High-throughput sequencing of circRNAs reveals novel insights into mechanisms of nigericin in pancreatic cancer.

abstract：BACKGROUND:Mycobacterium abscessus complex, the third most frequent mycobacterial complex responsible for community- and health care-associated infections in developed countries, comprises of M. abscessus subsp. abscessus and M. abscessus subsp. bolletii reviously referred as Mycobacterium bolletii and Mycobacterium ma...

journal_title：BMC genomics

authors： Sassi M,Drancourt M

更新日期：2014-05-12 00:00:00

abstract：BACKGROUND:Pectins are plant cell wall polysaccharides that can be acetylated on C2 and/or C3 of galacturonic acid residues. The degree of acetylation of pectin can be modulated by pectin acetylesterase (EC 3.1.1.6, PAE). The function and structure of plant PAEs remain poorly understood and the role of the fine-tuning ...

journal_title：BMC genomics

authors： Philippe F,Pelloux J,Rayon C

更新日期：2017-06-08 00:00:00

abstract：BACKGROUND:Decapods are an order of crustaceans which includes shrimps, crabs, lobsters and crayfish. They occur worldwide and are of great scientific interest as well as being of ecological and economic importance in fisheries and aquaculture. However, our knowledge of their biology mainly comes from the group which i...

journal_title：BMC genomics

authors： Nong W,Chai ZYH,Jiang X,Qin J,Ma KY,Chan KM,Chan TF,Chow BKC,Kwan HS,Wong CKC,Qiu JW,Hui JHL,Chu KH

更新日期：2020-01-09 00:00:00

abstract：BACKGROUND:Metal tolerance is often an integrative result of metal uptake and distribution, which are fine-tuned by a network of signaling cascades and metal transporters. Thus, with the goal of advancing the molecular understanding of such metal homeostatic mechanisms, comparative RNAseq-based transcriptome analysis w...

journal_title：BMC genomics

authors： Cheng D,Tan M,Yu H,Li L,Zhu D,Chen Y,Jiang M

更新日期：2018-09-26 00:00:00

abstract：BACKGROUND:Accurate de novo genome assembly has become reality with the advancements in sequencing technology. With the ever-increasing number of de novo genome assembly tools, assessing the quality of assemblies has become of great importance in genome research. Although many quality metrics have been proposed and sof...

journal_title：BMC genomics

authors： Yavas G,Hong H,Xiao W

更新日期：2019-09-11 00:00:00

abstract：BACKGROUND:Genome research in farm animals will expand our basic knowledge of the genetic control of complex traits, and the results will be applied in the livestock industry to improve meat quality and productivity, as well as to reduce the incidence of disease. A combination of quantitative trait locus mapping and mi...

journal_title：BMC genomics

authors： Kim TH,Kim NS,Lim D,Lee KT,Oh JH,Park HS,Jang GW,Kim HY,Jeon M,Choi BH,Lee HY,Chung HY,Kim H

更新日期：2006-02-27 00:00:00

abstract：BACKGROUND:Candida albicans is an opportunistic pathogenic yeast, which could become pathogenic in various stressful environmental factors including the spaceflight environment. In this study, we aim to explore the phenotypic changes and possible mechanisms of C. albicans after exposure to spaceflight conditions. RESU...

journal_title：BMC genomics

authors： Wang J,Liu Y,Zhao G,Gao J,Liu J,Wu X,Xu C,Li Y

更新日期：2020-01-17 00:00:00

abstract：BACKGROUND:Human T cell leukemia virus type 1 (HTLV-1) Tax is a potent activator of viral and cellular gene expression that interacts with a number of cellular proteins. Many reports show that Tax is capable of regulating cell cycle progression and apoptosis both positively and negatively. However, it still remains to ...

journal_title：BMC genomics

authors： Arainga M,Murakami H,Aida Y

更新日期：2012-06-22 00:00:00

abstract：BACKGROUND:There is growing recognition that horizontal DNA transfer, a process known to be common in prokaryotes, is also a significant source of genomic variation in eukaryotes. Horizontal transfer of transposable elements (HTT) may be especially prevalent in eukaryotes given the inherent mobility, widespread occurre...

journal_title：BMC genomics

authors： Gilbert C,Waters P,Feschotte C,Schaack S

更新日期：2013-02-27 00:00:00

abstract：BACKGROUND:Meloidogyne incognita is a devastating nematode that causes significant losses in cucumber production worldwide. Although numerous studies have emphasized on the susceptible response of plants after nematode infection, the exact regulation mechanism of M. incognita-resistance in cucumber remains elusive. Ver...

