Structured inhibitory activity dynamics in new virtual environments.

abstract：:Antiviral development is plagued by drug resistance and genetic barriers to resistance are needed. For HIV and hepatitis C virus (HCV), combination therapy has proved life-saving. The targets of direct-acting antivirals for HCV infection are NS3/4A protease, NS5A phosphoprotein and NS5B polymerase. Differential visual...

journal_title：eLife

authors： van Buuren N,Tellinghuisen TL,Richardson CD,Kirkegaard K

更新日期：2018-03-28 00:00:00

abstract：:The spliceosome is a complex machine composed of small nuclear ribonucleoproteins (snRNPs) and accessory proteins that excises introns from pre-mRNAs. After assembly the spliceosome is activated for catalysis by rearrangement of subunits to form an active site. How this rearrangement is coordinated is not well-underst...

journal_title：eLife

authors： Hoskins AA,Rodgers ML,Friedman LJ,Gelles J,Moore MJ

更新日期：2016-05-31 00:00:00

abstract：:Lissencephaly ('smooth brain') is a severe brain disease associated with numerous symptoms, including cognitive impairment, and shortened lifespan. The main causative gene of this disease - lissencephaly-1 (LIS1) - has been a focus of intense scrutiny since its first identification almost 30 years ago. LIS1 is a criti...

journal_title：eLife

authors： Markus SM,Marzo MG,McKenney RJ

更新日期：2020-07-21 00:00:00

abstract：:Eukaryotic kinetochores connect spindlemicrotubules to chromosomal centromeres. A group of proteins called the Ctf19 complex (Ctf19c) in yeast and the constitutive centromere associated network (CCAN) in other organisms creates the foundation of a kinetochore. The Ctf19c/CCAN influences the timing of kinetochore assem...

journal_title：eLife

authors： Hinshaw SM,Harrison SC

更新日期：2019-02-14 00:00:00

abstract：:TFIID-a complex of TATA-binding protein (TBP) and TBP-associated factors (TAFs)-is a central component of the Pol II promoter recognition apparatus. Recent studies have revealed significant downregulation of TFIID subunits in terminally differentiated myocytes, hepatocytes and adipocytes. Here, we report that TBP prot...

journal_title：eLife

authors： Li L,Martinez SS,Hu W,Liu Z,Tjian R

更新日期：2015-09-22 00:00:00

abstract：:The integration of direct bottom-up inputs with contextual information is a core feature of neocortical circuits. In area V1, neurons may reduce their firing rates when their receptive field input can be predicted by spatial context. Gamma-synchronized (30-80 Hz) firing may provide a complementary signal to rates, ref...

journal_title：eLife

authors： Peter A,Uran C,Klon-Lipok J,Roese R,van Stijn S,Barnes W,Dowdall JR,Singer W,Fries P,Vinck M

更新日期：2019-02-04 00:00:00

abstract：:We collated contact tracing data from COVID-19 clusters in Singapore and Tianjin, China and estimated the extent of pre-symptomatic transmission by estimating incubation periods and serial intervals. The mean incubation periods accounting for intermediate cases were 4.91 days (95%CI 4.35, 5.69) and 7.54 (95%CI 6.76, 8...

journal_title：eLife

authors： Tindale LC,Stockdale JE,Coombe M,Garlock ES,Lau WYV,Saraswat M,Zhang L,Chen D,Wallinga J,Colijn C

更新日期：2020-06-22 00:00:00

abstract：:Axonal conduction velocity can change substantially during ongoing activity, thus modifying spike interval structures and, potentially, temporal coding. We used a biophysical model to unmask mechanisms underlying the history-dependence of conduction. The model replicates activity in the unmyelinated axon of the crusta...

journal_title：eLife

authors： Zhang Y,Bucher D,Nadim F

更新日期：2017-07-10 00:00:00

abstract：:Presynaptic homeostatic plasticity stabilizes information transfer at synaptic connections in organisms ranging from insect to human. By analogy with principles of engineering and control theory, the molecular implementation of PHP is thought to require postsynaptic signaling modules that encode homeostatic sensors, a...

journal_title：eLife

authors： Hauswirth AG,Ford KJ,Wang T,Fetter RD,Tong A,Davis GW

更新日期：2018-01-05 00:00:00

abstract：:Sudden changes in the level of a coenzyme called NADPH might be the underlying cause of aging in cells. ...

