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Periodontal treatment does not result in detectable platelet activation in vivo.

Abstract：

OBJECTIVES:Periodontitis is associated with systemic inflammation, elevated platelet activation and enhanced risk for cardiovascular diseases, while periodontal treatment reduces tissue inflammation and shows desirable effects on the oral biofilm and dental health. However, subgingival debridement during conservative treatment can lead to local trauma and transient bacteraemia, which might affect cardiovascular risk in these patients. Therefore, we investigated the effect of periodontal treatment on systemic platelet activation. MATERIALS AND METHODS:In a prospective therapeutic trial, 26 patients underwent periodontal treatment and patient blood was analysed immediately before and immediately after intervention for platelet activation markers (flow cytometric analysis of P-selectin, CD63 and CD40L surface expression, integrin αIIbβ3 activation and fibrinogen binding, intra-platelet reactive oxygen species production, platelet-leukocyte aggregate formation and intra-platelet vasodilator-stimulated phosphoprotein phosphorylation) in response to adenosine diphosphate (ADP). RESULTS:The present study shows that basal platelet activation levels remain largely unaltered in response to periodontal treatment. We also did not observe significant changes in platelet reactivity in response to different concentrations of platelet agonist ADP. CONCLUSION:Subgingival debridement does not result in relevantly elevated platelet activation. Thus, augmented platelet activation seems unlikely to be a causative triggering factor that increases the short-term risk for platelet-mediated thrombotic events in response to subgingival debridement. CLINICAL RELEVANCE:Subgingival debridement is a safe procedure and does not increase the short-term risk for platelet-mediated thrombotic events.

journal_name

Clin Oral Investig

journal_title

Clinical oral investigations

authors

Laky M,Anscheringer I,Wolschner L,Heber S,Haririan H,Rausch-Fan X,Volf I,Moritz A,Assinger A

doi

10.1007/s00784-019-03049-x

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

1853-1859

issue

5

eissn

1432-6981

issn

1436-3771

pii

10.1007/s00784-019-03049-x

journal_volume

24

pub_type

临床试验,杂志文章

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