journal_title：BMC genomics

authors： Wang X,Cheng C,Zhang K,Tian Z,Xu J,Yang S,Lou Q,Li J,Chen JF

更新日期：2018-08-03 00:00:00

abstract：BACKGROUND:A systems toxicology investigation comparing and integrating transcriptomic and proteomic results was conducted to develop holistic effects characterizations for the wildlife bird model, Northern bobwhite (Colinus virginianus) dosed with the explosives degradation product 2-amino-4,6-dinitrotoluene (2A-DNT)....

journal_title：BMC genomics

authors： Gust KA,Nanduri B,Rawat A,Wilbanks MS,Ang CY,Johnson DR,Pendarvis K,Chen X,Quinn MJ Jr,Johnson MS,Burgess SC,Perkins EJ

更新日期：2015-08-07 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are a class of noncoding small RNAs (sRNAs) that are 20-24 nucleotides (nt) in length. Extensive studies have indicated that miRNAs play versatile roles in plants, functioning in processes such as growth, development and stress responses. Chilling is a common abiotic stress that seriously ...

journal_title：BMC genomics

authors： Cao X,Wu Z,Jiang F,Zhou R,Yang Z

更新日期：2014-12-17 00:00:00

abstract：BACKGROUND:Midgut invasion, a major bottleneck for malaria parasites transmission is considered as a potential target for vector-parasite interaction studies. New intervention strategies are required to explore the midgut proteins and their potential role in refractoriness for malaria control in Anopheles mosquitoes. T...

journal_title：BMC genomics

authors： Vijay S,Rawal R,Kadian K,Singh J,Adak T,Sharma A

更新日期：2018-05-08 00:00:00

abstract：BACKGROUND:Though genomic-level data are becoming widely available, many of the metazoan species sequenced are laboratory systems whose natural history is not well documented. In contrast, the wide array of species with very well-characterized natural history have, until recently, lacked genomics tools. It is now possi...

journal_title：BMC genomics

authors： Peterson MP,Whittaker DJ,Ambreth S,Sureshchandra S,Buechlein A,Podicheti R,Choi JH,Lai Z,Mockatis K,Colbourne J,Tang H,Ketterson ED

更新日期：2012-07-09 00:00:00

abstract：BACKGROUND:The steroid hormone environment in healthy horses seems to have a significant impact on the efficiency of their uterine immune response. The objective of this study was to characterize the changes in gene expression in the equine endometrium in response to the introduction of bacterial pathogens and the infl...

journal_title：BMC genomics

authors： Marth CD,Young ND,Glenton LY,Noden DM,Browning GF,Krekeler N

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:The purpose of this research was to develop a novel information theoretic method and an efficient algorithm for analyzing the gene-gene (GGI) and gene-environmental interactions (GEI) associated with quantitative traits (QT). The method is built on two information-theoretic metrics, the k-way interaction inf...

journal_title：BMC genomics

authors： Chanda P,Sucheston L,Liu S,Zhang A,Ramanathan M

更新日期：2009-11-04 00:00:00

abstract：BACKGROUND:Lack of power and reproducibility are caveats of genetic association studies of common complex diseases. Indeed, the heterogeneity of disease etiology demands that causal models consider the simultaneous involvement of multiple genes. Rothman's sufficient-cause model, which is well known in epidemiology, pro...

journal_title：BMC genomics

authors： Lynn KS,Lu CH,Yang HY,Hsu WL,Pan WH

更新日期：2013-07-23 00:00:00

abstract：BACKGROUND:Crocodilians (Order Crocodylia) are an ancient vertebrate group of tremendous ecological, social, and evolutionary importance. They are the only extant reptilian members of Archosauria, a monophyletic group that also includes birds, dinosaurs, and pterosaurs. Consequently, crocodilian genomes represent a gat...

journal_title：BMC genomics

authors： Shan X,Ray DA,Bunge JA,Peterson DG

更新日期：2009-07-14 00:00:00

abstract：BACKGROUND:Availability of molecular markers has proven to be an efficient tool in facilitating progress in plant breeding, which is particularly important in the case of less researched crops such as cotton. Considering the obvious advantages of single nucleotide polymorphisms (SNPs) and insertion-deletion polymorphis...

journal_title：BMC genomics

authors： Li X,Gao W,Guo H,Zhang X,Fang DD,Lin Z

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Long terminal repeat retrotransposons are the most abundant transposons in plants. They play important roles in alternative splicing, recombination, gene regulation, and defense mechanisms. Large-scale sequencing projects for plant genomes are currently underway. Software tools are important for annotating l...

