Abstract:
:While the centrality of withdrawal in the diagnosis of addiction has been decreasing with each successive edition of the Diagnostic and Statistical Manual of Mental Disorders, psychometric and neurobiological evidence provides withdrawal a central role in the development and maintenance of addiction. The current study offers insight into these conflicting positions by using secondary analyses to assess how a history of DSM-assessed withdrawal influences the magnitude of bias in neural reactivity to drug- and/or food-related reward cues. To this end, we separated an existing sample of cocaine-dependent participants (Denomme et al., 2018) into those with (WD) and without (N-WD) a history of withdrawal, and compared food- and drug-cue reactivity between these groups, and to a non-dependent control group (ND). Analyses indicated that biases in neural reactivity towards drug- versus food-related cues only occurred among the WD participants (within: left dorsomedial prefrontal cortex, left anterior cingulate cortex, left orbitofrontal cortex, left caudate nucleus, and right ventrolateral prefrontal cortex). Thus, withdrawal status may be an important factor to consider when interpreting dependence-related biases in neural reactivity following reward-related cues. Interestingly, while N-WD participants did not show these broad biases in neural reactivity, the magnitude of their bias correlated positively with years of lifetime substance use history, particularly when psychopathic traits were low. It may be that for individuals who's addiction has not yet reached a compulsive state (see Wise and Koob, 2014), the magnitude of their drug > food bias could serve as a valuable biomarker of addiction severity.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Denomme WJ,Shane MSdoi
10.1016/j.drugalcdep.2019.107815subject
Has Abstractpub_date
2020-03-01 00:00:00pages
107815eissn
0376-8716issn
1879-0046pii
S0376-8716(19)30592-7journal_volume
208pub_type
杂志文章abstract::We aimed to study the prevalence patterns and course of benzodiazepine (BZD) abuse in an Israeli methadone maintenance (MMT) clinic using repeated random observed urine analysis as well as self-report data. Lifetime and current prevalence of BZD abuse were found in 66.3 and 50.8% patients, respectively. It was found t...
journal_title:Drug and alcohol dependence
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2012.04.018
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
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更新日期:2019-01-01 00:00:00
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2017.03.016
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,评审
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2007.09.008
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(85)90083-3
更新日期:1985-09-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2015.02.032
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2007.11.017
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2018.03.041
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2008.10.024
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,评审
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更新日期:2010-05-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(97)00037-9
更新日期:1997-06-06 00:00:00
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pub_type: 杂志文章
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