Retinal vascular fractal dimension and cerebral blood flow, a pilot study.

Abstract:

PURPOSE:Ocular and brain microcirculation share embryological and histological similarities. The retinal vascular fractal dimension (FD) is a marker of retinal vascular complexity of the vascular tree. The purpose of this study was to explore the relationship between cerebral blood flow (CBF), retinal vascular FD and other retinal vascular markers. METHODS:Cross-sectional analysis comprising 26 individuals ≥65 years old from the Cognitive REServe and Clinical ENDOphenotype (CRESCENDO) cohort of relative healthy older adults. Retinal vascular FD was measured from fundus photographs by using the semi-automated Singapore Eye Vessel Assessment (SIVA) software. CBF was estimated using a 2D pulsed ASL MRI sequence. Associations between blood flow and retinal parameters were analysed using linear regression models adjusted for age and sex. RESULTS:Cerebral blood flow was positively associated with venular FD (R2  = 0.32, p = 0.03). This association was stronger in the anterior versus posterior brain territories (R2  = 0.35 [p = 0.001] versus R2  = 0.16 [p = 0.07], respectively). Global CBF was correlated with arteriolar branching angle (R2  = 0.23, p = 0.01) and tortuosity (R2  = 0.20, p = 0.02). Global CBF was not correlated with other SIVA parameters. CONCLUSIONS:Retinal venular complexity summarized by the FD was associated with cerebral blood flow as well as retinal arteriolar tortuosity and branching angle. Larger prospective clinical studies are needed to confirm these results.

journal_name

Acta Ophthalmol

journal_title

Acta ophthalmologica

authors

Nadal J,Deverdun J,de Champfleur NM,Carriere I,Creuzot-Garcher C,Delcourt C,Chiquet C,Kawasaki R,Villain M,Ritchie K,Le Bars E,Daien V

doi

10.1111/aos.14232

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

e63-e71

issue

1

eissn

1755-375X

issn

1755-3768

journal_volume

98

pub_type

杂志文章
  • Topical dexamethasone-cyclodextrin nanoparticle eye drops for non-infectious Uveitic macular oedema and vitritis - a pilot study.

    abstract:PURPOSE:To evaluate the safety and efficacy of 1.5% dexamethasone nanoparticle (DexNP) drops in eyes with non-infectious uveitic macular oedema and vitritis. METHODS:In a prospective pilot study, DexNP drops were administered four times a day for 4 weeks followed by drops tapering over a period of another 4 weeks. Fol...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12744

    authors: Shulman S,Jóhannesson G,Stefánsson E,Loewenstein A,Rosenblatt A,Habot-Wilner Z

    更新日期:2015-08-01 00:00:00

  • High prevalence of myopia in children and their parents in Hong Kong Chinese Population: the Hong Kong Children Eye Study.

    abstract:PURPOSE:To determine the myopia prevalence in Hong Kong Chinese children and their parents. METHODS:It was a population-based cross-sectional study. A total of 4257 children aged 6-8 years, and 5880 parents were recruited in the Hong Kong Children Eye Study. Cycloplegic autorefraction was measured for children; and no...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.14350

    authors: Yam JC,Tang SM,Kam KW,Chen LJ,Yu M,Law AK,Yip BH,Wang YM,Cheung CYL,Ng DSC,Young AL,Tham CC,Pang CP

    更新日期:2020-01-24 00:00:00

  • Endoscopic dacryocystorhinostomy: long-term experience and outcomes.

    abstract:PURPOSE:To report our experience in endoscopic dacryocystorhinostomy in treating nasolacrimal duct obstruction over a 14-year period. METHODS:Retrospective case series carried out over a 14-year period from 1999 to 2014. A total of 624 endoscopic dacryocystorhinostomy procedures were performed in 442 patients who were...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13217

    authors: Coumou AD,Genders SW,Smid TM,Saeed P

    更新日期:2017-02-01 00:00:00

  • Diabetic macular oedema quantified with spectral-domain optical coherence tomography--evaluation of boundary line artefacts and the effect on retinal thickness.

