Abstract：
:The p53 family of transcription factors plays key roles in development, genome stability, senescence and tumor development, and p53 is the most important tumor suppressor protein in humans. Although intensively investigated for many years, its initial evolutionary history is not yet fully elucidated. Using bioinformatic and structure prediction methods on current databases containing newly-sequenced genomes and transcriptomes, we present a detailed characterization of p53 family homologs in remote members of the Holozoa group, in the unicellular clades Filasterea, Ichthyosporea and Corallochytrea. Moreover, we show that these newly characterized homologous sequences contain domains that can form structures with high similarity to the human p53 family DNA-binding domain, and some also show similarities to the oligomerization and SAM domains. The presence of these remote homologs demonstrates an ancient origin of the p53 protein family.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Bartas M,Brázda V,Červeň J,Pečinka Pdoi
10.3390/ijms21010006subject
Has Abstractpub_date
2019-12-18 00:00:00issue
1issn
1422-0067pii
ijms21010006journal_volume
21pub_type
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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pub_type： 杂志文章,meta分析,评审
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更新日期：2020-04-22 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2013-04-02 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21030937
更新日期：2020-01-31 00:00:00
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更新日期：2020-06-20 00:00:00
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更新日期：2019-03-14 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-11-30 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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