Abstract:
:We investigated risk factors for postoperative serious adverse events (SAEs) in elderly patients with preoperative chronic hypoxaemia undergone total hip arthroplasty (THA) or hemiarthroplasty and performed an implementation to modify and improve clinical outcome. A retrospective medical record review was performed to identify geriatric patients who receiving THA or hemiarthroplasty at a single university teaching hospital, Kunming, Yunnan, China between January 2009 and August 2017. Total of 450 elderly patients were included in the study. Data were collected on baseline characteristics, detailed treatments, and adverse events. Univariate and multivariate logistic regression analysis were used to identify risk factors for SAEs. In multivariate regression analysis, a higher occurrence of general anaesthesia and multiple episodes of hypotension were associated with higher risk of SAEs (general anesthesia: odds ratio [OR] 5.09, 95% confidence interval [CI] 1.96-13.24, P = 0.001; hypotension time: OR 4.29, 95% CI 1.66-11.10, P = 0.003). After the multidisciplinary implementation, the postoperative length of stay was decreased from 15 days to 10 days (P < 0.0001); incidence of SAEs was decreased from 21.1% to 7.0% (P = 0.002), and the all-cause mortality rate within 30 days decreased from 4.6% to 1.0% (P = 0.040). Our observational study demonstrated that an increasing application of general anaesthesia and longer time of hypotension were associated with an increased risk of postoperative SAEs in patients after THA or hemiarthroplasty. Additionally, optimizing stable haemodynamics under higher application of combined-spinal epidural anaesthesia was associated with improved outcome up to 30 days after THA or hemiarthroplasty.
journal_name
Sci Repjournal_title
Scientific reportsauthors
He L,Zhang R,Yin J,Zhang H,Bu W,Wang F,Zhang Fdoi
10.1038/s41598-019-55607-8subject
Has Abstractpub_date
2019-12-16 00:00:00pages
19145issue
1issn
2045-2322pii
10.1038/s41598-019-55607-8journal_volume
9pub_type
杂志文章abstract::The current study aims to evaluate the burden of disease in Singapore by estimating the quality-adjusted life years (QALYs) lost due to mental disorders and chronic physical conditions. The second Singapore Mental Health Study (SMHS-2016) was conducted in 2016 among 6126 respondents aged 18 years and above. The World ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59604-0
更新日期:2020-02-14 00:00:00
abstract::The distribution of Modic changes (MCs) in the lumbar endplates and the evaluation of the relationships between MCs and risk factors are vital for research into MCs. The T1-weighted and T2-weighted sagittal MRI scans of 210 patients who exhibited lumbar intervertebral disc degeneration were retrospectively reviewed. T...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46341
更新日期:2017-04-12 00:00:00
abstract::In response to environmental and nutrient stress, adipose tissues must establish a new homeostatic state. Here we show that cold exposure of obese mice triggers an adaptive tissue remodeling in visceral adipose tissue (VAT) that involves extracellular matrix deposition, angiogenesis, sympathetic innervation, and adipo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45354-1
更新日期:2019-06-20 00:00:00
abstract::Information spreading in complex networks is often modeled as diffusing information with certain probability from nodes that possess it to their neighbors that do not. Information cascades are triggered when the activation of a set of initial nodes - seeds - results in diffusion to large number of nodes. Here, several...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00937-8
更新日期:2017-04-18 00:00:00
abstract::Despite phages' ubiquitous presence and great importance in shaping microbial communities, little is known about the diversity of specific phages in different ecological niches. Here, we isolated, sequenced, and characterized 38 Escherichia coli-infecting phages (coliphages) from poultry faeces to gain a better unders...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72177-2
更新日期:2020-09-16 00:00:00
abstract::Our understanding of the interaction between the gut microbiota and host health has recently improved dramatically. However, the effects of toxic metal exposure on the gut microbiota remain poorly characterized. As this microbiota creates a critical interface between the external environment and the host's cells, it m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24931-w
更新日期:2018-04-26 00:00:00
abstract::We present and demonstrate an approach for femtosecond laser processing by using patterned vector optical fields (PVOFs) composed of multiple individual vector optical fields. The PVOFs can be flexibly engineered due to the diversity of individual vector optical fields in spatial arrangement and distribution of states...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02281
