Three cooperative mechanisms required for recovery after brain damage.

abstract：:There has been a developing technology in algae with pharmaceuticals wastewater. However, the effect and the underlying mechanism of pharmaceuticals on algae are not well understood. To investigate the effect and mechanism of pharmaceuticalson microalgae, four pharmaceuticals of clofibric acid (CLF), ciprofloxacin (CI...

journal_title：Scientific reports

authors： Zhang Y,Guo J,Yao T,Zhang Y,Zhou X,Chu H

更新日期：2019-02-07 00:00:00

abstract：:Primary Sjögren's syndrome (pSS) is a complex autoimmune disease characterized by dysfunction of secretory epithelia with only palliative therapy. Patients present with a constellation of symptoms, and the diversity of symptomatic presentation has made it difficult to understand the underlying disease mechanisms. In t...

journal_title：Scientific reports

authors： Tanaka T,Warner BM,Odani T,Ji Y,Mo YQ,Nakamura H,Jang SI,Yin H,Michael DG,Hirata N,Suizu F,Ishigaki S,Oliveira FR,Motta ACF,Ribeiro-Silva A,Rocha EM,Atsumi T,Noguchi M,Chiorini JA

更新日期：2020-09-16 00:00:00

abstract：:The long-standing challenge for forming Al-based BMGs and their matrix composites with a critical size larger than 1 mm have not been answered over the past three decades. In this paper, we reported formation of a series of BMG matrix composites which contain a high Al content up to 55 at.%. These composites can be ca...

journal_title：Scientific reports

authors： Chen ZP,Gao JE,Wu Y,Wang H,Liu XJ,Lu ZP

更新日期：2013-11-27 00:00:00

abstract：:In 2018, the World Health Organization identified the Zika virus (ZIKV) as a pathogen that should be prioritized for public health research due to its epidemic potential. In this study, whole-genome sequencing (WGS) of travel-acquired ZIKV infections was used to examine the limitations of phylogenetic analysis. WGS an...

journal_title：Scientific reports

authors： Kamelian K,Montoya V,Olmstead A,Dong W,Harrigan R,Morshed M,Joy JB

更新日期：2019-11-11 00:00:00

abstract：:The ability to process time on the scale of milliseconds and seconds is essential for behaviour. A growing number of studies have started to focus on brain dynamics as a mechanism for temporal encoding. Although there is growing evidence in favour of this view from computational and in vitro studies, there is still a ...

journal_title：Scientific reports

authors： Bueno FD,Morita VC,de Camargo RY,Reyes MB,Caetano MS,Cravo AM

更新日期：2017-04-10 00:00:00

abstract：:Essential oils are volatile compounds commonly used by several industries, easily degradable, which restrains their applications. Therefore, we developed and validated a methodology for producing microcapsules loaded with orange essential oil, using a spray-drying process. The experimental design results showed that t...

journal_title：Scientific reports

authors： Aguiar MCS,das Graças Fernandes da Silva MF,Fernandes JB,Forim MR

更新日期：2020-07-16 00:00:00

abstract：:The population of hepatitis B combined with a number of metabolic disorders is increasing significantly. Resveratrol (RSV) has been used as a preclinical drug for the treatment of the metabolic disorders. However, the impact of RSV on HBV replication remains unknown. In this study, the HBV-expressing hepatocelluar car...

journal_title：Scientific reports

authors： Shi Y,Li Y,Huang C,Ying L,Xue J,Wu H,Chen Z,Yang Z

更新日期：2016-04-21 00:00:00

abstract：:The importance of self-feedback autaptic transmission in modulating spike-time irregularity is still poorly understood. By using a biophysical model that incorporates autaptic coupling, we here show that self-innervation of neurons participates in the modulation of irregular neuronal firing, primarily by regulating th...

journal_title：Scientific reports

authors： Guo D,Wu S,Chen M,Perc M,Zhang Y,Ma J,Cui Y,Xu P,Xia Y,Yao D

更新日期：2016-05-17 00:00:00

abstract：:The innovation of iconic gestures is essential to establishing the vocabularies of signed languages, but might iconicity also play a role in the origin of spoken words? Can people create novel vocalizations that are comprehensible to naïve listeners without prior convention? We launched a contest in which participants...

journal_title：Scientific reports

authors： Perlman M,Lupyan G

更新日期：2018-02-08 00:00:00

abstract：:Most enzymes that act on carbohydrates include non-catalytic carbohydrate-binding modules (CBMs) that recognize and target carbohydrates. CBMs bring their appended catalytic modules into close proximity with the target substrate and increase the hydrolytic rate of enzymes acting on insoluble substrates. We previously ...

