The bovine Lactoferrin-Osteopontin complex increases proliferation of human intestinal epithelial cells by activating the PI3K/Akt signaling pathway.

Abstract:

:Lactoferrin (LF) and osteopontin (OPN), multifunctional proteins involved in cell proliferation, can form a complex. LF binds iron, whereas OPN binds calcium. We investigated whether iron- and calcium-binding influences complex formation and the pro-proliferation property of the LF-OPN complex, and the mechanism behind this effect. LF-OPN complexes were prepared using bovine milk LF and OPN, and effects on proliferation of human intestinal epithelial cells (HIECs) were evaluated using a BrdU proliferation assay. Of the four complexes formed by apo- and holo-LF/OPN, the apo-Lf&holo-OPN complex (AH) exhibited the strongest pro-proliferative effect on HIECs, and we therefore focused on AH. AH was resistant to in vitro gastrointestinal digestion, co-localized with both LF and OPN receptors as revealed by confocal microscopy, and stimulated proliferation of HIECs by activating PI3K/Akt signaling. In conclusion, forming a LF-OPN complex may help both proteins to resist digestion and increase the capacity to promote intestinal development in infants.

journal_name

Food Chem

journal_title

Food chemistry

authors

Liu L,Jiang R,Liu J,Lönnerdal B

doi

10.1016/j.foodchem.2019.125919

subject

Has Abstract

pub_date

2020-04-25 00:00:00

pages

125919

eissn

0308-8146

issn

1873-7072

pii

S0308-8146(19)32057-6

journal_volume

310

pub_type

杂志文章
  • Fast and simple method of simultaneous preservative determination in different processed foods by QuEChERS and HPLC-UV: Method development, survey and estimate of daily intake.

    abstract::A fast and simple method, which employs QuEChERS and HPLC-UV, was developed to determine preservatives in processed foods from different classes. The method showed correlation coefficients above 0.99, LOQs between 0.13 and 0.33 mg kg-1 and recoveries between 91 and 107%, with RSD ≤ 5.3%. Levels of preservatives were u...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2019.04.094

    authors: de Oliveira Arias JL,Rocha CB,Santos ALQS,Marube LC,Kupski L,Caldas SS,Primel EG

    更新日期:2019-09-30 00:00:00

  • Determination of volatile organic compounds, catechins, caffeine and theanine in Jukro tea at three growth stages by chromatographic and spectrometric methods.

    abstract::Tea contains characteristic volatile organic compounds, polyphenols, caffeine and catechins, and is therefore among the most widely consumed beverages all over the world. In this study, fresh Jukro tea leaves collected from Damyang-gun (Jeollanam-do) at 40, 60 and 90day growth stages, were semi-fermented. The volatile...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2016.09.184

    authors: Jeon DB,Hong YS,Lee GH,Park YM,Lee CM,Nho EY,Choi JY,Jamila N,Khan N,Kim KS

    更新日期:2017-03-15 00:00:00

  • Determination of nitrofurans metabolites residues in aquatic products by ultra-performance liquid chromatography-tandem mass spectrometry.

    abstract::A method was described for monitoring four nitrofuran metabolites including 5-methylmorpholino-3-amino-2-oxazolidinone (AMOZ), 3-amino-2-oxazolidone (AOZ), 1-amino-hydantoin (AHD) and semicarbazide (SEM) in aquatic products. The analytes were quantified by ultra-performance liquid chromatography-tandem mass spectromet...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2015.07.035

    authors: Zhang Y,Qiao H,Chen C,Wang Z,Xia X

    更新日期:2016-02-01 00:00:00

  • Sunlight exclusion from Muscat grape alters volatile profiles during berry development.

    abstract::The effects of sunlight exclusion on the volatile profiles of grapes during different stages of berry development were investigated by placing clusters of grapes in special boxes. Terpenes and aldehydes were the main volatile compounds in the ripe 'Jingxiangyu' berries. Sunlight exclusion was found to change volatile ...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2014.05.012

    authors: Zhang H,Fan P,Liu C,Wu B,Li S,Liang Z

    更新日期:2014-12-01 00:00:00

  • Dynamic modeling of in vitro lipid digestion: individual fatty acid release and bioaccessibility kinetics.

    abstract::The aim of this study was to gain knowledge about the role of triacylglycerol (TAG) composition in fatty acids (FA) of o/w emulsions on both the pancreatic lipolysis kinetics and the bioaccessibility of released products (i.e. contained within the bile salt micellar phase). A mathematical model was developed and its p...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2015.08.125

    authors: Giang TM,Gaucel S,Brestaz P,Anton M,Meynier A,Trelea IC,Le Feunteun S

    更新日期:2016-03-01 00:00:00

  • Large-scale multi-class herbicides analysis in oilseeds by rapid one-step QuEChERS-based extraction and cleanup method using liquid chromatography-tandem mass spectrometry.

