当前位置： SCI文献检索 > FOLIA MORPHOLOGICA期刊下所有文献 > Reduced c-Fos expression in orexin neurons of the lateral hypothalamic area and the locus coeruleus following injection of spinosin into mice.

Reduced c-Fos expression in orexin neurons of the lateral hypothalamic area and the locus coeruleus following injection of spinosin into mice.

Abstract：

BACKGROUND:Spinosin, a major component of Samen Ziziphi spinosae, has been shown to modulate sedation and hypnosis; however, the underlying neuronal mechanisms of its stimulatory effects remain unclear. MATERIALS AND METHODS:In the present study, we injected spinosin (15 mg/kg) or saline into mice, which were killed after 90 min. We isolated the brains, which were immunohistochemically stained for c-Fos as a biomarker for neuronal activation and assessed the expression profile of c-Fos in various sleep-arousal brain areas. RESULTS:Our findings revealed that there were no statistically significant differences in the expression of c-Fos in the nucleus accumbens and ventrolateral preoptic area, the vertical limb of the diagonal band nucleus, horizontal limb of the diagonal band nucleus, ventral tuberomammillary nucleus, ventral tegmental area, and dorsal raphe nucleus relative to saline between saline and spinosin-treated mice. Unlike saline, spinosin markedly decreased c-Fos expression in the lateral hypothalamic area (LHA) as well as the locus coeruleus (LC). Compared to the saline injection, the application of spinosin also resulted in a marked decrease in c-Fos expression in the LHA orexin neurons. CONCLUSIONS:These findings suggest that spinosin administration results in a restricted pattern of c-Fos expression within the LHA orexin neurons and the LC, suggesting that this particular neuronal inactivation contributes to sedation and hypnosis.

journal_name

Folia Morphol (Warsz)

journal_title

Folia morphologica

authors

Zhang JP,Liao DQ,Li L,Chu L

doi

10.5603/FM.a2019.0118

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

429-437

issue

3

eissn

0015-5659

issn

1644-3284

pii

VM/OJS/J/65274

journal_volume

79

pub_type

杂志文章

相关文献

FOLIA MORPHOLOGICA文献大全
  • An asymmetrical inferior articular process of a lumbar vertebra.

    abstract：:The present case report describes the topographical anatomy and radiological study of an asymmetrical inferior articular process of a lumbar vertebra, which was detected during routine osteology teaching of undergraduate medical students. The inferior articular process of the lumbar vertebra on the left side was rudim...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：

    authors： Das S,Suri R,Kapur V

    更新日期：2006-02-01 00:00:00

  • Communicating branch between the musculocutaneous and median nerves in human.

    abstract：:Communicating branch between the musculocutaneous and median nerves was found bilaterally in 1 human cadaver. The topography of vessels was normal. ...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：

    authors： Kaus M,Wotowicz Z

    更新日期：1995-01-01 00:00:00

  • The distribution of ghrelin cells in the human and animal gastrointestinal tract: a review of the evidence.

    abstract：:The growth hormone and appetite are regulated by a 28-peptide hormone called ghrelin, which is produced in the stomach, pituitary gland, and other body tissues. The physiological roles fulfilled by ghrelin include regulation of food intake, cardiac output, reproductive system, proliferation of cells, and formation of ...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：10.5603/FM.a2020.0077

    authors： Mehdar KM

    更新日期：2020-07-09 00:00:00

  • Vertebral artery variations revised: origin, course, branches and embryonic development.

    abstract：BACKGROUND:The vertebral artery originates from the subclavian artery and is divided into four segments. The aim of this study is to investigate the anatomical variations in the course and branches of the vertebral artery. M: ATERIALS AND METHODS: : A research was performed via Pubmed database, using the terms; "variat...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：10.5603/FM.a2020.0022

    authors： Magklara EP,Pantelia ET,Solia E,Panagouli E,Piagkou M,Mazarakis A,Skandalakis P,Troupis T,Filippou D

    更新日期：2020-02-19 00:00:00

  • Multiple vessel variations in the retropubic region.

    abstract：:We encountered some multiple vessel variations in the retropubic region of a 55-year-old male cadaver. The obturator artery had its origin from the external iliac artery, and inferior epigastric artery from the femoral artery. Additionally, an anastomosis between obturator and inferior epigastric veins (venous Crown o...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：

    authors： Sarikcioglu L,Sindel M

    更新日期：2002-01-01 00:00:00

  • Anomalies of the inferior vena cava: a report of two cases and a short review of the literature.

