Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors.

abstract：:Lung adenocarcinoma remains a threat to human health due to its high rate of recurrence and distant metastasis. However, the molecular mechanism underlying lung adenocarcinoma metastasis remains yet incompletely understood. Here, we show that upregulated expression of polypeptide N-acetylgalactosaminyltransferase6 (GA...

journal_title：Cell death & disease

authors： Song J,Liu W,Wang J,Hao J,Wang Y,You X,Du X,Zhou Y,Ben J,Zhang X,Ye M,Wang Q

更新日期：2020-05-11 00:00:00

abstract：:Procaspase-3-activating compound 1 (PAC-1) induces procaspase-3 activation via zinc chelation. However, whether PAC-1 employs other mechanisms remains unknown. Here we systematically screened for potent PAC-1 targets using 29 enhanced green fluorescent protein-labeled reporter cell lines and identified hypoxia-inducib...

journal_title：Cell death & disease

authors： Li F,Wei A,Bu L,Long L,Chen W,Wang C,Zhao C,Wang L

更新日期：2018-10-04 00:00:00

abstract：:Triple negative breast cancers (TNBC) are highly aggressive and lack specific targeted therapies. Recent studies have reported high expression of the transcription factor Kaiso in triple negative tumors, and this correlates with their increased aggressiveness. However, little is known about the clinical relevance of K...

journal_title：Cell death & disease

authors： Bassey-Archibong BI,Rayner LG,Hercules SM,Aarts CW,Dvorkin-Gheva A,Bramson JL,Hassell JA,Daniel JM

更新日期：2017-03-23 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) and natural killer cells (NK)-mediated elimination of tumor cells is mostly dependent on Granzyme B apoptotic pathway, which is regulated by the wild type (wt) p53 protein. Because TP53 inactivating mutations, frequently found in human tumors, could interfere with Granzyme B-mediated cell...

journal_title：Cell death & disease

authors： Chollat-Namy M,Ben Safta-Saadoun T,Haferssas D,Meurice G,Chouaib S,Thiery J

更新日期：2019-09-20 00:00:00

abstract：:Wnt signaling pathways are a highly conserved pathway, which plays an important role from the embryonic development to bone formation. The effect of Wnt pathway on osteogenesis relies on their cellular environment and the expression of target genes. However, the molecular mechanism of that remains unclear. On the basi...

journal_title：Cell death & disease

authors： Liu W,Liu Y,Guo T,Hu C,Luo H,Zhang L,Shi S,Cai T,Ding Y,Jin Y

更新日期：2013-03-14 00:00:00

abstract：:During reproductive life, the mammary epithelium undergoes consecutive cycles of proliferation, differentiation and apoptosis. Doing so relies on the retained proliferative capacity, prolonged lifespan and developmental potency of mammary stem cells (MaSCs). ΔNp63α, the predominant TP63 isoform in mammary epithelia, i...

journal_title：Cell death & disease

authors： DeCastro AJ,Dunphy KA,Hutchinson J,Balboni AL,Cherukuri P,Jerry DJ,DiRenzo J

更新日期：2013-02-28 00:00:00

abstract：:β-Catenin has been widely implicated in the regulation of mammalian development and cellular homeostasis. However, the mechanisms by which Wnt/β-catenin signaling components regulate physiological events during brain development remain undetermined. Inactivation of glycogen synthase kinase (GSK)-3β leads to β-catenin ...

journal_title：Cell death & disease

authors： Shin J,Shin Y,Oh SM,Yang H,Yu WJ,Lee JP,Huh SO,Lee SH,Suh YH,Chung S,Kim HS

更新日期：2014-10-16 00:00:00

abstract：:Reticular dysgenesis is a human severe combined immunodeficiency that is primarily characterized by profound neutropenia and lymphopenia. The condition is caused by mutations in the adenylate kinase 2 (AK2) gene, resulting in the loss of mitochondrial AK2 protein expression. AK2 regulates the homeostasis of mitochondr...

