Ifosfamide, gemcitabine, and vinorelbine is an effective salvage regimen with excellent stem cell mobilization in relapsed or refractory pediatric Hodgkin lymphoma.

Abstract:

:We describe 12 pediatric patients (8-16 years) with primary refractory (N = 6) or first relapse (N = 6) Hodgkin lymphoma (HL) treated with ifosfamide, gemcitabine, and vinorelbine (IGEV). The overall response rate to IGEV was 100%, with seven (58%) complete responses (CR) and five (42%) partial responses. Successful CD34+ stem cell mobilization was achieved in all patients. Following subsequent autologous stem cell transplantation, 10 patients (83%) achieved CR. At a median follow-up of 71 months, 11 patients had no evidence of disease. Five-year second event-free survival and overall survival were 83% ± 11.0% and 90.0% ± 9.5%, respectively. IGEV is an effective salvage regimen for children with relapsed/refractory HL.

journal_name

Pediatr Blood Cancer

journal_title

Pediatric blood & cancer

authors

Marr K,Ronsley R,Nadel H,Douglas K,Gershony S,Strahlendorf C,Davis JH,Deyell RJ

doi

10.1002/pbc.28167

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

e28167

issue

4

eissn

1545-5009

issn

1545-5017

journal_volume

67

pub_type

临床试验,杂志文章
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