journal_title：BMC genomics

authors： Valencia JD,Girgis HZ

更新日期：2019-06-03 00:00:00

abstract：BACKGROUND:The complex genome of rapeseed (Brassica napus) is not well understood despite the economic importance of the species. Good knowledge of sequence variation is needed for genetics approaches and breeding purposes. We used a diversity set of B. napus representing eight different germplasm types to sequence gen...

journal_title：BMC genomics

authors： Bus A,Hecht J,Huettel B,Reinhardt R,Stich B

更新日期：2012-06-24 00:00:00

abstract：BACKGROUND:Understanding how and why genetic variation is partitioned across geographic space is of fundamental importance to understanding the nature of biological species. How geographical isolation and local adaptation contribute to the formation of ecotypically differentiated groups of plants is just beginning to b...

journal_title：BMC genomics

authors： Gould BA,Palacio-Mejia JD,Jenkins J,Mamidi S,Barry K,Schmutz J,Juenger TE,Lowry DB

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Malaria, caused by the parasitic protist Plasmodium falciparum, represents a major public health problem in the developing world. The P. falciparum genome has been sequenced, which provides new opportunities for the identification of novel drug targets. Eukaryotic protein kinases (ePKs) form a large family o...

journal_title：BMC genomics

authors： Ward P,Equinet L,Packer J,Doerig C

更新日期：2004-10-12 00:00:00

abstract：BACKGROUND:The Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway has been well-characterized as a crucial signal transduction cascade that regulates vital biological responses including development, immunity and oncogenesis. Additionally to its canonical pathway that uses the phosphorylat...

journal_title：BMC genomics

authors： Tsurumi A,Zhao C,Li WX

更新日期：2017-09-11 00:00:00

abstract：BACKGROUND:Hibernation is a physiological state exploited by many animals exposed to prolonged adverse environmental conditions associated with winter. Large changes in metabolism and cellular function occur, with many stress response pathways modulated to tolerate physiological challenges that might otherwise be letha...

journal_title：BMC genomics

authors： Capraro A,O'Meally D,Waters SA,Patel HR,Georges A,Waters PD

更新日期：2019-06-06 00:00:00

abstract：BACKGROUND:The transcription factor SOX10 is essential for all stages of Schwann cell development including myelination. SOX10 cooperates with other transcription factors to activate the expression of key myelin genes in Schwann cells and is therefore a context-dependent, pro-myelination transcription factor. As such, ...

journal_title：BMC genomics

authors： Gopinath C,Law WD,Rodríguez-Molina JF,Prasad AB,Song L,Crawford GE,Mullikin JC,Svaren J,Antonellis A

更新日期：2016-11-07 00:00:00

abstract：BACKGROUND:Developing effective strategies to reveal modular structures in protein interaction networks is crucial for better understanding of molecular mechanisms of underlying biological processes. In this paper, we propose a new density-based algorithm (ADHOC) for clustering vertices of a protein interaction network...

journal_title：BMC genomics

authors： Liu C,Li J,Zhao Y

更新日期：2010-12-02 00:00:00

abstract：BACKGROUND:Parasitic wasps constitute one of the largest group of venomous animals. Although some physiological effects of their venoms are well documented, relatively little is known at the molecular level on the protein composition of these secretions. To identify the majority of the venom proteins of the endoparasit...

journal_title：BMC genomics

authors： Vincent B,Kaeslin M,Roth T,Heller M,Poulain J,Cousserans F,Schaller J,Poirié M,Lanzrein B,Drezen JM,Moreau SJ

更新日期：2010-12-07 00:00:00

abstract：BACKGROUND:Intergenic splicing resulting in the combination of mRNAs sequences from distinct genes is a newly identified mechanism likely to contribute to protein diversity. Few cases have been described, most of them involving neighboring genes and thus suggesting a cotranscription event presumably due to transcriptio...

journal_title：BMC genomics

authors： Roux M,Levéziel H,Amarger V

更新日期：2006-04-04 00:00:00

abstract：BACKGROUND:High-throughput genotyping platforms play important roles in plant genomic studies. Cotton (Gossypium spp.) is the world's important natural textile fiber and oil crop. Upland cotton accounts for more than 90% of the world's cotton production, however, modern upland cotton cultivars have narrow genetic diver...

journal_title：BMC genomics

authors： Cai C,Zhu G,Zhang T,Guo W

更新日期：2017-08-23 00:00:00