当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Novel tamarind seed gum-alginate based multi-particulates for sustained release of dalfampridine using response surface methodology.

Novel tamarind seed gum-alginate based multi-particulates for sustained release of dalfampridine using response surface methodology.

Abstract：

:The current study involves development of novel tamarind seed gum - alginate complex microspheres for sustained release of dalfampridine by using Central Composite design in combination with response surface methodology. Polymer ratio (A), agitation speed (B) and concentration of CaCl2 (C) were selected as independent variables. Dalfampridine loaded microspheres are prepared by ionotropic gelation technique and were evaluated for responses. The software numerical optimization process, surface and contour plots predicted the level of independent variables A, B and C (2.6, 800.412 rpm and 1.1%w/w respectively), for maximum response of drug entrapment efficiency (86.09%), controlled release of drug at 1 h, 6 h, 12 h (29.84%, 67.92%, 86.42%) and optimized particle size (613.212 μm) respectively. Low magnitude of relative error for the optimized formulation confirms the validation of model. Optimized formulation was characterized for compatibility by Fourier Transform infrared spectroscopy and Differential scanning calorimetry. The drug release data was best fitted by first order and Higuchi square root model with non-Fickian diffusion kinetics. Therefore, such an attempt of fabrication of dalfampridine multi-particulates system by using tamarind seed gum and sodium alginate may be useful in a better way, for sustaining the release of drug over 12 h.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Doniparthi J,B JJ

doi

10.1016/j.ijbiomac.2019.11.203

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

725-741

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)36949-1

journal_volume

144

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Purification, physico-chemical characterization and thermodynamics of chitooligosaccharide binding to cucumber (Cucumis sativus) phloem lectin.

    abstract：:A chitooligosaccharide-specific lectin has been purified from the phloem exudate of cucumber (Cucumis sativus) by affinity chromatography on chitin. The molecular weight of the cucumber phloem lectin (CPL) was determined as 51912.8Da by mass spectrometry whereas SDS-PAGE yielded a single band with a subunit mass of 26...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.10.078

    authors： Nareddy PK,Bobbili KB,Swamy MJ

    更新日期：2017-02-01 00:00:00

  • Green synthesis of biopolymer-silver nanoparticle nanocomposite: an optical sensor for ammonia detection.

    abstract：:Biopolymer used for the production of nanoparticles (NPs) has attracted increasing attention. In the presence article we use aqueous solution of polysaccharide Cyamopsis tetragonaloba commonly known as guar gum (GG), from plants. GG acts as reductive preparation of silver nanoparticles which are found to be <10 nm in ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.06.033

    authors： Pandey S,Goswami GK,Nanda KK

    更新日期：2012-11-01 00:00:00

  • Chitosan-alginate immobilized lipase based catalytic constructs: Development, characterization and potential applications.

    abstract：:In this study, lipase (LIP) was isolated from Aspergillus crevinus, statistically optimized and purified via ammonium sulfate fractionation (ASF), and Sephadex G-100 gel permeation chromatography. LIP was 2.26-folds purified with a specific activity of 223.60 U/mg. The molecular mass was estimated to be 60 kDa on sodi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.07.192

    authors： Rashid R,Anwar Z,Zafar M,Rashid T,Butt I

    更新日期：2018-11-01 00:00:00

  • Inhibition of methemoglobin formation in aqueous solutions under aerobic conditions by the addition of amino acids.

    abstract：:Hemoglobin (Hb) as an important iron-containing oxygen-transport protein is easily oxidized to the ferric met-form, methemoglobin (metHb), and loses the capacity of binding oxygen during storage. In this study, the experimental data indicate that the presence of Tyr and Glu significantly suppress the metHb formation i...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.12.010

    authors： Wei Y,Li C,Zhang L,Su Z,Xu X

    更新日期：2014-03-01 00:00:00

  • Production and characterization of exopolysaccharides from Chlorella zofingiensis and Chlorella vulgaris with anti-colorectal cancer activity.

    abstract：:The production, physicochemical characteristics, antioxidant and antitumor activities of partial purified exopolysaccharides from Chlorella zofingiensis, Chlorella vulgaris were investigated. The final exopolysaccharides productions were 208.4, 364.3 mg/L and the average molecular weights were 2.66×104, 1.88×104 Da, r...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.05.117

    authors： Zhang J,Liu L,Chen F

    更新日期：2019-08-01 00:00:00

  • Stabilization of collagen using plant polyphenol: role of catechin.

