Abstract:
:A number of prospective cohort studies are ongoing worldwide to investigate the impact of foetal and neonatal exposures to chemical substances on child health. To assess multiple exposure (mixture) effects and low prevalence health outcomes it is useful to pool data from several studies and conduct mega-data-analysis. To discuss a path towards data harmonization, representatives from several large-scale birth cohort studies and a biomonitoring programme formed a collaborative group, the Environment and Child Health International Birth Cohort Group (ECHIBCG). In this study, an intra-laboratory trial was performed to harmonize existing blood lead measurements within the groups' studies. Then, decentralized analyses were conducted in individual countries' laboratories to evaluate blood lead levels (BLL) in each study. The measurements of pooled BLL samples in French, German and three Japanese laboratories resulted in an overall mean blood lead concentration of 8.66 μg l-1 (95% confidence interval: 8.59-8.72 μg l-1) with 3.0% relative standard deviation. Except for China's samples, BLL from each study were comparable with mean concentrations below or close to 10 μg l-1. The decentralized multivariate analyses revealed that all models had coefficients of determination below 0.1. Determinants of BLL were current smoking, age >35 years and overweight or obese status. The three variables were associated with an increase in BLL in each of the five studies, most strongly in France by almost 80% and the weakest effect being in Norway with only 15%; for Japan, with the far largest sample (~18,000), the difference was 36%. This study successfully demonstrated that the laboratory analytical methods were sufficiently similar to allow direct comparison of data and showed that it is possible to harmonize the epidemiological data for joint analysis. This exercise showed the challenges in decentralized data analyses and reinforces the need for data harmonization among studies.
journal_name
Int J Hyg Environ Healthauthors
Nakayama SF,Espina C,Kamijima M,Magnus P,Charles MA,Zhang J,Wolz B,Conrad A,Murawski A,Iwai-Shimada M,Zaros C,Caspersen IH,Kolossa-Gehring M,Meltzer HM,Olsen SF,Etzel RA,Schüz Jdoi
10.1016/j.ijheh.2019.07.005subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1059-1067issue
8eissn
1438-4639issn
1618-131Xpii
S1438-4639(19)30314-1journal_volume
222pub_type
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