Relationship between plasma volume and essential blood constituents in patients with heart failure and preserved ejection fraction.

Abstract:

INTRODUCTION:Notwithstanding recent progress on molecular mechanisms underlying heart failure with preserved ejection fraction (HFpEF), multiple pathophysiological aspects of this condition including the basis of anaemia and other haematological disorders remain unresolved. In this study, we sought to determine the relationship of plasma volume (PV), a plausible confounding factor for the concentration of solutes in blood, with key haematological markers in HFpEF patients. METHODS:Total circulating PV was determined with high precision, automated carbon monoxide rebreathing in 24 stable HFpEF patients (70 ± 8 years, left ventricular ejection fraction = 55±5%) and 18 healthy age- and sex-matched control (HC) individuals. Linear regression analyses were performed to determine the association of PV with a comprehensive set of haematological variables. RESULTS:Haematocrit (40·1 ± 4·9 versus 43·6 ± 2·7%, P = 0·004) and haemoglobin concentration (131 ± 16 versus 142 ± 7 g l-1 , P = 0·003) were reduced in HFpEF patients compared with HC individuals. In regression analyses, PV was negatively associated with haematocrit (r = -0·45, P = 0·029) and haemoglobin concentration (r = -0·44, P = 0·030) in HFpEF patients, whereas these variables were not associated with PV in HC individuals (P≥0·198). Regarding blood electrolytes, PV was negatively associated with K+ (r = -0·43, P = 0·036) and Ca2+ (r = -0·44, P = 0·032) in HFpEF patients but not in HC individuals (P≥0·734). None of the above associations were detected in HFpEF patients when using ideal instead of measured PV. CONCLUSION:The blood concentration of routine markers of anaemia and electrolyte balance is specifically and linearly associated with PV in HFpEF patients. Excess or deficit of circulating PV may confound clinical diagnosis in this population.

authors

Diaz-Canestro C,Haider T,Lundby C,Montero D

doi

10.1111/cpf.12614

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

131-138

issue

2

eissn

1475-0961

issn

1475-097X

journal_volume

40

pub_type

杂志文章
  • Seven-site versus three-site method of body composition using BodyMetrix ultrasound compared to dual-energy X-ray absorptiometry.

    abstract::Obesity is a steadily growing epidemic affecting all segments of the population including college-aged students. The weight gain that is evidenced amid the transitional stage of college years increases the risks associated with cardiovascular and metabolic diseases. The BodyMetrix® BX-2000 (ULTRA) using a seven-site m...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12307

    authors: Baranauskas MN,Johnson KE,Juvancic-Heltzel JA,Kappler RM,Richardson L,Jamieson S,Otterstetter R

    更新日期:2017-05-01 00:00:00

  • Comparison of stroke volume estimation for non-steady-state and steady-state graded exercise testing.

    abstract::The stroke volume (SV) during exercise is an important index of the heart's functional capacity. A new method has been developed for the non-invasive estimation of exercise SV (SVex). It requires the determination of the slope for the oxygen uptake versus heart rate relationship in the steady state of graded exercise ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2004.00585.x

    authors: Davis JA,Sorrentino KM,Soriano AC,Pham PH

    更新日期:2005-01-01 00:00:00

  • Objective analysis of whole lung and lobar ventilation/perfusion relationships in pulmonary embolism.

    abstract:PURPOSE:Lung scintigraphy using single photon emission computed tomography (SPECT) allows accurate regional measurement of the ventilation/perfusion (V/Q) relationship. Objective V/Q analysis has been shown to be useful in the diagnosis of pulmonary embolism (PE). By using anatomical information provided by co-register...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2007.00767.x

    authors: Harris B,Bailey DL,Chicco P,Bailey EA,Roach PJ,King GG

    更新日期:2008-01-01 00:00:00

  • Myocardial CT perfusion compared with transthoracic Doppler echocardiography in evaluation of the coronary microvascular function: An iPOWER substudy.