journal_title：eLife

authors： Barral Y

更新日期：2013-02-05 00:00:00

abstract：:Delineating the basic cellular components of cortical inhibitory circuits remains a fundamental issue in order to understand their specific contributions to microcircuit function. It is still unclear how current classifications of cortical interneuron subtypes relate to biological processes such as their developmental...

journal_title：eLife

authors： Niquille M,Limoni G,Markopoulos F,Cadilhac C,Prados J,Holtmaat A,Dayer A

更新日期：2018-03-20 00:00:00

abstract：:During cell locomotion and endocytosis, membrane-tethered WASP proteins stimulate actin filament nucleation by the Arp2/3 complex. This process generates highly branched arrays of filaments that grow toward the membrane to which they are tethered, a conflict that seemingly would restrict filament growth. Using three-c...

journal_title：eLife

authors： Smith BA,Padrick SB,Doolittle LK,Daugherty-Clarke K,Corrêa IR Jr,Xu MQ,Goode BL,Rosen MK,Gelles J

更新日期：2013-09-03 00:00:00

abstract：:Secretory (S) Immunoglobulin (Ig) A is the predominant mucosal antibody, which binds pathogens and commensal microbes. SIgA is a polymeric antibody, typically containing two copies of IgA that assemble with one joining-chain (JC) to form dimeric (d) IgA that is bound by the polymeric Ig-receptor ectodomain, called sec...

journal_title：eLife

authors： Kumar Bharathkar S,Parker BW,Malyutin AG,Haloi N,Huey-Tubman KE,Tajkhorshid E,Stadtmueller BM

更新日期：2020-10-27 00:00:00

abstract：:Nutritional regulation by ants emerges from a distributed process: food is collected by a small fraction of workers, stored within the crops of individuals, and spread via local ant-to-ant interactions. The precise individual-level underpinnings of this collective regulation have remained unclear mainly due to difficu...

journal_title：eLife

authors： Greenwald EE,Baltiansky L,Feinerman O

更新日期：2018-03-06 00:00:00

abstract：:Rising and more variable global temperatures pose a challenge for biodiversity, with reproduction and fertility being especially sensitive to heat. Here, we assessed the potential for thermal adaptation in sperm and egg function using Tribolium flour beetles, a warm-temperate-tropical insect model. Following temperatu...

journal_title：eLife

authors： Vasudeva R,Sutter A,Sales K,Dickinson ME,Lumley AJ,Gage MJ

更新日期：2019-10-01 00:00:00

abstract：:Recent advances in single-cell transcriptomics techniques have opened the door to the study of gene regulatory networks (GRNs) at the single-cell level. Here, we studied the GRNs controlling the emergence of hematopoietic stem and progenitor cells from mouse embryonic endothelium using a combination of single-cell tra...

journal_title：eLife

authors： Bergiers I,Andrews T,Vargel Bölükbaşı Ö,Buness A,Janosz E,Lopez-Anguita N,Ganter K,Kosim K,Celen C,Itır Perçin G,Collier P,Baying B,Benes V,Hemberg M,Lancrin C

更新日期：2018-03-20 00:00:00

abstract：:Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can undergo irreversible aggregation to the amyloid state. The dimer...

journal_title：eLife

authors： Brumshtein B,Esswein SR,Salwinski L,Phillips ML,Ly AT,Cascio D,Sawaya MR,Eisenberg DS

更新日期：2015-11-18 00:00:00

abstract：:Research on mutant tobacco plants shows that a pigment called β-carotene is not necessary for photosynthesis. ...

journal_title：eLife

authors： Telfer A

更新日期：2020-11-03 00:00:00

abstract：:A founding paradigm in virology is that the spatial unit of the viral replication cycle is an individual cell. Multipartite viruses have a segmented genome where each segment is encapsidated separately. In this situation the viral genome is not recapitulated in a single virus particle but in the viral population. How ...

journal_title：eLife

authors： Sicard A,Pirolles E,Gallet R,Vernerey MS,Yvon M,Urbino C,Peterschmitt M,Gutierrez S,Michalakis Y,Blanc S

更新日期：2019-03-12 00:00:00

abstract：:Gene copy number alterations, tumor cell stemness, and the development of platinum chemotherapy resistance contribute to high-grade serous ovarian cancer (HGSOC) recurrence. Stem phenotypes involving Wnt-β-catenin, aldehyde dehydrogenase activities, intrinsic platinum resistance, and tumorsphere formation are here ass...

