Abstract:
:Mitochondria play many critical roles in cells, not only by supplying energy, but also by supplying metabolites, buffering Ca2+ levels and regulating apoptosis. During oocyte maturation and subsequent embryo development, mitochondria change their morphology by membrane fusion and fission, and coordinately undergo multiple cellular events with the endoplasmic reticulum (ER) closely apposed. Mitochondrial fusion and fission, known as mitochondrial dynamics, are regulated by family members of dynamin GTPases. Oocytes in animal models with these regulators artificially altered exhibit morphological abnormalities in nearby mitochondria and at the ER interface that are reminiscent of major cytoplasmic dysmorphisms in human assisted reproductive technology, in which a portion of mature oocytes retrieved from patients contain cytoplasmic dysmorphisms associated with mitochondria and ER abnormal morphologies. Understanding organelle morpho-homeostasis in oocytes obtained from animal models will contribute to the development of novel methods for determining oocyte health and for how to deal with dysmorphic oocytes.
journal_name
J Biochemjournal_title
Journal of biochemistryauthors
Udagawa O,Ishihara Ndoi
10.1093/jb/mvz093subject
Has Abstractpub_date
2020-03-01 00:00:00pages
257-266issue
3eissn
0021-924Xissn
1756-2651pii
5670531journal_volume
167pub_type
杂志文章,评审abstract::Proton translocating ATPase (F0F1) from bovine heart mitochondria was reconstituted into planar phospholipid bilayers, and its electrogenicity was directly demonstrated. The F0F1 ATPase was solubilized using 3-[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonic acid (CHAPS) as a detergent followed by sucrose densi...
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1987-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-10-01 00:00:00
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journal_title:Journal of biochemistry
pub_type: 杂志文章,评审
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更新日期:2010-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-10-01 00:00:00
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journal_title:Journal of biochemistry
pub_type: 杂志文章
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更新日期:2000-02-01 00:00:00
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journal_title:Journal of biochemistry
pub_type: 杂志文章
doi:10.1093/oxfordjournals.jbchem.a003237
更新日期:2002-09-01 00:00:00
abstract::The enzymatic properties of novel cysteine proteases D3-alpha and beta which were purified from germinating soybean cotyledons were investigated. The enzyme activities were exhibited in the presence of a thiol reagent, such as 2-mercaptoethanol, and apparently inhibited by E-64, a cysteine protease inhibitor. Hydrolyt...
journal_title:Journal of biochemistry
pub_type: 杂志文章
doi:10.1093/oxfordjournals.jbchem.a022448
更新日期:1999-08-01 00:00:00
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journal_title:Journal of biochemistry
pub_type: 杂志文章
doi:10.1093/oxfordjournals.jbchem.a123050
更新日期:1990-03-01 00:00:00
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journal_title:Journal of biochemistry
pub_type: 杂志文章
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更新日期:1999-10-01 00:00:00
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journal_title:Journal of biochemistry
pub_type: 杂志文章
doi:
更新日期:1983-11-01 00:00:00
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journal_title:Journal of biochemistry
pub_type: 杂志文章
doi:10.1093/oxfordjournals.jbchem.a123081
更新日期:1990-04-01 00:00:00
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journal_title:Journal of biochemistry
pub_type: 杂志文章
doi:10.1093/jb/mvj002
更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1992-03-01 00:00:00
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更新日期:2000-09-01 00:00:00
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更新日期:2011-05-01 00:00:00
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更新日期:2013-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1980-01-01 00:00:00
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journal_title:Journal of biochemistry
pub_type: 杂志文章
doi:10.1093/oxfordjournals.jbchem.a123440
更新日期:1991-05-01 00:00:00
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journal_title:Journal of biochemistry
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更新日期:1994-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:1983-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1995-09-01 00:00:00
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journal_title:Journal of biochemistry
pub_type: 杂志文章
doi:10.1093/oxfordjournals.jbchem.a121868
更新日期:1986-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2000-02-01 00:00:00