    abstract：:Collagen, a unique connective tissue protein finds extensive application as biocompatible biomaterial in wound healing, as drug carriers, cosmetics, etc. A work has been undertaken to study the stabilization of type I collagen using the plant polyphenol catechin. Catechin treated collagen fibres showed a shrinkage tem...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2005.08.005

    authors： Madhan B,Subramanian V,Rao JR,Nair BU,Ramasami T

    更新日期：2005-10-30 00:00:00

  • Entrapment of carbon dioxide with chitosan-based core-shell particles containing changeable cores.

    abstract：:Water-soluble chitosan-based core-shell particles that contained changeable cores were successfully applied to anchor carbon dioxide. The entrapment capacity of the particles for carbon dioxide (EC) depended on the cores. It was found that EC of the particles contained aqueous cores was higher than that of the beads w...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.05.022

    authors： Dong Y,Fu Y,Lin X,Xiao C

    更新日期：2016-08-01 00:00:00

  • The xylose-rich pectins from pea hulls.

    abstract：:The hot acid extract of pea hull, HSP, was rich in galacturonic acid, arabinose and xylose. It was fractionated by copper precipitation followed by ion-exchange chromatography. The copper-soluble fraction represented 26% of HSP and was mostly composed of an arabinan with a low degree of branching, some heteroxylans an...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(97)00055-x

    authors： Renard CM,Weightman RM,Thibault JF

    更新日期：1997-08-01 00:00:00

  • Chromium (III) coordination capacity of chitosan.

    abstract：:Polycationic chitosan has a strong coordination to heavy metal ions due to its multifunctional hydroxyl and amino groups. However, due to the fast and facile dissolution of chitosan in acidic medium, it is difficult to measure the exact adsorption amount or coordination capacity accurately. In this work, a simple meth...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.01.203

    authors： Ganglo C,Rui J,Zhu Q,Shan J,Wang Z,Su F,Liu D,Xu J,Guo M,Qian J

    更新日期：2020-04-01 00:00:00

  • Methylglyoxal induced glycation and aggregation of human serum albumin: Biochemical and biophysical approach.

    abstract：:Serum protein glycation and formation of advanced glycation end products (AGEs) correlates with many diseases viz. diabetes signifying the importance of studying the glycation pattern of serum proteins. In our present study, methylglyoxal was investigated for its effect on the structure of human serum albumin (HSA); e...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.02.137

    authors： Ahmed A,Shamsi A,Khan MS,Husain FM,Bano B

    更新日期：2018-07-01 00:00:00

  • Characterization of sodium caseinate/Hydroxypropyl methylcellulose concentrated emulsions: Effect of mixing ratio, concentration and wax addition.

    abstract：:The effects of mixing ratio (1:1, 2:1 and 4:1 sodium caseinate: Hydroxypropyl methylcellulose, CN:HPMC), HPMC concentration (0, 0.6 and 1.2 wt%), CN concentration (0, 1.25 and 2.5) and beeswax addition (3%) on the physical stability of concentrated O/W emulsions (φoil = 0.6) were investigated. The emulsion stability, ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.01.208

    authors： Alizadeh L,Abdolmaleki K,Nayebzadeh K,Bahmaei M

    更新日期：2019-05-01 00:00:00

  • Isolation, purification, characterization, and antioxidant activity of low-molecular-weight polysaccharides from Sparassis latifolia.

    abstract：:Six polysaccharides (SF-FB11, SF-HW21, SF-CA31, SF-HA41, SF-FF51, and SF-FR61) of similar molecular weights (MW) (30-50 kDa) were extracted from the fermentation liquor, mycelia, and basidiomata of Sparassis latifolia by different methods. Structural analyses of these purified polysaccharides indicated that they were ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.06.177

    authors： Duan GL,Yu XB

    更新日期：2019-09-15 00:00:00

  • Betaine conjugated cationic pullulan as effective gene carrier.

    abstract：:Polyethyleneimne (PEI) is a very efficient transfecting agent but is toxic due to high charge density. To generate a vector which is efficient and less cytotoxic, PEI was conjugated with pullulan (PPEI). Further conjugation was done on PPEI with zwitter ionic betaine which possess antifouling property. PEI of molecula...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.09.043

    authors： Ambattu LA,Rekha MR

    更新日期：2015-01-01 00:00:00

  • A novel GH16 beta-agarase isolated from a marine bacterium, Microbulbifer sp. BN3 and its characterization and high-level expression in Pichia pastoris.

    abstract：:An agar-degrading bacterium, strain BN3, was isolated from a coastal soil sample collected in Taiwan Strait, China and identified to be a novel species of the genus Microbulbifer. The gene (N3-1) encoding for a novel β-agarase from the isolate was cloned and sequenced. It encoded a mature protein with 274 amino acids ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.08.053

    authors： Li RK,Chen Z,Ying XJ,Ng TB,Ye XY

    更新日期：2018-11-01 00:00:00

  • Fructose restrains fibrillogenesis in human serum albumin.

