Abstract：
:Sweet taste is a cue for calorie-rich food and is innately attractive to animals, including humans. In the context of modern diets, attraction to sweetness presents a significant challenge to human health. Most known sugars and sweeteners bind to the Venus Fly Trap domain of T1R2 subunit of the sweet taste heterodimer. Because the sweet taste receptor structure has not been experimentally solved yet, a possible approach to finding sweet molecules is virtual screening using compatibility of candidate molecules to homology models of sugar-binding site. Here, the constructed structural models, docking and scoring schemes were validated by their ability to rank known sweet-tasting compounds higher than properties-matched random molecules. The best performing models were next used in virtual screening, retrieving recently patented sweeteners and providing novel predictions.
journal_name
Food Chemjournal_title
Food chemistryauthors
Ben Shoshan-Galeczki Y,Niv MYdoi
10.1016/j.foodchem.2020.126286subject
Has Abstractpub_date
2020-06-15 00:00:00pages
126286eissn
0308-8146issn
1873-7072pii
S0308-8146(20)30134-5journal_volume
315pub_type
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