CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer.

abstract：:Many types of tumor cell are devoid of the extracellular matrix proteoglycan osteoglycin (Ogn), but its role in tumor biology is poorly studied. Here we show that RNAi of Ogn attenuates stress-triggered cell death, whereas its overexpression increases cell death. We found that the transcription factor C/EBPβ regulates...

journal_title：Cell death & disease

authors： Wassermann-Dozorets R,Rubinstein M

更新日期：2017-04-06 00:00:00

abstract：:Sepsis is a systemic inflammation caused by infection. The balance between M1-M2 macrophage polarization has an essential role in the pathogenesis of sepsis. However, the exact mechanism underlying macrophage polarization is unclear. We previously showed that levels of malignant fibrous histiocytoma amplified sequence...

journal_title：Cell death & disease

authors： Zhong J,Wang H,Chen W,Sun Z,Chen J,Xu Y,Weng M,Shi Q,Ma D,Miao C

更新日期：2017-05-04 00:00:00

abstract：:Hedgehog (Hh) inhibitors have emerged as valid tools in the treatment of a wide range of cancers. Indeed, aberrant activation of the Hh pathway occurring either by ligand-dependent or -independent mechanisms is a key driver in tumorigenesis. The smoothened (Smo) receptor is one of the main upstream transducers of the ...

journal_title：Cell death & disease

authors： Infante P,Alfonsi R,Ingallina C,Quaglio D,Ghirga F,D'Acquarica I,Bernardi F,Di Magno L,Canettieri G,Screpanti I,Gulino A,Botta B,Mori M,Di Marcotullio L

更新日期：2016-09-22 00:00:00

abstract：:Holliday junction recognition protein (HJURP) refers to a histone H3 chaperone that has been implicated in different kinds of malignancies. Yet, its character in pancreatic cancer remains unclear. The expression of HJURP was assessed in PDAC tissues by RT-qPCR, immunoblotting, and immunohistochemistry. HJURP-deficient...

journal_title：Cell death & disease

authors： Wang CJ,Li X,Shi P,Ding HY,Liu YP,Li T,Lin PP,Wang YS,Zhang GQ,Cao Y

更新日期：2020-05-21 00:00:00

abstract：:Apoptotic cysteine-aspartate proteases (caspases) are essential for the progression and execution of apoptosis, and detection of caspase fragmentation or activity is often used as markers of apoptosis. Cisplatin (cis-diamminedichloroplatinum (II)) is a chemotherapeutic drug that is clinically used for the treatment of...

journal_title：Cell death & disease

authors： Janson V,Johansson A,Grankvist K

更新日期：2010-09-23 00:00:00

abstract：:Hepatocytes undergo the metaplasia into ductal biliary epithelial cells (BECs) in response to chronic injury, and subsequently contribute to liver regeneration. The mechanism underlying hepatocyte-to-ductal metaplasia has not been explored until now. In mouse models of liver fibrosis, a florid BEC response was observe...

journal_title：Cell death & disease

authors： Xu T,Lu Z,Xiao Z,Liu F,Chen Y,Wang Z,Zhu S,Song Y

更新日期：2020-03-23 00:00:00

abstract：:KLF5 is frequently deleted and downregulated in prostate cancer, and recently it has been reported that KLF5 loss is enriched in the aggressive branches of prostate cancer evolution. However, why KLF5 loss is associated with prostate cancer aggressiveness is still not clear. Herein, we analyzed KLF5 expression in TCGA...

journal_title：Cell death & disease

authors： Ma JB,Bai JY,Zhang HB,Jia J,Shi Q,Yang C,Wang X,He D,Guo P

更新日期：2020-06-16 00:00:00

abstract：:Serum deprivation or withdrawal induces apoptosis in endothelial cells, resulting in endothelial cell dysfunction that is associated with cardiovascular disease. However, there is still limited information on the role of miRNA in serum deprivation-induced apoptosis. Here we found that serum deprivation increased caspa...

