Association between newborn screening analytes and hypoxic ischemic encephalopathy.

Abstract:

:Hypoxic ischemic encephalopathy (HIE) is a major cause of neonatal mortality and morbidity. Our study sought to examine whether patterns of newborn screening analytes differed between infants with and without neonatal HIE in order to identify opportunities for potential use of these analytes for diagnosis in routine clinical practice. We linked a population-based newborn screening registry with health databases to identify cases of HIE among term infants (≥37 weeks' gestation) in Ontario from 2010-2015. Correlations between HIE and screening analytes were examined using multivariable logistic regression models containing clinical factors and individual screening analytes (acyl-carnitines, amino acids, fetal-to-adult hemoglobin ratio, endocrine markers, and enzymes). Among 731,841 term infants, 3,010 were diagnosed with HIE during the neonatal period. Multivariable models indicated that clinical variables alone or in combination with hemoglobin values were not associated with HIE diagnosis. Although the model was improved after adding acyl-carnitines and amino acids, the ability of the model to identify infants with HIE was moderate. Our findings indicate that analytes associated with catabolic stress were altered in infants with HIE; however, future research is required to determine whether amino acid and acyl-carnitine profiles could hold clinical utility in the early diagnosis or clinical management of HIE. In particular, further research should examine whether cord blood analyses can be used to identify HIE within a clinically useful timeframe or to guide treatment and predict long-term health outcomes.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Wilson LA,Fell DB,Hawken S,Wong CA,Murphy MSQ,Little J,Potter BK,Walker M,Lacaze-Masmonteil T,Juul S,Chakraborty P,Wilson K

doi

10.1038/s41598-019-51919-x

subject

Has Abstract

pub_date

2019-10-31 00:00:00

pages

15704

issue

1

issn

2045-2322

pii

10.1038/s41598-019-51919-x

journal_volume

9

pub_type

杂志文章
  • Circulating androgen receptor combined with 18F-fluorocholine PET/CT metabolic activity and outcome to androgen receptor signalling-directed therapies in castration-resistant prostate cancer.

    abstract::The association between choline uptake and androgen receptor (AR) expression is suggested by the upregulation of choline kinase-alpha in prostate cancer. Recently, detection of AR aberration in cell-free DNA as well as early 18F-fluorocholine positron emission tomography/computed tomography (FCH-PET/CT) were associate...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-15928-y

    authors: Conteduca V,Scarpi E,Caroli P,Salvi S,Lolli C,Burgio SL,Menna C,Schepisi G,Testoni S,Gurioli G,Paganelli G,Casadio V,Matteucci F,De Giorgi U

    更新日期:2017-11-14 00:00:00

  • Tracing the mass flow from glucose and phenylalanine to pinoresinol and its glycosides in Phomopsis sp. XP-8 using stable isotope assisted TOF-MS.

    abstract::Phomopsis sp. XP-8, an endophytic fungus from the bark of Tu-Chung (Eucommia ulmoides Oliv) showed capability to biosynthesize pinoresinol (Pin) and pinoresinol diglucoside (PDG) from glucose (glu) and phenylalanine (Phe). To verify the mass flow in the biosynthesis pathway, [13C6]-labeled glu and [13C6]-labeled Phe w...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-54836-1

    authors: Zhang Y,Shi J,Ni Y,Liu Y,Zhao Z,Zhao X,Gao Z

    更新日期:2019-12-06 00:00:00

  • On the Relationship between MRI and Local Field Potential Measurements of Spatial and Temporal Variations in Functional Connectivity.

    abstract::Correlations between fluctuations in resting state BOLD fMRI signals are interpreted as measures of functional connectivity (FC), but the neural basis of their origins and their relationships to specific features of underlying electrophysiologic activity, have not been fully established. In particular, the dependence ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45404-8

    authors: Shi Z,Wilkes DM,Yang PF,Wang F,Wu R,Wu TL,Chen LM,Gore JC

    更新日期:2019-06-20 00:00:00

  • Optical Characterization of Neurosurgical Operating Microscopes: Quantitative Fluorescence and Assessment of PpIX Photobleaching.

