrawal syndrome.

    abstract::We describe a polysomnographic observation of the acute phase of the alcohol withdrawal syndrome, characterized by an alteration of the sleep-wake cycle and by the absence of non-rapid eye movement sleep. An atypical transitional state between rapid eye movement sleep and wake with hallucinations and enacting-dream be...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Plazzi G,Montagna P,Meletti S,Lugaresi E

    更新日期:2002-05-01 00:00:00

  • Sleep apnea increased incidence of primary central nervous system cancers: a nationwide cohort study.

    abstract:INTRODUCTION:Obstructive sleep apnea (OSA) was associated with increased incidence of all cancers. We aimed to determine the risk for primary central nervous system (CNS) cancers in patients with sleep apnea syndrome. METHODS:A total of 23,055 incident cases of newly diagnosed sleep apnea syndrome (sleep apnea group) ...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Chen JC,Hwang JH

    更新日期:2014-07-01 00:00:00

  • Decreased concentration of klotho and increased concentration of FGF23 in the cerebrospinal fluid of patients with narcolepsy.

    abstract:OBJECTIVE:to explore the status of concentration of klotho and fibroblast growth factor 23 (FGF23) in cerebrospinal fluid (CSF) of patients with narcolepsy. PATIENTS/METHODS:59 patients with narcolepsy and 17 control individuals were enrolled. We used radioimmunoassay, human klotho enzyme-linked immunosorbent assay (E...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: da Paz Oliveira G,Elias RM,Peres Fernandes GB,Moyses R,Tufik S,Bichuetti DB,Coelho FMS

    更新日期:2020-12-15 00:00:00

  • Multiscale entropic assessment of autonomic dysfunction in patients with obstructive sleep apnea and therapeutic impact of continuous positive airway pressure treatment.

    abstract:OBJECTIVE:Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular disease because of its associated autonomic nervous and vascular regulatory dysfunctions. We tested the hypothesis that the multiscale entropy (MSE) approach to heart rate variability analysis may be used for evaluating OSA severit...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Pan WY,Su MC,Wu HT,Su TJ,Lin MC,Sun CK

    更新日期:2016-04-01 00:00:00

  • A preliminary study of sleep-disordered breathing in major depressive disorder.

    abstract:BACKGROUND AND PURPOSE:Individuals with obstructive sleep-disordered breathing (OSDB) commonly report symptoms of depression; however, the percentage of individuals with major depressive disorder (MDD) who experience OSDB is less clear. This study aimed to examine OSDB in a sample of individuals with MDD, unselected fo...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Deldin PJ,Phillips LK,Thomas RJ

    更新日期:2006-03-01 00:00:00

  • Abnormal night sleep duration and poor sleep quality are independently and combinedly associated with elevated depressive symptoms in Chinese rural adults: Henan Rural Cohort.

    abstract:OBJECTIVE:To assess the independent and combined effects of night sleep duration and sleep quality on depressive symptoms. METHODS:A total of 28,202 participants (11,236 males and 16,966 females) aged 18-79 years from the Henan Rural Cohort were included in this study. Night sleep duration and sleep quality were defin...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Jiang J,Li Y,Mao Z,Wang F,Huo W,Liu R,Zhang H,Tian Z,Liu X,Zhang X,Tu R,Qian X,Liu X,Luo Z,Bie R,Wang C

    更新日期:2020-06-01 00:00:00

  • Bad sleep? Don't blame the moon! A population-based study.

    abstract:INTRODUCTION:The aim of this study was to evaluate if there is a significant effect of lunar phases on subjective and objective sleep variables in the general population. METHODS:A total of 2125 individuals (51.2% women, age 58.8 ± 11.2 years) participating in a population-based cohort study underwent a complete polys...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Haba-Rubio J,Marques-Vidal P,Tobback N,Andries D,Preisig M,Kuehner C,Vollenweider P,Waeber G,Luca G,Tafti M,Heinzer R

    更新日期:2015-11-01 00:00:00

  • Long-term side effects of sleep apnea treatment with oral appliances: nature, magnitude and predictors of long-term changes.

    abstract:OBJECTIVES:Oral appliances for the treatment of obstructive sleep apnea (OSA) reduce upper airway collapse by advancing the mandible (OAm) and associated soft tissues. OAm are well tolerated but have side effects, mainly dental movement. It is not yet clear whether there are irreversible skeletal changes associated wit...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Hamoda MM,Almeida FR,Pliska BT

    更新日期:2019-04-01 00:00:00

  • Insomnia in pediatric obsessive-compulsive disorder: prevalence and association with multimodal treatment outcomes in a naturalistic clinical setting.

    abstract:OBJECTIVE:Little is known about the prevalence and impact of insomnia on clinical outcomes in youth with obsessive-compulsive disorder (OCD). This study aimed to investigate this subject. PATIENTS/METHODS:A total of 193 patients from a specialist pediatric OCD clinic completed a range of diagnostic and clinical measur...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Sevilla-Cermeño L,Andrén P,Hillborg M,Silverberg-Morse M,Mataix-Cols D,Fernández de la Cruz L

    更新日期:2019-04-01 00:00:00

  • A convenient expiratory positive airway pressure nasal device for the treatment of sleep apnea in patients non-adherent with continuous positive airway pressure.

