Abstract：
:Epithelia act as a barrier to the external environment. The extracellular environment constantly changes, and the epithelia are required to regulate their function in accordance with the changes in the environment. It has been reported that a difference of the environment between the apical and basal sides of epithelia such as osmolality and hydrostatic pressure affects various epithelial functions including transepithelial transport, cytoskeleton, and cell proliferation. In this paper, we review the regulation of epithelial functions by the gradients of osmolality and hydrostatic pressure. We also examine the significance of this regulation in pathological conditions especially focusing on the role of the hydrostatic pressure gradient in the pathogenesis of carcinomas. Furthermore, we discuss the mechanism by which epithelia sense the osmotic and hydrostatic pressure gradients and the possible role of the tight junction as a sensor of the extracellular environment to regulate epithelial functions.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Tokuda S,Yu ASLdoi
10.3390/ijms20143513subject
Has Abstractpub_date
2019-07-17 00:00:00issue
14issn
1422-0067pii
ijms20143513journal_volume
20pub_type
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