Abstract:
BACKGROUND:Obesity and weight gain are established risk factors for atrial fibrillation (AF). OBJECTIVE:The purpose of this study was to investigate whether bodyweight variability is also a risk factor for AF development. METHODS:A nationwide population-based cohort of 8,091,401 adults from the Korean National Health Insurance Service database without a history of AF and with ≥3 measurements of bodyweight over a 5-year period were followed up for incident AF. Intraindividual bodyweight variability was calculated using variability independent of mean, and high bodyweight variability was defined as the quartile with the highest variability (Q4) with Q1-Q3 as reference. RESULTS:During median 8.1 years of follow-up, each increase of 1 SD in bodyweight variability was associated with a 5% increased risk of AF development, and the quartile with the highest bodyweight variability showed 14% increased risk of AF development compared to the quartile with the lowest variability (hazard ratio 1.14; 95% confidence interval 1.12-1.15), after adjustment for baseline bodyweight, height, age, sex, lifestyle factors, and comorbidities. High bodyweight variability was significantly associated with AF development in all baseline body mass index (BMI) groups except the very obese (BMI ≥30), and this association was stronger in subjects with lower bodyweight. High bodyweight variability was associated with increased risk of incident AF in all weight change groups, with a stronger association in those who lost weight. CONCLUSION:Bodyweight fluctuation was independently associated with an increased risk of AF development, especially in individuals with low bodyweight, and regardless of weight gain or loss.
journal_name
Heart Rhythmjournal_title
Heart rhythmauthors
Lee HJ,Choi EK,Han KD,Lee E,Moon I,Lee SR,Cha MJ,Oh S,Lip GYHdoi
10.1016/j.hrthm.2019.09.029subject
Has Abstractpub_date
2020-03-01 00:00:00pages
365-371issue
3eissn
1547-5271issn
1556-3871pii
S1547-5271(19)30904-Xjournal_volume
17pub_type
杂志文章相关文献
HEART RHYTHM文献大全abstract:BACKGROUND:Device replacement is the ideal time to reassess health care goals regarding continuing implantable cardioverter-defibrillator (ICD) therapy. Only few data are available on the decision making at this time. OBJECTIVES:The goals of this study were to identify factors associated with poor prognosis at the tim...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2020.11.024
更新日期:2020-11-27 00:00:00
abstract:BACKGROUND:There is controversy whether proceduralist-directed, nurse-administered propofol sedation (PDNAPS) is safe. OBJECTIVE:To assess the frequency of adverse events when PDNAPS is used for implantable cardioverter-defibrillator (ICD)-related procedures and to determine the patient and procedural characteristics ...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2011.10.009
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:The R582C mutation is one of many Long-QT Syndrome type 2 (LQT2)-causing mutations localized to the human ether-a-go-go related gene (hERG) channel's S5-P linker subdomain, yet its specific mechanism of dysfunction has not been examined. OBJECTIVE:This study sought to characterize the biophysical properties...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2011.02.035
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Phrenic nerve (PN) injury, a known complication of radiofrequency (RF) catheter ablation of atrial fibrillation (AF), has been more commonly reported with balloon-based pulmonary vein isolation. OBJECTIVE:We present a novel approach to locating the PN and predicting patients at higher risk of this complicat...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2010.03.027
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Findings from animal studies and small series of patients support the greater safety of cryoenergy over radiofrequency in the ablation of arrhythmic substrates near the AV node. OBJECTIVES:The purpose of this study was to systematically evaluate the electrophysiologic effects of successive cryoenergy applic...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2006.06.002
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Complete atrioventricular block (CAVB) causes arrhythmogenic remodeling and increases the risk of torsades de pointes arrhythmias. MicroRNAs (miRNAs) are key regulators of gene expression that contribute to cardiac remodeling. OBJECTIVE:The purpose of this study was to assess miRNA changes after CAVB and id...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2017.01.045
