当前位置： SCI文献检索 > ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY期刊下所有文献 > Responses in the crucian carp (Carassius auratus) exposed to environmentally relevant concentration of 17α-Ethinylestradiol based on metabolomics.

Responses in the crucian carp (Carassius auratus) exposed to environmentally relevant concentration of 17α-Ethinylestradiol based on metabolomics.

Abstract：

:17α-ethynylestradiol (EE2), a ubiquitous synthetic endocrine disrupting chemical, was the principal component of contraceptive drugs and one of common hormone medications. The detrimental impact of EE2 on the reproduction of organisms was widely recognized. However, the underlying mechanisms of physiological and metabolome effects of EE2 on freshwater fish are still unclear. This study investigated the toxic effects and related mechanisms of EE2 on freshwater fish crucian carp (Carassius auratus) based on metabolomics. Crucian carp were exposed to EE2 at environmentally relevant concentration for 9 days, 18 days, and 27 days, and the biological responses were explored through analysis of the physiological endpoints, steroid hormones, and metabolome. The physiological endpoints of crucian carp had no distinct change after EE2 exposure. However, metabolomics analysis probed significant deviation based on chemometrics, indicating that the metabolomics approach was more sensitive to the effects of EE2 at environmentally relevant concentration to freshwater fish than the traditional endpoints. The alterations of 24 metabolites in gonad and 16 metabolites in kidney were induced by treatment with EE2, respectively, which suggesting the perturbations in amino acid metabolism, lipid metabolism, energy metabolism, and oxidative stress. Moreover, EE2 exposure could induce the disruption of lipid metabolism and then broke the homeostasis of endogenous steroid hormones. Metabolomics provided a new strategy for the studies on contaminant exposure at a low dose in the short term and gave important information for the toxicology and mechanism of EE2.

journal_name

Ecotoxicol Environ Saf

journal_title

Ecotoxicology and environmental safety

authors

Zhou X,Li Y,Li H,Yang Z,Zuo C

doi

10.1016/j.ecoenv.2019.109501

subject

Has Abstract

pub_date

2019-11-15 00:00:00

pages

109501

eissn

0147-6513

issn

1090-2414

pii

S0147-6513(19)30832-2

journal_volume

183

pub_type

杂志文章

相关文献

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY文献大全
  • Bioaccumulation of heavy metals by aquatic macrophytes around Wrocław, Poland.

    abstract：:Studies were made of heavy metal accumulation in aquatic macrophytes growing in streams and ponds around Wroclaw, Poland, partly affected by atmospheric pollution, effluents of chemical factories, and groundwater contaminated by slagdumps from a smelter and power station. The highest concentrations of Cd, Co, Cr, Cu, ...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1006/eesa.1996.0106

    authors： Samecka-Cymerman A,Kempers AJ

    更新日期：1996-12-01 00:00:00

  • Nanoscale zero-valent iron assisted phytoremediation of Pb in sediment: Impacts on metal accumulation and antioxidative system of Lolium perenne.

    abstract：:Lead (Pb) is a highly toxic environmental pollutant, and could result in toxic effects on living organisms. The effects of 0, 100, 200, 500, 1000 and 2000 mg/kg of nZVI on plant growth, Pb accumulation and antioxidative responses of Lolium perenne were investigated. Results showed that the total Pb contents in L. pere...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2018.01.060

    authors： Huang D,Qin X,Peng Z,Liu Y,Gong X,Zeng G,Huang C,Cheng M,Xue W,Wang X,Hu Z

    更新日期：2018-05-30 00:00:00

  • Effects of chronic elevated ozone concentration on the redox state and fruit yield of red pepper plant Capsicum baccatum.

    abstract：:Ozone (O3) is one of the most harmful air pollutants to crops, contributing to high losses on crop yield. Tropospheric O3 background concentrations have increased since pre-industrial times reaching phytotoxic concentrations in many world regions. Capsicum peppers are the second most traded spice in the world, but few...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2013.09.035

    authors： Bortolin RC,Caregnato FF,Divan AM Jr,Reginatto FH,Gelain DP,Moreira JC

    更新日期：2014-02-01 00:00:00

  • Detoxification and decolorization of a simulated textile dye mixture by phytoremediation using Petunia grandiflora and, Gailardia grandiflora: a plant-plant consortial strategy.