journal_title：Cell death & disease

authors： Kim JH,Lee DK,Kim J,Choi S,Park W,Ha KS,Kim TH,Choe J,Won MH,Kwon YG,Kim YM

更新日期：2017-05-18 00:00:00

abstract：:Podocyte apoptosis is a major mechanism that leads to proteinuria in many chronic kidney diseases. However, the concert mechanisms that cause podocyte apoptosis in these kidney diseases are not fully understood. The Rho family of small GTPases has been shown to be required in maintaining podocyte structure and functio...

journal_title：Cell death & disease

authors： Huang Z,Zhang L,Chen Y,Zhang H,Zhang Q,Li R,Ma J,Li Z,Yu C,Lai Y,Lin T,Zhao X,Zhang B,Ye Z,Liu S,Wang W,Liang X,Liao R,Shi W

更新日期：2016-03-17 00:00:00

abstract：:The NF-κB family of transcription factors is important for many cellular functions, in particular initiation and propagation of inflammatory and immune responses. However, recent data has suggested that different subunits of the NF-κB family can suppress the inflammatory response. NF-κB1, from the locus nfκb1, can inh...

journal_title：Cell death & disease

authors： Fearn A,Situmorang GR,Fox C,Oakley F,Howarth R,Wilson CL,Kiosia A,Robson MG,Mann DA,Moles A,Sheerin NS

更新日期：2017-06-15 00:00:00

abstract：:Enhanced Myd88 expression has been found in various parenchymal tumors especially in hepatocellular carcinoma with little mechanism of its upregulation known. A lot of long non-coding RNAs are reported to regulate the protein-coding genes which have location association through various mechanisms. In our study we conf...

journal_title：Cell death & disease

authors： Xu X,Yin Y,Tang J,Xie Y,Han Z,Zhang X,Liu Q,Qin X,Huang X,Sun B

更新日期：2017-10-12 00:00:00

abstract：:We have recently found that primary rat embryonic fibroblasts (REFs) could be immortalized by overexpression of the human mitochondrial ribosomal protein MRPS18-2 (S18-2). A derived cell line, designated 18IM, expressed the embryonic stem cell markers SSEA-1 and Sox2. Upon inoculation into severe combined immunodefici...

journal_title：Cell death & disease

authors： Yenamandra SP,Darekar SD,Kashuba V,Matskova L,Klein G,Kashuba E

更新日期：2012-01-19 00:00:00

abstract：:In vertebrates, mitochondria are tightly preserved energy producing organelles, which sustain nervous system development and function. The understanding of proteins that regulate their homoeostasis in complex animals is therefore critical and doing so via means of systemic analysis pivotal to inform pathophysiological...

journal_title：Cell death & disease

authors： Martín-Jiménez R,Faccenda D,Allen E,Reichel HB,Arcos L,Ferraina C,Strobbe D,Russell C,Campanella M

更新日期：2018-06-04 00:00:00

abstract：:The high resistance against current therapies found in non-small-cell lung cancer (NSCLC) has been associated to cancer stem-like cells (CSCs), a population for which the identification of targets and biomarkers is still under development. In this study, primary cultures from early-stage NSCLC patients were establishe...

journal_title：Cell death & disease

authors： Herreros-Pomares A,de-Maya-Girones JD,Calabuig-Fariñas S,Lucas R,Martínez A,Pardo-Sánchez JM,Alonso S,Blasco A,Guijarro R,Martorell M,Escorihuela E,Chiara MD,Duréndez E,Gandía C,Forteza J,Sirera R,Jantus-Lewintre E,Farr

更新日期：2019-09-10 00:00:00

abstract：:The acquisition of MDR1-mediated chemoresistance poses a major obstacle to the success of conventional chemotherapeutic agents. HSF1 is also involved in chemoresistance, and several studies have demonstrated the relationship between HSF1 and MDR1 but without any consistent results. Paclitaxel- and doxorubicin-resistan...