journal_title：Cell death & disease

authors： Six E,Lagresle-Peyrou C,Susini S,De Chappedelaine C,Sigrist N,Sadek H,Chouteau M,Cagnard N,Fontenay M,Hermine O,Chomienne C,Reynier P,Fischer A,André-Schmutz I,Gueguen N,Cavazzana M

更新日期：2015-08-13 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disease characterized by Lewy body formation and progressive dopaminergic neuron death in the substantia nigra (SN). Genetic susceptibility is a strong risk factor for PD. Previously, a rare gain-of-function variant of GLUD2 glutamate dehydrogenase (T1492G) was re...

journal_title：Cell death & disease

authors： Zhang W,Gong J,Ding L,Zhang Z,Pan X,Chen X,Guo W,Zhang X,Yang X,Peng G,Lin Y,Gao F,Li Y,Zhu X,Xuan A,Wang S,Sun X,Zhang Y,Xu P

更新日期：2020-10-22 00:00:00

abstract：:The development of nephrotoxicity largely limits the clinical use of chemotherapy. MiRNAs are able to target various genes and involved in the regulation of diverse cellular processes, including cell apoptosis and death. Our study showed that miR-181a expression was significantly increased after 5-fluorouracil (5-FU) ...

journal_title：Cell death & disease

authors： Liu XY,Zhang FR,Shang JY,Liu YY,Lv XF,Yuan JN,Zhang TT,Li K,Lin XC,Liu X,Lei Q,Fu XD,Zhou JG,Liang SJ

更新日期：2018-05-23 00:00:00

abstract：:Therapeutic adoptive transfer of natural regulatory T cells (nTreg, CD4+ CD25+ Foxp3+ T cells) or in vivo selective expansion of nTreg cells has been demonstrated to improve the cardiac function in various cardiovascular disease models. The differentiation of nTreg cells is mediated by catecholamines via β1-adrenergic...

journal_title：Cell death & disease

authors： Xu W,Wu Y,Wang L,Bai Y,Du Y,Li Y,Cao N,Zhao Y,Zhang Y,Liu H

更新日期：2019-02-15 00:00:00

abstract：:STAT1, which carries tumor suppressor functions in several models, consists of two isoforms, namely STAT1α and STAT1β. The biological function and significance of STAT1β has never been examined in human cancer. We examined STAT1β function in esophageal squamous cell carcinoma (ESCC) by transfecting a STAT1β gene into ...

journal_title：Cell death & disease

authors： Zhang Y,Chen Y,Yun H,Liu Z,Su M,Lai R

更新日期：2017-10-05 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common brain tumour, characterized by a central and partially necrotic (i.e., hypoxic) core enriched in cancer stem cells (CSCs). We previously showed that the most hypoxic and immature (i.e., CSCs) GBM cells were resistant to Temozolomide (TMZ) in vitro, owing to a particular...

journal_title：Cell death & disease

authors： Persano L,Pistollato F,Rampazzo E,Della Puppa A,Abbadi S,Frasson C,Volpin F,Indraccolo S,Scienza R,Basso G

更新日期：2012-10-18 00:00:00

abstract：:Diffuse intrinsic pontine gliomas (DIPG) are the most aggressive brain tumors in children with 5-year survival rates of only 2%. About 85% of all DIPG are characterized by a lysine-to-methionine substitution in histone 3, which leads to global H3K27 hypomethylation accompanied by H3K27 hyperacetylation. Hyperacetylati...

journal_title：Cell death & disease

authors： Wiese M,Hamdan FH,Kubiak K,Diederichs C,Gielen GH,Nussbaumer G,Carcaboso AM,Hulleman E,Johnsen SA,Kramm CM

更新日期：2020-08-21 00:00:00

abstract：:The naturally occurring polyamine spermidine (Spd) has recently been shown to promote longevity across species in an autophagy-dependent manner. Here, we demonstrate that Spd improves both survival and locomotor activity of the fruit fly Drosophila melanogaster upon exposure to the superoxide generator and neurotoxic ...