    abstract：:In vitro grown Petunia grandiflora and Gaillardia grandiflora plantlets showed 76 percent and 62 percent American Dye Manufacturers Institute value (color) removal from a simulated dyes mixture within 36h respectively whereas their consortium gave 94 percent decolorization. P. grandiflora, G. grandiflora and their con...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2014.01.033

    authors： Watharkar AD,Jadhav JP

    更新日期：2014-05-01 00:00:00

  • Integrated metagenomics and molecular ecological network analysis of bacterial community composition during the phytoremediation of cadmium-contaminated soils by bioenergy crops.

    abstract：:Two energy crops (maize and soybean) were used in the remediation of cadmium-contaminated soils. These crops were used because they are fast growing, have a large biomass and are good sources for bioenergy production. The total accumulation of cadmium in maize and soybean plants was 393.01 and 263.24μg pot-1, respecti...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2017.07.019

    authors： Chen Z,Zheng Y,Ding C,Ren X,Yuan J,Sun F,Li Y

    更新日期：2017-11-01 00:00:00

  • "Assessing the potential of biochar and aged biochar to alleviate aluminum toxicity in an acid soil for achieving cabbage productivity".

    abstract：:Biochar has a significant effect on alleviating acid soil aluminum (Al) toxicity and promoting plant growth. The potential effects of aged biochar (long-term applied biochar in soil) on soil amendment have attracted increasing attention. Here, the effects of biochar and aged biochar were evaluated through a pot experi...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2018.06.010

    authors： Lin Q,Zhang L,Riaz M,Zhang M,Xia H,Lv B,Jiang C

    更新日期：2018-10-01 00:00:00

  • Measuring and modelling mixture toxicity of imidacloprid and thiacloprid on Caenorhabditis elegans and Eisenia fetida.

    abstract：:While the standard models of concentration addition and independent action predict overall toxicity of multicomponent mixtures reasonably, interactions may limit the predictive capability when a few compounds dominate a mixture. This study was conducted to test if statistically significant systematic deviations from c...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2008.07.006

    authors： Gomez-Eyles JL,Svendsen C,Lister L,Martin H,Hodson ME,Spurgeon DJ

    更新日期：2009-01-01 00:00:00

  • Polychlorinated biphenyls in mountain pine (Pinus uncinata) needles from Central Pyrenean high mountains (Catalonia, Spain).

    abstract：:The polychlorobiphenyl (PCB) composition of pine needles of Pinus uncinata from the Pyrenean high mountains has been investigated. Samples from four altitudes (1750, 1950, 2150, and 2250 m above sea level) were collected in March 2002 and June 2002 in a central area near Lake Redon. The observed concentrations were si...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2005.06.005

    authors： Grimalt JO,van Drooge BL

    更新日期：2006-01-01 00:00:00

  • Critical factors determining fluoride concentration in tea leaves produced from Anhui province, China.

    abstract：:This study investigated the fluoride present in tea plants (Camellia sinensis (L.) O. Kuntze) and its relationship to soils, varieties, seasons and tea leaf maturity. The study also explored how different manufacturing processes affect the leaching of fluoride into tea beverages. The fluoride concentration in the tea ...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2016.04.023

    authors： Cai H,Zhu X,Peng C,Xu W,Li D,Wang Y,Fang S,Li Y,Hu S,Wan X

    更新日期：2016-09-01 00:00:00

  • Preparation of activated carbons from Iris tectorum employing ferric nitrate as dopant for removal of tetracycline from aqueous solutions.

    abstract：:Ferric nitrate was employed to modify activated carbon prepared from Iris tectorum during H₃PO₄ activation and ability of prepared activated carbon for removal of tetracycline (TC) was investigated. The properties of the activated carbon samples with or without ferric nitrate, ITAC-Fe and ITAC, were measured by scanni...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2013.08.015

    authors： Li G,Zhang D,Wang M,Huang J,Huang L

    更新日期：2013-12-01 00:00:00

  • Microcystin-LR retards gonadal maturation through disrupting the growth hormone/insulin-like growth factors system in zebrafish.

