Abstract：
:Epithelia act as a barrier to the external environment. The extracellular environment constantly changes, and the epithelia are required to regulate their function in accordance with the changes in the environment. It has been reported that a difference of the environment between the apical and basal sides of epithelia such as osmolality and hydrostatic pressure affects various epithelial functions including transepithelial transport, cytoskeleton, and cell proliferation. In this paper, we review the regulation of epithelial functions by the gradients of osmolality and hydrostatic pressure. We also examine the significance of this regulation in pathological conditions especially focusing on the role of the hydrostatic pressure gradient in the pathogenesis of carcinomas. Furthermore, we discuss the mechanism by which epithelia sense the osmotic and hydrostatic pressure gradients and the possible role of the tight junction as a sensor of the extracellular environment to regulate epithelial functions.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Tokuda S,Yu ASLdoi
10.3390/ijms20143513subject
Has Abstractpub_date
2019-07-17 00:00:00issue
14issn
1422-0067pii
ijms20143513journal_volume
20pub_type
杂志文章,评审abstract：:Metallothioneins (MTs) are a family of metal-binding proteins virtually expressed in all organisms including prokaryotes, lower eukaryotes, invertebrates and mammals. These proteins regulate homeostasis of zinc (Zn) and copper (Cu), mitigate heavy metal poisoning, and alleviate superoxide stress. In recent years, MTs ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18102197
更新日期：2017-10-23 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-07-07 00:00:00
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更新日期：2018-02-08 00:00:00
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abstract：:We have been made aware that text, figures and experimental data reported in the title paper [1] are duplicated in another publication by Zihan Xu et al. [2].[...]. ...
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pub_type： 杂志文章,撤回出版物
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doi：10.3390/ijms150915377
更新日期：2014-09-01 00:00:00
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journal_title：International journal of molecular sciences
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pub_type： 杂志文章,评审
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更新日期：2020-09-18 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-08-02 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2015-07-22 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-12-05 00:00:00
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更新日期：2018-09-03 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-03-14 00:00:00
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更新日期：2015-07-29 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-08-13 00:00:00
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更新日期：2019-02-15 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2020-08-15 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184565
更新日期：2019-09-14 00:00:00