    abstract：:The inferior vena cava, also known as the posterior vena cava, is the large vein that carries de-oxygenated blood from the lower half of the body into the right atrium of the heart. Congenital anomalies of the inferior vena cava result from the persistence of the embryonic venous system. The majority of cases are clin...

    journal_title：Folia morphologica

    pub_type： 杂志文章,评审

    doi：

    authors： Kapetanakis S,Papadopoulos C,Galani P,Dimitrakopoulou G,Fiska A

    更新日期：2010-08-01 00:00:00

  • Anatomical description of the aortic arch of a rare species "the giant armadillo" (Priodontes maximus; Kerr, 1792).

    abstract：:The giant armadillo (Priodontes maximus) is found in diverse habitats from South America. A female adult giant armadillo with a body mass of 45 kg was used. The animal was a victim of trampling on highway AC-40, at 70 km, near the municipality of Capixaba-Acre and the corpse donated to the Animal Anatomy Laboratory at...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：10.5603/FM.a2019.0053

    authors： Santos R,Fernandes M,de Souza SF,Dos Santos-Sousa CA,de Carvalho YK

    更新日期：2020-01-01 00:00:00

  • Accumulation of membranes and photoreceptor degeneration in mouse retina.

    abstract：:Ultrastructural response of photoreceptors to 10 days of treatment with reserpine and bromocryptine, and to 10 days of illumination, was studied. Treatment with isoproterenol was also applied in some experiments with continuous illumination. Treatment with bromocryptine and reserpine induced elongation of rod outer se...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：

    authors： Kralj M,Pipan N

    更新日期：1998-01-01 00:00:00

  • Blood vascular organization of the walls of vermiform appendix from human fetus. Examination of vascular corrosion casts in SEM.

    abstract：:Ten human vermiform appendices obtained from fetal corpses (160.0-240.0 mm of CRL) were examined using injection-micro corrosion method. Blood vascular bed reproduced with this method was observed with scanning electron microscope (SEM). Blood vascular bed structure of foetal appendix has been described, simultaneousl...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：

    authors： Pityński K,Skawina A,Gorczyca J,Strek P,Nowogrodzka-Zarórska M

    更新日期：1993-01-01 00:00:00

  • Morphological variations of the vermiform appendix in Iranian cadavers: a study from developing countries.

    abstract：BACKGROUND:The vermiform appendix is a worm-like tube containing a large amount of lymphoid follicles. In our knowledge, there is a little standard data about the vermiform appendix in Iranian population. Therefore, the objective of this study was to investigate the normal appendix size in Iranian cadavers. MATERIALS ...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：10.5603/FM.a2017.0032

    authors： Mohammadi S,Hedjazi A,Sajjadian M,Rahmani M,Mohammadi M,Moghadam MD

    更新日期：2017-01-01 00:00:00

  • Normative size evaluation of internal auditory canal with magnetic resonance imaging: review of 3786 patients.

    abstract：BACKGROUND:A narrow internal auditory canal (IAC) is significantly associated with congenital sensorineural hearing loss. It would therefore seem likely that any patient with an IAC measured radiographically to be under the normal range represents an abnormality and probable IAC stenosis. If narrow IAC is diagnosed wit...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：

    authors： Erkoç MF,Imamoglu H,Okur A,Gümüş C,Dogan M

    更新日期：2012-11-01 00:00:00

  • Unilateral agenesis of the facial artery with compensation by a giant transverse facial artery.

    abstract：:During routine dissections carried out in the course of our medical gross anatomy work, an unusual structure was found unilaterally on the left side of an adult male cadaver. Upon investigation, this was determined to be a hugely dilated transverse facial artery. Also noted was the complete absence of the ipsilateral ...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：

    authors： Tubbs RS,Salter EG,Oakes WJ

    更新日期：2005-08-01 00:00:00

  • Radiomorphometric assessment of the pterygoid hamulus as a factor promoting the pterygoid hamulus bursitis.

    abstract：BACKGROUND:The pterygoid hamulus (PH) is a small protrusion on the base of the pterygoid process of the sphenoid bone. PH is a site of insertion of many muscles and ligaments. Its topography can determine predilection for developing the pterygoid hamulus bursitis (PHB). MATERIALS AND METHODS:The study was conducted ba...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：10.5603/FM.a2019.0049

    authors： Komarnitki I,Skadorwa T,Chloupek A

    更新日期：2020-01-01 00:00:00

  • Cadherin and vimentin immunoexpression in the testis of normal and induced infertility models of albino rats.