    abstract：:The endogenous deposition of protein aggregates with fibrillar morphology is known to govern the genesis of several neurodisorders. The investigation of naturally occurring small molecules which can restrict the fibrillation process can help in the design of rational therapeutics for neurodegenerative diseases. We rep...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.08.006

    authors： Pandey NK,Ghosh S,Dasgupta S

    更新日期：2013-10-01 00:00:00

  • Three flavanols delay starch digestion by inhibiting α-amylase and binding with starch.

    abstract：:The study aimed to reveal the different mechanisms of delaying starch digestion by ECG, EGCG and Procyanidin based on the perspective of α-amylase-flavanol interaction and starch-flavanol interaction. The interaction characteristics of flavanols with α-amylase were studied from five aspects: enzyme inhibition, kinetic...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2021.01.070

    authors： Jiang C,Chen Y,Ye X,Wang L,Shao J,Jing H,Jiang C,Wang H,Ma C

    更新日期：2021-01-15 00:00:00

  • Role of 13-(di)phenylalkyl berberine derivatives in the modulation of the activity of human topoisomerase IB.

    abstract：:Topoisomerases IB are anticancer and antimicrobial targets whose inhibition by several natural and non-natural compounds has been documented. The inhibition effect by berberine and some 13-(di)phenylalkyl berberine derivatives has been tested towards human topoisomerase IB. Derivatives belonging to the 13-diphenylalky...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.02.051

    authors： Vieira S,Castelli S,Falconi M,Takarada J,Fiorillo G,Buzzetti F,Lombardi P,Desideri A

    更新日期：2015-01-01 00:00:00

  • Novel insights into the treatment of SARS-CoV-2 infection: An overview of current clinical trials.

    abstract：:The emergence of the global pandemic caused by the novel SARS-CoV-2 virus has motivated scientists to find a definitive treatment or a vaccine against it in the shortest possible time. Current efforts towards this goal remain fruitless without a full understanding of the behavior of the virus and its adaptor proteins....

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2020.09.204

    authors： Oroojalian F,Haghbin A,Baradaran B,Hemmat N,Shahbazi MA,Baghi HB,Mokhtarzadeh A,Hamblin MR

    更新日期：2020-12-15 00:00:00

  • Chemical properties and antioxidant activity of a water-soluble polysaccharide from Dendrobium officinale.

    abstract：:In this report, a water-soluble polysaccharide was obtained from the dried stems of Dendrobium officinale Kimura et Migo by hot-water (70-75°C) extraction and 85% ethanol precipitation, and successively purification by DEAE-cellulose anion-exchange chromatography and gel-permeation chromatography. The D. officinale po...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.04.067

    authors： Luo QL,Tang ZH,Zhang XF,Zhong YH,Yao SZ,Wang LS,Lin CW,Luo X

    更新日期：2016-08-01 00:00:00

  • Anti-psoriatic and toxicity evaluation of methotrexate loaded chitin nanogel in imiquimod induced mice model.

    abstract：:Methotrexate loaded chitin nanogel (MCNG) was formulated for its topical use in psoriasis. MCNG was characterized by DLS, TEM and FTIR. The MCNG particles were spherical in shape with size of 196±14nm, having surface charge of +9.21±0.42 mv. MCNG exhibited greater swelling and drug release at acidic pH than neutral an...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.10.112

    authors： Panonnummal R,Sabitha M

    更新日期：2018-04-15 00:00:00

  • Hydrophobic starch nanocrystals preparations through crosslinking modification using citric acid.

    abstract：:Biodegradable starch nanocrystals prepared by an acid treatment process were modified through crosslinking modification using citric acid as reactant by a dry reaction method. The occurrence of crosslinking modification was evaluated by Fourier transform infrared spectroscopy and swelling degree. X-ray diffraction, we...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.06.082

    authors： Zhou J,Tong J,Su X,Ren L

    更新日期：2016-10-01 00:00:00

  • Observation of in vitro cellulose synthesis by bacterial cellulose synthase with time-resolved small angle X-ray scattering.

    abstract：:Cellulose synthase is the enzyme that produces cellulose in the living organisms like plant, and has two functions: polymerizing glucose residues (polymerization) and assembling these polymerized molecules into a crystalline microfibril with a "cellulose I" crystallographic structure (crystallization). Many studies, h...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.02.167

    authors： Tajima H,Penttilä PA,Imai T,Yamamoto K,Yuguchi Y

    更新日期：2019-06-01 00:00:00

  • Development and characterization of an LDPE/chitosan composite antimicrobial film for chilled fish storage.

