Post-treatment alpha-fetoprotein response predicts prognosis of patients with hepatocellular carcinoma: A meta-analysis.

Abstract:

BACKGROUND:Post-treatment alpha-fetoprotein (AFP) response has been reported to be associated with prognosis of hepatocellular carcinoma (HCC) patients, but the results were not consistent. This meta-analysis aimed to explore the relationship between AFP response and clinical outcomes of HCC. METHODS:PubMed, Embase, Medline and Cochrane library were searched for relevant articles published before March 20, 2019. The data were analyzed using RevMan5.3 software. RESULTS:Twenty-nine articles with 4726 HCC patients were finally included for analysis. The pooled results showed that post-treatment AFP response was significantly associated with overall survival (OS) (hazard ratio (HR) = 0.41, 95% confidence interval (CI): 0.35-0.47, P <.001), progression free survival (PFS) (HR = 0.46, 95% CI: 0.39-0.54, P <.001) and recurrence free survival (RFS) (HR = 0.41, 95% CI: 0.29-0.56, P <.001) of HCC patients. CONCLUSION:post-treatment AFP response might be a useful prognostic marker for HCC patients.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

He C,Peng W,Liu X,Li C,Li X,Wen TF

doi

10.1097/MD.0000000000016557

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

e16557

issue

31

eissn

0025-7974

issn

1536-5964

pii

00005792-201908020-00018

journal_volume

98

pub_type

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