Emerging Trends in Nanotechnology: Nanozymes, Imaging Probes and Biosensors and Nanocarriers.

abstract：:The pressing need for targeting, detecting, monitoring, and treating diseased cells concomitantly gives rise to multi-functional nanomedicines, especially those that can combine diagnostic and therapeutic abilities, which are referred to as nanotheranostics. Recently, nanotheranostics are of significant clinical inter...

journal_title：Current drug metabolism

authors： Han N,Yang YY,Wang S,Zheng S,Fan W

更新日期：2013-07-01 00:00:00

abstract：:Accompanying with hot discussions on developing multi-target drugs for the therapy of multi-gene diseases, herbal medicines are receiving more and more attention worldwide in both academic and industrial fields. Pharmacokinetic and metabolic research is one of the important issues for intensive understanding of therap...

journal_title：Current drug metabolism

authors： Wu L,Hao H,Wang G

更新日期：2012-11-01 00:00:00

abstract：:The assessment of in vitro inhibition and induction of the cytochrome P450 enzymes of the liver is a critical part of the drug discovery and development process in order to ensure that two or more drugs can be safely coadministered without alterations in exposure. Early assessment of potential candidates using high th...

journal_title：Current drug metabolism

authors： Walsky RL,Boldt SE

更新日期：2008-11-01 00:00:00

abstract：:Advances in high-throughput technologies to measure genome-scale changes of genes, proteins, and other biomolecular components ('omics') in complex biological systems have dramatically revolutionized biomedical research. However, the benefits of utilizing omics information in drug development have not yet been fully r...

journal_title：Current drug metabolism

authors： Fang H,Wang K,Zhang J

更新日期：2008-12-01 00:00:00

abstract：:Despite the introduction of newer drugs, the atypical antipsychotic clozapine remains the most effective drug in psychotic patients who are resistant to treatment with conventional agents. Optimal therapeutic responses to clozapine have been reported with serum concentrations between 350 microg/L and 1000 microg/L. Cl...

journal_title：Current drug metabolism

authors： Chetty M,Murray M

更新日期：2007-05-01 00:00:00

abstract：:Since conventional therapeutic approaches in cancer are highly invasive they hardly prolong patient survival for more than few months. Having the ability to stimulate both cellular and humoural immune responses, immunisation with naked plasmid DNA encoding tumour-associated antigens or tumour-specific antigens has rec...

journal_title：Current drug metabolism

authors： Chiarella P,Fazio VM,Signori E

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Malignant tumors are the leading cause of death in humans. Due to the tedious efforts and investigations made in the field of marine drug discovery, there is now a scientific bridge between marine and pharmaceutical sciences. However, currently only few marine drugs have been lined towards anticancer directi...

journal_title：Current drug metabolism

authors： Shakeel E,Arora D,Jamal QMS,Akhtar S,Khan MKA,Kamal MA,Siddiqui MH,Lohani M,Arif JM

更新日期：2018-01-01 00:00:00

abstract：:Chronic heart failure (CHF) is now recognized as a multisystem disorder with increased sympathetic tone, hormonal derangements, an anabolic/catabolic imbalance, endothelial dysfunction, and systemic low-grade inflammation affecting various organ systems. Pro-inflammatory cytokines appear to play important roles in tha...

journal_title：Current drug metabolism

authors： Sandek A,Anker SD,von Haehling S

更新日期：2009-01-01 00:00:00

abstract：:Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted a lot of interest due to their widespread diagnostic and therapeutic applications in neuro-oncology. Functinalization of the particles surface with targeting molecules that recognize tumor receptors might be exploited for the specific brain tumor targe...

journal_title：Current drug metabolism

authors： Shevtsov MA

更新日期：2016-06-15 00:00:00

abstract：:Drug metabolite identification and metabolic characteristics analysis play a crucial role in new drug research and development, because they can lead to varied efficacy, severe adverse reactions, and even toxicity. Classical methodologies for metabolite identification have mainly been based on mass spectrometry (MS) c...

