Abstract：
:Betel quid is one of the most widely used psychoactive substances, and is consumed by approximately 10% of the world's population. In addition to its carcinogenicity, betel quid has also been reported to affect many organs, including the brain, heart, lungs, gastrointestinal tract, and reproductive organs. As betel quid contains several neurotoxic ingredients, we hypothesize that it also possesses ototoxicity and may lead to sensorineural hearing impairment (SNHI). In this study, we investigated the contribution of betel quid consumption to SNHI in a large clinical cohort, and validated the pathogenetic mechanisms in ex vivo tissue explants. We enrolled a total of 2364 volunteers, and determined their audiologic results based on Z-scores converted from their original frequency-specific hearing thresholds. Using generalized linear regression, we identified a positive correlation between betel quid consumption and the Z-scores across different frequencies. Subsequently, we explored the toxicity of arecoline, the main neuroactive component of betel quid, on tissue explants from murine cochleae. Arecoline reduced cell activity in the explant cultures and induced apoptosis in the hair cells, probably through the effects of oxidative stress. These findings have expanded the potential hazards of betel quid to common neurological disorders, and provide insights into preventive strategies against SNHI caused by neurotoxic substances.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Chan YH,Liu TC,Liao CK,Cheng YF,Tsai CH,Lu YC,Hu CJ,Lin HJ,Lee YL,Wu CC,Hsu CJdoi
10.1038/s41598-019-49815-5subject
Has Abstractpub_date
2019-10-10 00:00:00pages
14554issue
1issn
2045-2322pii
10.1038/s41598-019-49815-5journal_volume
9pub_type
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