Abstract：
BACKGROUND:Bone reconstruction of the maxillary bone defects is an urgent issue due to its functional and aesthetic influence. MicroRNAs (miRNAs) are a class of non-coding RNAs that function in diverse biological and pathological processes. Recently, microRNA-21 (miR-21) was reported to play significant roles in bone formation, suggesting that miR-21 can be novel biomarker and therapeutic target for bone remodelling and skeletal diseases. However, the role of miR-21 in maxillary bone defects remains unclear. OBJECTIVE AND METHODS:This study aimed to investigate the effect of miR-21 on the bone reconstruction by inducing maxillary bone defects in wild-type (WT) and miR-21 knockout (miR-21-KO) mice and explore these mice as maxillary bone defect models. RESULTS:Micro-computed tomography (micro-CT) and histochemistry showed that the miR-21-KO mice had reduced bone reformation ability compared with the WT mice. The expression levels of alkaline phosphatase (ALP) and osteocalcin (OCN) were dramatically decreased in the miR-21-KO mice. In addition, injection of miR-21 agomir intra-peritoneally into miR-21-KO mice (miR-21-KO+ agomir) following the maxillary bone defects surgery displayed a significantly enhanced bone formation -promoting ability, which indicated that miR-21 agomir could ameliorate maxillary bone defects in miR-21-KO mice in vivo. Furthermore, immunohistochemistry suggested that ALP and OCN expressions were prominently increased in miR-21-KO+ agomir mice. CONCLUSION:These findings demonstrated that miR-21 deficiency impaired bone reformation and miR-21 contributed to the bone reconstruction of the maxillary bone defects. The evidence also supported the use of WT and miR-21-KO mice as maxillary bone defect models for further research.
journal_name
J Oral Rehabiljournal_title
Journal of oral rehabilitationauthors
Wang H,Wang H,Li X,Zhang Z,Zhao X,Wang C,Wei Fdoi
10.1111/joor.12896subject
Has Abstractpub_date
2020-11-01 00:00:00pages
4-11eissn
0305-182Xissn
1365-2842journal_volume
47 Suppl 1pub_type
杂志文章abstract：:A longitudinal radiographic cephalometric and electromyographic investigation was performed on eighteen subjects provided with an immediate complete upper and a partial lower denture. The observation stages were: before final extractions and 7 weeks, 6 months and 1 year after denture insertion. The cephalometric analy...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1111/j.1365-2842.1986.tb00665.x
更新日期：1986-07-01 00:00:00
abstract：:The tensile bond strengths of composites to enamel etched with various concentrations of phosphoric acid have been shown to correlate closely with the phase diagram for the system Ca(OH)2/H3PO4/H2O. Bond strengths were independent of the adhesive used and were a maximum when using approximately 20% phosphoric acid as ...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1111/j.1365-2842.1978.tb00393.x
更新日期：1978-01-01 00:00:00
abstract：:Quality control is very important in relation to invasive and lengthy treatments, such as integrated orthodontic and surgical correction of dentofacial deformities. The aim of this cross-sectional study was to compare self-reported somatosensory disturbances and quantitative sensory testing (QST) findings between two ...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1111/j.1365-2842.2010.02059.x
更新日期：2010-05-01 00:00:00
abstract：:The in vivo corrosion of Dispersalloy amalgam restorations was characterized by scanning electron microscopy and energy dispersive X-ray analysis. It was observed that the corrosion of CuSn resulted in pitting on the restoration surface. Corrosion of Sn-rich grain boundaries led to intergranular separation of gamma 1 ...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1111/j.1365-2842.1984.tb00586.x
更新日期：1984-07-01 00:00:00
abstract：:The purpose of this study was to examine the relationship between masticatory performance and maximal occlusal force in dentate subjects, using test foods of varying hardness. Subjects were 20 young males with natural dentitions. Gummy jellies with two different degrees of hardness have been used as test foods to eval...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1046/j.1365-2842.2003.01009.x
更新日期：2003-03-01 00:00:00
abstract：:The buccolingual position of artificial teeth is one of the important factors affecting denture stability, chewing efficiency, and pressure distribution on the supporting tissue under a denture. This study compared the pressure values on the supporting tissue under a denture during chewing in denture wearers, each of ...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1111/j.1365-2842.1996.tb00879.x
更新日期：1996-07-01 00:00:00
abstract：:Acoustic evaluation is valuable for guiding the treatment of maxillofacial defects and determining the effectiveness of rehabilitation with an obturator prosthesis. Model simulations are important in terms of pre-surgical planning and pre- and post-operative speech function. This study aimed to evaluate the acoustic c...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1111/joor.12306
更新日期：2015-09-01 00:00:00
abstract：:The aim of this study was to evaluate the association between self-reported sleep bruxism and the age, gender, clinical subtypes of temporomandibular disorders (TMD), pain intensity and grade of chronic pain in patients previously diagnosed with TMD. Thousand two-hundred and twenty patients of the Andalusian Health Se...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1111/joor.12172
更新日期：2014-08-01 00:00:00
abstract：:The periodontal regeneration of interproximal bone defects of the posterior teeth produced by guided tissue regeneration (GTR), with expanded Polytetrafluoroethylene barrier membranes and conventional therapy, was clinically evaluated in 20 intrabony periodontal defects in 10 patients. The material included the presen...