journal_title：Scientific reports

authors： Duan CJ,Feng YL,Cao QL,Huang MY,Feng JX

更新日期：2016-01-14 00:00:00

abstract：:ATM is an important cancer susceptibility gene that encodes a critical apical kinase of the DNA damage response (DDR) pathway. We show that a key nonsense-mediated RNA decay switch exon (NSE) in ATM is repressed by U2AF, PUF60 and hnRNPA1. The NSE activation was haplotype-specific and was most promoted by cytosine at ...

journal_title：Scientific reports

authors： Kralovicova J,Knut M,Cross NC,Vorechovsky I

更新日期：2016-01-06 00:00:00

abstract：:Diabetes mellitus (DM) significantly increases myocardial ischemia/reperfusion (MI/R) injury. During DM, cardioprotection induced by conventional pre-conditioning (PreCon) is decreased due to impaired AMP-activated protein kinase (AMPK) signaling. The current study investigated whether PreCon with inhaled anesthetic s...

journal_title：Scientific reports

authors： Xie D,Zhao J,Guo R,Jiao L,Zhang Y,Lau WB,Lopez B,Christopher T,Gao E,Cao J,Ma X,Wang Y

更新日期：2020-01-08 00:00:00

abstract：:Metabotropic glutamate receptor subtype 1 (mGluR1) is a crucial pharmacological target for several central nervous system disorders. In this study, we aimed to monitor in vivo regional changes of mGluR1 related to neuroinflammation in the brains of rats after pilocarpine-induced status epilepticus (PISE) using longitu...

journal_title：Scientific reports

authors： Yamasaki T,Fujinaga M,Mori W,Zhang Y,Wakizaka H,Nengaki N,Xie L,Hatori A,Zhang MR

更新日期：2017-11-02 00:00:00

abstract：:Maize streak virus disease (MSVD), caused by Maize streak virus (MSV; genus Mastrevirus), is one of the most severe and widespread viral diseases that adversely reduces maize yield and threatens food security in Africa. An effective control and management of MSVD requires robust and sensitive diagnostic tests capable ...

journal_title：Scientific reports

authors： Tembo M,Adediji AO,Bouvaine S,Chikoti PC,Seal SE,Silva G

更新日期：2020-11-12 00:00:00

abstract：:Brain tumors are fast proliferating and destructive within the brain microenvironment. Effective chemotherapeutic strategies are currently lacking which combat this deadly disease curatively. The glioma-specific chloride ion channel represents a specific target for therapy. Chlorotoxin (CTX), a peptide derived from sc...

journal_title：Scientific reports

authors： Xu T,Fan Z,Li W,Dietel B,Wu Y,Beckmann MW,Wrosch JK,Buchfelder M,Eyupoglu IY,Cao Z,Savaskan NE

更新日期：2016-02-02 00:00:00

abstract：:Drug discovery efforts against the pathogen Mycobacterium tuberculosis (Mtb) have been advanced through phenotypic screens of extensive compound libraries. Such a screen revealed sulfolane 1 and indoline-5-sulfonamides 2 and 3 as potent inhibitors of mycobacterial growth. Optimization in the sulfolane series led to co...

journal_title：Scientific reports

authors： Abrahams KA,Cox JAG,Fütterer K,Rullas J,Ortega-Muro F,Loman NJ,Moynihan PJ,Pérez-Herrán E,Jiménez E,Esquivias J,Barros D,Ballell L,Alemparte C,Besra GS

更新日期：2017-08-25 00:00:00

abstract：:There is lack of consensus regarding the prognostic significance of primary tumor location of upper tract urothelial carcinoma(UTUC). We performed a meta-analysis to evaluate the impact of primary tumor location on prognosis in patients with UTUC who had undergone radical nephroureterectomy(RNU). We included eligible ...

journal_title：Scientific reports

authors： Wu Y,Dong Q,Liu L,Han P,Wei Q

更新日期：2014-09-15 00:00:00

abstract：:Atropine eye drops and myopic retinal defocus each slow progression of myopia (short-sight). They also cause thickening of the choroid, and it has been suggested that the thickening is a precursor for reduced eye growth and slowed myopia progression. We investigated whether choroidal thickening due to optical defocus ...

journal_title：Scientific reports

authors： Chiang ST,Turnbull PRK,Phillips JR

更新日期：2020-10-27 00:00:00

abstract：:High throughput genomics technologies are applied widely to microbiomes in humans, animals, soil and water, to detect changes in bacterial communities or the genes they carry, between different environments or treatments. We describe a method to test the statistical significance of differences in bacterial population ...

journal_title：Scientific reports

authors： Shaw LM,Blanchard A,Chen Q,An X,Davies P,Tötemeyer S,Zhu YG,Stekel DJ

更新日期：2019-02-20 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Yoon K,Kim JJ,Seong WM,Lee MH,Kang K

更新日期：2018-07-04 00:00:00

abstract：:Nitrogen (N) deposition is a key factor that affects terrestrial biogeochemical cycles with a growing trend, especially in the southeast region of China, where shortage of available phosphorus (P) is particularly acute and P has become a major factor limiting plant growth and productivity. Arbuscular mycorrhizal fungi...