    abstract::Protoporphyrin IX (PpIX) induced by 5-aminolevulinic acid (5-ALA) is increasingly used as a fluorescent marker for fluorescence-guided resection of malignant gliomas. Understanding how the properties of the excitation light source and PpIX fluorescence interact with the surgical microscope is critical for effective us...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-30247-6

    authors: Belykh E,Miller EJ,Patel AA,Bozkurt B,Yağmurlu K,Robinson TR,Nakaji P,Spetzler RF,Lawton MT,Nelson LY,Seibel EJ,Preul MC

    更新日期:2018-08-22 00:00:00

  • Mice lacking Programmed cell death-1 show a role for CD8(+) T cells in long-term immunity against blood-stage malaria.

    abstract::Even after years of experiencing malaria, caused by infection with Plasmodium species, individuals still have incomplete immunity and develop low-density parasitemia on re-infection. Previous studies using the P. chabaudi (Pch) mouse model to understand the reason for chronic malaria, found that mice with a deletion o...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26210

    authors: Horne-Debets JM,Karunarathne DS,Faleiro RJ,Poh CM,Renia L,Wykes MN

    更新日期:2016-05-24 00:00:00

  • Impact of Diabetes Mellitus on Head and Neck Cancer Patients Undergoing Concurrent Chemoradiotherapy.

    abstract::In this retrospective study, we investigated the impact of diabetes mellitus (DM) on patients with head and neck cancer (HNC) undergoing concurrent chemoradiotherapy (CCRT). We analyzed the demographic and clinical characteristics, treatment tolerance, and toxicities of patients with HNC undergoing primary or adjuvant...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-64844-1

    authors: Kuo HC,Chang PH,Wang CH

    更新日期:2020-05-07 00:00:00

  • Enhanced Prediction of Hot Spots at Protein-Protein Interfaces Using Extreme Gradient Boosting.

    abstract::Identification of hot spots, a small portion of protein-protein interface residues that contribute the majority of the binding free energy, can provide crucial information for understanding the function of proteins and studying their interactions. Based on our previous method (PredHS), we propose a new computational a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32511-1

    authors: Wang H,Liu C,Deng L

    更新日期:2018-09-24 00:00:00

  • Dosimetric analysis of isocentrically shielded volumetric modulated arc therapy for locally recurrent nasopharyngeal cancer.

    abstract::This study aimed to investigate the dosimetric characteristics of an isocentrically shielded RapidArc (IS-RA) technique for treatment of locally recurrent nasopharyngeal cancer (lrNPC). In IS-RA, the isocenter was placed at the center of the pre-irradiated brainstem (BS)/spinal cord (SC) and the jaws were set to shiel...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25959

    authors: Lu JY,Huang BT,Xing L,Chang DT,Peng X,Xie LX,Lin ZX,Li M

    更新日期:2016-05-13 00:00:00

  • Quantum control and characterization of ultrafast ionization with orthogonal two-color laser pulses.

    abstract::We study ultrafast ionization dynamics using orthogonally polarized two-color (OTC) laser pulses involving the resonant "first plus second" (ω + 2ω) scheme. The scheme is illustrated by numerical simulations of the time-dependent Schrödinger equation and recording the photoelectron momentum distribution. On the basis ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-57125-z

    authors: Agueny H

    更新日期:2020-01-14 00:00:00

  • Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites.

    abstract::Activation-induced cytidine deaminase (AID) triggers antibody diversification in B cells by catalysing deamination and subsequently mutating immunoglobulin (Ig) genes. Association of AID with RNA Pol II and occurrence of epigenetic changes during Ig gene diversification suggest participation of AID in epigenetic regul...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-07380-9

    authors: Rodríguez-Cortez VC,Martínez-Redondo P,Català-Moll F,Rodríguez-Ubreva J,Garcia-Gomez A,Poorani-Subramani G,Ciudad L,Hernando H,Pérez-García A,Company C,Urquiza JM,Ramiro AR,Di Noia JM,Vaquero A,Ballestar E

