Abstract:
:To compare the efficacy of low dose fentanyl infusion and 24% oral sucrose in providing optimal pain relief during laser for retinopathy of prematurity (ROP), we enrolled fifty-eight spontaneously breathing preterm infants undergoing laser. The preterm infants were randomized to either fentanyl infusion (1 mcg/kg/hr) or 24% oral sucrose (2 ml). We evaluated and compared the proportion of time spent crying during the procedure, salivary cortisol before and after the procedure, premature infant pain profile- revised (PIPP-R) scores during the procedure, apnoea during and after the procedure, need for mechanical ventilation, and feed intolerance and urinary retention 24 h after the procedure between the two groups. We found that the proportion of time spent crying during the procedure was significantly less in the fentanyl group [62.5% (50.7-74.2) vs 73.8% (55.6-83.4); P = 0.02]. Average PIPP-R score during the procedure was significantly less in the fentanyl group [7.2 vs 9.0; (mean difference of - 1.8; P = 0.01)]. There was no difference in other outcomes between the two groups.Conclusion: During laser for ROP, low dose fentanyl infusion was found to be efficacious in reducing pain as compared with 24% sucrose.What is Known:• Preterm infants undergoing laser photocoagulation for ROP suffer significant amount of pain.• Standard of care for pain relief in infants undergoing laser therapy in developed countries is general anesthesia (GA) or combination of sedation, analgesia, and paralysis (SAP).What is New:• During laser photocoagulation for ROP, fentanyl infusion at low dose (1 mcg/kg/hr) is efficacious in reducing pain as compared to 24% oral sucrose.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Sethi A,Sankar MJ,Kulkarni S,Thukral A,Chandra P,Agarwal Rdoi
10.1007/s00431-019-03514-5subject
Has Abstractpub_date
2020-02-01 00:00:00pages
285-292issue
2eissn
0340-6199issn
1432-1076pii
10.1007/s00431-019-03514-5journal_volume
179pub_type
杂志文章,随机对照试验abstract::Regional variations in the human leucocyte antigen (HLA) distribution patterns of coeliac disease (CD) have been reported. This study focuses on phenotype frequencies of a cohort of Austrian paediatric CD patients in comparison with those recorded in the literature. HLA class I and II typing was performed in 136 CD pa...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01958759
更新日期:1991-08-01 00:00:00
abstract::This is a report on two mentally retarded sibs with similar anomalies (sagittal craniosynostosis, complex cardiovascular malformations, mandibular ankylosis) and various dysmorphic features. They could represent a "new" probably monogenic syndrome. ...
journal_title:European journal of pediatrics
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abstract::A 9-year-old girl presented with a red scaly rash confined to sun-exposed areas which started at 2 years of age and had the appearance of pellagra. Investigation of urinary tryptophan metabolites following an oral tryptophan load, showed increased excretion of kynurenine and kynurenic acid but reduced excretion of 3-h...
journal_title:European journal of pediatrics
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doi:10.1007/BF01958432
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abstract:UNLABELLED:The surgical approach to the inguinal canal in girls is identical to that in boys. The sliding hernia which contains the ovary with or without the fallopian tube occurs occasionally in female patients. In our clinical experience, we found that a hydrocele in the labium, also presenting with an asymptomatic p...
journal_title:European journal of pediatrics
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doi:10.1007/s00431-003-1226-7
更新日期:2003-07-01 00:00:00
abstract::Early diagnosis and treatment of phenylketonuria (PKU) in Poland was started in 1965, initially on a voluntary and then on a obligatory basis. Guthrie tests have been used for newborn screening. For confirmation of diagnosis changing with time methods of blood phenylalanine (Phe) and tyrosine estimation were used. In ...
journal_title:European journal of pediatrics
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doi:10.1007/pl00014250
更新日期:1996-07-01 00:00:00
abstract::The new coronavirus disease outbreak in 2019 (COVID-19) represents a dramatic challenge for healthcare systems worldwide. As to viral tropism, lungs are not the only COVID-19 target but also the heart may be involved in a not negligible percentage of the infected patients. Myocarditis-related cardiac dysfunction and p...
journal_title:European journal of pediatrics
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doi:10.1007/s00431-020-03699-0
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abstract::Surfactant-associated protein (SP-A) was measured in tracheal aspirates of ventilated infants with (n = 51) and without (n = 21) respiratory distress syndrome (RDS). SP-A concentrations in samples collected after birth were significantly lower in RDS than in infants ventilated for other reasons than RDS (median 0.03 v...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01957730
更新日期:1992-08-01 00:00:00
abstract::Before promoting certain types of physical activities, the Health Promotion and Disease Prevention Department of Malta wanted to know whether children knew how to perform them in the first place, and if not, what barriers they had encountered. A cross-sectional, self-reported study involved 11-year-old students (boys ...