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Public access defibrillation programs have demonstrated a survival benefit in persons with out-of-hospital cardiac arrest. However, little is known about the effectiveness of early defibrillation in young competitive athletes with sudden cardiac arrest (SCA). OBJECTIVES:The purpose of this study was to inve...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2006.03.023
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Percutaneous left atrial appendage closure (pLAAC) emerged as an option for stroke prevention in patients with atrial fibrillation ineligible for long-term anticoagulation. Real-world data on pLAAC's in-hospital and 30-day readmission measures are limited. OBJECTIVE:We sought to report the nationwide incide...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2019.09.018
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Recent research findings have revealed a key role of oxidative DNA damage in the pathogenesis of atrial fibrillation (AF). Therefore, the circulating oxidative DNA damage marker 8-hydroxy-2'-deoxyguanosine (8-OHdG) may represent a biomarker for staging AF and identifying patients at risk for AF recurrence an...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2020.09.017
更新日期:2020-10-05 00:00:00
abstract:BACKGROUND:Long QT syndrome (LQTS) genetic test reports commonly exclude potentially proarrhythmic common variants such as p.Asp85Asn-KCNE1. OBJECTIVE:The purpose of this study was to determine whether a discernible phenotype is associated with p.Asp85Asn-KCNE1 and whether relatively common KCNE1 variants underlie tra...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2018.03.038
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Selective inhibitors of Kv1.5 channels are being developed for the treatment of atrial fibrillation (AF). OBJECTIVES:The purpose of this study was to investigate the effects of the highly selective Kv1.5 inhibitor XEN-D0103 on human atrial action potentials (APs) at high excitation rates and to assess safet...
journal_title:Heart rhythm
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.hrthm.2015.10.003
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Cardiac contractility modulation signals are associated with acutely improved hemodynamics, but chronic clinical impact is not defined. OBJECTIVES:The purpose of this randomized, double-blind, pilot study was to determine the feasibility of safely and effectively delivering cardiac contractility modulation ...
journal_title:Heart rhythm
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.hrthm.2006.06.031
更新日期:2006-10-01 00:00:00
abstract::We present an update on clinical and electrophysiological criteria used for the differential diagnosis of regular supraventricular tachycardias. Although several electrocardiographic clues may assist in the differential diagnosis, this is usually accomplished at electrophysiology study, and most often, the differentia...
journal_title:Heart rhythm
pub_type: 杂志文章,评审
doi:10.1016/j.hrthm.2015.03.046
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Ranolazine exhibits a synergistic effect in combination with class III drugs to suppress atrial fibrillation. OBJECTIVE:To investigate whether a combination therapy affects repolarization and provokes ventricular tachyarrhythmias (VT) in a sensitive model of proarrhythmia. METHODS:Thirty-seven rabbits were...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2012.08.029
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:New approaches to ablation of atrial fibrillation (AF) include focal impulse and rotor modulation (FIRM). Studies of this technology with short-term follow-up have shown favorable outcomes. OBJECTIVE:The purpose of this study was to characterize the long-term results of FIRM ablation in a cohort of patients...
journal_title:Heart rhythm
pub_type: 杂志文章,多中心研究
doi:10.1016/j.hrthm.2015.10.031
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Cardiac resynchronization therapy (CRT) reduces mortality, improves functional status, and induces reverse left ventricular remodeling in selected populations with heart failure (HF). The magnitude of reverse remodeling predicts survival with many HF medical therapies. However, there are few studies assessin...