更新日期:2013-01-01 00:00:00
abstract::An effective metal oxide coating with solution processes by the metal organic decomposition method as deposited at room temperature (RT) poses great challenge. In this study, we report the characterization and evaluation of the semiconductor properties of a zinc hydroxide thin film with RT just as deposition by soluti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27953-6
更新日期:2018-07-20 00:00:00
abstract::The standardization of apiceutical products like as propolis extracts has been widely debated worldwide and variations in the propolis chemical composition are still very relevant topics for use-standardized of different propolis-type as medication by much of the world's population. The present manuscript discuss impo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54591-3
更新日期:2019-12-04 00:00:00
abstract::L-Asparaginase (L-asparagine aminohydrolase, E.C. 3.5.1.1) has been proven to be competent in treating Acute Lymphoblastic Leukaemia (ALL), which is widely observed in paediatric and adult groups. Currently, clinical L-Asparaginase formulations are derived from bacterial sources such as Escherichia coli and Erwinia ch...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38094-1
更新日期:2019-02-05 00:00:00
abstract::Alternative splicing contributes to phenotypic diversity at multiple biological scales, and its dysregulation is implicated in both ageing and age-associated diseases in human. Cross-tissue variability in splicing further complicates its links to age-associated phenotypes and elucidating these links requires a compreh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29086-2
更新日期:2018-07-19 00:00:00
abstract::Modelling the biokinetics of radionuclide excretion or retention is important in nuclear medicine and following accidental/malicious radioactivity releases. Sums of discrete exponential decay rates are often used, but we hypothesized that continuous probability distributions (CPD) of decay rates can describe the data ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38046-9
更新日期:2019-02-04 00:00:00
abstract::Finger-oximeters are ubiquitously used for patient monitoring in hospitals worldwide. Recently, remote measurement of arterial blood oxygenation (SpO2) with a camera has been demonstrated. Both contact and remote measurements, however, require the subject to remain static for accurate SpO2 values. This is due to the u...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38609
更新日期:2016-12-07 00:00:00
abstract::In the paradigm of materials informatics for accelerated materials discovery, the choice of feature set (i.e. attributes that capture aspects of structure, chemistry and/or bonding) is critical. Ideally, the feature sets should provide a simple physical basis for extracting major structural and chemical trends and fur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13285
更新日期:2015-08-25 00:00:00
abstract::It has been hypothesised that speed information, encoded by 'speed cells', is important for updating spatial representation in the hippocampus and entorhinal cortex to reflect ongoing self-movement during locomotion. However, systematic characterisation of speed representation is still lacking. In this study, we compa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58194-1
更新日期:2020-01-29 00:00:00
abstract::F-box and WD40 domain protein 7 (FBXW7) is a component of the SKP1-CUL1-F-box protein (SCF) complex that mediates the ubiquitination of diverse oncogenic target proteins. The exploration of FBXW7 mutations in human primary cancer has revealed three mutation hotspots at conserved arginine residues (Arg465, Arg479, and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19769-1
更新日期:2018-01-31 00:00:00
abstract::Previous studies have documented that decompression led to endothelial dysfunction with controversial results. This study aimed to clarify the relationship between endothelial dysfunction, bubble formation and decompression rate. Rats were subjected to simulated air dives with one of four decompression rates: one slow...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33390
更新日期:2016-09-12 00:00:00
abstract::Most Group I Clostridium botulinum strains harbor botulinum neurotoxin (bont) genes on their chromosome, while some carry these genes (including bont/a, bont/b, and bont/f) on large plasmids. Prior work in our laboratory demonstrated that Group I BoNT plasmids were mobilized to C. botulinum recipient strains containin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21342-9
更新日期:2018-02-15 00:00:00