    abstract：:Recent studies have documented that microcystins (MCs) have potential toxic effects on growth and reproduction in fish. However, no systematic data exist on whether MCs cause gonadal development retardation through disrupting the growth hormone/insulin-like growth factors (GH/IGFs) system. To this end, zebrafish hatch...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2017.01.025

    authors： Hou J,Su Y,Lin W,Guo H,Xie P,Chen J,Gu Z,Li L

    更新日期：2017-05-01 00:00:00

  • Enhanced removal of Cr(III)-EDTA chelates from high-salinity water by ternary complex formation on DETA functionalized magnetic carbon-based adsorbents.

    abstract：:A novel amino-functionalized magnetic adsorbent (Fe3O4@C@DETA) was developed for adsorption of Cr(III) and Cr(III)-EDTA from wastewater. Fe3O4@C@DETA were successfully prepared by modification of Fe3O4@C with diethylenediamine (DETA), which exhibits a core-shell structure and sufficient saturation magnetization. Fe3O4...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2020.111858

    authors： Wang J,Chen Y,Sun T,Saleem A,Wang C

    更新日期：2021-02-01 00:00:00

  • Effects of metals and detergents on biotransformation and detoxification enzymes of leaping mullet (Liza saliens).

    abstract：:In this study, feral leaping mullet (Liza saliens) liver microsomal 7-ethoxyresorufin O-deethylase (EROD), and cytosolic glutathione S-transferases (GSTs) activities were investigated using 7-ethoxyresorufin, 1-chloro-2,4-dinitrobenzene (CDNB), and ethacrynic acid (EA) as substrates, respectively. The average EROD act...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2006.08.007

    authors： Sen A,Semiz A

    更新日期：2007-11-01 00:00:00

  • Characterization of a small plasmid (pMBCP) from bovine Pseudomonas pickettii that confers cadmium resistance.

    abstract：:This is the first report of isolation of Pseudomonas pickettii from a normal adult bovine duodenum. This organism was one of several bacteria isolated as part of a study to examine cadmium resistance genes (cad(r)) for use in generating transgenic plants to reclaim cadmium-contaminated soils in Kansas. P. pickettii co...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/s0147-6513(02)00076-3

    authors： Bruins MR,Kapil S,Oehme FW

    更新日期：2003-03-01 00:00:00

  • Effects of the fungicide azoxystrobin on Atlantic salmon (Salmo salar L.) smolt.

    abstract：:Atlantic salmon smolts were exposed to three doses of the fungicide azoxystrobin for 4 days, and physiological blood parameters and transcriptional effects in liver and muscle were evaluated in search for potential negative effects. Azoxystrobin exposure mediated up-regulation of catalase, MAPK1 and IGFBP1 in liver ti...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2010.07.017

    authors： Olsvik PA,Kroglund F,Finstad B,Kristensen T

    更新日期：2010-11-01 00:00:00

  • Seasonal changes of basic erythrocyte-metric parameters in Pelophylaxridibundus (Amphibia: Ranidae) from anthropogenically polluted biotopes in Southern Bulgaria and their role as bioindicators.

    abstract：:The purpose of this research work is to present data that show the seasonal changes (spring-summer-autumn) of basic erythrocyte-metric parameters (ЕL: Erythrocyte length, ЕW: Erythrocyte width, ЕL/ЕW, ES: Erythrocyte size; NL: Nucleus length, NW: Nucleus width, NL/NW; NS: Nucleus size, NS/ES: Nucleus-cytoplasmic ratio...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2015.11.011

    authors： Zhelev ZM,Mehterov NH,Popgeorgiev GS

    更新日期：2016-02-01 00:00:00

  • Toxicodynamics of subacute co-exposure to groundwater contaminant arsenic and analgesic-antipyretic drug acetaminophen in rats.