journal_title:Heart rhythm
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.hrthm.2014.11.014
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:The best periprocedural anticoagulation strategy at the time of pulmonary vein isolation (PVI) is not known. Most centers stop administering warfarin (Coumadin) and use bridging with heparin or enoxaparin. OBJECTIVE:The purpose of this study was to evaluate the efficacy and safety of PVI under therapeutic i...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2009.07.007
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:QRS transition zone is related to the electrical axis of the heart in the horizontal plane and is easily determined from the precordial leads of a standard 12-lead ECG. However, whether delayed QRS transition, or clockwise rotation of the heart, carries prognostic implications and predicts sudden cardiac dea...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2014.08.014
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Frequent premature ventricular complexes (PVCs) have been associated with increased mortality. However, the optimal approach to the risk stratification of these patients is unclear. OBJECTIVE:The purpose of this study was to prospectively assess the use of cardiac magnetic resonance imaging (MRI) and progra...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2017.06.040
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Effective treatment of atrial fibrillation (AF) remains an unmet need. Human K2P3.1 (TASK-1) K(+) channels display atrial-specific expression and may serve as novel antiarrhythmic targets. In rodents, inhibition of K2P3.1 causes prolongation of action potentials and QT intervals. We used a porcine model to f...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2014.06.020
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:An accurate estimate of the incidence of sudden cardiac arrest (SCA) in high school student athletes is needed to guide prevention strategies. OBJECTIVE:To prospectively investigate SCA rates in high school student athletes vs student nonathletes. METHODS:A prospective observational study of 2149 US high s...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2014.04.017
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Interventions to improve physical and psychological outcomes in recipients with an initial implantable cardioverter-defibrillator (ICD) and their intimate partners are largely unstudied, though likely to have a major impact on adjustment to the ICD and general well-being. OBJECTIVE:The purpose of this study...
journal_title:Heart rhythm
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.hrthm.2018.10.011
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:In recent years, upgrade and revision procedures of cardiac implantable electronic devices (CIEDs) have become increasingly frequent. Patency of the access veins is critical for procedural success. OBJECTIVE:The purpose of this study was to determine the incidence of venous obstruction at the time of system...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2019.08.012
更新日期:2020-02-01 00:00:00
abstract::Newer generations of pacemakers and implantable cardioverter defibrillators have enhanced diagnostic features that permit detection and storage of information about the frequency, duration, time of onset, and rate characteristics of multiple consecutive episodes of atrial tachycardia and atrial fibrillation (AF). Para...
journal_title:Heart rhythm
pub_type: 杂志文章,评审
doi:10.1016/j.hrthm.2004.03.075
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to assess the long-term effects of ablation of infarct-related ventricular tachycardia (VT) and the subsequent requirement for implantable cardioverter-defibrillator (ICD) therapy. BACKGROUND:The long-term consequences after initially successful catheter ablation of infarct-rel...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2005.01.017
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:The QT interval on the ECG is prolonged by more than 50 marketed drugs, an effect that has been associated with syncope and/or sudden cardiac death due to an arrhythmia. Because changes in heart rate also change the QT interval, it has become standard practice to use a correction formula, such as the Bazett ...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2006.05.023
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:The function of the Purkinje system (PS) is to ensure fast and uniform activation of the heart. Although this vital role during sinus rhythm is well understood, this is not the case when shocks are applied to the heart, especially in the case of failed defibrillation. The PS activates differently from the my...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2009.08.023
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:The introduction of quadripolar (QP) cardiac resynchronization therapy (CRT) leads aimed to improve procedural and clinical outcomes. OBJECTIVE:The National Cardiovascular Data Registry was analyzed to characterize the use as well as the procedural and clinical outcomes of QP leads in comparison with unipol...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2019.07.028
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:We previously showed that omega-3 polyunsaturated fatty acids (PUFAs) reduce vulnerability to atrial fibrillation (AF). The mechanisms underlying this effect are unknown. OBJECTIVE:The purpose of this study was to use a genome-wide approach to identify gene expression profiles involved in a new model of AF ...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2009.12.016
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Myocardial fibrosis (macroscopic scar or diffuse reactive fibrosis) is one of the determinants of impaired left ventricular (LV) global longitudinal strain (GLS) in heart failure (HF) patients. OBJECTIVE:The purpose of this study was to evaluate the prognostic value of LV GLS in HF patients treated with car...
journal_title:Heart rhythm
pub_type: 杂志文章
doi:10.1016/j.hrthm.2018.03.034
更新日期:2018-10-01 00:00:00