    abstract：:An antimicrobial packaging material was developed by uniformly embedding 1, 3 and 5% chitosan (w/w) in low density polyethylene matrix using maleic anhydride grafted LDPE as a compatible agent. The materials were mixed by compounding and blown into monolayer films via blown film extrusion. The developed films showed g...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.06.016

    authors： Reesha KV,Panda SK,Bindu J,Varghese TO

    更新日期：2015-08-01 00:00:00

  • Structural characterization of an immunostimulating polysaccharide from the stems of a new medicinal Dendrobium species: Dendrobium Taiseed Tosnobile.

    abstract：:Dendrobium Taiseed Tosnobile, a new Dendrobium species developed by crossbreeding Dendrobium tosaense and Dendrobium nobile, exhibits the characteristics of high mass production and high polysaccharide content. This study investigated the structural characterization and immunostimulating effects of a polysaccharide is...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.05.185

    authors： Yang LC,Hsieh CC,Wen CL,Chiu CH,Lin WC

    更新日期：2017-10-01 00:00:00

  • Immobilization and stabilization of cholesterol oxidase on modified sepharose particles.

    abstract：:For the cholesterol oxidase from Brevibacterium sp. M201008 was not stable as free enzyme form, it had been covalently immobilized onto functionalized sepharose particles that were activated with N-ethyl-N'-3-dimethylaminopropyl carbodiimide (EDC).The optimal conditions of enzyme immobilization were determined, and th...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.01.026

    authors： Chen Y,Xin Y,Yang H,Zhang L,Zhang Y,Xia X,Tong Y,Wang W

    更新日期：2013-05-01 00:00:00

  • Covalent immobilization of chitosan and heparin on PLGA surface.

    abstract：:Chitosan and heparin were covalently immobilized onto a poly(lactic acid-co-glycolic acid) (PLGA) surface using N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide (EDC), N-hydroxysuccinimide (NHS) in a 2-morpholinoethane sulfonic acid (MES) buffer system. The properties of the modified PLGA surface and the control were in...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(03)00072-2

    authors： Wang XH,Li DP,Wang WJ,Feng QL,Cui FZ,Xu YX,Song XH

    更新日期：2003-11-01 00:00:00

  • Extractions and rheological properties of polysaccharide from okra pulp under mild conditions.

    abstract：:This study investigated the extraction of polysaccharide from okra pulp (POP), its chemical components, and rheological properties. The results showed that the optimal extraction temperature, time, and the ration of water to material were 20-30 °C, 30 mins, and 150, respectively, giving a maximum yield of 29.4%. The P...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2020.01.163

    authors： Li Y,Wang X,Lv X,Wang X,Wang X,Cui J,Yan M

    更新日期：2020-04-01 00:00:00

  • Bioinspired sodium alginate based thermosensitive hydrogel membranes for accelerated wound healing.

    abstract：:Despite substantial progress made in the development of wound dressings, wound management remains a great challenge, which compels significant burden to the patient and healthcare system. Owing to its intricate pathophysiology particularly, wounds with bacterial burden impose substantial challenges to the conventional...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.03.248

    authors： Abbasi AR,Sohail M,Minhas MU,Khaliq T,Kousar M,Khan S,Hussain Z,Munir A

    更新日期：2020-07-15 00:00:00

  • Mitochondrial genomes and 28S rDNA contradict the proposed obsoletion of the order Tetraonchidea (Platyhelminthes: Monogenea).

    abstract：:Due to the incongruence of morphology-based hypotheses and scarcity of molecular data, validity of the order Tetraonchidea remains contentious. The only complete mitogenome currently available for the entire order is that of Paratetraonchoides inermis (Tetraonchoididae). To study the phylogeny of Tetraonchidea from mi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.09.150

    authors： Zhang D,Li WX,Zou H,Wu SG,Li M,Jakovlić I,Zhang J,Chen R,Wang GT

    更新日期：2020-01-15 00:00:00

  • Influence of temperature, mono- and divalent cations on dilute solution properties of sage seed gum.

    abstract：:The functional properties of food hydrocolloids are remarkably affected by the quality of solvent/cosolutes and temperature in a food system. In this paper, dilute solution properties of sage seed gum (SSG) as a function of salt type (NaCl, KCl, MgCl2 and CaCl2), salt concentration (10, 50, 100 and 200mM) and temperat...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.03.026

    authors： Yousefi AR,Razavi SM,Khodabakhsh Aghdam SH

    更新日期：2014-06-01 00:00:00