Risk factors for recurrence after drug withdrawal in childhood epilepsy.

Abstract:

BACKGROUND:Several studies have been conducted to determine the risk of recurrence after withdrawal of antiepileptic drugs (AEDs) in recent years. There is no consensus concerning the circumstances affecting discontinuation of AEDs. This study was designed to determine the recurrence rate of epilepsy after withdrawal of AEDs and the risk factors related with recurrence. METHODS:Children with epilepsy onset between 1 month and 16 years of age who were followed up at least 3 years after AED treatment withdrawal were enrolled. Patients were classified into groups according to defined risk factors for recurrence. RESULTS:A total of 284 patients, 137 (48.2%) girls and 147 (51.8%) boys were included, and seizures recurred after withdrawal in 51 patients (18%). Thirty-three (64.7%) patients had recurrence in the first year after withdrawal. The recurrence risk was calculated based on the electro-clinical syndromes classification; the recurrence risk was the highest in the juvenile myoclonic/absence group and lowest in the benign infantile seizure group. No recurrence was observed in the infantile spasm group. Data evaluated by multivariable analysis showed that having the structural-metabolic and unknown epilepsy and <3 years seizure free period before withdrawal of AEDs were the main risk factors for recurrence after AED withdrawal in our study. CONCLUSION:We suggest a seizure-free period of at least 3 years under AED medication and we must be cautious in patients with structural-metabolic and unknown epilepsy before AED withdrawal.

journal_name

Brain Dev

journal_title

Brain & development

authors

Karalok ZS,Guven A,Öztürk Z,Gurkas E

doi

10.1016/j.braindev.2019.08.012

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

35-40

issue

1

eissn

0387-7604

issn

1872-7131

pii

S0387-7604(19)30261-X

journal_volume

42

pub_type

杂志文章
  • MR imaging and 1H-MR spectroscopy of a case of van der Knaap disease.

    abstract::Van der Knaap disease, characterized by megalencephalic leukoencephalopathy and subcortical cysts, is a rare and recently defined condition. We discuss here the MR image (MRI) and MR spectroscopy (MRS) features in a 30-year-old man with S93L homozygous mutation in the MLC1 gene. MRI demonstrated high intensity diffuse...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2005.12.006

    authors: Morita H,Imamura A,Matsuo N,Tatebayashi K,Omoya K,Takahashi Y,Tsujino S

    更新日期:2006-08-01 00:00:00

  • Mass screening electroencephalography.

    abstract::From 1971 to 1978, 5,202 schoolchildren from the first to the 9th grade underwent mass screening EEG. Paroxysmal discharges were recognized in 1.7%. Focal paroxysmal discharges appeared most frequently and the temporal, occipital, and central areas were the most common sites. Children having autonomic seizures, psycho...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(81)80054-x

    authors: Tsuchiya S

    更新日期:1981-01-01 00:00:00

  • A rare infective cause of stroke in an immunocompetent child.

    abstract:BACKGROUND:Infections are a common cause of childhood stroke with variable presentation. The current case describes a rare infective cause of venous and arterial stroke in an immunocompetent girl with management implications. CASE DESCRIPTION:A 12 year old girl, presented with history of fever for 10 days, painful swe...

    journal_title:Brain & development

    pub_type:

    doi:10.1016/j.braindev.2020.07.016

    authors: Gupta J,Chakrabarty B,Singh G,Singh S,Kumar A,Xess I,Jauhari P,Gulati S

    更新日期:2021-01-01 00:00:00

  • Two siblings with partial trisomy 1(q42.3-ter).

    abstract::Two brothers, aged 6 and 4 years, with an unbalanced chromosome translocation (partial trisomy 1), and their mother, a balanced carrier of the translocation, t(1;3)(q42.3;p26.3), were described. Both patients show minor anomalies; a large head with a prominent forehead, low-set and soaring ears, a high-arched palate, ...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/0387-7604(93)90048-d

    authors: Sunaga Y,Ohtsuka T,Nagashima K,Kuroume T

    更新日期:1993-03-01 00:00:00

  • An extra-axial hemangioma mimicking a large prenatal brain tumor.

