Effect of mild and chronic neonatal hypothyroidism on sensory information processing in a rodent model: A behavioral and electrophysiological study.

abstract：:Accumulating evidence points to the amyloid-β (Aβ) peptide as the culprit in the pathogenesis of Alzheimer's disease (AD). β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is a protease that is responsible for initiating Aβ production. Although precise mechanisms that trigger Aβ accumulation remain unc...

journal_title：Brain research bulletin

authors： Ohno M

更新日期：2016-09-01 00:00:00

abstract：:Rats received bilateral intracerebroventricular (ICV) infusions of either AF64A (1.5 nmol/ventricle; n = 9) or vehicle (3.0 microliters/ventricle; n = 7). Four weeks later, the animals were anesthetized and their brains processed to visualize and quantify choline acetyltransferase (ChAT) immunoreactive (IR) and parval...

journal_title：Brain research bulletin

authors： Dong XW,Hanin I,Lorens SA

更新日期：1994-01-01 00:00:00

abstract：:Here we asked if insulin activation of the nucleus accumbens in vitro is reflected by an increase in (3)H-deoxyglucose ([(3)H]DG) uptake, thus subserving a new model to study molecular mechanisms of central insulin actions. Additionally, we investigated the dependence of this insulin effect on endocannabinoids and cor...

journal_title：Brain research bulletin

authors： Pinheiro BS,Lemos C,Neutzling Kaufmann F,Marques JM,da Silva-Santos CS,Carvalho E,Mackie K,Rodrigues RJ,Cunha RA,Köfalvi A

更新日期：2016-06-01 00:00:00

abstract：:Serotonergic modulation of acetylcholine (ACh) release after neuron-specific increase of the expression of 5-HT(1B) receptors by gene transfer was studied in vitro and in vivo. The increased expression of the 5-HT(1B) receptor in vitro was induced by treating rat primary fetal septal cell cultures for 3 days with a vi...

journal_title：Brain research bulletin

authors： Riegert C,Rothmaier AK,Leemhuis J,Sexton TJ,Neumaier JF,Cassel JC,Jackisch R

更新日期：2008-07-01 00:00:00

abstract：:In animal models of Fetal Alcohol Syndrome, ethanol causes a number of changes in brain development, with many of these changes being very transient. This is especially true for the process of synaptogenesis in different brain areas. Our quantitative electron microscopic study of synaptogenesis in the molecular layer ...

journal_title：Brain research bulletin

authors： Hoff SF

更新日期：1988-07-01 00:00:00

abstract：:It is generally assumed that the primary response of the rat flash evoked potential (FEP) is activated by a retino-geniculate path, and that the secondary response reflects input to the cortex by way of the superior colliculus (SC) or other brainstem structures. In the present study, male Long-Evans rats were implante...

journal_title：Brain research bulletin

authors： Barnes MI,Dyer RS

更新日期：1986-02-01 00:00:00

abstract：:We carried out a study to establish ribonucleic acid (RNA) content in the nucleus and cytoplasm of single neuronal cells from the dorsal lateral geniculate nucleus (dLGN) of 3-30 month-old rats. Mean RNA content was calculated as the product of RNA concentration and nuclear or cytoplasmic surface. The analysis of neur...

journal_title：Brain research bulletin

authors： Villena A,Díaz F,Chavarria I,Requena V,Peláez A,Pérez De Vargas I

更新日期：1998-06-01 00:00:00

abstract：:The purinergic signaling system, including P2 receptors, plays an important role in various central nervous system (CNS) disorders. Over the last few decades, a substantial amount of accumulated data suggest that most P2 receptor subtypes (P2X1, 2, 3, 4, 6, and 7, and P2Y1, 2, 6, 12, and 13) regulate neuronal/neurogli...

journal_title：Brain research bulletin

authors： Huang L,Otrokocsi L,Sperlágh B

更新日期：2019-09-01 00:00:00

abstract：:We recently reported that human recombinant interleukin-6 (hrIL-6) microinjected into the preoptic area (POA) of guinea pigs induced fever at high doses, suggesting that IL-6 may be another endogenous pyrogen. This study was undertaken to determine whether hrIL-6 affects the single-unit activity of thermosensitive and...

journal_title：Brain research bulletin

authors： Xin L,Blatteis CM

更新日期：1992-07-01 00:00:00

abstract：:The discovery of spontaneous neuronal replacement in the adult vertebrate brain has changed the way in which we think about the biology of memory. This is because neuronal replacement is likely to have an impact on what a brain remembers and what it learns. Neuronal replacement has also changed the way in which we go ...