    abstract::A simple, sensitive and rapid method is proposed for simultaneous determination of 120 various classes of herbicides in oilseed samples. A one-step QuEChERS-based approach to extraction and cleanup has been developed. LC-MS/MS was used to evaluate the proposed sample treatment methodologies. The new one-step QuEChERS ...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2017.03.076

    authors: Kaczyński P

    更新日期:2017-09-01 00:00:00

  • From malt to wheat beer: A comprehensive multi-toxin screening, transfer assessment and its influence on basic fermentation parameters.

    abstract::The aim was to determine the mycotoxin transfer rate into beer during a semi-industrial production process and the effect of fungicide treatment in the field on mycotoxins concentrations in beer. To ensure the usual practical agronomical conditions, sample A was treated with fungicide Prosaro® 250, and sample B was in...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2018.02.005

    authors: Mastanjević K,Šarkanj B,Krska R,Sulyok M,Warth B,Mastanjević K,Šantek B,Krstanović V

    更新日期:2018-07-15 00:00:00

  • Experimental approaches for the estimation of uncertainty in analysis of trace inorganic contaminants in foodstuffs by ICP-MS.

    abstract::Total Diet Studies to estimate dietary exposure to food contaminants need to evaluate laboratory measurements data variance. In this process it is critical that data from analytical methods are reliable to correctly scrutinize and compare values over time and between countries. In Europe it is widely recognized that t...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2013.03.040

    authors: Coelho I,Gueifão S,Matos AS,Roe M,Castanheira I

    更新日期:2013-11-01 00:00:00

  • Utilization of watermelon pulp for lycopene extraction by response surface methodology.

    abstract::Lycopene extraction was optimized from watermelon pulp using response surface methodology using independent variables:solvent/meal ratio (4:1-12:1v/w), number of extractions (1-5), temperature (20-60°C) and extraction time (4-20min). Watermelon pulp had 59.95mglycopene/100g on fresh weight basis. The experimental valu...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2017.04.038

    authors: Oberoi DPS,Sogi DS

    更新日期:2017-10-01 00:00:00

  • LC MS/MS identification of large structural proteins from bull muscle and their degradation products during post mortem storage.

    abstract::Large proteins (>100kDa) in bovine M. longissimus dorsi and their degradation products during post mortem ageing were investigated by gel electrophoresis and LC-MS/MS analysis. Seventeen protein bands from SDS-PAGE were analysed and 26 proteins were identified. Intact titin, nebulin and filamin were shown to break dow...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2013.10.158

    authors: Wu G,Clerens S,Farouk MM

    更新日期:2014-05-01 00:00:00

  • A study on biomimetic immunoassay-capillary electrophoresis method based on molecularly imprinted polymer for determination of trace trichlorfon residue in vegetables.

    abstract::Pesticide residue in vegetables is a serious problem that has adverse effects on human health. In our study, we designed and synthesized a molecularly imprinted polymer that can selectively recognize trichlorfon. Using the polymer material as biomimetic antibody, we developed a biomimetic immunoassay-capillary electro...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2016.11.028

    authors: Li J,Lu J,Qiao X,Xu Z

    更新日期:2017-04-15 00:00:00

  • Microbial transglutaminase-modified protein network and its importance in enhancing the quality of high-fiber tofu with okara.

    abstract::Introducing okara to develop high-fiber tofu (HFT) can effectively increase the utilization of soy residues as well as enhance the nutrition of tofu. However, okara degrades the glucono-δ-lactone (GDL)-induced tofu quality. Current results showed that microbial transglutaminase (TGase) remarkably enhanced the gel stre...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2019.03.038

    authors: Zhang M,Wang P,Zou M,Yang R,Tian M,Gu Z

    更新日期:2019-08-15 00:00:00

  • Rapid detection of melamine adulteration in dairy milk by SB-ATR-Fourier transform infrared spectroscopy.

    abstract::Melamine is a nitrogenous chemical substance used principally as a starting material for the manufacture of synthetic resins. Due to its very high proportion of nitrogen melamine has been added illegitimately to foods and feeds to increase the measured protein content, which determines the value of the product. These ...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2013.05.106

    authors: Jawaid S,Talpur FN,Sherazi ST,Nizamani SM,Khaskheli AA

    更新日期:2013-12-01 00:00:00

  • Enhancement of lycopene bioaccessibility from tomato juice using excipient emulsions: Influence of lipid droplet size.