journal_title：Current drug metabolism

authors： Lu W,Xu Y,Zhao Y,Cen X

更新日期：2014-01-01 00:00:00

abstract：:Human genome sequencing highlights the involvement of genetic variation towards differential risk of human diseases, presence of different phenotypes, and response to pharmacological elements. This brings the field of personalized medicine to forefront in the era of modern health care. Numerous recent approaches have ...

journal_title：Current drug metabolism

authors： Prakash S,Agrawal S

更新日期：2016-01-01 00:00:00

abstract：:Transporters for organic anions and organic cations in kidney, liver, intestine, brain, and placenta play essential roles in drug disposition. The cloning and characterization of these transporters have significantly advanced our understanding of the molecular and cellular mechanisms of the drug disposition process. T...

journal_title：Current drug metabolism

authors： You G

更新日期：2004-02-01 00:00:00

abstract：:Ageing is characterized by a progressive decline in the functional reserve of multiple organs and systems, which can influence drug disposition. In addition, comorbidity and polypharmacy are highly prevalent in the elderly. As ageing is associated with some reduction in first-pass metabolism, bioavailability of a few ...

journal_title：Current drug metabolism

authors： Shi S,Klotz U

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Increasing incidences of type 2 diabetes make it necessary to have a better understanding of the risk factors for its prediction. Taking a note of resilience in risk factors, dynamics of the emerging factors other than traditional ones are showing a great interest in recent years which imprints a significant...

journal_title：Current drug metabolism

authors： Yadav D,Cho KH

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Mutation in the B RAF at V600E has been well implicated in the carcinogenesis that makes it as an attractive therapeutictarget. In the present study, we sought to identify the basis of V600E mutation at functional and structural grounds. The study also endeavors in identification of small molecule as a poten...

journal_title：Current drug metabolism

authors： Bandaru S,Sumithnath TG,Sharda S,Lakhotia S,Sharma A,Jain A,Hussain T,Nayarisseri A,Singh SK

更新日期：2017-07-21 00:00:00

abstract：BACKGROUND:Drug-induced cholestasis is a risk factor in the progression of drug candidates, and poses a serious health hazard if not detected before going into a human. Intrahepatic accumulation of Bile Acids (BAs) represents a characteristic phenomenon associated with drug-induced cholestasis. METHODS:This review wil...

journal_title：Current drug metabolism

authors： Chatterjee S,Annaert P

更新日期：2018-01-01 00:00:00

abstract：:L-Carnitine has important roles in intermediary metabolism and patients with end-stage renal disease who are undergoing hemodialysis may develop a secondary L-carnitine deficiency. The extent of accumulation of the metabolites trimethylamine and trimethylamine-N-oxide when L-carnitine is administered orally has not be...

journal_title：Current drug metabolism

authors： Bain MA,Faull R,Milne RW,Evans AM

更新日期：2006-10-01 00:00:00

abstract：:The biochemical activities of plant flavonoids and stilbenoids point to many health-related applications, hampered however by a low bioavailability associated with rapid metabolic modification. A possible approach to overcome this obstacle is the development of prodrugs. In this review we provide some background infor...

journal_title：Current drug metabolism

authors： Biasutto L,Zoratti M

更新日期：2014-01-01 00:00:00

abstract：:For the pharmaceutical industry, one of the challenges in evaluating the risk of future compound attrition at the discovery stage is the successful prediction of the major routes of clearance in humans. For compounds cleared by metabolism, such information will help to avoid the development of compounds that will exhi...

journal_title：Current drug metabolism

authors： Williams JA,Hurst SI,Bauman J,Jones BC,Hyland R,Gibbs JP,Obach RS,Ball SE

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Nobel laureate Sir James Black's molecule, propranolol, still has broad potential in cardiovascular diseases, infantile haemangiomas and anxiety. A comprehensive and systematic review of the literature for the summarization of pharmacokinetic parameters would be effective to explore the new safe uses of prop...