journal_title：Brain research bulletin

authors： Nottebohm F

更新日期：2002-04-01 00:00:00

abstract：:Mutations in PLA2G6, which encodes calcium-independent phospholipase A(2) group VIA (iPLA2-VIA), underlie the autosomal recessive disorder infantile neuroaxonal dystrophy (INAD). INAD typically presents in the first year of life, and leads to optic atrophy and psychomotor regression. We have examined PLA2G6 expression...

journal_title：Brain research bulletin

authors： Polster B,Crosier M,Lindsay S,Hayflick S

更新日期：2010-11-20 00:00:00

abstract：:Scientific reports suggest that the exposure to long-term stressors throughout or during late gestation increase anxiety- and depression-like behaviors of offspring in their later life. Moreover, several studies concluded that increasing age correlates with increased anxiety behaviors in humans and rodents. In the pre...

journal_title：Brain research bulletin

authors： Enayati M,Solati J,Hosseini MH,Shahi HR,Saki G,Salari AA

更新日期：2012-02-10 00:00:00

abstract：:Neonatal hippocampal lesions in rats produce behavioral and neurochemical abnormalities post-puberty that are used in animal models for developmentally linked pathology in schizophrenia. In one model, adult rats exhibit enhanced sensitivity to the locomotor-activating effects of amphetamine, if they had sustained exci...

journal_title：Brain research bulletin

authors： Swerdlow NR,Halim N,Hanlon FM,Platten A,Auerbach PP

更新日期：2001-05-01 00:00:00

abstract：:Three sets of experiments have been conducted that suggest that adrenal glucocorticoids play a role in the long-term control of intake and in dietary preferences. First, obesity is dependent upon glucocorticoid-modulated metabolic pathways. Surgical or pharmacological manipulations in obese animals that eliminate or d...

journal_title：Brain research bulletin

authors： Castonguay TW

更新日期：1991-09-01 00:00:00

abstract：:Autoradiography was employed to investigate the efferent projections from the lateral hypothalamus in the guinea pig. Lateral hypothalamic axons were traced along the medial forebrain bundle in both ascending and descending directions. Anteriorly, the label was traced along the medial forebrain bundle in both ascendin...

journal_title：Brain research bulletin

authors： Shen CL

更新日期：1983-09-01 00:00:00

abstract：:The elevated plus-maze is an animal model used to study anxiety. In a second session, rats show a reduction in the exploratory behavior even when the two sessions are separated by intervals as large as 7 days. The aim of the present study was to investigate whether the reduction in the exploratory behavior is maintain...

journal_title：Brain research bulletin

authors： Galvis-Alonso OY,Garcia AM,Orejarena MJ,Lamprea MR,Botelho S,Conde CA,Morato S,Garcia-Cairasco N

更新日期：2010-04-05 00:00:00

abstract：:Prior results (37) showed that morphine pretreatment reduces the escape response of the crab Chasmagnathus to a shadow passing overhead and prevents the acquisition of a long-term habituation. These results were explained by a reduction in the danger signalled by the stimulus, and to test this hypothesis methods other...

journal_title：Brain research bulletin

authors： Tomsic D,Maldonado H,Rakitin A

更新日期：1991-05-01 00:00:00

abstract：:The vestibular nuclei and posterior cerebellum are the destination of vestibular primary afferents and the subject of this review. The vestibular nuclei include four major nuclei (medial, descending, superior and lateral). In addition, smaller vestibular nuclei include: Y-group, parasolitary nucleus, and nucleus inter...

journal_title：Brain research bulletin

authors： Barmack NH

更新日期：2003-06-15 00:00:00

abstract：:Methylphenidate (MPD) is currently one of the most prescribed drug therapies for attention deficit/hyperactivity disorder (ADHD) and moreover is abused for cognitive enhancement and used for recreation by the young and adults. Methylphenidate is used for prolonged periods of time and its mechanism of action on the bra...

journal_title：Brain research bulletin

authors： Claussen C,Dafny N

更新日期：2012-03-10 00:00:00

abstract：:Diabetic encephalopathy has recently been recognized late complication of diabetes resulting in progressive cognitive deficits. Emerging evidence has indicated that endoplasmic reticulum (ER) stress-mediated apoptosis is involved in the pathogenesis of diabetic eye and kidney as well as non-diabetic neurodegeneration....