journal_title：Scientific reports

authors： Lin C,Wang Y,Liu M,Li Q,Xiao W,Song X

更新日期：2020-07-23 00:00:00

abstract：:Optical elastography is undergoing extensive development as an imaging tool to map mechanical contrast in tissue. Here, we present a new platform for optical elastography by generating sub-millimetre-scale mechanical contrast from a simple digital camera. This cost-effective, compact and easy-to-implement approach ope...

journal_title：Scientific reports

authors： Sanderson RW,Fang Q,Curatolo A,Adams W,Lakhiani DD,Ismail HM,Foo KY,Dessauvagie BF,Latham B,Yeomans C,Saunders CM,Kennedy BF

更新日期：2020-09-29 00:00:00

abstract：:The anhydrofructose pathway is an alternate pathway for glycogen degradation by α-1,4-glucan lyase. The sugar 1,5-anhydro-D-fructose (1,5-AF) acts as the central intermediate of this pathway, but its physiological role of in mammals is unclear. Glycation reactions forming advanced glycation end-products (AGEs) are imp...

journal_title：Scientific reports

authors： Sakasai-Sakai A,Takata T,Suzuki H,Maruyama I,Motomiya Y,Takeuchi M

更新日期：2019-07-15 00:00:00

abstract：:The Mycobacterium tuberculosis complex (MTBC) is the collective term given to the group of bacteria that cause tuberculosis (TB) in mammals. It has been reported that M. tuberculosis H37Rv, a standard reference MTBC strain, is attenuated in cattle compared to Mycobacterium bovis. However, as M. tuberculosis H37Rv was ...

journal_title：Scientific reports

authors： Villarreal-Ramos B,Berg S,Whelan A,Holbert S,Carreras F,Salguero FJ,Khatri BL,Malone K,Rue-Albrecht K,Shaughnessy R,Smyth A,Ameni G,Aseffa A,Sarradin P,Winter N,Vordermeier M,Gordon SV

更新日期：2018-01-17 00:00:00

abstract：:E. coli is the main causative agent of mastitis in dairy cows, but the mechanism of molecular regulation underlying the occurrence and development of mastitis has not yet been fully elucidated. In this study, an E. coli-induced mastitis model was created and RNASeq technology was used to measure the miRNA expression p...

journal_title：Scientific reports

authors： Luoreng ZM,Wang XP,Mei CG,Zan LS

更新日期：2018-08-23 00:00:00

abstract：:The Sinorhizobium meliloti (S. meliloti) strain CCNWSX0020 displayed tolerance to high levels exposures of multiple metals and growth promotion of legume plants grown in metal-contaminated soil. However, the mechanism of metal-resistant strain remains unknown. We used five P1B-ATPases deletions by designating as ∆copA...

journal_title：Scientific reports

authors： Lu M,Li Z,Liang J,Wei Y,Rensing C,Wei G

更新日期：2016-07-05 00:00:00

abstract：:Multidimensional correlation magnetic resonance imaging (MRI) is an emerging imaging modality that is capable of disentangling highly heterogeneous and opaque systems according to chemical and physical interactions of water within them. Using this approach, the conventional three dimensional MR scalar images are repla...

journal_title：Scientific reports

authors： Pas K,Komlosh ME,Perl DP,Basser PJ,Benjamini D

更新日期：2020-02-24 00:00:00

abstract：:With about 350 million people chronically infected around the world hepatitis B is a major health problem. Template for progeny HBV synthesis is the viral genome, organized as a minichromosome (cccDNA) inside the hepatocyte nucleus. How viral cccDNA gene expression is regulated by its chromatin structure; more importa...

journal_title：Scientific reports

authors： Alarcon V,Hernández S,Rubio L,Alvarez F,Flores Y,Varas-Godoy M,De Ferrari GV,Kann M,Villanueva RA,Loyola A

更新日期：2016-05-13 00:00:00

abstract：:Evaluation of precipitation and nitrogen (N) deposition in desert ecosystems helps to elucidate the reaction of desert ecosystems to future environmental changes. An in-situ field experiment was established to examine the influence of a long-term enhanced precipitation and N deposition on the photosynthetic traits and...

journal_title：Scientific reports

authors： Zhao WQ,Lv XH,Li YG,Wang ZK,Zhang W,Zhuang L

更新日期：2019-03-08 00:00:00

abstract：:Saturn rings are most beautiful and dynamic places in the solar system, consisting of ice particles in a constant battle between the gravitational forces of Saturn and its many moons. Fan, spiral, propellers, moonlets and streamer-channels observed by CASSINI in the F-ring have been attributed to encounters by Prometh...

journal_title：Scientific reports

authors： Sutton PJ,Kusmartsev FV

更新日期：2013-01-01 00:00:00