Abstract:
:Cells respond to changes in their environment through signaling networks that modulate cytoskeleton and membrane organization to coordinate cell-cycle progression, polarized cell growth and multicellular development. Here, we define a novel regulatory mechanism by which the motor activity and function of the fission yeast type one myosin, Myo1, is modulated by TORC2-signalling-dependent phosphorylation. Phosphorylation of the conserved serine at position 742 (S742) within the neck region changes both the conformation of the neck region and the interactions between Myo1 and its associating calmodulin light chains. S742 phosphorylation thereby couples the calcium and TOR signaling networks that are involved in the modulation of myosin-1 dynamics to co-ordinate actin polymerization and membrane reorganization at sites of endocytosis and polarised cell growth in response to environmental and cell-cycle cues.
journal_name
Elifejournal_title
eLifeauthors
Baker K,Gyamfi IA,Mashanov GI,Molloy JE,Geeves MA,Mulvihill DPdoi
10.7554/eLife.51150subject
Has Abstractpub_date
2019-09-30 00:00:00issn
2050-084Xpii
51150journal_volume
8pub_type
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