    abstract::The use of excipient emulsions to increase the bioaccessibility of lycopene in tomato juice was studied by simulating gastrointestinal conditions. The influence of droplet diameter (d=0.17 or 19μm) and thermal treatment (90°C, 10min) on lycopene bioaccessibility was evaluated. Lycopene bioaccessibility was relatively ...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2016.04.125

    authors: Salvia-Trujillo L,McClements DJ

    更新日期:2016-11-01 00:00:00

  • Sonication treatment convalesce the overall quality of hand-pressed strawberry juice.

    abstract::Hand-pressed strawberry juice samples were subjected to sonication treatments (0, 15 and 30min at 20°C, 25kHz frequency). Physicochemical properties (°Brix, pH, water activity, viscosity, titratable acidity, cloud assessment and turbidity), antioxidant compounds and activity (total phenolics, ascorbic acid, anthocyani...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2016.07.160

    authors: Bhat R,Goh KM

    更新日期:2017-01-15 00:00:00

  • Trace element content of fish feed and bluegill sunfish (Lepomis macrochirus) from aquaculture and wild source in Missouri.

    abstract::Trace element content of fish feed and bluegill sunfish muscles (Lepomis macrochirus) from aquaculture and natural pond in Missouri were determined using the inductively coupled-plasma optical emission spectrometer (ICP-OES) and the direct mercury analyzer (DMA). Dietary intake rates of trace elements were estimated. ...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2008.02.003

    authors: Ikem A,Egilla J

    更新日期:2008-09-15 00:00:00

  • Polyphenols and carotenoids in pickled bell pepper from organic and conventional production.

    abstract::Sweet bell pepper is a perfect source of flavonoids and carotenoids. Some experiments indicated that fresh organic vegetables contained more of these bioactive compounds in comparison to the conventional ones. It could be expected that pickled organic vegetables also contain more antioxidant compounds. The aim of this...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2018.11.052

    authors: Hallmann E,Marszałek K,Lipowski J,Jasińska U,Kazimierczak R,Średnicka-Tober D,Rembiałkowska E

    更新日期:2019-04-25 00:00:00

  • Effects of controlled-frequency moderate electric fields on pectin methylesterase and polygalacturonase activities in tomato homogenate.

    abstract::The effect of controlled-frequency moderate electric field treatments on pectin methylesterase and polygalcturonase activities in tomato homogenate was investigated by subjecting identically treated control and electrically-treated samples to the same temperature history. Additionally, a model was developed for the mo...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2015.12.010

    authors: Samaranayake CP,Sastry SK

    更新日期:2016-05-15 00:00:00

  • Involvement of chloroplast peroxidase on chlorophyll degradation in postharvest broccoli florets and its control by UV-B treatment.

    abstract::Chlorophyll (Chl)-degrading peroxidase (POX) was purified from green and green-yellow broccoli florets to elucidate the physiological role and cell localisation of Chl-degrading POX. Effect of UV-B treatment on Chl-degrading POX activity was also determined. The Chl-degrading POX activity was separated by an ion excha...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2014.05.108

    authors: Aiamla-Or S,Shigyo M,Ito S,Yamauchi N

    更新日期:2014-12-15 00:00:00

  • Improvement of feed pellet characteristics by dietary pre-gelatinized starch and their subsequent effects on growth and physiology in tilapia.

    abstract::A 9-week study was conducted to compare dietary corn starch (CS) or tapioca starch (TS), with or without being pre-gelatinized (PG), on the growth, feeding efficiencies, plasma and muscle biochemistry, intestinal short chain fatty acids (SCFA), and liver glycogen of triplicate groups of 20 red hybrid tilapia (Orecohro...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2017.07.061

    authors: Kanmani N,Romano N,Ebrahimi M,Nurul Amin SM,Kamarudin MS,Karami A,Kumar V

    更新日期:2018-01-15 00:00:00

  • In vitro fermentation of juçara pulp (Euterpe edulis) by human colonic microbiota.

    abstract::This study was carried out to investigate the potential fermentation properties of juçara pulp, using pH-controlled anaerobic batch cultures reflective of the distal region of the human large intestine. Effects upon major groups of the microbiota were monitored over 24h incubations by fluorescence in situ hybridisatio...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2015.09.048

    authors: Guergoletto KB,Costabile A,Flores G,Garcia S,Gibson GR

    更新日期:2016-04-01 00:00:00

  • 1,3-Dichloro-2-propanol inhibits progesterone production through the expression of steroidogenic enzymes and cAMP concentration in Leydig cells.

    abstract::1,3-Dichloro-2-propanol (1,3-DCP) is a well-known food processing contaminant that has been shown to impede male reproductive function. However, its mechanism of action remains elusive. In this study, the effects of 1,3-DCP on progesterone production were investigated using the R2C Leydig cell model. 1,3-DCP significa...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2014.01.017

    authors: Sun J,Bai S,Bai W,Zou F,Zhang L,Li G,Hu Y,Li M,Yan R,Su Z,Huang Y

    更新日期:2014-07-01 00:00:00

  • Attapulgite/hydrophilic molecularly imprinted monolithic resin composite for the selective recognition and sensitive determination of plant growth regulators in cucumbers.