    abstract:BACKGROUND:A significant number of women with angina and no obstructive coronary artery disease (CAD; <50% stenosis) have coronary microvascular dysfunction (CMD) which carries an adverse cardiovascular prognosis. Coronary microvascular function can be evaluated by transthoracic Doppler echocardiography (TTDE) as a cor...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12669

    authors: Bechsgaard DF,Hove JD,Michelsen MM,Mygind ND,Pena A,Hansen PR,Hansen HS,Kastrup J,Høst N,Gustafsson I,Prescott E

    更新日期:2021-01-01 00:00:00

  • Comparison between magnetic resonance imaging and B-mode ultrasound in detecting and estimating the extent of human carotid atherosclerosis.

    abstract:BACKGROUND:In MRI studies of carotid plaques, ultrasound is used to find plaques, which are later imaged using MRI. The performance in plaque detection has not been compared between the modalities. The aim of the current study was to compare the performance of MRI and ultrasound in detecting carotid artery plaques and ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12415

    authors: Hjelmgren O,Schmidt C,Johansson L,Bergström GML

    更新日期:2018-03-01 00:00:00

  • Detection of chronic rejection by quantitative ventilation scintigrams in lung-transplanted patients: a pilot study.

    abstract::The suspicion of chronic rejection [bronchiolithis obliterans syndrome (BOS)] is usually based on deteriorating forced expired volume in 1 s. It is however, desirable to develop more sensitive methods as increased anti-inflammatory therapy is thought to stop progression of the rejection. The aim of the present study w...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2005.00609.x

    authors: Johansson A,Moonen M,Enocson A,Mårtensson G,Bake B

    更新日期:2005-05-01 00:00:00

  • Quantification of left ventricular volumes and ejection fraction from gated 99mTc-MIBI SPECT: MRI validation of the EXINI heart software package.

    abstract:UNLABELLED:The aim of the study was to validate the accuracy of the EXINI heart software (EXINI) package in assessing left ventricular end-diastolic/systolic volumes (EDV, ESV) and ejection fraction (LVEF) from gated (99m)Tc-MIBI single-photon emission tomography (SPECT). Cardiac magnetic resonance imaging (cMRI) was u...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2008.00840.x

    authors: Winz OH,Meyer PT,Knollmann D,Lipke CS,Kühl HP,Oelve C,Schaefer WM

    更新日期:2009-04-01 00:00:00

  • Cardiovascular effects of ophthalmic 0.5% timolol aqueous solution and 0.1% timolol hydrogel.

    abstract::The objective of this randomized, double-masked, cross-over study was to compare the cardiovascular effects of two glaucoma formulations, ophthalmic 0.5% timolol aqueous solution and 0.1% timolol hydrogel. Twenty-four young healthy subjects received for 2 weeks either twice daily 0.5% timolol solution or once daily 0....

    journal_title:Clinical physiology and functional imaging

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1475-097x.2002.00430.x

    authors: Niño J,Tahvanainen K,Uusitalo H,Turjanmaa V,Hutri-Kähönen N,Kaila T,Ropo A,Kuusela T,Kähönen M

    更新日期:2002-07-01 00:00:00

  • Determination of the ability of high-frequency ECG to estimate left ventricular mass in humans, determined by magnetic resonance imaging.

    abstract:BACKGROUND:Previous studies have shown a significantly higher correlation between left ventricular mass index (LVMi) and high-frequency QRS components (HF-QRS) than between LVMi and QRS amplitudes in the standard frequency range in rabbits. The purpose of the present study was to compare ECG measurements from standard ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2006.00662.x

    authors: Trägårdh E,Arheden H,Pettersson J,Wagner GS,Pahlm O

    更新日期:2006-05-01 00:00:00

  • Deoxygenation of inspiratory muscles during cycling, hyperpnoea and loaded breathing in health and disease: a systematic review.