    更新日期:2017-08-08 00:00:00

  • Early Postnatal Cardiomyocyte Proliferation Requires High Oxidative Energy Metabolism.

    abstract::Cardiac energy metabolism must cope with early postnatal changes in tissue oxygen tensions, hemodynamics, and cell proliferation to sustain development. Here, we tested the hypothesis that proliferating neonatal cardiomyocytes are dependent on high oxidative energy metabolism. We show that energy-related gene expressi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-15656-3

    authors: de Carvalho AETS,Bassaneze V,Forni MF,Keusseyan AA,Kowaltowski AJ,Krieger JE

    更新日期:2017-11-13 00:00:00

  • Parallel Analysis of 124 Universal SNPs for Human Identification by Targeted Semiconductor Sequencing.

    abstract::SNPs, abundant in human genome with lower mutation rate, are attractive to genetic application like forensic, anthropological and evolutionary studies. Universal SNPs showing little allelic frequency variation among populations while remaining highly informative for human identification were obtained from previous stu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep18683

    authors: Zhang S,Bian Y,Zhang Z,Zheng H,Wang Z,Zha L,Cai J,Gao Y,Ji C,Hou Y,Li C

    更新日期:2015-12-22 00:00:00

  • Polymorphisms in the P2X7 receptor, and differential expression of Toll-like receptor-mediated cytokines and defensins, in a Canadian Indigenous group.

    abstract::Canadian Indigenous peoples (First Nations and Inuit) exhibit a high burden of infectious diseases including tuberculosis influenced by societal factors, and biological determinants. Toll-like receptor (TLR)-mediated innate immune responses are the first line of defence against infections. We examined the production o...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50596-0

    authors: Semple C,Choi KG,Kroeker A,Denechezhe L,Orr P,Mookherjee N,Larcombe L

    更新日期:2019-10-02 00:00:00

  • Self-organized alternating chimera states in oscillatory media.

    abstract::Oscillatory media can exhibit the coexistence of synchronized and desynchronized regions, so-called chimera states, for uniform parameters and symmetrical coupling. In a phase-balanced chimera state, where the totals of synchronized and desynchronized regions, respectively, are of the same size, the symmetry of the sy...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep09883

    authors: Haugland SW,Schmidt L,Krischer K

    更新日期:2015-04-30 00:00:00

  • A new high-resolution melting analysis for the detection and identification of Plasmodium in human and Anopheles vectors of malaria.

    abstract::Among vector-borne diseases malaria is the leading cause of morbidity in the world, with more than 200 million cases per year and a large number of deaths. The techniques traditionally used for the detection of Plasmodium in humans and Anopheles mosquitoes include microscopy, IRMA, ELISA, antibody or molecular assays,...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-36515-9

    authors: Murillo E,Muskus C,Agudelo LA,Vélez ID,Ruiz-Lopez F

    更新日期:2019-02-08 00:00:00

  • Caesium-rich micro-particles: A window into the meltdown events at the Fukushima Daiichi Nuclear Power Plant.

    abstract::The nuclear disaster at the Fukushima Daiichi Nuclear Power Plant (FDNPP) in March 2011 caused partial meltdowns of three reactors. During the meltdowns, a type of condensed particle, a caesium-rich micro-particle (CsMP), formed inside the reactors via unknown processes. Here we report the chemical and physical proces...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep42731

    authors: Furuki G,Imoto J,Ochiai A,Yamasaki S,Nanba K,Ohnuki T,Grambow B,Ewing RC,Utsunomiya S

    更新日期:2017-02-15 00:00:00

  • Plasma dipeptidyl-peptidase-4 activity is associated with left ventricular systolic function in patients with ST-segment elevation myocardial infarction.

