Emerging CAR T cell therapies: clinical landscape and patent technological routes.

abstract：BACKGROUND:We studied completeness and timeliness of vaccination and determinants for low and delayed uptake in children born between 2008 and 2009 in Zhejiang province in eastern China. METHODS:We used data from a cross-sectional cluster survey conducted in 2011, which included 1146 children born from 1 Jan 2008 to 3...

journal_title：Human vaccines & immunotherapeutics

authors： Hu Y,Chen Y,Guo J,Tang X,Shen L

更新日期：2014-01-01 00:00:00

abstract：:Malaria has long been recognized as a public health problem. At the community level, vector control, and antimalarial medicines are the main means for reducing incidence, morbidity, and mortality of malaria. A vaccine not only would bring streamlining in the prevention of morbidity and mortality from malaria but also ...

journal_title：Human vaccines & immunotherapeutics

authors： Jindal H,Bhatt B,Malik JS,Sk S,Mehta B

更新日期：2014-01-01 00:00:00

abstract：:Human papillomavirus (HPV) infection is common in women and also the main cause of cervical cancer. Based on a dynamic compartmental model, we aimed to evaluate the population impact and cost-effectiveness of strategies that combined cervical cancer screening and HPV schoolgirl vaccination for Chinese women. The effec...

journal_title：Human vaccines & immunotherapeutics

authors： Ma X,Harripersaud K,Smith K,Fairley CK,Zou H,Zou Z,Wang Y,Zhuang G,Zhang L

更新日期：2020-12-03 00:00:00

abstract：:Kyasanur Forest Disease (KFD) is a tick-borne hemorrhagic fever of human, caused by Kyasanur forest disease virus (KFDV) in India. The tick, Haemaphysalis spinigera, has been incriminated as the vector of KFDV. In human, KFD clinically presents with high fever, frontal headache, and severe myalgia, followed by bleedin...

journal_title：Human vaccines & immunotherapeutics

authors： Rajaiah P

更新日期：2019-01-01 00:00:00

abstract：:Integrating additive or synergistic antitumor effects that focus on distinct elements of tumor biology are the most rational strategies for cancer treatment. Treatments for breast cancer have increased overall survival, but remain limited by lack of efficacy in a subset of breast cancer patients. The real challenge is...

journal_title：Human vaccines & immunotherapeutics

authors： Kieber-Emmons T,Monzavi-Karbassi B,Hutchins LF,Pennisi A,Makhoul I

更新日期：2017-02-01 00:00:00

abstract：:Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that play an important role in stimulating an immune response of both CD4(+) T helper cells and CD8(+) cytotoxic T lymphocytes (CTLs). As such, DCs have been studied extensively in cancer immunotherapy for their capability to induce a specific anti...

journal_title：Human vaccines & immunotherapeutics

authors： Schneble EJ,Yu X,Wagner TE,Peoples GE

更新日期：2014-01-01 00:00:00

abstract：:Assessing the beliefs and attitudes of Health Care Workers (HCW) to influenza and influenza vaccination can be useful in overcoming low compliance rates. The purpose of our study is to evaluate the opinion of HCW and students regarding influenza, influenza vaccine and the factors associated with vaccination compliance...

journal_title：Human vaccines & immunotherapeutics

authors： Bonaccorsi G,Lorini C,Santomauro F,Guarducci S,Pellegrino E,Puggelli F,Balli M,Bonanni P

更新日期：2013-12-01 00:00:00

abstract：:Although immunotherapies have been employed for many decades, immune checkpoint inhibitors have only recently entered the oncologic landscape. Avelumab is a fully human monoclonal antibody that blocks the interaction between PD-L1 on tumor cells and PD-1 on T cells, thereby inhibiting immunosuppression in the tumor mi...

journal_title：Human vaccines & immunotherapeutics

authors： Collins JM,Gulley JL

更新日期：2019-01-01 00:00:00

abstract：:This survey study compared pre- and post-pandemic knowledge, attitudes, beliefs, and intended behaviors of pregnant women regarding influenza vaccination (seasonal and/or pandemic) during pregnancy in order to determine key factors influencing their decision to adhere to influenza vaccine recommendations. Only 36% of ...

journal_title：Human vaccines & immunotherapeutics

authors： Halperin BA,MacKinnon-Cameron D,McNeil S,Kalil J,Halperin SA

更新日期：2014-01-01 00:00:00

abstract：:School-based vaccination, as a means to mitigate seasonal influenza outbreak, depends on attaining adequate coverage rate. We evaluated the potential of a fully subsidized school outreach vaccination (SOV) program to achieve epidemic prevention potential in Hong Kong. The purpose of this study was to evaluate the impa...

