Abstract:
:Insulin signaling governs many processes including glucose homeostasis and metabolism, and is therapeutically used to treat hyperglycemia in diabetes. We demonstrated that insulin-induced Akt activation enhances the sensitivity to TGF-β by directing an increase in cell surface TGF-β receptors from a pool of intracellular TGF-β receptors. Consequently, increased autocrine TGF-β signaling in response to insulin participates in insulin-induced angiogenic responses of endothelial cells. With TGF-β signaling controlling many cell responses, including differentiation and extracellular matrix deposition, and pathologically promoting fibrosis and cancer cell dissemination, we addressed to which extent autocrine TGF-β signaling participates in insulin-induced gene responses of human endothelial cells. Transcriptome analyses of the insulin response, in the absence or presence of a TGF-β receptor kinase inhibitor, revealed substantial positive and negative contributions of autocrine TGF-β signaling in insulin-responsive gene responses. Furthermore, insulin-induced responses of many genes depended on or resulted from autocrine TGF-β signaling. Our analyses also highlight extensive contributions of autocrine TGF-β signaling to basal gene expression in the absence of insulin, and identified many novel TGF-β-responsive genes. This data resource may aid in the appreciation of the roles of autocrine TGF-β signaling in normal physiological responses to insulin, and implications of therapeutic insulin usage.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Budi EH,Hoffman S,Gao S,Zhang YE,Derynck Rdoi
10.1038/s41598-019-53490-xsubject
Has Abstractpub_date
2019-11-18 00:00:00pages
16992issue
1issn
2045-2322pii
10.1038/s41598-019-53490-xjournal_volume
9pub_type
杂志文章abstract::Conifer wood is an exceptionally stiff and strong material when its cellulose microfibrils are well aligned. However, it is not well understood how the polymer components cellulose, hemicelluloses and lignin co-operate to resist tensile stress in wood. From X-ray scattering, neutron scattering and spectroscopic data, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79676-2
更新日期:2021-01-11 00:00:00
abstract::Using the Ermakov-Lewis invariants appearing in KvN mechanics, the time-dependent frequency harmonic oscillator is studied. The analysis builds upon the operational dynamical model, from which it is possible to infer quantum or classical dynamics; thus, the mathematical structure governing the evolution will be the sa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26759-w
更新日期:2018-05-30 00:00:00
abstract::Cnidarians, in general, are long-lived organisms and hence may repeatedly encounter common pathogens during their lifespans. It remains unknown whether these early diverging animals possess some type of immunological reaction that strengthens the defense response upon repeated infections, such as that described in mor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17425
更新日期:2015-12-02 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-44657-7
更新日期:2019-06-05 00:00:00
abstract::The challenge of balancing biodiversity protection with economic growth is epitomized by the development of renewable and unconventional energy, whose adoption is aimed at stemming the impacts of global climate change, yet has outpaced our understanding of biodiversity impacts. We evaluated the potential conflict betw...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64501-7
更新日期:2020-05-05 00:00:00
abstract::Recently, a genome-wide analysis identified DNA methylation of the HIF3A (hypoxia-inducible factor 3A) as strongest correlate of BMI. Here we tested the hypothesis that HIF3A mRNA expression and CpG-sites methylation in adipose tissue (AT) and genetic variants in HIF3A are related to parameters of AT distribution and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27969
更新日期:2016-06-27 00:00:00
abstract::This corrects the article DOI: 10.1038/srep34617. ...
journal_title:Scientific reports
pub_type: 杂志文章,已发布勘误
doi:10.1038/srep42267
更新日期:2017-09-27 00:00:00
abstract::Cesium (Cs) removal from nuclear liquid wastewater has become an emerging issue for safeguarding public health after the accident at the Fukushima Daiichi Nuclear Power Plant. A novel macrocyclic ligand of o-benzo-p-xylyl-22-crown-6-ether (OBPX22C6) was developed and successfully immobilized onto mesoporous silica for...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19937
更新日期:2016-01-28 00:00:00
abstract::G protein-coupled receptors (GPCRs), including dopamine receptors, represent a group of important pharmacological targets. An increased formation of dopamine receptor D2 homodimers has been suggested to be associated with the pathophysiology of schizophrenia. Selective labeling and ligand-induced modulation of dimeriz...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33233
更新日期:2016-09-12 00:00:00
abstract::Oviposition site-selection in insects is mediated through innate recognition templates (IRTs) tuned to specific chemical cues. These cues aid gravid insects in choosing suitable oviposition sites and may even enhance the fitness of their offspring by warding off predators and parasitoids. However, studies on the evolu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07472
更新日期:2014-12-15 00:00:00
abstract::In this paper we report for the first time an n-type carbon nanotube field effect transistor which is air- and water-stable, a necessary requirement for electrolyte gated CMOS circuit operation. The device is obtained through a simple process, where the native p-type transistor is converted to an n-type. This conversi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29882-w
更新日期:2018-07-30 00:00:00
abstract::Dark-operative protochlorophyllide oxidoreductase (DPOR) is a key enzyme to produce chlorophyll in the dark. Among photosynthetic eukaryotes, all three subunits chlL, chlN, and chlB are encoded by plastid genomes. In some gymnosperms, two codons of chlB mRNA are changed by RNA editing to codons encoding evolutionarily...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02630-2
更新日期:2017-05-24 00:00:00
abstract::Human respiratory syncytial virus (RSV) A ON1 genotype, first detected in 2010 in Ontario, Canada, has been documented in 21 countries to date. This study investigated persistence and transmission dynamics of ON1 by grouping 406 randomly selected RSV-positive specimens submitted to Public Health Ontario from August 20...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14268
更新日期:2015-09-30 00:00:00
abstract::Keratoconus is a common degenerative corneal disease that can lead to significant visual morbidity, and both genetic and environmental factors have been implicated in its pathogenesis. We compared the transcriptome of keratoconus and control epithelium using RNA-Seq. Epithelial tissues were obtained prior to surgery f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18480-x