journal_title：Current drug metabolism

authors： Kalam MN,Rasool MF,Rehman AU,Ahmed N

更新日期：2020-01-01 00:00:00

abstract：:Metabolism of xenobiotics is often seen as an exclusive function of the liver, but some current findings support the notion that the lungs, kidneys and intestine may contribute considerably. After the establishment of the use of liver slices as a useful in vitro model to study metabolism and toxicity of xenobiotics, t...

journal_title：Current drug metabolism

authors： de Kanter R,Monshouwer M,Meijer DK,Groothuis GM

更新日期：2002-02-01 00:00:00

abstract：:One of the major advances in the recent history of the treatment of HIV infections has been the development of different classes of effective antiretroviral drugs. In particular, the reverse transcriptase (RT) inhibitors still represent the majority of the clinically used anti-HIV drugs and constitute the main backbon...

journal_title：Current drug metabolism

authors： Locatelli GA,Cancio R,Spadari S,Maga G

更新日期：2004-08-01 00:00:00

abstract：:The combined treatment with anticonvulsant and antidepressant drugs is reported in both neurologic and psychiatric practice; it is, therefore, evident that the issue of managing such type of polytherapy is frequently encountered by clinicians. To review current literature on pharmacokinetic interactions between antico...

journal_title：Current drug metabolism

authors： Mula M

更新日期：2008-10-01 00:00:00

abstract：:The in vivo hepatic clearance of tanshinone IIA in the rat was predicted using microsome, cytosol and S9 fractions combined with two different cofactor systems, NADPH-regenerating and UDPGA system. Two different models, the well stirred model and the parallel-tube model, were used in predicting the in vivo clearance i...

journal_title：Current drug metabolism

authors： Li P,Wang GJ,Li J,Zhang Q,Liu X,Khlentzos A,Roberts MS

更新日期：2008-01-01 00:00:00

abstract：:Diabetes is associated with an increase risk for cardiovascular disease (CVD). Recently, macrovascular complications of diabetes have been shown to start before the development of diabetes. Indeed, several clinical studies have confirmed the increased risk of CVD in patients with impaired glucose tolerance (IGT). Sinc...

journal_title：Current drug metabolism

authors： Yamagishi S,Matsui T,Ueda S,Fukami K,Okuda S

更新日期：2009-02-01 00:00:00

abstract：:Transplantation has become an established and successful therapy. Rejections and infections are the principal immune-related complications in the post-transplant course. A reliable and early diagnosis is necessary to prevent graft failure and patient morbidity. Despite the immunologic nature of these complications the...

journal_title：Current drug metabolism

authors： Grebe SO,Mueller TF

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:Clinical studies during pregnancy are rare due to ethical and practical limitations. Giving pregnant females the same dosing regimen used in adult males or nonpregnant females is inappropriate. Pregnancy physiologically-based pharmacokinetic modeling is a powerful tool that can be used to refine pharmacother...

journal_title：Current drug metabolism

authors： Alsmadi MM,Idkaidek N

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Wound healing is a composite and vital process in which devitalized tissue layers and cellular structures repair themselves. Bronchiolitis is generally prompted by respiratory syncytial virus or human metapneumovirus; this condition is an acute inflammatory injury of bronchioles. Heart problems that develop ...

journal_title：Current drug metabolism

authors： AlMatar M,Batool T,Makky EA

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:Induction or inhibition of cytochrome P450 (CYP) enzyme activities, enzymes that activate or detoxify xenobiotics, is one mechanism by which vegetables may alter cancer risk. As the effect of food on CYP enzyme activities have not been studied in the Jordanian population, we examined the effect of supplement...

journal_title：Current drug metabolism

authors： Hakooz N,Hamdan I

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The management of ischemic nephropathy due to atherosclerotic renal artery stenosis has become increasingly conservative in the modern era, with current guidelines recommending optimized medical therapy as the initial step. The doubts raised by the recently published trials of revascularization strategies ha...

journal_title：Current drug metabolism

authors： Rivoli L,Di Mario F,Coppolino G,Gigante A,Barbano B,Farrah TE,Rosato E,Fuiano G,Cianci R

更新日期：2016-01-01 00:00:00