Abstract：
PURPOSE OF REVIEW:To describe lipid abnormalities in diabetes, when they occur and the evidence base for lipid management with established and new drugs to prevent diabetes complications. We also discuss how to manage statin intolerance. RECENT FINDINGS:Statins remain first-line therapy in patients with diabetes, though newer therapies to reduce LDL-C have emerged, including ezetimibe as an add-on therapy to statins, and injectable PCSK9 inhibitors, both of which are safe and effective in diabetes. Emerging evidence suggests a need to consider lipid-lowering therapies more often in younger patients with both type 1 and type 2 diabetes. Statins remain the cornerstone of lipid management in diabetes but other options are increasing. There is also now evidence for better managing apparent statin intolerance. Notably, younger patients lose the most life years from their diabetes, an observation that future guidelines need to consider.
journal_name
Curr Cardiol Repjournal_title
Current cardiology reportsauthors
Sillars A,Sattar Ndoi
10.1007/s11886-019-1246-1subject
Has Abstractpub_date
2019-11-22 00:00:00pages
147issue
11eissn
1523-3782issn
1534-3170pii
10.1007/s11886-019-1246-1journal_volume
21pub_type
杂志文章,评审abstract：:Revascularization in stable ischemic heart disease (SIHD) is indicated in patients on optimal medical therapy with angina and/or demonstrable ischemia and a significant stenosis in one or more epicardial coronary arteries. Angiography alone, however, cannot accurately determine the hemodynamic significance of coronary...
journal_title：Current cardiology reports
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journal_title：Current cardiology reports
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journal_title：Current cardiology reports
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journal_title：Current cardiology reports
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journal_title：Current cardiology reports
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更新日期：2016-04-01 00:00:00
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journal_title：Current cardiology reports
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journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-016-0804-z
更新日期：2016-12-01 00:00:00
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journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-013-0358-2
更新日期：2013-05-01 00:00:00
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journal_title：Current cardiology reports
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更新日期：2008-07-01 00:00:00
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journal_title：Current cardiology reports
pub_type： 杂志文章,评审
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journal_title：Current cardiology reports
pub_type： 杂志文章,评审
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更新日期：2017-06-01 00:00:00
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journal_title：Current cardiology reports
pub_type： 杂志文章,评审
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更新日期：2016-05-01 00:00:00
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journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-011-0168-3
更新日期：2011-04-01 00:00:00
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journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-020-01419-6
更新日期：2020-10-10 00:00:00
abstract：PURPOSE OF REVIEW:To create awareness for the devastating influence of high cholesterol in familial hypercholesterolaemia (FH) on vessel walls. Persons with high LDL-C and a known mutation associated with FH have a 22-fold increase in CVD compared with those with a normal LDL-C and no genetic mutation. If the awareness...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
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更新日期：2018-08-09 00:00:00
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journal_title：Current cardiology reports
pub_type： 杂志文章,评审
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更新日期：2008-03-01 00:00:00
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journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-013-0387-x
更新日期：2013-08-01 00:00:00
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journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-020-01321-1
更新日期：2020-06-19 00:00:00
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journal_title：Current cardiology reports
pub_type： 杂志文章
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更新日期：2000-09-01 00:00:00
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journal_title：Current cardiology reports
pub_type： 杂志文章,评审
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更新日期：2019-11-16 00:00:00
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journal_title：Current cardiology reports
pub_type： 杂志文章,评审
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journal_title：Current cardiology reports
pub_type： 杂志文章,评审
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更新日期：2013-01-01 00:00:00
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journal_title：Current cardiology reports
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更新日期：2003-01-01 00:00:00
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journal_title：Current cardiology reports
pub_type： 杂志文章,评审
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journal_title：Current cardiology reports
pub_type： 杂志文章,评审
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更新日期：2005-03-01 00:00:00
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journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-012-0253-2
更新日期：2012-06-01 00:00:00
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journal_title：Current cardiology reports
pub_type： 杂志文章,评审
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更新日期：2017-06-01 00:00:00
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journal_title：Current cardiology reports
pub_type： 杂志文章
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journal_title：Current cardiology reports
pub_type： 杂志文章,评审
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更新日期：2015-11-01 00:00:00
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journal_title：Current cardiology reports
pub_type： 杂志文章,评审
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更新日期：2013-08-01 00:00:00
