Assignment of human coagulation factor XII (fXII) to chromosome 5 by cDNA hybridization to DNA from somatic cell hybrids.

Abstract:

:Human coagulation factor XII (fXII), a serine protease synthesized in liver and active in plasma, is involved in a wide variety of functions, including blood coagulation, fibrinolysis, bradykinin and complement activation. A complementary DNA (597 bp) encoding amino acid -16 to amino acid 183 of fXII protein was used to determine the chromosomal location of the fXII gene. DNAs from hamster-human somatic cell hybrids were digested with restriction enzymes and hybridized with the fXII cDNA. By the Southern method it was shown that restriction fragments able to hybridize to fXII cDNA are present only in DNA extracted from clones retaining human chromosome 5.

journal_name

Hum Genet

journal_title

Human genetics

authors

Citarella F,Tripodi M,Fantoni A,Bernardi F,Romeo G,Rocchi M

doi

10.1007/BF00273661

subject

Has Abstract

pub_date

1988-12-01 00:00:00

pages

397-8

issue

4

eissn

0340-6717

issn

1432-1203

journal_volume

80

pub_type

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