journal_title:European journal of pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1007/s00431-010-1185-8
更新日期:2010-09-01 00:00:00
abstract:UNLABELLED:The phenotypes of chromosomal 22q11.2 microdeletion are quite variable among individuals and hypoparathyroidism (HP) constitutes a definite portion of the clinical spectrum. For the correct diagnosis and pertinent follow up of the HP children due to del22q11.2, we tried to delineate the clinical characterist...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s004310050762
更新日期:1998-01-01 00:00:00
abstract:UNLABELLED:Scorpion envenomation is a health problem in children in tropical and subtropical regions. The aim of this study was to evaluate demographic and clinical characteristics as well as outcomes in referred children to Assiut University Children Hospital during the year 2012 with a history of scorpion sting. The ...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-013-2244-8
更新日期:2014-06-01 00:00:00
abstract::Cortisol and growth hormone (GH) secretion (spontaneous variations at night and the release induced by insulin hypoglycaemia) were investigated in 69 children and adolescents. Statistical analysis of approximately 600 pairs of cortisol and GH values in this study demonstrated that physiological fluctuations of cortiso...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00496996
更新日期:1978-06-20 00:00:00
abstract:UNLABELLED:The pathogenesis of sporadic hemiplegic migraine remains unclear, and perfusion-weighted magnetic resonance imaging (PWI) has been used for characterization of hemodynamic changes in migraine aura. We report a case of sporadic hemiplegic migraine in which magnetic resonance perfusion imaging showed left cere...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-015-2609-2
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abstract::Congenital syphilis is now rare in Australia, particularly in suburban areas. The disease is both preventable and treatable, however, missed or late diagnosis can lead to catastrophic effects. We report an infant who developed congenital syphilis after multiple opportunities for preventing this condition were missed. ...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-005-0050-7
更新日期:2006-05-01 00:00:00
abstract::Twenty-eight children whose parents reported sleep apnoea were investigated. In 15 infants apnoeic periods during sleep could be confirmed during clinical observation. Ventilatory responses to CO2 were measured in all infants, in 23 during sleep in 5 only when awake. A very wide range of CO2 sensitivities was found. I...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00496030
更新日期:1986-04-01 00:00:00
abstract::West syndrome or infantile spasms is one of the most frequent epileptic syndromes in the first year of life. The clinical symptoms of infantile spasms are very different than any other type of seizure because of both the absence of paroxysmal motor phenomena (i.e., as in a convulsion) and the lack of significant durat...
journal_title:European journal of pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1007/s00431-012-1813-6
更新日期:2012-11-01 00:00:00
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journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s004310100828
更新日期:2001-12-01 00:00:00
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journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-011-1666-4
更新日期:2012-06-01 00:00:00
abstract::Congenital high airway obstruction syndrome (CHAOS) is a rare prenatal diagnosis consisting of a typical fetal triad of large hyperechogenic lungs, flattened or inverted diaphragms and ascites. Most cases are sporadic with unknown incidence. Before attempts of fetoscopic fetal salvage or ex utero intrapartum treatment...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-006-0134-z
更新日期:2006-10-01 00:00:00
abstract::Patients suffering from a mitochondrial (encephalo-)myopathy have a remarkable clinical heterogeneity. A reliable and extensive investigation must be performed in order to obtain a correct diagnosis, but many factors may influence the ultimate results of these investigations leading, under certain circumstances, to an...
journal_title:European journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF01956139
更新日期:1993-03-01 00:00:00
abstract::Association between the use of infant formula and risks for infants' health is seldom studied in western countries. We set up a historical cohort based on record linkage analysis, combining the data from administrative databases providing individual data. Infants receiving the second dose of pediatric immunization bet...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-019-03462-0
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abstract::A comprehensive program for proficiency testing of biochemical genetics laboratories is described. Inborn errors of metabolism of amino acids, organic acids, glycosaminoglycans and oligosaccharides are covered, as well as the assay of galactose-1-phosphate. Participants are not only required to report the analytical r...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02138772
更新日期:1994-01-01 00:00:00
abstract::The total height gain was studied in 19 adult male subjects with non-tumorous hypopituitarism after they had been treated with human growth hormone (hGH) for more than 3 years and achieved final adult height. In patients with a history of breech delivery or severe perinatal asphyxia, a high multiple correlation was fo...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00442688
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abstract:UNLABELLED:Adipsic hypernatraemia is an uncommon disorder in childhood caused by a defect in the osmoregulation of thirst, leading to impairment of water homeostasis and chronic hyperosmolality of body fluids. Adipsia is often associated with an abnormality in osmoregulated vasopressin secretion due to the close proxim...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-004-1495-9
更新日期:2004-10-01 00:00:00
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journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-007-0523-y
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abstract:UNLABELLED:Sleep duration has been identified as risk factor for obesity already in children. Besides investigating the role of fat mass (FM), this study addressed the question whether endocrine mechanisms act as intermediates in the association between sleep duration and overweight/obesity. Within the framework of the...
journal_title:European journal of pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1007/s00431-011-1670-8
更新日期:2012-07-01 00:00:00
abstract::The fatty acid status of an unselected group of 84 Congolese children was determined by estimating the fatty acid composition of the plasma phospholipid (PL) and cholesterolester (CE) fractions using capillary gas chromatography. In comparison with North American and European children a wide range of values and low me...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00445928
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abstract::Proper nutrition throughout childhood and adolescence is crucial for normal bone development. We investigated whether adherence to Christian Orthodox Church fasting is characterized by periodic avoidance of animal foods (including dairy products), since childhood affects stature or bone health in young adults. This cr...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-019-03542-1
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journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-020-03735-z
更新日期:2021-01-01 00:00:00
abstract::Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant delivery. No statist...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-020-03572-0
更新日期:2020-08-01 00:00:00
abstract::This article summarizes some research on the development of motion perception in early infancy. The sensitivity for slow and rapid motion was studied with 1-month-old and 3-month-old babies. The findings suggest that there are different developmental courses for the detection of slow and rapid motion. The ability to d...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02191506
更新日期:1995-01-01 00:00:00