    abstract::Assessing inspiratory muscle deoxygenation and blood flow can provide insight into anaerobic stress, recruitment strategies and mechanisms of inspiratory muscle limitation. Therefore, this review aimed to synthesize measurements of inspiratory muscle oxyhaemoglobin (O2 Hb), deoxyhaemoglobin (HHb), blood volume and flo...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章,评审

    doi:10.1111/cpf.12473

    authors: Tanaka T,Basoudan N,Melo LT,Wickerson L,Brochard LJ,Goligher EC,Reid WD

    更新日期:2018-07-01 00:00:00

  • Sequence effects of combined resistance exercises with step choreography in the same session in women's oxygen uptake during and postexercise.

    abstract::The combination of step choreography (SC) with resistance training exercises (RE) in the same session is common in class fitness rooms populated mainly by women to increase energy expenditure. The aim of this study was to evaluate the differences in the exercise oxygen uptake and postexercise between two different com...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12382

    authors: Vilaça-Alves J,Regado A,Marinho D,Neves EB,Rosa C,Saavedra F,Reis VM

    更新日期:2018-01-01 00:00:00

  • Acute effects on the ventricular function in Swedish snuffers: an echocardiographic study.

    abstract:AIMS:Cigarettes and Swedish snuff contain nicotine, which influence the cardiovascular system. Cigarette smoke has been shown to give an acute impairment in diastolic heart parameters. The systolic and diastolic heart function in snuff users is not thoroughly enough investigated. The aim of this study was to investigat...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2011.01062.x

    authors: Sundström D,Waldenborg M,Emilsson K

    更新日期:2012-03-01 00:00:00

  • Neonatal ACE inhibition in rats interferes with lung development.

    abstract::The renin-angiotensin system (RAS) is developmentally up-regulated and it is essential for kidney development in several species. Given the fact that the rat lung undergoes postnatal development, the mammalian lung possesses the highest angiotensin-converting enzyme (ACE) levels and ACE activity increases during the f...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1046/j.1475-0961.2003.00530.x

    authors: Lasaitiene D,Chen Y,Nannmark U,Wollmer P,Friberg P

    更新日期:2004-01-01 00:00:00

  • Nicotine effects on exercise performance and physiological responses in nicotine-naïve individuals: a systematic review.

    abstract::The purpose of this systematic review was to evaluate the effects of smokeless forms of nicotine on physiological responses and exercise performance. Methodology and reporting were based on the PRISMA statement. The intervention was defined as any product containing nicotine that did not require smoking. Searches were...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章,评审

    doi:10.1111/cpf.12443

    authors: Johnston R,Doma K,Crowe M

    更新日期:2018-07-01 00:00:00

  • Evaluation of changes in Bone Scan Index at different acquisition time-points in bone scintigraphy.

    abstract::Bone Scan Index (BSI) is a validated imaging biomarker to objectively assess tumour burden in bone in patients with prostate cancer, and can be used to monitor treatment response. It is not known if BSI is significantly altered when images are acquired at a time difference of 1 h. The aim of this study was to investig...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12518

    authors: Kaboteh R,Minarik D,Reza M,Sadik M,Trägårdh E

    更新日期:2018-04-06 00:00:00

  • Does postexercise modelled capillary blood flow accurately reflect cardiovascular effects by different exercise intensities?

    abstract::Blood flow (BF) in exercising muscles is an important factor for exercise capacity. Recently, a non-invasive method to estimate capillary BF (Qcap ) was introduced. Using this method, the Fick principle is re-arranged by using relative differences in deoxygenated haemoglobin (ΔHHb) as a surrogate for arteriovenous O2 ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12434

    authors: Stöcker F,Von Oldershausen C,Paternoster FK,Schulz T,Oberhoffer R

    更新日期:2018-05-01 00:00:00

  • The effects of unilateral transcutaneous electrical nerve stimulation of the median nerve on bilateral somatosensory thresholds.