journal_title：Human vaccines & immunotherapeutics

authors： Lau YL,Wong WHS,Hattangdi-Haridas SR,Chow CB

更新日期：2020-04-02 00:00:00

abstract：:Background: To assess the knowledge and attitudes of middle school students toward vaccination, we measured their understanding of vaccine safety and effectiveness, expectations for communication with heath care providers, and their desired role in the vaccination decision-making process. Methods: A cross-sectional, s...

journal_title：Human vaccines & immunotherapeutics

authors： Herman R,McNutt LA,Mehta M,Salmon DA,Bednarczyk RA,Shaw J

更新日期：2019-01-01 00:00:00

abstract：:Maternal immunization holds tremendous promise to improve maternal and neonatal health for a number of infectious conditions. The unique susceptibilities of pregnant women to infectious conditions, as well as the ability of maternally-derived antibody to offer vital neonatal protection (via placental transfer), togeth...

journal_title：Human vaccines & immunotherapeutics

authors： Moniz MH,Beigi RH

更新日期：2014-01-01 00:00:00

abstract：:Eight months after the mass immunization campaign of November 2015 against measles and rubella in the southeast of Iran, in order to evaluate the sero-immunity level of the people living in the mentioned region, a serosurvey study was performed. Using a multi-stage probability proportional to size cluster sampling, th...

journal_title：Human vaccines & immunotherapeutics

authors： Izadi S,Zahraei SM,Mokhtari-Azad T

更新日期：2018-06-03 00:00:00

abstract：:This cross-sectional survey determined the vaccine hesitancy related to Human papillomavirus (HPV) and the determinants among parents of adolescents aged 12 and 13 years in Italy. Data was collected through a self-administered questionnaire. Two-thirds of the parents (66.7%) had heard of HPV infection and knew that th...

journal_title：Human vaccines & immunotherapeutics

authors： Della Polla G,Pelullo CP,Napolitano F,Angelillo IF

更新日期：2020-11-01 00:00:00

abstract：:Tuberculosis (TB) is a significant cause of illness and death worldwide. Immunotherapy has been investigated in the treatment of TB. The purpose of this study was to perform a meta-analysis investigating the effectiveness of the M. vaccae vaccine. Medline, Cochrane, EMBASE, and Google Scholar were searched until Novem...

journal_title：Human vaccines & immunotherapeutics

authors： Huang CY,Hsieh WY

更新日期：2017-09-02 00:00:00

abstract：:We investigated the relationship between reported cases of influenza in Catalonia (Spain). Covariates analyzed were: population, age, data of report of influenza, and health region during 2010-2014 using data obtained from the SISAP program (Institut Catala de la Salut - Generalitat of Catalonia). Reported cases were ...

journal_title：Human vaccines & immunotherapeutics

authors： Oviedo M,Domínguez Á,Pilar Muñoz M

更新日期：2015-01-01 00:00:00

abstract：:Streptococcus pneumoniae causes pneumonia, meningitis, otitis media, and bacteremia. The mortality and morbidity of invasive pneumococcal disease are high among adults aged >65 years or those with underlying chronic or immunosuppressive conditions. A recent systematic review showed that patients treated with immunosup...

journal_title：Human vaccines & immunotherapeutics

authors： Kuronuma K,Takahashi H

更新日期：2019-01-01 00:00:00

abstract：:Highly pathogenic avian influenza (HPAI) H5N1 is an ongoing global health concern due to its severe sporadic outbreaks in Asia, Africa and Europe, which poses a potential pandemic threat. The development of safe and cost-effective vaccine candidates for HPAI is considered the best strategy for managing the disease and...

journal_title：Human vaccines & immunotherapeutics

authors： Pua TL,Chan XY,Loh HS,Omar AR,Yusibov V,Musiychuk K,Hall AC,Coffin MV,Shoji Y,Chichester JA,Bi H,Streatfield SJ

更新日期：2017-02-01 00:00:00

abstract：:Vaccine preventable diseases have been responsible for a significant portion of childhood mortality in low-income countries, and have been re-emerging in medium- and high-income countries. The effectiveness of routine childhood immunization programs relies on multiple factors. Social determinants have the potential to...

journal_title：Human vaccines & immunotherapeutics

authors： Glatman-Freedman A,Nichols K

更新日期：2012-03-01 00:00:00

abstract：:Varicella zoster virus (VZV) is primarily known for causing varicella in childhood, but can reactivate again as herpes zoster (HZ) after a period of latency, mainly in persons older than 50 years. Universal varicella vaccination was introduced in Germany in 2004, while HZ vaccination has not been recommended yet. We a...

journal_title：Human vaccines & immunotherapeutics

authors： Horn J,Karch A,Damm O,Kretzschmar ME,Siedler A,Ultsch B,Weidemann F,Wichmann O,Hengel H,Greiner W,Mikolajczyk RT

更新日期：2016-07-02 00:00:00

abstract：:Rapid population aging has become a major challenge in the industrialized world and progressive aging is a key reason for making improvement in vaccination a cornerstone of public health strategy. An increase in age-related disorders and conditions is likely to be seen in the near future, and these are risk factors fo...