    abstract：:Arsenic is an environmental contaminant, while acetaminophen is an extensively used nonsteroidal analgesic-antipyretic drug. We evaluated whether subacute co-exposure to arsenic and acetaminophen would produce more toxicity than that caused by exposure to either of the xenobiotics in rats. Toxicity was evaluated throu...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2009.09.005

    authors： Manimaran A,Sarkar SN,Sankar P

    更新日期：2010-01-01 00:00:00

  • Effects of copper on the growth, antioxidant enzymes and photosynthesis of spinach seedlings.

    abstract：:Examination of plants with strong Cu tolerance and an understanding of their Cu-tolerance mechanisms are of considerable significance for the remediation of Cu-contaminated soil. Although spinach may be a plant with strong Cu tolerance, the threshold of Cu tolerance in this plant and its physiological response mechani...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2019.01.016

    authors： Gong Q,Wang L,Dai T,Zhou J,Kang Q,Chen H,Li K,Li Z

    更新日期：2019-04-30 00:00:00

  • Dissolved organic matter characterization in high and low ammonium groundwater of Dongting Plain, central China.

    abstract：:High levels of ammonium in groundwater is a potential threat to drinking water security and ecological status. The role of dissolved organic matter (DOM) in mobilization of natural ammonium in groundwater is crucial but the intrinsic link between them has still been poorly understood. This study used high-pressure siz...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2020.111779

    authors： Huang Y,Du Y,Ma T,Deng Y,Tao Y,Xu Y,Leng Z

    更新日期：2021-01-15 00:00:00

  • The impact of an additional ecotoxicity test on ecological quality standards.

    abstract：:The present study aims to support decisions on whether or not to perform an extra toxicity test in order to improve environmental quality standards (EQSs). The impact of an additional ecotoxicity test was analyzed by predicting new ecotoxicity values with three different estimation methods and adding them to existing ...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2009.08.009

    authors： Henning-de Jong I,Ragas AM,Hendriks HW,Huijbregts MA,Posthuma L,Wintersen A,Jan Hendriks A

    更新日期：2009-11-01 00:00:00

  • Early genotoxic damage through micronucleus test in exfoliated buccal cells and occupational dust exposure in construction workers: a cross-sectional study in L'Aquila, Italy.

    abstract：AIM:The city of L'Aquila (central Italy) was hit by a strong earthquake in 2009 that caused the collapse of several buildings, deaths and injured people. In the following years, a great number of building sites were activated, building workers resulted intensely exposed and represent a relevant target for research on e...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2020.110989

    authors： Leonardi S,Poma AM,Colafarina S,D'Aloisio F,Scatigna M,Zarivi O,Mastrantonio R,Tobia L,Fabiani L

    更新日期：2020-10-15 00:00:00

  • Short-term effects of benzalkonium chloride and atrazine on Elodea canadensis using a miniaturised microbioreactor system for an online monitoring of physiologic parameters.

    abstract：:The study evaluated the effects of benzalkonium chloride (BAC) and atrazine on the macrophyte Elodea canadensis (Michaux) using a miniaturised monitoring test system consisting of a microbioreactor of reduced volume and integrated sensors for the online measurement of physiologic parameters, like oxygen production and...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2007.02.001

    authors： Vervliet-Scheebaum M,Ritzenthaler R,Normann J,Wagner E

    更新日期：2008-02-01 00:00:00

  • Combined effects of traffic air pollution and home environmental factors on preterm birth in China.

    abstract：BACKGROUND:Although mounting evidence have linked traffic-related air pollution (TRAP) with increased risk of preterm birth (PTB), whether it can interact with indoor environmental factors remains unknown, and its window(s) susceptibility at the stage of gestation is unclear. OBJECTIVE:To explore PTB risk for prenatal...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2019.109639

    authors： Lu C,Cao L,Norbäck D,Li Y,Chen J,Deng Q

    更新日期：2019-11-30 00:00:00

  • CombiSimilarity, an innovative method to compare environmental and health data sets with different attribute sizes example: eighteen Organochlorine Pesticides in soil and human breast milk samples.