    abstract::A rare case of a congenital brain tumor was diagnosed by sonography in a fetus at 37weeks' gestation. The ultrasound examination showed a large area of both increased echogenicity and echolucency in one hemisphere suggestive of brain tumor or hemorrhage. Extensive surgical removal of the tumor was performed and reveal...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2010.02.006

    authors: Yang CY,Hsu JF,Lin KL,Jung SM,Lien R,Chang YL

    更新日期:2010-11-01 00:00:00

  • Schizencephaly: clinical and imaging features in 30 infantile cases.

    abstract::Schizencephaly is an uncommon structural disorder of cerebral cortical development, characterized by congenital clefts spanning the cerebral hemispheres from the pial surface to the lateral ventricles and lined by cortical gray matter. Either an antenatal environmental incident or a genetic origin could be responsible...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(00)00173-x

    authors: Denis D,Chateil JF,Brun M,Brissaud O,Lacombe D,Fontan D,Flurin V,Pedespan J

    更新日期:2000-12-01 00:00:00

  • Nerve growth factor and the neurotrophic factor hypothesis.

    abstract::The discovery of nerve growth factor (NGF) over 40 years ago led to the formulation of the "Neurotrophic Factor Hypothesis". This hypothesis states that developing neurons compete with each other for a limited supply of a neurotrophic factor (NTF) provided by the target tissue. Successful competitors survive; unsucces...

    journal_title:Brain & development

    pub_type: 杂志文章,评审

    doi:10.1016/0387-7604(96)00051-4

    authors: Yuen EC,Howe CL,Li Y,Holtzman DM,Mobley WC

    更新日期:1996-09-01 00:00:00

  • Epilepsy phenotypes in siblings with Norrie disease.

    abstract::Norrie disease is an X-linked recessive disorder that is characterized by congenital blindness. Although epileptic seizures are observed in some patients with Norrie disease, little is known about this phenomenon. Here, we report the manifestation of epilepsy in siblings with Norrie disease to increase our knowledge o...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2015.04.004

    authors: Okumura A,Arai E,Kitamura Y,Abe S,Ikeno M,Fujimaki T,Yamamoto T,Shimizu T

    更新日期:2015-11-01 00:00:00

  • Carbamazepine as a sole anticonvulsant for partial seizures.

    abstract::The efficacy, serum concentration and side effects of CBZ for partial seizures in children were evaluated. The study was undertaken on 27 patients with partial seizures ranging from 5 to 17 years of age. Further 15 patients with various types of epilepsy taking CBZ with other anticonvulsants were selected as controls ...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(79)80017-0

    authors: Sato H,Doi M,Okuno T

    更新日期:1979-01-01 00:00:00

  • Vitamin B6 in acute encephalopathy with biphasic seizures and late reduced diffusion.

    abstract:BACKGROUND:The initial presentation of acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is indistinguishable from that of complex febrile seizures (FS), which poses a great diagnostic challenge for clinicians. Excitotoxicity is speculated to be the pathogenesis of AESD. Vitamin B6 (VB6) is ...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2020.02.002

    authors: Akiyama T,Toda S,Kimura N,Mogami Y,Hanaoka Y,Tokorodani C,Ito T,Miyahara H,Hyodo Y,Kobayashi K

    更新日期:2020-05-01 00:00:00

  • The treatment of acute polyradiculoneuritis with respiratory paralysis.

    abstract::This paper reports 504 cases admitted with acute polyradiculoneuritis (AP) to Beijing Children's Hospital from 1975 through 1984. 343 of the 504 cases (68.1%) with AP had respiratory paralysis and in 198/504 (39.3%), tracheotomy was performed. In this study, none of the patients received steroids. We attempted to asse...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:

    authors: Wu HS,Yei QF,Liu TC,Zhang WC

    更新日期:1988-01-01 00:00:00

  • Molybdenum cofactor deficiency associated with Dandy-Walker complex.

