Abstract:
:Functional dyspepsia (FD) is one of the most prevalent functional gastrointestinal disorders, and more and more multicomponent drugs represented by traditional Chinese medicines have provided a favorable therapeutic effect in its treatment. However, their precise localization in the clinic, as well as corresponding mechanism, is ambiguous, thus hindering their widespread use. To meet this requirement, a precise and systematic approach based on a restriction of special disease-related molecules and the following network pharmacology analysis was developed and applied to a multicomponent conventional drug, XiaoErFuPi (XEFP) granules. Experimental verification of the results indicates that this approach can facilitate the prediction, and the precise and systematic efficacy of XEFP could be easily revealed, which shows that XEFP has an advantage over the positive control drug on lactate, gastrin, interleukin 4 and calcitonin gene-related peptide. Moreover, by the proteomics analysis, its superposition of multi-target effects was revealed and a new candidate target for the treatment of FD, striatin, was obtained and verified. This study provides a practicable precise approach for the investigation of the efficacy of multicomponent drugs against FD and offers a promising alternative for the systematical management of FD.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wei J,Man Q,Guo F,Xian M,Wang T,Tang C,Zhang Y,Li D,Tang D,Yang H,Huang Ldoi
10.1038/s41598-019-47300-7subject
Has Abstractpub_date
2019-07-24 00:00:00pages
10713issue
1issn
2045-2322pii
10.1038/s41598-019-47300-7journal_volume
9pub_type
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