    abstract：BACKGROUND:Sertoli cells are important in determining the fate of spermatogenic cells by providing nutrition and structural support via cell junctions. Adhesion between Sertoli and germ cells is important for spermatogenesis. Cadherin are transmembrane proteins that mediate cell-cell adhesion, while, vimentin, the cyto...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：10.5603/FM.2014.0050

    authors： ElGhamrawy TA,Helmy D,Elall HF

    更新日期：2014-08-01 00:00:00

  • Partial pancreatic resection along the embryological fusion plane - no longer a fantasy.

    abstract：BACKGROUND:The embryological connection between the dorsal and ventral pancreatic regions divides the pancreas into two segments. This anatomical dependence allows segmental pancreatic resection through the embryological fusion plane (EFP). The advantages of limited pancreatic resection are the preservation of the natu...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：10.5603/FM.a2019.0121

    authors： Łącka M,Łaski D,Hać S,Szymański M

    更新日期：2019-11-21 00:00:00

  • Dentin dysplasia type I.

    abstract：:This paper describes a rare case of genetically determined dentin dysplasia type Iin 26-year-old male patient. The paper highlights anatomical and radiologicalaspects of dental abnormalities and emphasizes the significance of the educationof both general practitioners and paediatricians as regards referring patients w...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：10.5603/FM.a2019.0012

    authors： Kobus A,Świsłocka M,Kierklo A,Borys J,Domel E,Różycki J,Ławicki S,Bagińska J

    更新日期：2019-01-01 00:00:00

  • Relationship of vascular variations with liver remnant volume in living liver transplant donors.

    abstract：BACKGROUND:In this study, we investigated the relationship between the portal vein and hepatic artery variations and the remaining liver volume in living donors in liver transplantation. MATERIALS AND METHODS:In the study, triphasic abdominal CT images of 180 live liver donor candidates were analyzed retrospectively. ...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：10.5603/FM.a2020.0080

    authors： Yılmaz Çankaya B,Polat G,Aksungur N,Yalçın A,Korkut E,Sade R,Pirimoğlu RB,Kara S,Ay M,Altuntaş N,Alper F

    更新日期：2020-08-04 00:00:00

  • Diastema size and type of upper lip midline frenulum attachment.

    abstract：BACKGROUND:Diastema is a space between teeth. The most often is maxillary midline diastema between upper central incisors. One of the main causes of diastema is enlarged upper lip frenulum attachment. The aim of the study was to assess frenulum attachment in patients with diastema and investigate if type of upper lip f...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：10.5603/FM.a2016.0079

    authors： Sękowska A,Chałas R

    更新日期：2017-01-01 00:00:00

  • Assessment of morphological and functional changes in neonate vitrified testis grafts after host treatment with melatonin.

    abstract：:This study was conducted to assess the effect of melatonin on the structure of testis and spermatogenesis dynamics in neonate vitrified testis grafts. Neonate vitrified testes, candidates for transplantation heterotopically to experiment or control groups, were warmed in thawing media which had or did not have a suppl...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：

    authors： Hemadi M,Zargar M,Sobhani A,Sobhani A

    更新日期：2011-05-01 00:00:00

  • Progress in myelin formation of the thoracic sympathetic trunk in human fetus aged 17 weeks.

    abstract：:In 17th week old fetus the interganglionic rami of the thoracic sympathetic trunk are mainly composed of bundles of unmylinated fibers. The well myelinated fibers have 11 compact myelin lamellae. Although many fibers are already myelinated, fibers in various phases of myelinogenesis are found. ...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：

    authors： Bruska M,Woźniak W

    更新日期：1997-01-01 00:00:00

  • Infraorbital groove localisation for the endoscopic decompression of the orbit in Graves' disease.

    abstract：BACKGROUND:The aim of our study was to determine the localisation of the inferior margin of the optic canal in relation to the infraorbital canal/groove complex (IOC/G complex) and zygomaticoorbitale (ZO) as the potential useful landmarks for reducing dangerous complications following surgical and invasive procedures. ...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：10.5603/FM.2015.0013

    authors： Przygocka A,Jędrzejewski K,Szymański J,Wysiadecki G,Topol M,Polguj M

    更新日期：2015-01-01 00:00:00

  • Remarks on the arterial vascularization of double kidney.