journal_title：Cell death & disease

authors： Minois N,Carmona-Gutierrez D,Bauer MA,Rockenfeller P,Eisenberg T,Brandhorst S,Sigrist SJ,Kroemer G,Madeo F

更新日期：2012-10-11 00:00:00

abstract：:Death-associated protein kinase 1 (DAPK1, DAPk, DAPK) is known for its involvement in apoptosis and autophagy-associated cell death. Here, we identified an unexpected function of DAPK1 in suppressing necroptosis. DAPK1-deficiency renders macrophages and dendritic cells susceptible to necroptotic death. We also observe...

journal_title：Cell death & disease

authors： Wu YH,Chou TF,Young L,Hsieh FY,Pan HY,Mo ST,Brown SB,Chen RH,Kimchi A,Lai MZ

更新日期：2020-05-04 00:00:00

abstract：:Emerging evidence has shown that the PIM serine/threonine kinase family, including PIM1, PIM2 and PIM3, is associated with tumour progression towards metastasis. PIM1, an attractive molecular target, has been identified as a potential prognostic biomarker for haematological and epithelial malignancies. However, to dat...

journal_title：Cell death & disease

authors： Zhao B,Liu L,Mao J,Zhang Z,Wang Q,Li Q

更新日期：2018-02-22 00:00:00

abstract：:Although increasing evidence indicated that deregulation of microRNAs (miRNAs) contributed to tumor initiation and progression, but little is known about the biological role of miR-340 in ovarian cancer (OC). In this study, we found that miR-340 expression was downregulated in OC tissues compared with its expression i...

journal_title：Cell death & disease

authors： Huang Z,Li Q,Luo K,Zhang Q,Geng J,Zhou X,Xu Y,Qian M,Zhang JA,Ji L,Wu J

更新日期：2019-05-08 00:00:00

abstract：:Cigarette smoking is one of the most important and preventable risk factors for atherosclerosis. However, because of the complex composition of cigarette smoke, the detailed pathophysiological mechanisms are not fully understood. Based on controversial reports on the pro-atherogenic activity of cigarette smoke condens...

journal_title：Cell death & disease

authors： Messner B,Frotschnig S,Steinacher-Nigisch A,Winter B,Eichmair E,Gebetsberger J,Schwaiger S,Ploner C,Laufer G,Bernhard D

更新日期：2012-11-15 00:00:00

abstract：:The multi-BCL-2 homology domain pro-apoptotic BCL-2 family members BAK and BAX have critical roles in apoptosis. They are essential for mitochondrial outer-membrane permeabilization, leading to the release of apoptogenic factors such as cytochrome-c, which promote activation of the caspase cascade and cellular demolit...

journal_title：Cell death & disease

authors： Ke F,Bouillet P,Kaufmann T,Strasser A,Kerr J,Voss AK

更新日期：2013-06-06 00:00:00

abstract：:Only a few types of inflammasomes have been described in central nervous system cells. Among these, the absent in melanoma 2 (AIM2) inflammasome is primarily found in neurons, is highly specific and can be activated only by double-stranded DNA. Although it has been demonstrated that the AIM2 inflammasome is activated ...

journal_title：Cell death & disease

authors： Yuan B,Zhou XM,You ZQ,Xu WD,Fan JM,Chen SJ,Han YL,Wu Q,Zhang X

更新日期：2020-01-30 00:00:00

abstract：:HIV-1 Nef protein has key roles at almost all stages of the viral life cycle. We assessed the role of the Nef/eEF1A (eukaryotic translation elongation factor 1-alpha) complex in nucleocytoplasmic shuttling in primary human macrophages. Nuclear retention experiments and inhibition of the exportin-t (Exp-t) pathway sugg...

journal_title：Cell death & disease

authors： Abbas W,Khan KA,Tripathy MK,Dichamp I,Keita M,Rohr O,Herbein G

更新日期：2012-04-05 00:00:00

abstract：:The mechanism of pathological osteogenesis in Ankylosing spondylitis (AS) is largely unknown. Our previous studies demonstrated that the imbalance between BMP-2 and Noggin secretion induces abnormal osteogenic differentiation of marrow-derived mesenchymal stem cells (MSCs) from AS patients in a two-dimensional culture...