    abstract：:Human health and the health of the environment have entwined. In this paper we underpin this position by presenting a modeling approach named CombiSimilarity, which has been developed by the first author in the software tool PyHasse comprising a wide variety of partial ordering tools. A case study of 18 Organochlorine...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2014.03.031

    authors： Bruggemann R,Scherb H,Schramm KW,Cok I,Voigt K

    更新日期：2014-07-01 00:00:00

  • Mobility and potential bioavailability of antimony in contaminated soils: Short-term impact on microbial community and soil biochemical functioning.

    abstract：:Antimony (Sb) and its compounds are emerging priority pollutants which pose a serious threat to the environment. The aim of this study was to evaluate the short-term fate of antimonate added to different soils (S1 and S2) with respect to its mobility and impact on soil microbial communities and soil biochemical functi...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2020.110576

    authors： Diquattro S,Garau G,Mangia NP,Drigo B,Lombi E,Vasileiadis S,Castaldi P

    更新日期：2020-06-15 00:00:00

  • Resveratrol alleviates chronic "real-world" ambient particulate matter-induced lung inflammation and fibrosis by inhibiting NLRP3 inflammasome activation in mice.

    abstract：BACKGROUND:Inhalation of fine particulate matter (PM2.5) induces the occurrence of lung inflammation and fibrosis, but its molecular mechanism remains unclear. Resveratrol (RES) is known to have anti-inflammatory properties in many pulmonary diseases. Here, we aimed to investigate the effect of long-term "real-world" am...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2019.109425

    authors： Ding S,Wang H,Wang M,Bai L,Yu P,Wu W

    更新日期：2019-10-30 00:00:00

  • Experimental field exposure of brown trout to river water receiving effluent from an integrated newsprint mill.

    abstract：:Effects of effluents from mechanical pulp production on brown trout were studied for 8 weeks at environmentally relevant concentrations. The exposure took place in laboratory-based pools upstream and downstream of the effluent discharge point of an integrated newsprint mill using ground wood/thermomechanical pulp. The...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1006/eesa.1998.1683

    authors： Johnsen K,Tana J,Lehtinen KJ,Stuthridge T,Mattsson K,Hemming J,Carlberg GE

    更新日期：1998-07-01 00:00:00

  • Mercury and heavy metal profiles of maternal and umbilical cord RBCs in Japanese population.

    abstract：:Mercury (Hg) and other heavy metal profiles, namely, lead (Pb), arsenic (As), cadmium (Cd), and selenium (Se) were investigated in maternal and umbilical cord (cord) red blood cells (RBCs) at parturition in Japanese population. Correlation coefficients of Hg, Pb, As, Cd, and Se between maternal and cord RBCs were 0.91...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2009.09.010

    authors： Sakamoto M,Murata K,Kubota M,Nakai K,Satoh H

    更新日期：2010-01-01 00:00:00

  • Responses of fish populations and communities to pulp mill effluents: a holistic assessment.

    abstract：:Fish populations residing in a river receiving bleached kraft mill effluents (BKME) and in an uncontaminated river were investigated to evaluate causal relationships between exposure to BKME and various indicators of fish health. The Index of Biotic Integrity demonstrated that species richness and composition were muc...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/0147-6513(92)90011-q

    authors： Adams SM,Crumby WD,Greeley MS Jr,Shugart LR,Saylor CF

    更新日期：1992-12-01 00:00:00

  • Sensitivity of macrophyte-dominated freshwater microcosms to chronic levels of the herbicide linuron. I. Primary producers.

    abstract：:Effects of chronic concentrations of linuron (0, 0.5, 5, 15, 50, and 150 micrograms/L) were studied in indoor, macrophyte dominated, freshwater microcosms. The concentrations were kept at a constant level for 4 weeks. This paper is the first in a series of two and summarizes the course of the linuron concentrations in...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1006/eesa.1997.1555

    authors： Van den Brink PJ,Hartgers EM,Fettweis U,Crum SJ,Van Donk E,Brock TC

    更新日期：1997-10-01 00:00:00