    abstract::In this study, through in-situ polymerization process, a novel composite of attapulgite/hydrophilic molecularly imprinted monolithic resin (AT/HMIMR) were prepared in pipette tips for extraction trace plant growth regulators in cucumbers. In the preparation procedure, fibrillar attapulgite nanoparticles were embedded ...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2019.124974

    authors: Cao J,Wang M,Han D,Qiao F,Yan H

    更新日期:2019-11-01 00:00:00

  • Valorization of keratin from food wastes via crosslinking using non-toxic oligosaccharide derivatives.

    abstract::Oligosaccharide derivatives were developed to crosslink keratin materials from poultry feathers, swine bristles and ox hairs to valorize these major wastes from meat industry. Global butchery generates more than 8,600,000 tons of keratinous wastes annually. Keratin was considered a promising resource for developing bi...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2019.125181

    authors: Mi X,Chang Y,Xu H,Yang Y

    更新日期:2019-12-01 00:00:00

  • High pressure treatment of brine enhanced pork affects endopeptidase activity, protein solubility, and peptide formation.

    abstract::In order to study the effect of high-pressure (HP) treatment and two different methods of brine addition (important for lysosomal membrane destabilisation) on lysosomal enzymes activity and protein degradation, pork semitendinosus muscle was brine enhanced by injection or tumbling, and HP treated at 600 MPa following ...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2012.03.089

    authors: Grossi A,Gkarane V,Otte JA,Ertbjerg P,Orlien V

    更新日期:2012-10-01 00:00:00

  • Development of a bi-enzyme tracer competitive enzyme-linked immunosorbent assay for detection of thiacloprid and imidaclothiz in agricultural samples.

    abstract::A bi-enzyme tracer direct competitive enzyme-linked immunosorbent assay (dc-ELISA) was developed based on anti-imidaclothiz and anti-thiacloprid antibodies. Several affected physicochemical factors were optimised, including methanol concentration, ionic strength and pH value. Under the optimised conditions, 50% inhibi...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2014.05.037

    authors: Li H,Yan X,Shi H,Yang X

    更新日期:2014-12-01 00:00:00

  • 16-O-methylcafestol is present in ground roast Arabica coffees: Implications for authenticity testing.

    abstract::High-field and low-field proton NMR spectroscopy were used to analyse lipophilic extracts from ground roast coffees. Using a sample preparation method that produced concentrated extracts, a small marker peak at 3.16 ppm was observed in 30 Arabica coffees of assured origin. This signal has previously been believed abse...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2017.12.034

    authors: Gunning Y,Defernez M,Watson AD,Beadman N,Colquhoun IJ,Le Gall G,Philo M,Garwood H,Williamson D,Davis AP,Kemsley EK

    更新日期:2018-05-15 00:00:00

  • Quality characteristics and antioxidant activities of goat milk yogurt with added jujube pulp.

    abstract::This study aimed to evaluate the effects of the added jujube pulp on the quality characteristics and antioxidant activities of goat milk yogurt (GMY) during 28 days of refrigerated storage. Four GMY formulations were prepared, each varying in the added jujube pulp amount (Y0: not containing jujube pulp; YJ3, YJ6, YJ9:...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2018.10.104

    authors: Feng C,Wang B,Zhao A,Wei L,Shao Y,Wang Y,Cao B,Zhang F

    更新日期:2019-03-30 00:00:00

  • Fermentation in nutrient salt mixtures affects green Spanish-style Manzanilla table olive characteristics.

    abstract::This work studies the effects of the substitution of NaCl with KCl and CaCl2 on the physicochemical, mineral and sensory profile of fermented green Spanish-style Manzanilla olives, using an enlarged centroid mixture design. An increasing presence of CaCl2 in the initial brines improved the colour index, L(∗), b(∗) val...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2016.05.093

    authors: López-López A,Bautista-Gallego J,Moreno-Baquero JM,Garrido-Fernández A

    更新日期:2016-11-15 00:00:00

  • The composition of cell walls from grape marcs is affected by grape origin and enological technique.

    abstract::The grape marc obtained after vinification could be a source of high value compounds and the different winemaking techniques could influence such compounds. The composition of skin cell walls from Monastrell grapes grown in three different locations near Murcia (S.E. Spain) has been studied. The grapes were winemaked ...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2014.07.030

    authors: Apolinar-Valiente R,Romero-Cascales I,Gómez-Plaza E,López-Roca JM,Ros-García JM

    更新日期:2015-01-15 00:00:00