    abstract：:In the material of 300 kidneys, collected from adult corpses of both sexes, the presence of double renal pelvis and duplicated ureter within the renal hilus was detected in 4 cases. In the investigated double kidneys the number of segmental arteries ranged from 4 to 6. In two out of the examined organs there were doub...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：

    authors： Kosiński H

    更新日期：1997-01-01 00:00:00

  • The ultrastructure and processing properties of Straumann Bone Ceramic and NanoBone.

    abstract：:The ultrastructure, fundamental chemistry, and processing modes of fully synthetic bone grafting materials are relevant to the reconstruction of osseous defects. Rapid progress in the profitable market of biomaterials has led to the development of various bone substitutes. Despite all these efforts, an ideal and full ...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：

    authors： Dietze S,Bayerlein T,Proff P,Hoffmann A,Gedrange T

    更新日期：2006-02-01 00:00:00

  • Contributions to the study of the foetal development of physiological intimal thickening in the human uterine artery.

    abstract：:The morphological study of the development of "intimal thickenings" of the human uterine artery in physiological condition was performed on 72 uterine arteries obtained from foetuses from the 12th week of gestation up to birth. Our results indicate that intimal thickening is formed by the migration and displacement of...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：

    authors： Whyte JO,Cisneros AI,Alvarez M,Alconchel MD,Yus C,Torres A,Sarrat R

    更新日期：2001-08-01 00:00:00

  • Evidence of increased axillary blood flow velocity without increased handgrip strength and endurance in persons with a fibromuscular axillary arch.

    abstract：BACKGROUND:The purpose of this in vivo study was to compare axillary artery blood flow velocity, and maximal handgrip strength and endurance performance in young subjects with and without an axillary arch (AA). MATERIALS AND METHODS:One hundred and fifty-six young adults were screened for the presence of an AA on thei...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：10.5603/FM.2015.0112

    authors： Scafoglieri A,De Maeseneer M,Debondt A,Boulet C,Tresignie J,De Mey J,Clarys JP

    更新日期：2015-01-01 00:00:00

  • Septal perforators stemming from a very long left main coronary artery.

    abstract：:We report a case of a very long left main coronary artery (58 mm) with septal perforators before bifurcation. The coronary arteries were seen clear of plaques. To the best of our knowledge, this case is very rare because of the existence of the first and second septal perforator arteries originating from a very lon...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：

    authors： Kucukdurmaz Z,Karapinar H,Gul I,Kosar MÍ,Yilmaz A

    更新日期：2012-11-01 00:00:00

  • The thyroid gland and its variations: a cadaveric study.

    abstract：:The size and shape of the thyroid gland is subject to much variation, as stated by Wood Jones. Literature is replete with a large number of variations of the gland. By utilizing various techniques like gross dissection, histology, developmental anatomy, and recently thyroid scans and scintigraphy, some common and cert...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：

    authors： Joshi SD,Joshi SS,Daimi SR,Athavale SA

    更新日期：2010-02-01 00:00:00

  • Congenital coronary artery anomalies in adult population detected using dual source ECG-gated CTA in a single institution.

    abstract：BACKGROUND:Congenital anomalies of the coronary arteries (CAs) are rare and are often diagnosed incidentally during a conventional coronary angiography. Recently, the incidence of these congenital defects is on the rise particularly after the introduction of the electrocardiography (ECG) gated coronary computed tomogra...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：10.5603/FM.a2016.0053

    authors： Mathai RT,Fahmy DM,Sadek HL,Renno WM

    更新日期：2017-01-01 00:00:00

  • Myocardial necrosis due to vitamin D3 overdose -- scanning electron microscopic observations.

    abstract：:Our studies were carried out on the hearts of virgin female Wistar rats treated with 100,000 i.u. of vitamin D3 (calciol) per os for 3 consecutive days. Multifocal cardionecrosis was established macroscopically in 70% of the vitamin D-treated rats on the 7th day of the experiment when the rats were in the acute phase ...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：

    authors： Walentynowicz O,Kubasik-Juraniec J,Rudzińska-Kisiel T

    更新日期：2004-11-01 00:00:00

  • The oculomotor nuclear complex at the end of the embryonic period (stage 23).

    abstract：:Investigations were made on serial sections of human embryos at developmental stage 23 (56 days). The oculomotor complex in embryos at this stage consists of lateral, median, and accessory nuclei. The lateral (chief) nucleus forms the greatest part of the oculomotor complex and it is subdivided into ventromedial and d...

    journal_title：Folia morphologica

    pub_type： 杂志文章

    doi：

    authors： Szyszka-Mróz J

    更新日期：1999-01-01 00:00:00