abstract::Local communities are assembled from larger-scale species pools via dispersal, environmental filtering, biotic interactions, and local stochastic demographic processes. The relative importance, scaling and interplay of these assembly processes can be elucidated by comparing local communities to variously circumscribed...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09337
更新日期:2015-03-23 00:00:00
abstract::Coincident climatic and human effects strongly influence water-quality properties in estuarine-coastal ecosystems around the world. Time-series data for a number of ecosystems reveal high spatio-temporal variability superimposed on secular trends traceable to nutrient over-enrichment. In this paper, we present new ana...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43036-6
更新日期:2019-04-30 00:00:00
abstract::The study aimed at investigating the extent to which the brain adaptively exploits or compensates interaction torque (IT) during movement control in various velocity and load conditions. Participants performed arm pointing movements toward a horizontal plane without a prescribed reach endpoint at slow, neutral and rap...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38845
更新日期:2016-12-12 00:00:00
abstract::Most biodiesel currently in use consists of fatty acid methyl esters (FAMEs) produced by transesterification of plant oils with methanol. To reduce competition with food supplies, it would be desirable to directly produce biodiesel in microorganisms. To date, the most effective pathway for the production of biodiesel ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24239
更新日期:2016-04-07 00:00:00
abstract::In this study, we made a comparative efficacy and safety assessment of two different fixed combinations of drugs, viz., tafluprost/timolol (TAF/TIM) and latanoprost/carteolol (LAT/CAR), by determining their effects on intraocular pressure (IOP) in ocular normotensive monkeys and examining their toxic effects on ocular...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44028-2
更新日期:2019-05-16 00:00:00
abstract::Uterosacral ligaments (USLs) provide structural support to the female pelvic floor, and a loss of USL structural integrity or biomechanical function may induce pelvic organ prolapse (POP). Alterations in extracellular matrix composition and organization dictate USL mechanical function. Changes in USL microstructure an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64192-0
更新日期:2020-04-30 00:00:00
abstract::The prognosis of pancreatic cancer remains dismal, with little advance in chemotherapy because of its high frequency of chemoresistance. Metformin is widely used to treat type II diabetes, and was shown recently to inhibit pancreatic cancer stem cell proliferation. In the present study, we investigated the role of met...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14404
更新日期:2015-09-22 00:00:00
abstract::The controllability of a network is a theoretical problem of relevance in a variety of contexts ranging from financial markets to the brain. Until now, network controllability has been characterized only on isolated networks, while the vast majority of complex systems are formed by multilayer networks. Here we build a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20706
更新日期:2016-02-12 00:00:00
abstract::Converging evidence supports the involvement of pro-inflammatory pathways and the gut microbiome in major depressive disorder (MDD). Pre-clinical and clinical studies suggest that decreasing pro-inflammatory signaling may provide clinical benefit in MDD. In this study, we used the chronic unpredictable stress (CUS) pa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38055-8
更新日期:2019-04-23 00:00:00
abstract::Upon illumination, a dielectric microsphere (μS) can generate a photonic nanojet (PNJ), which plays a role in the super-resolution imaging of a sample placed in the μS's immediate proximity. Recent microscopy implementations pioneered this concept but, despite the experimental characterization and theoretical modeling...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33604-7
更新日期:2018-10-12 00:00:00
abstract::Scleroderma is a refractory autoimmune skin fibrotic disorder. Alterations of microRNAs in lesional skin could be a new approach to treating the disease. Here, we found that expression of miR-155 was up regulated in lesional skin tissue from patients with either systemic or localized scleroderma, and correlated with f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20314
更新日期:2016-02-01 00:00:00
abstract::Given that observational associations may be inaccurate, we used offspring blood pressure (BP) to provide alternative estimates of the associations between own BP and mortality. Observational associations between BP and mortality, estimated as hazard ratios (HRs) from Cox regression, were compared to HRs obtained usin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12399
更新日期:2015-07-22 00:00:00