journal_title：eLife

authors： Diaz Osterman CJ,Ozmadenci D,Kleinschmidt EG,Taylor KN,Barrie AM,Jiang S,Bean LM,Sulzmaier FJ,Jean C,Tancioni I,Anderson K,Uryu S,Cordasco EA,Li J,Chen XL,Fu G,Ojalill M,Rappu P,Heino J,Mark AM,Xu G,Fisch KM,K

更新日期：2019-09-03 00:00:00

abstract：:Progression through the mitotic cell cycle requires periodic regulation of gene function at the levels of transcription, translation, protein-protein interactions, post-translational modification and degradation. However, the role of alternative splicing (AS) in the temporal control of cell cycle is not well understoo...

journal_title：eLife

authors： Dominguez D,Tsai YH,Weatheritt R,Wang Y,Blencowe BJ,Wang Z

更新日期：2016-03-25 00:00:00

abstract：:Learning to perform a complex motor task requires the optimization of specific behavioral features to cope with task constraints. We show that when mice learn a novel motor paradigm they differentially refine specific behavioral features. Animals trained to perform progressively faster sequences of lever presses to ob...

journal_title：eLife

authors： Santos FJ,Oliveira RF,Jin X,Costa RM

更新日期：2015-09-29 00:00:00

abstract：:How mammalian tissues maintain their architecture and tissue-specificity is poorly understood. Previously, we documented both the indispensable role of the extracellular matrix (ECM) protein, laminin-111 (LN1), in the formation of normal breast acini, and the phenotypic reversion of cancer cells to acini-like structur...

journal_title：eLife

authors： Furuta S,Ren G,Mao JH,Bissell MJ

更新日期：2018-03-21 00:00:00

abstract：:Loss of polarity correlates with progression of epithelial cancers, but how plasma membrane misorganization drives oncogenic transcriptional events remains unclear. The polarity regulators of the Drosophila Scribble (Scrib) module are potent tumor suppressors and provide a model for mechanistic investigation. RNA prof...

journal_title：eLife

authors： Bunker BD,Nellimoottil TT,Boileau RM,Classen AK,Bilder D

更新日期：2015-02-26 00:00:00

abstract：:Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelle...

journal_title：eLife

authors： Banerjee JJ,Aerne BL,Holder MV,Hauri S,Gstaiger M,Tapon N

更新日期：2017-06-30 00:00:00

abstract：:Most cellular features have a range of states, but understanding the mechanisms responsible for interspecific divergence is a challenge for evolutionary cell biology. Models are developed for the distribution of mean phenotypes likely to evolve under the joint forces of mutation and genetic drift in the face of consta...

journal_title：eLife

authors： Lynch M

更新日期：2018-06-21 00:00:00

abstract：:Systemic metabolic reprogramming induced by infection exerts profound, pathogen-specific effects on infection outcome. Here, we detail the host immune and metabolic response during sickness and recovery in a mouse model of malaria. We describe extensive alterations in metabolism during acute infection, and identify in...

journal_title：eLife

authors： Lissner MM,Cumnock K,Davis NM,Vilches-Moure JG,Basak P,Navarrete DJ,Allen JA,Schneider D

更新日期：2020-10-06 00:00:00

abstract：:MyD88 is the main adaptor molecule for TLR and IL-1R family members. Here, we demonstrated that T-cell intrinsic MyD88 signaling is required for proliferation, protection from apoptosis and expression of activation/memory genes during infection with the intracellular parasite Trypanosoma cruzi, as evidenced by transcr...

journal_title：eLife

authors： Oliveira AC,Gomes-Neto JF,Barbosa CD,Granato A,Reis BS,Santos BM,Fucs R,Canto FB,Nakaya HI,Nóbrega A,Bellio M

更新日期：2017-09-12 00:00:00

abstract：:There has been a longstanding debate on whether original fear memory is inhibited or erased after extinction. One possibility that reconciles this uncertainty is that the inhibition and erasure mechanisms are engaged in different phases (early or late) of extinction. In this study, using single-session extinction trai...

journal_title：eLife

authors： An B,Kim J,Park K,Lee S,Song S,Choi S

更新日期：2017-07-03 00:00:00

abstract：:Humans and other animals routinely identify and attend to sensory stimuli so as to rapidly acquire rewards or avoid aversive experiences. Emotional arousal, a process mediated by the amygdala, can enhance attention to stimuli in a non-spatial manner. However, amygdala neural activity was recently shown to encode spati...

journal_title：eLife

authors： Peck CJ,Salzman CD

更新日期：2014-10-30 00:00:00