    abstract:BACKGROUND:While continuous positive airway pressure (CPAP) effectively treats obstructive sleep apnea (OSA), adherence to CPAP is suboptimal. The short-term efficacy of and adherence with a convenient expiratory positive airway pressure (EPAP) nasal device was evaluated in OSA patients non-adherent with CPAP. METHODS...

    journal_title:Sleep medicine

    pub_type: 临床试验,杂志文章


    authors: Walsh JK,Griffin KS,Forst EH,Ahmed HH,Eisenstein RD,Curry DT,Hall-Porter JM,Schweitzer PK

    更新日期:2011-02-01 00:00:00

  • Chronotype, social jet lag, sleep debt and food timing in inflammatory bowel disease.

    abstract::The preference of the sleep/wake cycle can be grouped into categories or chronotypes. Inflammatory bowel disease (IBD) has been linked to poor sleep quality which correlates with disease severity. Social jet lag (SJL) is the difference between sleep timing on work and free days and is a marker for circadian misalignme...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Chakradeo PS,Keshavarzian A,Singh S,Dera AE,Esteban JPG,Lee AA,Burgess HJ,Fogg L,Swanson GR

    更新日期:2018-12-01 00:00:00

  • U-shaped relationships between sleep duration and metabolic syndrome and metabolic syndrome components in males: a prospective cohort study.

    abstract:OBJECTIVE:Based on cross-sectional studies, sleep duration has been shown to have a relationship with the prevalence of metabolic syndrome (MS); however, no prospective studies have verified a correlation between the incidence of MS and the gender difference. Herein we prospectively determined the association between M...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Li X,Lin L,Lv L,Pang X,Du S,Zhang W,Na G,Ma H,Zhang Q,Jiang S,Deng H,Han T,Sun C,Li Y

    更新日期:2015-08-01 00:00:00

  • Preliminary results on CSF biomarkers for hypothalamic dysfunction in Kleine-Levin syndrome.

    abstract:OBJECTIVE:To measure CSF biomarkers of hypothalamic dysfunction in patients with typical Kleine-Levin syndrome (KLS) during symptomatic and asymptomatic periods. PATIENTS/METHODS:Two patients with typical KLS were admitted during symptomatic and asymptomatic periods to a research Sleep Disorders Center. Cerebrospinalf...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Lopez R,Barateau L,Chenini S,Dauvilliers Y

    更新日期:2015-01-01 00:00:00

  • Moving into poverty during childhood is associated with later sleep problems.

    abstract:OBJECTIVE:A social gradient in sleep has been demonstrated across the life span, but previous studies have been cross-sectional and used self-reported socioeconomic status (SES) indicators. Using registry-based data on family income trajectories, the current study examined the association between relative poverty in ch...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Sivertsen B,Bøe T,Skogen JC,Petrie KJ,Hysing M

    更新日期:2017-09-01 00:00:00

  • Clinical markers of early nigrostriatal neurodegeneration in idiopathic rapid eye movement sleep behavior disorder.

    abstract:BACKGROUND:Rapid eye movement sleep behavior disorder (RBD) is an early feature in α synucleinopathies and may precede other clinical manifestations of disease for several years. Olfactory dysfunction and mild motor abnormalities (MMAs) are highly prevalent in prodromal α synucleinopathies such as RBD and are suspected...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Rupprecht S,Walther B,Gudziol H,Steenbeck J,Freesmeyer M,Witte OW,Günther A,Schwab M

    更新日期:2013-11-01 00:00:00

  • Narcolepsy and the ability to resist sleep.

    abstract::We describe five patients who presented with irresistible daytime sleepiness and who have the clinical and laboratory features of narcolepsy but differ from most patients with narcolepsy in their ability to resist falling asleep during the daytime. All of the patients described partial or complete remission of their s...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Shechter-Amir D,Wade JA,Moldofsky H

    更新日期:2000-04-01 00:00:00

  • Night-waking and behavior in preschoolers: a developmental trajectory approach.

    abstract:OBJECTIVE:The aim was to study, with a developmental approach, the longitudinal association between night-waking from age 2 to 5-6 years and behavior at age 5-6 years. METHODS:Within the French birth cohort study Etude sur les Déterminants pré et post natals du développement et de la santé de l'ENfant (EDEN), repeated...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Reynaud E,Forhan A,Heude B,Charles MA,Plancoulaine S,EDEN Mother−Child Cohort Study Group.

    更新日期:2018-03-01 00:00:00

  • Different maturational changes of fast and slow sleep spindles in the first four years of life.

    abstract:OBJECTIVE/BACKGROUND:Massive changes in brain morphology and function in the first years of life reveal a postero-anterior trajectory of cortical maturation accompanied by regional modifications of NREM sleep. One of the most sensible marker of this maturation process is represented by electroencephalographic (EEG) act...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: D'Atri A,Novelli L,Ferrara M,Bruni O,De Gennaro L

    更新日期:2018-02-01 00:00:00

  • Sleep apnea in Machado-Joseph disease: a clinical and polysomnographic evaluation.

    abstract:OBJECTIVE/BACKGROUND:Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is the most common type of autosomal dominant spinocerebellar ataxia (SCA). Sleep disorders have been described as frequent non-motor symptoms in MJD, and with marked impairment on quality of life. However, few studies have evalua...

    journal_title:Sleep medicine

    pub_type: 杂志文章


    authors: Folha Santos FA,de Carvalho LBC,Prado LFD,do Prado GF,Barsottini OG,Pedroso JL

    更新日期:2018-08-01 00:00:00