    abstract::Transcutaneous electrical nerve stimulation (TENS) is used to relieve acute and chronic pain. TENS electrodes are applied at the site of pain or in segments related to the pain, although there is limited research to support either approach. This study investigated the effects of unilateral TENS on mechanical and therm...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2006.00689.x

    authors: Dean J,Bowsher D,Johnson MI

    更新日期:2006-09-01 00:00:00

  • Gender differences in circulating bubble production after SCUBA diving.

    abstract:OBJECTIVE:Differences in circulating bubble production have been described after exposures in altitude chambers between men and women. The present study was designed to examine gender differences in circulating bubble production after a dive. METHODS:Fifty-two men and 52 women performed the same dive profile (25 min t...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2009.00884.x

    authors: Boussuges A,Retali G,Bodéré-Melin M,Gardette B,Carturan D

    更新日期:2009-11-01 00:00:00

  • Use of temperature alterations to characterize vascular reactivity.

    abstract::Monitoring alterations in fingertip temperature during ischaemia and the subsequent hyperaemia provides a novel way of studying microvascular reactivity. The relations between parameters characterizing blood perfusion and the thermal response of fingertips were studied using experimental and theoretical approaches. Du...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2010.00981.x

    authors: Ley O,Dhindsa M,Sommerlad SM,Barnes JN,Devan AE,Naghavi M,Tanaka H

    更新日期:2011-01-01 00:00:00

  • Telemetry-derived heart rate variability responses to a physical stressor.

    abstract::Analysis of heart rate variability (HRV) responses to an orthostatic challenge can be used to investigate autonomic control of heart rate, an index of cardiovascular function. HRV is typically assessed using the electrocardiogram (ECG), which can be impractical for use with large population-based studies. PURPOSE:To ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12320

    authors: Montaño A,Brown F,Credeur DP,Williams MA,Stoner L

    更新日期:2017-07-01 00:00:00

  • Tracer kinetics analysis of dynamic contrast-enhanced CT and MR data in patients with squamous cell carcinoma of the upper aerodigestive tract: comparison of the results.

    abstract:PURPOSE:(i) To evaluate the feasibility of tracer kinetics analysis of dynamic contrast-enhanced (DCE) CT and T2-weighted MR data of squamous cell carcinoma (SCCA) of the upper aerodigestive tract. (ii) To compare functional parameters derived by both modalities and examine the interchangeability of them as well as the...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2009.00876.x

    authors: Bisdas S,Baghi M,Wagenblast J,Bisdas T,Thng CH,Mack MG,Koh TS,Ernemann U

    更新日期:2009-09-01 00:00:00

  • The acute hemodynamic effects of blood flow restriction in the absence of exercise.

    abstract::The purpose was to investigate the acute effects of blood flow restriction (BFR) on arterial and venous hemodynamic parameters. Nine participants completed a 10-min time control (resting condition) and then a lower body BFR protocol. The protocol was five, 5-min bouts of restrictive cuff inflation with 3-min of deflat...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2012.01157.x

    authors: Loenneke JP,Fahs CA,Thiebaud RS,Rossow LM,Abe T,Ye X,Kim D,Bemben MG

    更新日期:2013-01-01 00:00:00

  • Lumbar bone mineral content and density measured using a Lunar DPX densitometer in healthy full-term infants during the first year of life.

    abstract::This cross-sectional study provides values for lumbar spine bone mineral content (BMC) and density (BMD) in 41 healthy full-term born Finnish infants, 19 boys and 22 girls, during the first year of life measured by dual energy X-ray absorptiometry (DXA) using the Lunar DPX densitometer. Lumbar BMC correlated with the ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1046/j.1475-097x.2002.00422.x

    authors: Kurl S,Heinonen K,Jurvelin JS,Länsimies E

    更新日期:2002-05-01 00:00:00

  • Near infrared spectroscopy for frontal lobe oxygenation during non-vascular abdominal surgery.