journal_title：Brain research bulletin

authors： Zhao Y,Yan Y,Zhao Z,Li S,Yin J

更新日期：2015-02-01 00:00:00

abstract：:The roles of prostaglandins (PGs) involved in opioidergic, cholinergic, and serotonergic regulation of the diurnal changes of tuberoinfundibular dopaminergic (TIDA) neuronal activities were investigated in ovariectomized, estrogen-treated rats. Treatment with naloxone [10 mg/kg, intraperitoneal (i.p.)], atropine (5 mg...

journal_title：Brain research bulletin

authors： Chu YC,Tsou MY,Pan JT

更新日期：2001-09-01 00:00:00

abstract：:In a previous study, it was shown that the lateral entorhinal cortex (LEC) in the left hemisphere contains higher concentration of glutamate than in the right hemisphere. The purpose of the present study was to examine potential relationship between this neurochemical asymmetry and behavior. Rats with either left, rig...

journal_title：Brain research bulletin

authors： Myhrer T,Iversen EG

更新日期：1990-08-01 00:00:00

abstract：:Nutritional factors and nutritional deficiencies have been repeatedly associated with cognitive impairment. Most of the evidence is based on cross-sectional studies, which cannot prove whether a nutritional deficit is the cause or the consequence of an impaired cognitive status. In fact, cognitive impairment, in turn,...

journal_title：Brain research bulletin

authors： Del Parigi A,Panza F,Capurso C,Solfrizzi V

更新日期：2006-03-15 00:00:00

abstract：:Entrainment of the dominant circadian pacemaker localised to the hypothalamic suprachiasmatic nuclei (SCN) is mediated partially via the indirect retino-geniculo-hypothalamic projection to the SCN, which is presumed to utilise enkephalin and other neurotransmitters, to modulate circadian rhythmicity. In the present st...

journal_title：Brain research bulletin

authors： Cutler DJ,Mundey MK,Mason R

更新日期：1999-09-15 00:00:00

abstract：:Metformin (MET),an antidiabetic drug, has shown antioxidative and neuroprotective effects. In the present investigation, we aimed to study the probable effects of MET on cerebral ischemia/reperfusion in rats. Rats underwent cerebral ischemia/reperfusion and MET was administered orally at doses of 100 and 200 mg/kg for...

journal_title：Brain research bulletin

authors： Fatemi I,Saeed-Askari P,Hakimizadeh E,Kaeidi A,Esmaeil-Moghaddam S,Pak-Hashemi M,Allahtavakoli M

更新日期：2020-10-01 00:00:00

abstract：:Behavioral adaptations exhibited by two African fossorial mammals for the reception of vibrational signals are discussed. The Namib Desert golden mole (Eremitalpa granti namibensis) is a functionally blind, nocturnal insectivore in the family Chrysochloridae that surface forages nightly in the Namib desert. Both geoph...

journal_title：Brain research bulletin

authors： Narins PM,Lewis ER,Jarvis JJ,O'Riain J

更新日期：1997-01-01 00:00:00

abstract：:Various reports have suggested that penehyclidine hydrochloride (PHC), a new cholinergic antagonist, exhibits a variety of biological actions such as anti-tumor and cardioprotective effects. This study aimed to investigate the effects of PHC on cerebral ischemia/reperfusion (I/R) injury and evaluate whether the c-Jun ...

journal_title：Brain research bulletin

authors： Shu Y,Yang Y,Zhang P

更新日期：2016-03-01 00:00:00

abstract：:Rats were unilaterally deprived of odor stimulation by surgically sealing one naris 1, 30 or 60 days after birth. Thirty days later the laminar volumes of the olfactory bulb ipsilateral to the occluded naris were compared with those ipsilateral to the normal side. Deprivation from days 1-30 resulted in approximately 2...

journal_title：Brain research bulletin

authors： Brunjes PC,Borror MJ

更新日期：1983-11-01 00:00:00

abstract：:Increases in expression of α4βδ GABAA receptors (GABARs), triggered by fluctuations in the neurosteroid THP (3α-OH-5α[β]-pregnan-20-one), are associated with changes in mood and cognition. We tested whether α4βδ trafficking and surface expression would be altered by in vitro exposure to flumazenil, a benzodiazepine li...

journal_title：Brain research bulletin

authors： Kuver A,Smith SS

更新日期：2016-01-01 00:00:00

abstract：:Over the last 15 years, many publications described the use of peptide sequences that have been dubbed cell penetrating peptides (CPP), Trojan Horse peptides, protein transduction domains, or membrane-translocating sequences. These mostly positively charged domains bring attached cargo across biological membranes. One...

journal_title：Brain research bulletin

authors： Dietz GP,Bähr M

更新日期：2005-12-15 00:00:00