    abstract:PURPOSE:To characterize frequency, morphological cause and time-dependent change of boundary line artefacts in optical coherence tomography (OCT) examinations of centre-involved diabetic macular oedema (ciDME) patients who underwent ranibizumab treatment with 1-year follow-up and to evaluate the impact of artefacts on ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12494

    authors: Hodzic-Hadzibegovic D,Sander BA,Lund-Andersen H

    更新日期:2015-02-01 00:00:00

  • The interrelation between hypothyroidism and glaucoma: a critical review and meta-analyses.

    abstract::Data on the association between hypothyroidism and glaucoma are conflicting. We sought to shed light on this by conducting a critical review and meta-analyses. The meta-analyses were conducted in adherence with the widely accepted MOOSE guidelines. Using the Medical Subject Heading (MeSH) terms: hypothyroidism, myxoed...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/aos.13412

    authors: Thvilum M,Brandt F,Brix TH,Hegedüs L

    更新日期:2017-12-01 00:00:00

  • Retinal neurodegeneration, macular circulation and morphology of the foveal avascular zone in diabetic patients: quantitative cross-sectional study using OCT-A.

    abstract:PURPOSE:Using OCT-A to investigate the association between neurodegeneration and vascular morphology in diabetic retinopathy (DR). METHODS:Cross-sectional study. One hundred and sixty-two patients were enrolled and following fundoscopy were assigned to two groups according to DR severity: 54 patients to the group of n...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.14754

    authors: Bontzos G,Kabanarou SA,Gkizis I,Ragkousis A,Xirou T,Peto T

    更新日期:2021-01-10 00:00:00

  • Vascular risk factors for optical coherence tomography-detected macular cysts: The Maastricht Study.

    abstract:PURPOSE:To investigate whether higher blood pressure and greater arterial stiffness are associated with the presence of macular cysts and whether this association is already present in the absence of micro-aneurysms in individuals with and without type 2 diabetes. METHODS:Using spectral domain optical coherence tomogr...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.14677

    authors: De Clerck EEB,Schouten JSAG,Berendschot TTJM,Goezinne F,Liesenborghs I,Dagnelie PC,Schaper NC,Kroon AA,Henry RMA,Reesink KD,Schram MT,Stehouwer CDA,Webers CAB

    更新日期:2020-11-30 00:00:00

  • Pseudoexfoliation syndrome and relating factors in a rural Japanese population: the Kumejima Study.

    abstract:PURPOSE:To report the prevalence of pseudoexfoliation (PEX) syndrome and glaucoma associated with PEX (PEX-G) and their relating factors of them in a south-western island of Japan. METHODS:A population-based survey of all residents aged ≥ 40 years was conducted in Kumejima, Okinawa, Japan, and 3762 subjects (participa...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.14396

    authors: Arakaki Y,Sawaguchi S,Iwase A,Tomidokoro A,Araie M

    更新日期:2020-11-01 00:00:00

  • One hundred-year-old human corneal and transplanted corneal graft endothelium.

    abstract:PURPOSE:To investigate and analyse one hundred-year-old endothelial cells of human transplanted corneal grafts and compare them with intact endothelium of unoperated eyes. SUBJECTS AND METHODS:Specular microscopy was performed on seven individuals (14 eyes) aged >100 years and on seven transplanted corneas with endoth...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12715

    authors: Ruusuvaara P,Vesti E,Koskela E,Setälä K

    更新日期:2015-09-01 00:00:00

  • E-PTFE (Gore-Tex) implant with or without low-dosage mitomycin-C as an adjuvant in penetrating glaucoma surgery: 2 year randomized clinical trial.

    abstract:PURPOSE:To test the expanded polytetrafluoroethylene (ePTFE) as a new adjuvant in trabeculectomy. METHODS:Consecutive glaucoma surgical inpatients were observed at the Department of Ophthalmology of Palermo University. Sixty patients (60 eyes) were randomly assigned to undergo trabeculectomy (T), trabeculectomy with m...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1600-0420.2007.01036.x

    authors: Cillino S,Zeppa L,Di Pace F,Casuccio A,Morreale D,Bocchetta F,Lodato G

    更新日期:2008-05-01 00:00:00

  • Lens autofluorescence is not increased at high altitude.