    abstract:PURPOSE:Cerebral deoxygenation, as determined by near infrared spectroscopy (NIRS), seems to predict postoperative complications following cardiac surgery. We identify the type of non-vascular abdominal surgery associated with cerebral deoxygenation and/or hyperoxygenation, how such deviations affect patient outcome, a...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/cpf.12244

    authors: Sørensen H,Grocott HP,Secher NH

    更新日期:2016-11-01 00:00:00

  • Intradialytic exercise as anabolic therapy in haemodialysis patients -- a pilot study.

    abstract::Haemodialysis (HD) patients are characterized by muscle wasting and consequently decreased physical functioning and poor outcome. This pilot study investigated if a novel intradialytic exercise programme could increase lean mass via up-regulation of the insulin-like growth factor (IGF) system. Nine HD patients were as...

    journal_title:Clinical physiology and functional imaging

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1475-097X.2004.00600.x

    authors: Macdonald JH,Marcora SM,Jibani M,Phanish MK,Holly J,Lemmey AB

    更新日期:2005-03-01 00:00:00

  • CO2 elimination at varying inspiratory pause in acute lung injury.

    abstract::Previous studies have indicated that, during mechanical ventilation, an inspiratory pause enhances gas exchange. This has been attributed to prolonged time during which fresh gas of the tidal volume is present in the respiratory zone and is available for distribution in the lung periphery. The mean distribution time o...

    journal_title:Clinical physiology and functional imaging

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1475-097X.2007.00699.x

    authors: Aboab J,Niklason L,Uttman L,Kouatchet A,Brochard L,Jonson B

    更新日期:2007-01-01 00:00:00

  • Subject-specific aortic wall shear stress estimations using semi-automatic segmentation.

    abstract::Atherosclerosis development is strongly believed to be influenced by hemodynamic forces such as wall shear stress (WSS). To estimate such an entity in-vivo in humans, image-based computational fluid dynamics (CFD) is a useful tool. In this study, we use a combination of magnetic resonance imaging (MRI) and CFD to esti...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2012.01146.x

    authors: Renner J,Nadali Najafabadi H,Modin D,Länne T,Karlsson M

    更新日期:2012-11-01 00:00:00

  • An assessment of pulmonary function testing and ventilatory kinematics by optoelectronic plethysmography.

    abstract::New advances in computer processing and imaging have allowed the development of innovative techniques to assess lung function. A promising methodology is optoelectronic plethysmography (OEP). OEP evaluates ventilatory kinematics through the use of infrared imaging. Markers are placed, and images read on the chest, bac...

    journal_title:Clinical physiology and functional imaging

    pub_type: 历史文章,杂志文章,评审

    doi:10.1111/j.1475-097X.2011.01028.x

    authors: Layton AM,Garber CE,Basner RC,Bartels MN

    更新日期:2011-09-01 00:00:00

  • Validity and interobserver agreement of lower extremity local tissue water measurements in healthy women using tissue dielectric constant.

    abstract:BACKGROUND:Tissue dielectric constant (TDC) measurement may become an important tool in the clinical evaluation of chronic lower extremity swelling in women; however, several factors are known to influence TDC measurements, and comparative data on healthy lower extremities are few. METHODS:Thirty-four healthy women vo...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2012.01129.x

    authors: Jensen MR,Birkballe S,Nørregaard S,Karlsmark T

    更新日期:2012-07-01 00:00:00

  • Gender aspects on exercise-induced ECG changes in relation to scintigraphic evidence of myocardial ischaemia.

    abstract:BACKGROUND:This retrospective study aimed to determine the diagnostic performance of exercise-induced ST response in relation to findings by myocardial perfusion single photon emission computed tomography (MPS), with focus on gender differences, in patients with suspected or established stable ischemic heart disease. ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12483

    authors: Akil S,Hedén B,Pahlm O,Carlsson M,Arheden H,Engblom H

    更新日期:2018-09-01 00:00:00