journal_title：Cell death & disease

authors： Mun GI,Choi E,Lee Y,Lee YS

更新日期：2020-05-26 00:00:00

abstract：:Psoriasis is characterized by keratinocyte hyperproliferation. While significant progress has been made in understanding the molecular mechanism regulating the proliferation of keratinocytes, little is known about the epigenetic factors that control this process. EZH2 and EZH2 mediated trimethylation of histone H3 lys...

journal_title：Cell death & disease

authors： Zhang T,Yang L,Ke Y,Lei J,Shen S,Shao S,Zhang C,Zhu Z,Dang E,Wang G

更新日期：2020-10-03 00:00:00

abstract：:β-Catenin has been widely implicated in the regulation of mammalian development and cellular homeostasis. However, the mechanisms by which Wnt/β-catenin signaling components regulate physiological events during brain development remain undetermined. Inactivation of glycogen synthase kinase (GSK)-3β leads to β-catenin ...

journal_title：Cell death & disease

authors： Shin J,Shin Y,Oh SM,Yang H,Yu WJ,Lee JP,Huh SO,Lee SH,Suh YH,Chung S,Kim HS

更新日期：2014-10-16 00:00:00

abstract：:Gastric cancer (GC) ranks among the top five malignant tumors worldwide by the incidence and mortality rate. However, the mechanisms underlying its progression are poorly understood. In this study, we investigated the role of SIRT1, a class III deacetylase, in the invasion and metastasis of GC. Here, we found that kno...

journal_title：Cell death & disease

authors： Dong G,Wang B,An Y,Li J,Wang X,Jia J,Yang Q

更新日期：2018-09-24 00:00:00

abstract：:Disrupting microtubule dynamics with spindle poisons activates the spindle-assembly checkpoint (SAC) and induces mitotic cell death. However, mitotic exit can occur prematurely without proper chromosomal segregation or cytokinesis by a process termed mitotic slippage. It remains controversial whether mitotic slippage ...

journal_title：Cell death & disease

authors： Zeng X,Xu WK,Lok TM,Ma HT,Poon RYC

更新日期：2019-04-05 00:00:00

abstract：:Due to limited treatment options, pre-eclampsia (PE) is associated with fetal perinatal and maternal morbidity and mortality. During the causes of PE, failure of uterine spiral artery remodeling which might be related to functioning abnormally of trophoblast cells, result in the occurrence and progression of PE. Recen...

journal_title：Cell death & disease

authors： Xu Y,Ge Z,Zhang E,Zuo Q,Huang S,Yang N,Wu D,Zhang Y,Chen Y,Xu H,Huang H,Jiang Z,Sun L

更新日期：2017-10-12 00:00:00

abstract：:SAM and SH3 domain-containing 1 (SASH1), a scaffold protein, is regarded as a tumor suppressor. Recent studies have verified the decreased expression of SASH1 in many tumors. Our previous clinical investigation found that SASH1 was widely expressed in normal brain tissues but reduced or absent in glioma tissues. Howev...

journal_title：Cell death & disease

authors： Wu R,Yan Y,Ma C,Chen H,Dong Z,Wang Y,Liu Y,Liu M,Yang L

更新日期：2019-05-28 00:00:00

abstract：:The aim of our study was to investigate the role of autophagy, a homeostatic process involved in the lysosomal degradation of damaged cell organelles and proteins, in regulating the survival of mesangial cells treated with advanced glycation end products (AGEs). In the present study, AGEs induced mitochondrial depolar...

journal_title：Cell death & disease

authors： Xu L,Fan Q,Wang X,Zhao X,Wang L

更新日期：2016-11-03 00:00:00

abstract：:B-cell lymphoma-2 (Bcl-2) proteins mediate intrinsic-, or mitochondrial-, initiated apoptosis. We have investigated the structure and function of the least characterized Bcl-2 family member, Bcl-B, solving the crystal structure of a Bcl-B:Bim complex to 1.9 Å resolution. Bcl-B is distinguished from other Bcl-2 family ...