    abstract:PURPOSE:To study the relation between ambient environmental ultraviolet radiation exposure and lens fluorescence. METHODS:Non-invasive lens fluorometry measurements were compared in healthy Bolivian and Danish subjects. Background ultraviolet radiation was 4.5 times higher in Bolivia than in Denmark. RESULTS:No signi...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/j.1755-3768.2008.01488.x

    authors: Kessel L,Kofoed PK,Zubieta-Calleja G,Larsen M

    更新日期:2010-03-01 00:00:00

  • Vitreomacular traction and exudative age-related macular degeneration.

    abstract::Vitreomacular traction resulting from lacking, incomplete or anomalous posterior vitreous detachment is suspected to play a crucial role in the pathogenesis of different forms of age-related macular degeneration (AMD) along with the known mechanisms. It is probable that the fundamental pathomechanisms of AMD formation...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,评审

    doi:10.1111/j.1755-3768.2008.01210.x

    authors: Schulze S,Hoerle S,Mennel S,Kroll P

    更新日期:2008-08-01 00:00:00

  • Presence and distribution of L-kynurenine aminotransferases immunoreactivity in human cataractous lenses.

    abstract:PURPOSE:To investigate the presence and distribution of l-kynurenine aminotransferases immunoreactivity in human and animal lenses during cataract formation. METHODS:Immunohistochemistry was conducted using polyclonal antibodies against KAT I, KAT II and KAT III on sections of 26 anterior capsules from patients underg...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12138

    authors: Rejdak R,Oleszczuk A,Rummelt C,Turski WA,Choragiewicz T,Nowomiejska K,Ksiazek K,Thaler S,Zarnowski T,Okuno E,Grieb P,Zrenner E,Kruse F,Junemann AG

    更新日期:2013-09-01 00:00:00

  • Retinal oxygen saturation as a non-invasive estimate for mixed venous oxygen saturation and cardiac output.

    abstract:PURPOSE:To investigate the correlation between retinal vessel oxygen saturation and mixed venous oxygen saturation (SvO2-mixed ) and cardiac output (CO). METHODS:Retinal arterial (SaO2-retinal ) and venous (SvO2-retinal ) oxygen saturation were measured non-invasively with dual-wavelength retinal oximetry in subjects ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13890

    authors: Van Keer K,Van Keer J,Barbosa Breda J,Nassiri V,Van Cleemput J,Abegão Pinto L,Stalmans I,Vandewalle E

    更新日期:2019-03-01 00:00:00

  • Preoperative and postoperative measurements of retinal vessel oxygen saturation in patients with different grades of cataracts.

    abstract:PURPOSE:To assess the retinal vessel blood oxygen saturation preoperatively and postoperatively in patients with different grades of cataracts. METHODS:This study included 40 eyes from 40 patients with senile cataracts ranging from grade 1 to 3. All 40 eyes received standard phacoemulsification and intraocular lens im...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13332

    authors: Chen H,Lin H,Chen W,Zhang B,Xiang W,Gao Q,Chen W,Liu Y

    更新日期:2017-09-01 00:00:00

  • Optical performance after bilateral implantation of apodized aspheric diffractive multifocal intraocular lenses with +3.00-D addition power.

    abstract:PURPOSE:To determine whether bilateral implantation of an aspheric apodized diffractive multifocal intraocular lens (IOL) with +3.00 diopters (D) results in optical adverse effects compared with an aspheric monofocal IOL. METHODS:  In a prospective, randomized study of 204 eyes (102 patients) with bilateral implantati...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1755-3768.2012.02497.x

    authors: Peng C,Zhao J,Ma L,Qu B,Sun Q,Zhang J

    更新日期:2012-12-01 00:00:00

  • Anisometropia of spherical equivalent and astigmatism among myopes: a 23-year follow-up study of prevalence and changes from childhood to adulthood.

