Abstract：
:Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, and in the occurrence of drug resistance. However, while their overexpression is usually associated with highly aggressive tumor phenotypes, their mechanistic role in cancer progression is still to be determined to develop new therapeutic strategies. In this review, we highlight the literature related to the role of the cysteine cathepsins in cancer biology, with particular emphasis on their input into tumor biology.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Rudzińska M,Parodi A,Soond SM,Vinarov AZ,Korolev DO,Morozov AO,Daglioglu C,Tutar Y,Zamyatnin AA Jrdoi
10.3390/ijms20143602subject
Has Abstractpub_date
2019-07-23 00:00:00issue
14issn
1422-0067pii
ijms20143602journal_volume
20pub_type
杂志文章,评审abstract：:The p53 family of transcription factors plays key roles in development, genome stability, senescence and tumor development, and p53 is the most important tumor suppressor protein in humans. Although intensively investigated for many years, its initial evolutionary history is not yet fully elucidated. Using bioinformat...
journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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