journal_title：Cell death & disease

authors： Zheng G,Xie Z,Wang P,Li J,Li M,Cen S,Tang S,Liu W,Ye G,Li Y,Wang S,Wu X,Su H,Wu Y,Shen H

更新日期：2019-04-25 00:00:00

abstract：:The aberrant expression of long noncoding RNAs (lncRNAs) has been reported frequently in specific cancers, including high-grade serous ovarian cancer (HGSOC). The purpose of the present study was to explore the clinical significance and underlying mechanisms of a significantly dysregulated lncRNA (NEAT1) in HGSOC. Our...

journal_title：Cell death & disease

authors： Yong W,Yu D,Jun Z,Yachen D,Weiwei W,Midie X,Xingzhu J,Xiaohua W

更新日期：2018-08-28 00:00:00

abstract：:Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays important roles in regulating immune and metabolic homeostasis. Activation of the mechanistic target of rapamycin (mTOR) and hypoxia-inducible factor (HIF) transcription factors are crucial for the regulation of immune cell fu...

journal_title：Cell death & disease

authors： Zhu Q,Wang H,Jiang B,Ni X,Jiang L,Li C,Wang X,Zhang F,Ke B,Lu L

更新日期：2018-09-05 00:00:00

abstract：:The development of prostate cancer (PCa) from androgen-deprivation therapy (ADT) sensitive to castration resistant (CRPC) seriously impacts life quality and survival of PCa patients. Emerging evidence shows that long noncoding RNAs (lncRNAs) play vital roles in cancer initiation and progression. However, the inherited...

journal_title：Cell death & disease

authors： Yao M,Shi X,Li Y,Xiao Y,Butler W,Huang Y,Du L,Wu T,Bian X,Shi G,Ye D,Fu G,Wang J,Ren S

更新日期：2020-08-15 00:00:00

abstract：:Mounting evidence has revealed that impaired spiral artery remodeling, placental dysfunction, and inadequate trophoblast invasion are closely correlated with the etiology and pathogenesis of pre-eclampsia (PE). Moreover, defective trophoblast invasion may trigger poor maternal-fetal circulation and placental hypoxia, ...

journal_title：Cell death & disease

authors： Ou Y,Zhu L,Wei X,Bai S,Chen M,Chen H,Zhang J

更新日期：2020-06-25 00:00:00

abstract：:Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of several toxic and damaging molecules. These are necessary to figh...

journal_title：Cell death & disease

authors： Cauwels A,Rogge E,Vandendriessche B,Shiva S,Brouckaert P

更新日期：2014-03-06 00:00:00

abstract：:We previously showed that injury by partial duct ligation (PDL) in adult mouse pancreas activates Neurogenin 3 (Ngn3)(+) progenitor cells that can differentiate to β cells ex vivo. Here we evaluate the role of Ngn3(+) cells in β cell expansion in situ. PDL not only induced doubling of the β cell volume but also increa...

journal_title：Cell death & disease

authors： Van de Casteele M,Leuckx G,Baeyens L,Cai Y,Yuchi Y,Coppens V,De Groef S,Eriksson M,Svensson C,Ahlgren U,Ahnfelt-Rønne J,Madsen OD,Waisman A,Dor Y,Jensen JN,Heimberg H

更新日期：2013-03-07 00:00:00

abstract：:We explored the activity of SIRT1 activators (SRT501 and SRT2183) alone and in combination with panobinostat in a panel of malignant lymphoid cell lines in terms of biological and gene expression responses. SRT501 and SRT2183 induced growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and r...

journal_title：Cell death & disease

authors： Scuto A,Kirschbaum M,Buettner R,Kujawski M,Cermak JM,Atadja P,Jove R

更新日期：2013-05-16 00:00:00