journal_title：Cell death & disease

authors： Rautureau GJ,Yabal M,Yang H,Huang DC,Kvansakul M,Hinds MG

更新日期：2012-12-13 00:00:00

abstract：:Recombinant human bone morphogenetic protein-2 (rhBMP-2) is widely used in the clinic for bone defect reconstruction because of its powerful osteoinductive capacity. However, commercially available rhBMP-2 requires a high concentration in the clinical setting for consistent bone formation. A high dose of rhBMP-2 induc...

journal_title：Cell death & disease

authors： Huang RL,Sun Y,Ho CK,Liu K,Tang QQ,Xie Y,Li Q

更新日期：2018-02-02 00:00:00

abstract：:Excessive fibrogenic response in the liver disrupts normal hepatic anatomy and function heralding such end-stage liver diseases as hepatocellular carcinoma and cirrhosis. Sinusoidal endothelial cells contribute to myofibroblast activation and liver fibrosis by undergoing endothelial-mesenchymal transition (EndMT). The...

journal_title：Cell death & disease

authors： Li Z,Chen B,Dong W,Kong M,Fan Z,Yu L,Wu D,Lu J,Xu Y

更新日期：2019-11-27 00:00:00

abstract：:HIV-1 Nef protein has key roles at almost all stages of the viral life cycle. We assessed the role of the Nef/eEF1A (eukaryotic translation elongation factor 1-alpha) complex in nucleocytoplasmic shuttling in primary human macrophages. Nuclear retention experiments and inhibition of the exportin-t (Exp-t) pathway sugg...

journal_title：Cell death & disease

authors： Abbas W,Khan KA,Tripathy MK,Dichamp I,Keita M,Rohr O,Herbein G

更新日期：2012-04-05 00:00:00

abstract：:Noncoding RNAs plays an important role in hepatocellular carcinoma (HCC). Here, we show that miR-124 was downregulated in HCC tissues and that the ectopic expression of miR-124 inhibited the proliferation and migration of HCC cells. We proposed that aquaporin 3 (AQP3) is a direct target of miR-124. AQP3 was upregulate...

journal_title：Cell death & disease

authors： Chen G,Shi Y,Liu M,Sun J

更新日期：2018-02-07 00:00:00

abstract：:The subversion of the normal function exerted by the cellular prion protein (PrP(C)) in neurons by pathogenic prions is assumed to have a central role in the pathogenesis of transmissible spongiform encephalopathies. Using two murine models of prion infection, the 1C11 neuronal cell line and neurospheres, we document ...

journal_title：Cell death & disease

authors： Pradines E,Hernandez-Rapp J,Villa-Diaz A,Dakowski C,Ardila-Osorio H,Haik S,Schneider B,Launay JM,Kellermann O,Torres JM,Mouillet-Richard S

更新日期：2013-01-10 00:00:00

abstract：:DDX3 is a highly conserved member of ATP-dependent DEAD-box RNA helicases with multiple functions in RNA metabolism and cellular signaling. Here, we describe a novel function for DDX3 in regulating the mitochondrial stress response in the parasitic protozoan Leishmania. We show that genetic inactivation of DDX3 leads ...

journal_title：Cell death & disease

authors： Padmanabhan PK,Zghidi-Abouzid O,Samant M,Dumas C,Aguiar BG,Estaquier J,Papadopoulou B

更新日期：2016-10-13 00:00:00

abstract：:Reticular dysgenesis is a human severe combined immunodeficiency that is primarily characterized by profound neutropenia and lymphopenia. The condition is caused by mutations in the adenylate kinase 2 (AK2) gene, resulting in the loss of mitochondrial AK2 protein expression. AK2 regulates the homeostasis of mitochondr...

journal_title：Cell death & disease

authors： Six E,Lagresle-Peyrou C,Susini S,De Chappedelaine C,Sigrist N,Sadek H,Chouteau M,Cagnard N,Fontenay M,Hermine O,Chomienne C,Reynier P,Fischer A,André-Schmutz I,Gueguen N,Cavazzana M

更新日期：2015-08-13 00:00:00