journal_title：Journal of oral rehabilitation
pub_type： 临床试验,杂志文章
doi：10.1046/j.1365-2842.1996.d01-206.x
更新日期：1996-09-01 00:00:00
abstract：:Thermal diffusivity values for glass ionomer and polycarboxylate cements have been determined for varying proportions of cement powder and liquid. Diffusivity is observed to be an increasing function of powder/liquid ratio. This is discussed in relation to the application of these cements as cavity bases. ...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1111/j.1365-2842.1984.tb00578.x
更新日期：1984-05-01 00:00:00
abstract：:Referring to the temporomandibular joint (TMJ) of the human mandibular locomotor system, it has been asserted that displacement of the TMJ disc and inflammation of TMJ tissues are the results of acute and indirect trauma to the TMJ; on occasion this is allegedly experienced in motor vehicle accidents and commonly know...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2842.1998.00321.x
更新日期：1998-10-01 00:00:00
abstract：:Full-arch immediate loading implant rehabilitations provide patients with compromised dentition an effective treatment to improve their aesthetic and function. Aim of this prospective cohort study was to investigate the correlation between masticatory ability and gastric emptying rates among these patients. Ten subjec...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1111/joor.12301
更新日期：2015-09-01 00:00:00
abstract：:The purpose of this study was to evaluate the relationship between balancing-side occlusal contact patterns and the prevalence of the internal derangement of the temporomandibular joint (TMJ). Forty-one patients were used for the magnetic resonance image (MRI) analysis of TMJ and occlusal examination. Balancing-side o...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1046/j.1365-2842.2003.01000.x
更新日期：2003-01-01 00:00:00
abstract：:This article provides a review of somatosensory and motor pathways and processes involved in oral sensorimotor function and dysfunction. It reviews somatosensory processes in peripheral tissues, brainstem and higher brain centres such as thalamus and cerebral cortex, with a particular emphasis on nociceptive mechanism...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2842.2006.01623.x
更新日期：2006-04-01 00:00:00
abstract：:It becomes increasingly clear that some sleep disorders have important diagnostic and/or management links to the dental domain, hence the emergence of the discipline 'Dental Sleep Medicine'. In this review, the following topics are discussed: 1. the reciprocal associations between oro-facial pain and sleep; 2. the ass...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章,评审
doi：10.1111/joor.13075
更新日期：2020-12-01 00:00:00
abstract：:In the literature, most researchers evaluate individuals' nutritional status and chewing ability by types of foods chosen or blood test. However, most of previous researches enrolled small sample size and the results might be influenced by personal preference of foods as well as the individuals' response to invasive e...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1111/joor.12115
更新日期：2014-02-01 00:00:00
abstract：:This paper explores seven different factors which should be considered when prescribing the lower anterior prosthesis: alignment as seen from the incisal; height of the incisal edges; degree of irregularity of the teeth; character of the incisal edge; height of the cuspid; mesio-incisal angle of the cuspid; and ridge ...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1111/j.1365-2842.1983.tb00130.x
更新日期：1983-07-01 00:00:00
abstract：:Glass ionomer restorative cements have been used in anterior restorations for a number of years but have not been considered strong enough for use in posterior restorations. The compressive strengths of a number of materials currently available were measured at 30 min, 1 hour and 24 hours. It was concluded that some o...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1111/j.1365-2842.1989.tb01368.x
更新日期：1989-09-01 00:00:00
abstract：:This review evaluates the evidence for the diagnostic efficacy of cone beam computed tomography (CBCT) for impacted teeth and associated features. PubMed, Embase and the Cochrane Library were searched using specific indexing terms and reference lists were hand searched. Two reviewers selected relevant publications on ...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2842.2010.02141.x
更新日期：2011-03-01 00:00:00