    abstract:PURPOSE:To study anisometropia of spherical equivalent and astigmatism from the onset of myopia at school age to adulthood. METHODS:A total of 240 myopic schoolchildren (mean age 10.9 years), with no previous spectacles, were recruited during 1983-1984 to a randomized 3-year clinical trial of bifocal treatment of myop...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aos.13405

    authors: Pärssinen O,Kauppinen M

    更新日期:2017-08-01 00:00:00

  • Fine structure in diabetic retinopathy lesions as observed by adaptive optics imaging. A qualitative study.

    abstract:PURPOSE:Diabetic retinopathy is diagnosed by fundus photography and optical coherence tomography (OCT) scanning. However, adaptive optics (AO) imaging can be expected to add new aspects to the knowledge of diabetic retinopathy because photographic resolution is improved by reducing the influence of optical aberrations ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12464

    authors: Bek T

    更新日期:2014-12-01 00:00:00

  • Simulation-based certification for cataract surgery.

    abstract:PURPOSE:To evaluate the EyeSi(™) simulator in regard to assessing competence in cataract surgery. The primary objective was to explore all simulator metrics to establish a proficiency-based test with solid evidence. The secondary objective was to evaluate whether the skill assessment was specific to cataract surgery. ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12691

    authors: Thomsen AS,Kiilgaard JF,Kjaerbo H,la Cour M,Konge L

    更新日期:2015-08-01 00:00:00

  • Bicanalicular double silicone intubation in external dacryocystorhinostomy and canaliculoplasty for distal canalicular obstruction.

    abstract:PURPOSE:We aimed to evaluate the effectiveness of bicanalicular double silicone intubation in dacryocystorhinostomy (DCR) and canaliculoplasty for distal or common canalicular obstruction. METHODS:We reviewed the medical records of patients with distal or common canalicular obstruction who had undergone bicanalicular ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/j.1755-3768.2008.01292.x

    authors: Hwang SW,Khwarg SI,Kim JH,Choung HK,Kim NJ

    更新日期:2009-06-01 00:00:00

  • Refractive, anterior corneal and internal astigmatism in the pseudophakic eye.

    abstract:PURPOSE:To evaluate the correlation between refractive astigmatism (RA) and anterior corneal astigmatism (ACA), and determine the internal astigmatism (IA) in 184 pseudophakic eyes. METHODS:The study was a prospective non-masked single-centre study. Patients were examined 8 weeks after phacoemulsification with implant...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12418

    authors: Bregnhøj JF,Mataji P,Naeser K

    更新日期:2015-02-01 00:00:00

  • Optical coherence tomography evaluation of patients with macula-off retinal detachment after different postoperative posturing: a randomized pilot study.

    abstract:PURPOSE:To assess the presence of outer and inner retinal folds (RFs) and drop-out of the ellipsoid zone (EZ) occurring after surgical repair of macula-off rhegmatogenous retinal detachment (RRD) with different postoperative posture and preoperative use of adjuvant perfluorocarbon liquid (PFCO). METHODS:In this prospe...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13397

    authors: Peiretti E,Nasini F,Buschini E,Caminiti G,Lesnik Oberstein SY,Willig A,Bijl HM,Mura M

    更新日期:2017-08-01 00:00:00

  • Effects of core vitrectomy in the treatment of age-related macular degeneration.

    abstract:PURPOSE:To investigate the clinical efficacy and safety of an additional core vitrectomy to the standard therapy in patients with exudative age-related macular degeneration (ARMD). METHODS:In this prospective, controlled, single-centre study, 50 eyes of 50 patients (mean age: 74.1 ± 7.1; median 74 (69/78)) with ARMD w...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aos.12326

    authors: Schramm K,Mueller M,Koch FH,Singh P,Kohnen T,Koss MJ

    更新日期:2014-08-01 00:00:00

  • Intraocular cytokine profile and autoimmune reactions in retinitis pigmentosa, age-related macular degeneration, glaucoma and cataract.

    abstract:PURPOSE:To analyse intraocular cytokine levels and prevalence of intraocular antiretinal antibodies (ARAs) in patients with retinitis pigmentosa (RP), age-related macular degeneration (AMD), glaucoma and cataract, and correlate the results to clinical manifestations. METHODS:We collected intraocular fluid samples from...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.13899

    authors: Ten Berge JC,Fazil Z,van den Born I,Wolfs RCW,Schreurs MWJ,Dik WA,Rothova A