    abstract::Molybdenum cofactor deficiency is a rare and devastating disease leading to intractable seizures in the neonatal period. Severe loss of neocortical neurons, gliosis, and cystic necrosis of cerebral white matter resulting in significant cerebral volume loss are the neuropathological findings. The mechanism of cerebral ...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(01)00316-3

    authors: Arslanoglu S,Yalaz M,Gökşen D,Coker M,Tütüncüoglu S,Akisu M,Darcan S,Kultursay N,Ciriş M,Demirtaş E

    更新日期:2001-12-01 00:00:00

  • Functional and morphometrical maturation of the brainstem auditory pathway.

    abstract::The correlation between the functional and morphological maturation of the auditory pathway was studied in preterm and term infants, children and adults. As to the auditory brainstem response (ABR), peak latencies and I-V interpeak latencies (central transmission) gradually decreased during the third trimester and the...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(87)80092-x

    authors: Inagaki M,Tomita Y,Takashima S,Ohtani K,Andoh G,Takeshita K

    更新日期:1987-01-01 00:00:00

  • Clinical and MRI findings in a case of D-2-hydroxyglutaric aciduria.

    abstract::We report the 3rd case in the literature of a 3-year-old boy with D-2-hydroxyglutaric (D-2-HG) aciduria, who presented primarily generalized hypotonia and feeding difficulty during the neonatal period, with eventual development of generalized myoclonic seizures. Gas chromatographic analysis of urinary organic acids sh...

    journal_title:Brain & development

    pub_type: 杂志文章,评审

    doi:10.1016/0387-7604(94)00123-f

    authors: Sugita K,Kakinuma H,Okajima Y,Ogawa A,Watanabe H,Niimi H

    更新日期:1995-03-01 00:00:00

  • Positron emission tomography with glucose hypermetabolism of a hypothalamic hamartoma in infantile spasms associated with Pallister-Hall syndrome.

    abstract::Although hypothalamic hamartomas (HHs) have been shown to be intrinsically epileptogenic and to participate in the generation of gelastic seizures, no evidence has been reported regarding its contribution to the pathogenesis of infantile spasms. We describe a male infant with Pallister-Hall syndrome who had a large HH...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2009.09.003

    authors: Wakamoto H,Sumi A,Motoki T,Ohmori H

    更新日期:2010-09-01 00:00:00

  • Screening of the LIX1 gene in Japanese and Malaysian patients with SMA and/or SMA-like disorder.

    abstract:BACKGROUND:The majority of spinal muscular atrophy (SMA) patients showed homozygous deletion or other mutations of SMN1. However, the genetic etiology of a significant number of SMA patients has not been clarified. Recently, mutation in the gene underlying cat SMA, limb expression 1 (LIX1), has been reported. Similarit...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2009.06.008

    authors: Sasongko TH,Gunadi,Yusoff S,Atif AB,Fatemeh H,Rani A,Marini M,Ab Aziz CB,Zabidi-Hussin ZA,Nishio H,Zilfalil BA

    更新日期:2010-05-01 00:00:00

  • Multimodality evoked potentials in progression of metachromatic leukodystrophy.

    abstract::A 2-yr-3-mo-old girl with metachromatic leukodystrophy (MLD) was examined using serial multiple electrophysiological procedures. Sensory nerve conduction velocity was delayed earlier and more severely than motor nerve conduction velocity. Visual evoked potentials (VEPs) showed prolonged latency of wave IV. Auditory br...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(85)80141-8

    authors: Takakura H,Nakano C,Kasagi S,Takashima S,Takeshita K

    更新日期:1985-01-01 00:00:00

  • Molecular basis of neurogenetic diseases.