journal_title：Human vaccines & immunotherapeutics

authors： Esposito S,Bonanni P,Maggi S,Tan L,Ansaldi F,Lopalco PL,Dagan R,Michel JP,van Damme P,Gaillat J,Prymula R,Vesikari T,Mussini C,Frank U,Osterhaus A,Celentano LP,Rossi M,Guercio V,Gavazzi G

更新日期：2016-07-02 00:00:00

abstract：:Rotavirus is the most common cause of diarrhea leading to hospitalization in young children. Rotavirus vaccines are available in Canada but have not been introduced in all provinces. In a controlled trial, 2 study sites (Prince Edward Island and the Capital District Health Authority (District 9, Nova Scotia) introduce...

journal_title：Human vaccines & immunotherapeutics

authors： Sanford C,Langley JM,Halperin SA,Zelman M,Mvrvp

更新日期：2015-01-01 00:00:00

abstract：:Pertussis has had a resurgence with the highest incidence and complication rates in young infants, and deaths occurring mainly at < age 3 months. Infants are infected by older individuals whose immunity has waned. Strategies such as targeted immunization of infant caregivers have had limited success. Pertussis vaccina...

journal_title：Human vaccines & immunotherapeutics

authors： Healy CM

更新日期：2016-08-02 00:00:00

abstract：BACKGROUND:Adolescents are the primary target population for human papillomavirus (HPV) vaccination. The objective of this study is to explore the acceptability of HPV vaccines and evaluate factors related to willingness to be vaccinated among Chinese adolescents. METHODS:A nation-wide survey was conducted across 14 s...

journal_title：Human vaccines & immunotherapeutics

authors： Zhang X,Wang Z,Ren Z,Li Z,Ma W,Gao X,Zhang R,Qiao Y,Li J

更新日期：2020-10-29 00:00:00

abstract：:The main objective of this post hoc analysis is to compare the magnitude of the immune response to HPV31/33/45/52 and 58 after a dose of 9vHPV vaccine given to naïve (previously unvaccinated) subjects and subjects previously vaccinated with a dose of 2vHPV or 4vHPV vaccine. Results from two clinical trials conducted i...

journal_title：Human vaccines & immunotherapeutics

authors： Sauvageau C,Panicker G,Unger ER,De Serres G,Schiller J,Ouakki M,Gilca V

更新日期：2020-03-03 00:00:00

abstract：:The usual treatments for patients with non-small-cell lung cancer (NSCLC), such as advanced lung adenocarcinoma, are unspecific and aggressive, and include lung resection, radiotherapy and chemotherapy. Recently, treatment with monoclonal antibodies and biological inhibitors has emerged as an effective alternative, ge...

journal_title：Human vaccines & immunotherapeutics

authors： Silva AP,Coelho PV,Anazetti M,Simioni PU

更新日期：2017-04-03 00:00:00

abstract：:Attenuated measles virus (MV) is one of the most effective and safe vaccines available, making it attractive candidate vector to prevent infectious diseases. Attenuated MV have acquired the ability to use the complement regulator CD46 as a major receptor to mediate virus entry and intercellular fusion. Therefore, atte...

journal_title：Human vaccines & immunotherapeutics

authors： Baldo A,Galanis E,Tangy F,Herman P

更新日期：2016-05-03 00:00:00

abstract：:Cellular immunotherapy can be an effective adjuvant treatment for multiple myeloma (MM), as demonstrated by induction of durable remissions after allogeneic stem cell transplantation. However, anti-myeloma immunity is often hampered by suppressive mechanisms in the tumor micro-environment resulting in relapse or disea...

journal_title：Human vaccines & immunotherapeutics

authors： Roeven MW,Hobo W,Schaap N,Dolstra H

更新日期：2014-01-01 00:00:00

abstract：:The combined diphtheria-tetanus-acellular pertussis-hepatitis B-poliomyelitis/Haemophilus influenza vaccine (DTPa-HBV-IPV/Hib: Infanrix™ hexa, GlaxoSmithKline Vaccines) is used for primary vaccination of infants in a range of schedules world-wide. Antibody persistence after 4 DTPa-HBV-IPV/Hib doses in the first 2 y of...

journal_title：Human vaccines & immunotherapeutics

authors： Silfverdal SA,Assudani D,Kuriyakose S,Van Der Meeren O

更新日期：2014-01-01 00:00:00

abstract：:Meningococcal meningitis is caused by Neisseria meningitidis, a gram-negative, aerobic, encapsulated diplococcus. Meningococci are divided into numerous serogroups based on the composition of their capsular polysaccharide (Ps) antigens. At least 13 serogroups have been described: A, B, C, D, 29E, H, I, K, L, W-135, X,...

journal_title：Human vaccines & immunotherapeutics

authors： Verma R,Khanna P

更新日期：2012-12-01 00:00:00