    abstract::Plasma dipeptidyl-peptidase-4 activity (DPP4a) is inversely associated with left ventricular function in patients with heart failure (HF) or diabetes. However, the association between DPP4a and left ventricular function in ST-segment elevation myocardial infarction (STEMI) patients has not been reported. We studied th...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-06514-3

    authors: Li JW,Chen YD,Liu YQ,Wang JD,Chen WR,Zhang YQ,Ma Q

    更新日期:2017-07-21 00:00:00

  • Rare earth ion Tb3+ doped natural sodium feldspar (NaAlSi3O8) Luminescent properties and energy transfer.

    abstract::In this study, Tb3+-doped natural sodium feldspar (NaAlSi3O8) phosphors have been successfully prepared using high-temperature solid-state method with natural sodium feldspar as a substrate. Energy-dispersive X-ray spectrometry analysis (EDX) of NaAlSi3O8 showed that 0.03 wt% of Eu element was present, and elemental d...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51171-3

    authors: Halmurat D,Yusufu T,Wang QL,He J,Sidike A

    更新日期:2019-10-10 00:00:00

  • The diet of the first Europeans from Atapuerca.

    abstract::Hominin dietary specialization is crucial to understanding the evolutionary changes of craniofacial biomechanics and the interaction of food processing methods' effects on teeth. However, the diet-related dental wear processes of the earliest European hominins remain unknown because most of the academic attention has ...

    journal_title:Scientific reports

    pub_type: 历史文章,杂志文章

    doi:10.1038/srep43319

    authors: Pérez-Pérez A,Lozano M,Romero A,Martínez LM,Galbany J,Pinilla B,Estebaranz-Sánchez F,Bermúdez de Castro JM,Carbonell E,Arsuaga JL

    更新日期:2017-02-27 00:00:00

  • The effect of particle properties on the depth profile of buoyant plastics in the ocean.

    abstract::Most studies on buoyant microplastics in the marine environment rely on sea surface sampling. Consequently, microplastic amounts can be underestimated, as turbulence leads to vertical mixing. Models that correct for vertical mixing are based on limited data. In this study we report measurements of the depth profile of...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep33882

    authors: Kooi M,Reisser J,Slat B,Ferrari FF,Schmid MS,Cunsolo S,Brambini R,Noble K,Sirks LA,Linders TE,Schoeneich-Argent RI,Koelmans AA

    更新日期:2016-10-10 00:00:00

  • Analytical ultracentrifugation in saliva research: Impact of green tea astringency and its significance on the in-vivo aroma release.

    abstract::Current saliva testing methods rely on cutting edge yet expensive techniques for the detection and analysis of genetic material, proteins and biomarkers for clinical use. However, these techniques are limited in scope and often cannot be used with complex food materials. We propose an efficient ex-vivo tool for evalua...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-31625-w

    authors: Dinu V,Liu C,Ali J,Ayed C,Gershkovich P,Adams GG,Harding SE,Fisk ID

    更新日期:2018-09-06 00:00:00

  • Gender and Child Behavior Problems in Rural Nepal: Differential Expectations and Responses.

    abstract::Whereas epidemiologic studies consistently identify different rates and types of problematic behavior in boys and girls, there has been little research examining the ecocultural context in which these gender differences in child behavior problems develop, especially in non-Western settings. This qualitative study in r...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43972-3

    authors: Langer JA,Ramos JV,Ghimire L,Rai S,Kohrt BA,Burkey MD

    更新日期:2019-05-21 00:00:00

  • Phenotypic diversity within a Pseudomonas aeruginosa population infecting an adult with cystic fibrosis.

    abstract::Chronic airway infections caused by Pseudomonas aeruginosa contribute to the progression of pulmonary disease in individuals with cystic fibrosis (CF). In the setting of CF, within-patient adaptation of a P. aeruginosa strain generates phenotypic diversity that can complicate microbiological analysis of patient sample...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep10932

    authors: Clark ST,Diaz Caballero J,Cheang M,Coburn B,Wang PW,Donaldson SL,Zhang Y,Liu M,Keshavjee S,Yau YC,Waters VJ,Elizabeth Tullis D,Guttman DS,Hwang DM