    abstract::Molecular background of neurogenetic disease is briefly reviewed. Importance and usefulness of genetic testing are emphasized. Molecular genetics is a powerful tool for investigation of epileptic syndromes. Diagnosis based on gene analysis will give a new insight for pathophysiology and clinical outcome of the patient...

    journal_title:Brain & development

    pub_type: 历史文章,杂志文章,评审

    doi:10.1016/j.braindev.2011.01.007

    authors: Suzuki Y

    更新日期:2011-10-01 00:00:00

  • Efficacy and safety of intravenous thiamylal in pediatric procedural sedation for magnetic resonance imaging.

    abstract:OBJECTIVE:To evaluate the efficacy and safety of intravenous (i.v.) thiamylal in pediatric magnetic resonance imaging (MRI) sedation. METHODS:Infants and children from 1 month up to 8 years of age who underwent MRI in our hospital between April 2017 and March 2019 were included in this prospective observational study....

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2020.04.005

    authors: Irie S,Hirai K,Kano K,Yanabe S,Migita M

    更新日期:2020-08-01 00:00:00

  • Clinical analysis of catastrophic epilepsy in infancy and early childhood: results of the Far-East Asia Catastrophic Epilepsy (FACE) study group.

    abstract:PURPOSE:We studied children younger than 6years old who developed catastrophic epilepsy and were registered in the FACE study group to clarify their clinical characteristics and prevalence of seizure as well as epilepsy types. SUBJECTS:Subjects were prospectively recruited from children with epilepsy who satisfied the...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2013.02.004

    authors: Oguni H,Otsuki T,Kobayashi K,Inoue Y,Watanabe E,Sugai K,Takahashi A,Hirose S,Kameyama S,Yamamoto H,Hamano S,Baba K,Baba H,Hong SC,Kim HD,Kang HC,Luan G,Wong TT

    更新日期:2013-09-01 00:00:00

  • Progressive multifocal leukoencephalopathy in purine nucleoside phosphorylase deficiency.

    abstract::Progressive multifocal leukoencephalopathy is a demyelinating disease caused by JC virus, an opportunistic infection of the central nervous system. Although the majority of cases are infected with the human immunodeficiency virus (HIV), other immunocompromised patients are also at risk. Purine nucleoside phosphorylase...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2006.07.008

    authors: Parvaneh N,Ashrafi MR,Yeganeh M,Pouladi N,Sayarifar F,Parvaneh L

    更新日期:2007-03-01 00:00:00

  • Serotonin transporter gene promoter polymorphism and autism: a family-based genetic association study in Japanese population.

    abstract::Autism is now widely accepted as a biological disorder which, by and large, starts before birth. It has been shown that serotonin (5-HT) is associated with several psychological processes and hyperserotoninemia is observed in some autistic patients. The results of previous reports about family-based association studie...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2005.09.003

    authors: Koishi S,Yamamoto K,Matsumoto H,Koishi S,Enseki Y,Oya A,Asakura A,Aoki Y,Atsumi M,Iga T,Inomata J,Inoko H,Sasaki T,Nanba E,Kato N,Ishii T,Yamazaki K

    更新日期:2006-05-01 00:00:00

  • Childhood absence epilepsy: Elctroclinical features and diagnostic criteria.

    abstract:OBJECTIVE:To analyze the electroclinical features of children with childhood absence epilepsy (CAE) and discuss the diagnostic criteria for CAE. METHODS:The video-electroencephalogram (VEEG) database in our hospital was searched using "absence seizures" and "3-Hz generalized spike and waves (GSW)" as key-words. Other ...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2010.02.004

    authors: Ma X,Zhang Y,Yang Z,Liu X,Sun H,Qin J,Wu X,Liang J

    更新日期:2011-02-01 00:00:00

  • Convulsive syncope following placement of sphenoidal electrodes.

