Abstract:
:Human coagulation factor XII (fXII), a serine protease synthesized in liver and active in plasma, is involved in a wide variety of functions, including blood coagulation, fibrinolysis, bradykinin and complement activation. A complementary DNA (597 bp) encoding amino acid -16 to amino acid 183 of fXII protein was used to determine the chromosomal location of the fXII gene. DNAs from hamster-human somatic cell hybrids were digested with restriction enzymes and hybridized with the fXII cDNA. By the Southern method it was shown that restriction fragments able to hybridize to fXII cDNA are present only in DNA extracted from clones retaining human chromosome 5.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Citarella F,Tripodi M,Fantoni A,Bernardi F,Romeo G,Rocchi Mdoi
10.1007/BF00273661subject
Has Abstractpub_date
1988-12-01 00:00:00pages
397-8issue
4eissn
0340-6717issn
1432-1203journal_volume
80pub_type
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