更新日期:2018-01-10 00:00:00
abstract::The accumulation of repetitive DNA sequences on the sex-limited W or Y chromosomes is a well-known process that is likely triggered by the suppression of recombination between the sex chromosomes, which leads to major differences in their sizes and genetic content. Here, we report an analysis conducted on the satellit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42383-8
更新日期:2019-04-10 00:00:00
abstract::Microbial detoxification has been proposed as a new alternative for removing toxins and pollutants. In this study, the biodetoxification activities of yeasts against aflatoxin B1 and zinc were evaluated by HPLC and voltammetric techniques. The strains with the best activity were also subjected to complementary assays,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68154-4
更新日期:2020-07-09 00:00:00
abstract::The Early Cretaceous Greater Ontong Java Event in the Pacific Ocean may have covered ca. 1% of the Earth's surface with volcanism. It has puzzled scientists trying to explain its origin by several mechanisms possible on Earth, leading others to propose an extraterrestrial trigger to explain this event. A large oceanic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00268
更新日期:2012-01-01 00:00:00
abstract::After its recent rediscovery, the Hula painted frog (Latonia nigriventer) has remained one of the world's rarest and least understood amphibian species. Together with its apparently low dispersal capability and highly disturbed niche, the low abundance of this living fossil calls for urgent conservation measures. We u...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23587-w
更新日期:2018-04-03 00:00:00
abstract::MRI of hyperpolarized media, such as (129)Xe and (3)He, shows great potential for clinical applications. The optimal use of the available spin polarization requires accurate flip angle calibrations and T1 measurements. Traditional flip angle calibration methods are time-consuming and suffer from polarization losses du...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25854
更新日期:2016-05-12 00:00:00
abstract::Cyanobacteria exhibit a great capacity to adapt to different environmental conditions through changes in gene expression. Although this plasticity has been extensively studied in the model cyanobacterium Synechocystis sp. PCC 6803, a detailed analysis of the coordinated transcriptional adaption across varying conditio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22168
更新日期:2016-02-29 00:00:00
abstract::Maturity stage in harvesting time greatly affects seed vigour. This work aimed to scientific harvesting time of hybrid rice for being high vigour with high & stable seed yield. Field experiments of different harvesting time were conducted in 2013-2014, and germination percentage (GP), vigour index (VI), seed moisture ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29021-5
更新日期:2018-07-23 00:00:00
abstract::Rangelands play a critical role in the global carbon cycle. However, the eco-physiological mechanisms associated with the effects of grazing on leaf photosynthesis and soil respiration remain poorly understood. To examine the impacts of grazing on leaf photosynthesis and soil respiration, we measured the photosyntheti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30087
更新日期:2016-07-25 00:00:00
abstract::Maize is rapidly replacing traditionally cultivated dual purpose crops of South Asia, primarily due to the better economic remuneration. This has created an impetus for improving maize for both grain productivity and stover traits. Molecular techniques can largely assist breeders in determining approaches for effectiv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80118-2
更新日期:2021-01-12 00:00:00
abstract::Cancer-specific promoter driven replication of oncolytic adenovirus (Ad) is cancer-specific, but shows low transcriptional activity. Thus, we generated several chimeric α-fetoprotein (AFP) promoter variants, containing reconstituted enhancer and silencer regions, to preferentially drive Ad replication in hepatocellula...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20268-6
更新日期:2018-02-02 00:00:00
abstract::It is now well established that invasive plants may induce drifts in the quantity and/or quality of floral resources. They are then often pointed out as a potential driver of bee decline. However, their impact on bee population remains quite unclear and still controversial, as bee responses are highly variable among s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16054-5
更新日期:2017-11-24 00:00:00
abstract::Pluripotent cells can be subdivided into two distinct states, the naïve and the primed state, the latter being further advanced on the path of differentiation. There are substantial differences in the regulation of pluripotency between human and mouse, and in humans only stem cells that resemble the primed state in mo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07927
更新日期:2015-01-21 00:00:00
abstract::We study the dynamical Casimir-Polder force on a two-level atom with different initial states in the one-dimensional dielectric cavity with output coupling, and obtain the analytical expression of the expectation value of dynamical Casimir-Polder force. Results show that the expectation values of dynamical Casimir-Pol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68546-6
更新日期:2020-07-20 00:00:00
abstract::Demand is increasing for superhydrophobic materials in many applications, such as membrane distillation, separation and special coating technologies. In this study, we report a chemical vapor deposition (CVD) process to fabricate superhydrophobic carbon nanomaterials (CNM) on nickel (Ni)-doped powder activated carbon ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21051-3
更新日期:2018-02-09 00:00:00
abstract::Optimal mental workload plays a key role in driving performance. Thus, driver-assisting systems that automatically adapt to a drivers current mental workload via brain-computer interfacing might greatly contribute to traffic safety. To design economic brain computer interfaces that do not compromise driver comfort, it...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80477-w
更新日期:2021-01-12 00:00:00
abstract::Cellular membrane distortion invokes variations in cellular physiology. However, lack of an appropriate system to control the stress and facilitate molecular analyses has hampered progress of relevant studies. In this study, a microfluidic system that finely manipulates membrane distortion of Chlamydomonas reinhardtii...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04675
更新日期:2014-04-14 00:00:00