    abstract::Two cases of convulsive syncope following the insertion of sphenoidal electrodes are reported. The episodes occurred shortly after an uneventful insertion of the needle. Both patients exhibited behavioral arrest with loss of muscle tone, followed by flexor posturing, jerking of the extremities, then followed by what a...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(99)00006-6

    authors: DeToledo JC

    更新日期:1999-04-01 00:00:00

  • Comparison of the strengths and difficulties questionnaire (SDQ) scores between children with high-functioning autism spectrum disorder (HFASD) and attention-deficit/hyperactivity disorder (AD/HD).

    abstract::The aim of this research was to compare the Strengths and Difficulties Questionnaire (SDQ) scores and subscale scores in children with high-functioning autism spectrum disorder (HFASD) and attention-deficit/hyperactivity disorder (AD/HD), and also to clarify the differences between parent- and teacher-assessed SDQ sco...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2009.09.009

    authors: Iizuka C,Yamashita Y,Nagamitsu S,Yamashita T,Araki Y,Ohya T,Hara M,Shibuya I,Kakuma T,Matsuishi T

    更新日期:2010-09-01 00:00:00

  • Paroxysmal EEG abnormalities and epilepsy in pervasive developmental disorders: follow-up study until adolescence and beyond.

    abstract::This study examined paroxysmal abnormalities and epilepsy in EEG for individuals with pervasive developmental disorders (PDD) in two parts: first with a large number of subjects (n=1624); and second with extracted subjects followed from 5 years into adolescence and beyond (n=92). Many paroxysms in PDD patients in thei...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2010.06.004

    authors: Kawasaki Y,Shinomiya M,Takayanagi M,Niwa S

    更新日期:2010-10-01 00:00:00

  • Megalencephaly and leukodystrophy with mild clinical course: a report on 12 new cases.

    abstract::Twelve patients with early infancy onset megalencephaly and leukodystrophy with a mild clinical course are reported. The neuroradiological, clinical, and genetic aspects of this recently recognized familial leukodystrophy syndrome were reviewed. Five were affected siblings, and all patients had consanguineous parents....

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(98)00002-3

    authors: Topcu M,Saatci I,Topcuoglu MA,Kose G,Kunak B

    更新日期:1998-04-01 00:00:00

  • Alterations of tetrahydrobiopterin biosynthesis and pteridine levels in mouse tissues during growth and aging.

    abstract::In the present study, we investigated age-related changes in pteridine levels and enzymatic activity responsible for tetrahydrobiopterin biosynthesis in mouse tissues. Until about 15 weeks after the birth, the remarkable change of tetrahydrobiopterin (BH4) was observed in all tissues tested. Between 20 and 50 weeks af...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/s0387-7604(00)00144-3

    authors: Yoshida YI,Eda S,Masada M

    更新日期:2000-09-01 00:00:00

  • Refractory and severe status epilepticus in a patient with ring chromosome 20 syndrome.

    abstract::Ring chromosome 20 [r(20)] syndrome is a rare chromosomal disorder that is characterized by the development of refractory epilepsy during childhood with gradual declines in cognitive performance and behavior. Although the prognoses of seizures and intellectual disability associated with this condition are poor, life-t...

    journal_title:Brain & development

    pub_type: 杂志文章

    doi:10.1016/j.braindev.2016.02.013

    authors: Hirano Y,Oguni H,Nagata S

    更新日期:2016-09-01 00:00:00

  • Deflazacort vs. prednisone in Duchenne muscular dystrophy: trends of an ongoing study.

    abstract::Several studies have demonstrated the slowing effect of corticosteroids on the decline of muscle strength in Duchenne muscular dystrophy (DMD). Deflazacort (DFC) is supposed to have fewer side effects than prednisone (PRED). An ongoing double blind multicenter study is comparing the effects and side effects of deflaza...

    journal_title:Brain & development

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Reitter B

    更新日期:1995-01-01 00:00:00