abstract：:As one of the dental differentiations in The Netherlands, temporomandibular disorders (TMD) focuses on the diagnosis and treatment of pain and dysfunction of the masticatory system. Bruxism (i.e. tooth clenching and/or grinding) is thought to play an important aetiological role in TMD. Among others, bruxism may result...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1046/j.0305-182X.2003.01244.x
更新日期：2004-03-01 00:00:00
abstract：:The aim of this study was to examine the effectiveness of single-step self-etching adhesives in preventing nanoleakage over a 90-day water-storage period, and analyse the ultramorphological characteristics of resin-dentin interfaces. Three single-step self-etching adhesives were evaluated: Adper Prompt L-Pop - LP (3M ...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1111/j.1365-2842.2006.01656.x
更新日期：2007-03-01 00:00:00
abstract：:This study investigated the masticatory rehabilitation of subjects wearing different types of prostheses. Biting abilities per person (biting force, biting pressure and occlusal contact area) were assessed with a pressure detecting sheet (Prescale(R)). Five hundred and ninety volunteers were divided into four groups a...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1046/j.1365-2842.2000.00620.x
更新日期：2000-12-01 00:00:00
abstract：:Earlier work revealed that creep of a particular dental amalgam can be described by the model F(t) = F0 exp (t/t0)m. Here F(t) is the creep compliance at time t, whereas F0, t0 and m are constants of the model. In the previous study only three alloys were used. It was the aim of this study to investigate the factor al...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1111/j.1365-2842.1983.tb00129.x
更新日期：1983-07-01 00:00:00
abstract：:The occlusal contact area wear resistance of two new composite restoratives (Z250 and P60) was investigated and compared with two existing materials (Silux and Z100) using a reciprocal compression-sliding test apparatus. Six wear specimens were made for each material and subjected to wear testing at 20 MPa with artifi...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1046/j.1365-2842.2002.00814.x
更新日期：2002-02-01 00:00:00
abstract：:This study investigated the effect of a 30% hydrogen peroxide bleaching agent on bovine enamel in terms of mineral loss. Contents of mineral elements both in the teeth and bleaching agent were evaluated to estimate the effect of hydrogen peroxide on teeth. Finely polished non-carious bovine incisors (n = 5) were immer...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1111/j.1365-2842.2004.01360.x
更新日期：2006-03-01 00:00:00
abstract：:The aim of these clinical reports was to describe two different approaches to prosthetic rehabilitation after facial disfigurement because of a total rhinectomy. A man with a total rhinectomy was scheduled for craniofacial implants in the nasal residual defect. Three oral implants were used instead of craniofacial one...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1111/j.1365-2842.2007.01684.x
更新日期：2007-04-01 00:00:00
abstract：:The purpose of this follow-up study was to measure the resonance frequency of Astra Tech TiO(2) blasted implants at second surgery, at one and 3 years of loading. Secondly, it was investigated whether resonance frequency at second surgery could discriminate between successful implants and those that will fail over a 3...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1111/j.1365-2842.2009.02021.x
更新日期：2010-01-01 00:00:00
abstract：:The histological effects of a temporary crown and bridge material (Scutan) on the pulp of canine teeth of ferrets was investigated at time intervals up to 6 months. After 24 h a moderate to severe pulpal response was observed which persisted up to 6 months. A case of contact sensitivity to Scutan is reported. ...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1111/j.1365-2842.1980.tb00457.x
更新日期：1980-09-01 00:00:00
abstract：:This study examined properties of four composite veneering materials polymerized with two different photo-curing units for the purpose of evaluating curing performance of the combination of composite material and curing unit. Two microfilled (Dentacolor and Thermoresin LC II) and two hybrid (Cesead II and Solidex) com...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1046/j.1365-2842.1998.00241.x
更新日期：1998-05-01 00:00:00
abstract：:Forces required by complete dentures for penetrating some commonly used food items were measured experimentally. These forces were compared with the maximal bite forces of twenty-seven complete denture wearers. Food items that required the greatest forces in direct closure were rye bread (167 N), raw carrot (118 N), b...
journal_title：Journal of oral rehabilitation
pub_type： 杂志文章
doi：10.1111/j.1365-2842.1987.tb00757.x
更新日期：1987-11-01 00:00:00