    更新日期:2015-06-05 00:00:00

  • Dietary flavonoids, lignans and colorectal cancer prognosis.

    abstract::Flavonoids and lignans are polyphenol classes with anticarcinogenic activities against colorectal cancer (CRC). However, very limited epidemiological evidence exists on their effects on CRC prognosis. This study aimed to evaluate the association between flavonoid and lignan intakes with the risk of CRC recurrence and ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14148

    authors: Zamora-Ros R,Guinó E,Alonso MH,Vidal C,Barenys M,Soriano A,Moreno V

    更新日期:2015-09-15 00:00:00

  • Numerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure.

    abstract::Biological research requires wide-field optical imaging techniques with resolution down to the nanometer scale to study the biological process in a sub-cell or single molecular level. To meet this requirement, wide-field structured illumination method (WFSIM) has been extensively studied. The resolution of WFSIM is de...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01521-w

    authors: Cao S,Wang T,Yang J,Hu B,Levy U,Yu W

    更新日期:2017-05-02 00:00:00

  • Plasma cupping induces VEGF expression in skin cells through nitric oxide-mediated activation of hypoxia inducible factor 1.

    abstract::Despite a long history, the clinical efficacy of cupping therapy is still under debate. This is likely due to the lack of direct evidence for the biological actions of cupping, since the short exposure of cells to vacuum condition rarely has affects cellular activity. In this study, the medicinal properties of a recen...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40086-8

    authors: Lee HY,Lee HJ,Kim GC,Choi JH,Hong JW

    更新日期:2019-03-07 00:00:00

  • Coalescence preference in densely packed microbubbles.

    abstract::A bubble merged from two parent bubbles with different size tends to be placed closer to the larger parent. This phenomenon is known as the coalescence preference. Here we demonstrate that the coalescence preference can be blocked inside a densely packed cluster of bubbles. We utilized high-speed high-resolution X-ray...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep07739

    authors: Kim Y,Lim SJ,Gim B,Weon BM

    更新日期:2015-01-13 00:00:00

  • Circadian rhythmicity persists through the Polar night and midnight sun in Svalbard reindeer.

    abstract::Studies of locomotor activity in Svalbard reindeer reported the temporary absence of diel rhythms under Arctic photic conditions. However, using Lomb-Scargle periodogram analyses with high statistical power we found diel or circadian rhythmicity throughout the entire year in measures of behaviour, temperature in the r...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32778-4

    authors: Arnold W,Ruf T,Loe LE,Irvine RJ,Ropstad E,Veiberg V,Albon SD

    更新日期:2018-09-27 00:00:00

  • Acquisition of the capsule locus by horizontal gene transfer in Neisseria meningitidis is often accompanied by the loss of UDP-GalNAc synthesis.

    abstract::Pathogenic meningococci have acquired a 24 kb capsule synthesis island (cps) by horizontal gene transfer which consists of a synthetic locus and associated capsule transport genes flanked by repetitive Regions D and D'. Regions D and D' contain an intact gene encoding a UDP-galactose epimerase (galE1) and a truncated ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep44442

    authors: Bartley SN,Mowlaboccus S,Mullally CA,Stubbs KA,Vrielink A,Maiden MC,Harrison OB,Perkins TT,Kahler CM

    更新日期:2017-03-14 00:00:00

  • Overexpression of LINC00152 correlates with poor patient survival and knockdown impairs cell proliferation in lung cancer.

    abstract::We employed RNA sequencing analysis to reveal dysregulated lncRNAs in lung cancer utilizing 461 lung adenocarcinomas and 156 normal lung tissues from 3 separate cohorts. We found that LINC00152 was highly overexpressed in lung tumors as compared to their adjacent normal tissues. Patients with high LINC00152 expression...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03043-x

    authors: Feng S,Zhang J,Su W,Bai S,Xiao L,Chen X,Lin J,Reddy RM,Chang AC,Beer DG,Chen G

    更新日期:2017-06-07 00:00:00