    更新日期:2019-03-01 00:00:00

  • Intraocular pressure and corneal biomechanics in Fuchs' endothelial dystrophy and after posterior lamellar keratoplasty.

    abstract:PURPOSE:  To evaluate the precision of techniques for measuring intraocular pressure (IOP) in corneas with presumably altered biomechanical properties. METHODS:  Intraocular pressure was measured with a Goldmann applanation tonometer (GAT), ocular response analyzer (ORA) and dynamic contour tonometer (DCT) in 70 eyes....

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12137

    authors: Clemmensen K,Hjortdal J

    更新日期:2014-06-01 00:00:00

  • There is no relation between the occurrence of proliferative vitreoretinopathy and the location of the donor site after transplantation of a free autologous retinal pigment epithelium-choroid graft.

    abstract:PURPOSE:A free autologous retinal pigment epithelium (RPE)-choroid graft can be harvested during transplantation surgery from a 6 or 12 o'clock site in the midperiphery. This study evaluated whether proliferative vitreoretinopathy (PVR) occurs more frequently in patients with an inferior donor site retinotomy, which is...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12178

    authors: van Zeeburg EJ,Maaijwee K,van Meurs JC

    更新日期:2014-05-01 00:00:00

  • Evaluation of adding item-response theory analysis for evaluation of the European Board of Ophthalmology Diploma examination.

    abstract:PURPOSE:To investigate whether introduction of item-response theory (IRT) analysis, in parallel to the 'traditional' statistical analysis methods available for performance evaluation of multiple T/F items as used in the European Board of Ophthalmology Diploma (EBOD) examination, has proved beneficial, and secondly, to ...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.12135

    authors: Mathysen DG,Aclimandos W,Roelant E,Wouters K,Creuzot-Garcher C,Ringens PJ,Hawlina M,Tassignon MJ

    更新日期:2013-11-01 00:00:00

  • Homocysteine and risk of age-related macular degeneration: a systematic review and meta-analysis.

    abstract::There is still no agreement on total plasma homocysteine (tHcy) role in age-related macular degeneration (AMD), the leading cause of new blindness in industrialized countries. We performed a systematic review and meta-analysis of the published data on the correlation between tHcy and AMD. MEDLINE/PubMed and ISI Web of...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/aos.13343

    authors: Pinna A,Zaccheddu F,Boscia F,Carru C,Solinas G

    更新日期:2018-05-01 00:00:00

  • Design, synthesis and antiamoebic activity of dysprosium-based nanoparticles using contact lenses as carriers against Acanthamoeba sp.

    abstract:PURPOSE:Contact lenses have direct contact with the corneal surface and can induce sight-threatening infection of the cornea known as Acanthamoeba keratitis. The objective of this study was to evaluate the dysprosium-based nanoparticles (Dy-based NPs), namely Fe3 O4 -PEG-Dy2 O3 nanocomposites and Dy(OH)3 nanorods, as a...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/aos.14541

    authors: Kusrini E,Sabira K,Hashim F,Abdullah NA,Usman A,Putra N,Prasetyanto EA

    更新日期:2020-07-23 00:00:00

  • Coexistence of macro- and micro-vascular abnormalities in newly diagnosed normal tension glaucoma patients.

    abstract:PURPOSE:To investigate the coexistence of ocular microvascular and systemic macrovascular abnormalities in early stage, newly diagnosed and previously untreated normal tension glaucoma patients (NTG). METHODS:Retinal vascular reactivity to flickering light was assessed in 19 NTG and 28 age-matched controls by means of...

    journal_title:Acta ophthalmologica

    pub_type: 杂志文章

    doi:10.1111/j.1755-3768.2012.02494.x

    authors: Mroczkowska S,Ekart A,Sung V,Negi A,Qin L,Patel SR,Jacob S,Atkins C,Benavente-Perez A,Gherghel D

    更新日期:2012-11-01 00:00:00